Efonidipine hydrochlorideProduct ingredient for Efonidipine
- Name
- Efonidipine hydrochloride
- Drug Entry
- Efonidipine
Efonidipine is a calcium channel blocker of the dihydropyridine class, commercialized by Shionogi & Co. (Japan). Initially, it was marketed in 1995 under the trade name, Landel. The drug has been shown to block T-type in addition to L-type calcium channels 1,2. It has also been studied in atherosclerosis and acute renal failure 2. This drug is also known as NZ-105, and several studies have been done on its pharmacokinetics in animals 13.
- Accession Number
- DBSALT001268
- Structure
- Synonyms
- Efonidipine HCl
- UNII
- 3BR983K69O
- CAS Number
- 111011-53-1
- Weight
- Average: 668.12
Monoisotopic: 667.2214153 - Chemical Formula
- C34H39ClN3O7P
- InChI Key
- OXVTXPCIJDYQIS-UHFFFAOYSA-N
- InChI
- InChI=1S/C34H38N3O7P.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;1H
- IUPAC Name
- 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate hydrochloride
- SMILES
- Cl.CC1=C(C(C2=CC=CC(=C2)[N+]([O-])=O)C(=C(C)N1)P1(=O)OCC(C)(C)CO1)C(=O)OCCN(CC1=CC=CC=C1)C1=CC=CC=C1
- External Links
- ChemSpider
- 106462
- Predicted Properties
Property Value Source Water Solubility 0.000248 mg/mL ALOGPS logP 5.35 ALOGPS logP 5.44 Chemaxon logS -6.4 ALOGPS pKa (Strongest Acidic) 19.49 Chemaxon pKa (Strongest Basic) 2.33 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 120.24 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 175.4 m3·mol-1 Chemaxon Polarizability 64.89 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon