Choline fenofibrateProduct ingredient for Fenofibric acid
- Name
- Choline fenofibrate
- Drug Entry
- Fenofibric acid
Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.1,5 Due to its high hydrophilicity and poor absorption profile,1 prodrug ,fenofibrate, and other conjugated compounds of fenofibric acid, such as choline fenofibrate, have been developed for improved solubility, gastrointestinal absorption, and bioavailability, and more convenient administration.1,3
- Accession Number
- DBSALT001885
- Structure
Structure for Choline fenofibrate (DBSALT001885)
- Synonyms
- Fenofibric acid choline salt
- External IDs
- ABT-335
- UNII
- 4BMH7IZT98
- CAS Number
- 856676-23-8
- Weight
- Average: 421.92
Monoisotopic: 421.1656007 - Chemical Formula
- C22H28ClNO5
- InChI Key
- JWAZHODZSADEHB-UHFFFAOYSA-M
- InChI
- InChI=1S/C17H15ClO4.C5H14NO/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11;1-6(2,3)4-5-7/h3-10H,1-2H3,(H,20,21);7H,4-5H2,1-3H3/q;+1/p-1
- IUPAC Name
- (2-hydroxyethyl)trimethylazanium 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
- SMILES
- C[N+](C)(C)CCO.CC(C)(OC1=CC=C(C=C1)C(=O)C1=CC=C(Cl)C=C1)C([O-])=O
- External Links
- ChemSpider
- 9525637
- ChEMBL
- CHEMBL1201745
- Predicted Properties
Property Value Source Water Solubility 0.000678 mg/mL ALOGPS logP 0.76 ALOGPS logP 4.36 Chemaxon logS -5.8 ALOGPS pKa (Strongest Acidic) 3.1 Chemaxon pKa (Strongest Basic) -4.9 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 66.43 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 94.03 m3·mol-1 Chemaxon Polarizability 31.94 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon