Filanesib HydrochlorideProduct ingredient for Filanesib
- Name
- Filanesib Hydrochloride
- Drug Entry
- Filanesib
Filanesib is a potent Kinesin Spindle Protein (KSP) inhibitor that caused marked tumor regression in preclinical models of human solid tumors and human leukemias, often leading to durable responses.
- Accession Number
- DBSALT001990
- Structure
Structure for Filanesib Hydrochloride (DBSALT001990)
- Synonyms
- Not Available
- UNII
- N98S79PF2I
- CAS Number
- 1385020-40-5
- Weight
- Average: 456.94
Monoisotopic: 456.1198312 - Chemical Formula
- C20H23ClF2N4O2S
- InChI Key
- CTAIFVHCDONNPS-BDQAORGHSA-N
- InChI
- InChI=1S/C20H22F2N4O2S.ClH/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22;/h3-5,7-10,13H,6,11-12,23H2,1-2H3;1H/t20-;/m0./s1
- IUPAC Name
- (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-2,3-dihydro-1,3,4-thiadiazole-3-carboxamide hydrochloride
- SMILES
- Cl.CON(C)C(=O)N1N=C(S[C@@]1(CCCN)C1=CC=CC=C1)C1=CC(F)=CC=C1F
- External Links
- ChemSpider
- 32700506
- ChEMBL
- CHEMBL3544920
- Predicted Properties
Property Value Source Water Solubility 0.0045 mg/mL ALOGPS logP 3.31 ALOGPS logP 4.08 Chemaxon logS -5 ALOGPS pKa (Strongest Basic) 9.9 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 71.16 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 109.66 m3·mol-1 Chemaxon Polarizability 42.09 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon