Nomifensine maleateProduct ingredient for Nomifensine
- Name
- Nomifensine maleate
- Drug Entry
- Nomifensine
Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA published a notice of its determination that Merital capsules were removed from the market for safety reasons (see the Federal Register of June 17, 1986 (51 FR 21981)). Approval of the NDA for Merital capsules was withdrawn on March 20, 1992 (see the Federal Register of March 20, 1992 (57 FR 9729)). Also withdrawn from the Canadian and UK markets.
- Accession Number
- DBSALT002854
- Structure
- Synonyms
- (+-)-Nomifensine hydrogen maleate / Nomifensine hydrogen maleate / Nomifensine maleate
- External IDs
- HOE 984
- UNII
- 76S8CUH5MR
- CAS Number
- 32795-47-4
- Weight
- Average: 354.406
Monoisotopic: 354.157957196 - Chemical Formula
- C20H22N2O4
- InChI Key
- GEOCVSMCLVIOEV-BTJKTKAUSA-N
- InChI
- InChI=1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
- IUPAC Name
- (2Z)-but-2-enedioic acid; 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine
- SMILES
- OC(=O)\C=C/C(O)=O.CN1CC(C2=CC=CC=C2)C2=C(C1)C(N)=CC=C2
- External Links
- ChemSpider
- 4513974
- ChEMBL
- CHEMBL1256842
- Predicted Properties
Property Value Source Water Solubility 0.318 mg/mL ALOGPS logP 2.94 ALOGPS logP 2.62 Chemaxon logS -2.9 ALOGPS pKa (Strongest Basic) 8.8 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 29.26 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 77.18 m3·mol-1 Chemaxon Polarizability 27.53 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon