Furosemide sodiumProduct ingredient for Furosemide

Name
Furosemide sodium
Drug Entry
Furosemide

Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative.9 Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure.10 It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients.1 The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.9

Accession Number
DBSALT003113
Structure
Synonyms
Sodium furosemide
External IDs
255-526-5
UNII
101EM454S7
CAS Number
41733-55-5
Weight
Average: 352.72
Monoisotopic: 351.9896646
Chemical Formula
C12H10ClN2NaO5S
InChI Key
DLFCAVBMDSKMEY-UHFFFAOYSA-M
InChI
InChI=1S/C12H11ClN2O5S.Na/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19;/h1-5,15H,6H2,(H,16,17)(H2,14,18,19);/q;+1/p-1
IUPAC Name
sodium 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoate
SMILES
[Na+].NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C([O-])=O
ChemSpider
142662
Predicted Properties
PropertyValueSource
Water Solubility0.0978 mg/mLALOGPS
logP2.32ALOGPS
logP1.75Chemaxon
logS-3.6ALOGPS
pKa (Strongest Acidic)4.25Chemaxon
pKa (Strongest Basic)-1.5Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area125.46 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity88.31 m3·mol-1Chemaxon
Polarizability28.96 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon