Furosemide sodiumProduct ingredient for Furosemide
- Name
- Furosemide sodium
- Drug Entry
- Furosemide
Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative.9 Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure.10 It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients.1 The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.9
- Accession Number
- DBSALT003113
- Structure
- Synonyms
- Sodium furosemide
- External IDs
- 255-526-5
- UNII
- 101EM454S7
- CAS Number
- 41733-55-5
- Weight
- Average: 352.72
Monoisotopic: 351.9896646 - Chemical Formula
- C12H10ClN2NaO5S
- InChI Key
- DLFCAVBMDSKMEY-UHFFFAOYSA-M
- InChI
- InChI=1S/C12H11ClN2O5S.Na/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19;/h1-5,15H,6H2,(H,16,17)(H2,14,18,19);/q;+1/p-1
- IUPAC Name
- sodium 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoate
- SMILES
- [Na+].NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C([O-])=O
- External Links
- ChemSpider
- 142662
- Predicted Properties
Property Value Source Water Solubility 0.0978 mg/mL ALOGPS logP 2.32 ALOGPS logP 1.75 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 4.25 Chemaxon pKa (Strongest Basic) -1.5 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 125.46 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 88.31 m3·mol-1 Chemaxon Polarizability 28.96 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon