Amcipatricin diascorbateProduct ingredient for Amcipatricin

Name

Amcipatricin diascorbate

Drug Entry

Amcipatricin

Amcipatricin has been used in trials studying the treatment of Cryptococcosis or Aspergillosis Infections. Amcipatricin (as amcipatricin diascorbate; SPK-843) is a water-soluble partricin derivative patented by SPA Societa Prodotti Antibiotici S.p.A. and developed by Aparts and Kaken for the potential treatment of systemic fungal infections. In preclinical models, SPK-843 shows in vitro inhibitory activity comparable to or better than that of Amphotericin B against Candida spp., Cryptococcus neoformans, and Aspergillus spp. SPK-843 exhibits dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibit no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) and liposomal amphotericin B.

See full entry for Amcipatricin

Accession Number

DBSALT003177

Structure

Similar Structures

Synonyms

Not Available

External IDs

SPA S 843 / SPA-S-843 / SPK 843 / SPK-843 / SPK843

UNII

7T591796IJ

CAS Number

202748-83-2

Weight

Average: 1810.949
Monoisotopic: 1809.820990049

Chemical Formula

C₈₅H₁₂₇N₅O₃₇

InChI Key

VUJFLULIGNDMNL-VJVWVGQESA-N

InChI

InChI=1S/C67H103N5O19.2C6H8O6/c1-42-21-19-17-15-13-11-9-10-12-14-16-18-20-22-54(89-66-63(85)61(62(84)44(3)88-66)70-58(82)41-72(7)8)38-57-60(65(86)69-29-30-71(5)6)56(81)40-67(87,91-57)39-53(79)35-51(77)33-49(75)31-48(74)32-50(76)34-52(78)37-59(83)90-64(42)43(2)23-28-47(73)36-55(80)45-24-26-46(68-4)27-25-45;2*7-1-2(8)5-3(9)4(10)6(11)12-5/h9-22,24-27,42-44,47-49,51-54,56-57,60-64,66,68,73-75,77-79,81,84-85,87H,23,28-41H2,1-8H3,(H,69,86)(H,70,82);2*2,5,7-10H,1H2/b10-9+,13-11+,14-12+,17-15+,18-16+,21-19+,22-20+;;/t42-,43-,44+,47?,48+,49-,51-,52+,53-,54-,56-,57-,60+,61-,62+,63-,64-,66-,67+;2*2-,5+/m000/s1

IUPAC Name

SMILES

[H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO.[H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO.[H][C@]12C[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O)[C@H](NC(=O)CN(C)C)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@]([H])(OC(=O)C[C@H](O)CC(=O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(=O)NCCN(C)C)O2)[C@@H](C)CCC(O)CC(=O)C1=CC=C(NC)C=C1

External Links

ChemSpider: 34987434

Predicted Properties

Property	Value	Source
Water Solubility	0.0554 mg/mL	ALOGPS
logP	1.97	ALOGPS
logS	-4.4	ALOGPS
Rule of Five	No	Chemaxon
Ghose Filter	No	Chemaxon

Amcipatricin diascorbateProduct ingredient for Amcipatricin

Structure for Amcipatricin diascorbate (DBSALT003177)