Eltrombopag cholineProduct ingredient for Eltrombopag
- Name
- Eltrombopag choline
- Drug Entry
- Eltrombopag
Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
- Accession Number
- DBSALT003495
- Structure
Structure for Eltrombopag choline (DBSALT003495)
- Synonyms
- Not Available
- UNII
- F9G8XE24IB
- CAS Number
- 2336813-25-1
- Weight
- Average: 545.64
Monoisotopic: 545.263819247 - Chemical Formula
- C30H35N5O5
- InChI Key
- XSHFVAAXJHNDKZ-OUFJFOJPSA-M
- InChI
- InChI=1S/C25H22N4O4.C5H14NO/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33;1-6(2,3)4-5-7/h4-13,26,30H,1-3H3,(H,32,33);7H,4-5H2,1-3H3/q;+1/p-1/b27-22-;
- IUPAC Name
- (2-hydroxyethyl)trimethylazanium 3'-{2-[(4Z)-1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
- SMILES
- C[N+](C)(C)CCO.CC1=NN(C(=O)\C1=N/NC1=C(O)C(=CC=C1)C1=CC(=CC=C1)C([O-])=O)C1=CC=C(C)C(C)=C1
- External Links
- Wikipedia
- Eltrombopag
- Predicted Properties
Property Value Source logP 6.03 Chemaxon pKa (Strongest Acidic) 3.97 Chemaxon pKa (Strongest Basic) -0.69 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 117.42 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 137.32 m3·mol-1 Chemaxon Polarizability 47.22 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon