The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NMDA-phencyclidine receptor complex.
Article Details
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Stirling JM, Cross AJ, Green AR
The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NMDA-phencyclidine receptor complex.
Neuropharmacology. 1989 Jan;28(1):1-7.
- PubMed ID
- 2538766 [ View in PubMed]
- Abstract
The high affinity binding of the phencyclidine derivative [3H]TCP to cortical membranes of the rat was investigated. In an extensively washed membrane preparation the binding of [3H]TCP was enhanced in the presence of L-glutamate and NMDA. The stimulation of the binding of [3H]TCP by L-glutamate was inhibited competitively by AP5 and non-competitively by MK801. The binding of [3H]TCP was also enhanced in the presence of glycine; this effect was insensitive to strychnine and inhibited non-competitively by AP5. Saturation experiments demonstrated that MK801 was a competitive inhibitor of the binding of [3H]TCP. These results suggest that [3H]TCP binds to a site similar to that which binds MK801; this site may be associated with the ion channel of the NMDA receptor.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tenocyclidine Glutamate receptor ionotropic, NMDA 2A Protein Humans YesAntagonistDetails Tenocyclidine Glutamate receptor ionotropic, NMDA 2B Protein Humans YesAntagonistDetails Tenocyclidine Glutamate receptor ionotropic, NMDA 2C Protein Humans YesAntagonistDetails Tenocyclidine Glutamate receptor ionotropic, NMDA 2D Protein Humans UnknownAntagonistDetails Tenocyclidine Glutamate receptor ionotropic, NMDA 3A Protein Humans YesAntagonistDetails Tenocyclidine Glutamate receptor ionotropic, NMDA 3B Protein Humans YesAntagonistDetails