Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein.
Article Details
- CitationCopy to clipboard
Ferry DG, Caplan NB, Cubeddu LX
Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein.
J Pharm Sci. 1986 Feb;75(2):146-9. doi: 10.1002/jps.2600750208.
- PubMed ID
- 2870173 [ View in PubMed]
- Abstract
alpha 1-Receptor antagonists and antidepressant agents are basic (cationic) drugs that are known to bind to alpha 1-acid glycoprotein (AAG). Since these drugs are frequently co-administered and since they bind to the same protein, this investigation was designed to evaluate the "in vitro" ability of antidepressants, alpha 1-receptor antagonists, and propranolol to displace [3H]imipramine and [3H]prazosin from the AAG binding site(s). Equilibrium dialysis was employed. Of the drugs studied, the following order of potency in displacing [3H]prazosin was found: trazodone greater than prazosin greater than doxazosin greater than propranolol greater than doxepin = amoxapine = trimazosin = amitriptyline greater than imipramine greater than nortriptyline = desipramine = nomifensine greater than bupropion = maprotiline. [3H]lmipramine binding from AAG was displaced with the following potency order: prazosin greater than imipramine greater than propranolol greater than doxazosin greater than nortriptyline greater than desipramine greater than trimazosin. Tricyclic antidepressants produced similar degrees of displacement of both [3H]imipramine and [3H]prazosin from AAG; whereas, alpha 1-receptor antagonists were more effective displacers of [3H]prazosin than of [3H]imipramine. Furthermore, the demethylated metabolites of imipramine and amitriptyline were less potent displacers than their parent compounds. These results suggest that more than a single binding site may be available for binding to AAG and that hydrophobic bonding is important in the binding of drugs to AAG.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Nortriptyline Alpha-1A adrenergic receptor Protein Humans NoAntagonistDetails - Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Amitriptyline Alpha-1-acid glycoprotein 1 Protein Humans NoBinderDetails Amoxapine Alpha-1-acid glycoprotein 1 Protein Humans NoNot Available Details Bupropion Alpha-1-acid glycoprotein 1 Protein Humans NoAntagonistDetails Desipramine Alpha-1-acid glycoprotein 1 Protein Humans NoNot Available Details Imipramine Alpha-1-acid glycoprotein 1 Protein Humans NoNot Available Details Maprotiline Alpha-1-acid glycoprotein 1 Protein Humans NoNot Available Details Nomifensine Alpha-1-acid glycoprotein 1 Protein Humans NoNot Available Details Nortriptyline Alpha-1-acid glycoprotein 1 Protein Humans NoBinderDetails Prazosin Alpha-1-acid glycoprotein 1 Protein Humans NoSubstrateDetails Propranolol Alpha-1-acid glycoprotein 1 Protein Humans NoNot Available Details - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareBromocriptineProtriptyline Protriptyline may increase the vasopressor activities of Bromocriptine. BromocriptineAmineptine Amineptine may increase the vasopressor activities of Bromocriptine. BromocriptineDimetacrine Dimetacrine may increase the vasopressor activities of Bromocriptine. BromocriptineButriptyline Butriptyline may increase the vasopressor activities of Bromocriptine. BromocriptineDosulepin Dosulepin may increase the vasopressor activities of Bromocriptine.