Identification

Name
Propranolol
Accession Number
DB00571  (APRD00194)
Type
Small Molecule
Groups
Approved, Investigational
Description

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. [PubChem]

Structure
Thumb
Synonyms
  • 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
  • 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
  • beta-Propranolol
  • Propanalol
  • Propanolol
  • Propranolol
  • Propranololo
  • Propranololum
  • β-Propranolol
Product Ingredients
IngredientUNIICASInChI Key
Propranolol HydrochlorideF8A3652H1V318-98-9ZMRUPTIKESYGQW-UHFFFAOYSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Propranolol Tab 10mgTablet10 mgOralApotex Corporation1980-12-31Not applicableCanada
Apo Propranolol Tab 120mgTablet120 mgOralApotex Corporation1981-12-31Not applicableCanada
Apo Propranolol Tab 40mgTablet40 mgOralApotex Corporation1980-12-31Not applicableCanada
Apo Propranolol Tab 80mgTablet80 mgOralApotex Corporation1980-12-31Not applicableCanada
Detensol Tab 10mgTablet10 mgOralDesbergers LtÉe, Division Of Technilab Inc.1980-12-311999-09-17Canada
Detensol Tab 120mgTablet120 mgOralDesbergers LtÉe, Division Of Technilab Inc.1981-12-311999-09-17Canada
Detensol Tab 40mgTablet40 mgOralDesbergers LtÉe, Division Of Technilab Inc.1980-12-311999-09-17Canada
Detensol Tab 80mgTablet80 mgOralDesbergers LtÉe, Division Of Technilab Inc.1980-12-311999-09-17Canada
HemangeolSolution4.28 mg/mLOralPierre Fabre Laboratories2014-04-14Not applicableUs
HemangiolSolution3.75 mgOralPierre Fabre Dermo Cosmetique Usa, Inc.2017-03-23Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-propranolol Tab 20mgTablet20 mgOralApotex Corporation1986-12-31Not applicableCanada
Dom-propranolol TabletsTablet10 mgOralDominion Pharmacal1996-12-312016-10-25Canada
Dom-propranolol TabletsTablet40 mgOralDominion Pharmacal1996-12-312016-10-25Canada
Dom-propranolol Tablets - 80mgTablet80 mgOralDominion Pharmacal1996-12-312016-10-25Canada
Novo-pranol Tab 120mgTablet120 mgOralNovopharm Limited1982-12-312005-08-10Canada
Nu-propranolol Tab 10mgTablet10 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nu-propranolol Tab 120mgTablet120 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nu-propranolol Tab 20mgTablet20 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nu-propranolol Tab 40mgTablet40 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nu-propranolol Tab 80mgTablet80 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Inderide-40 TabPropranolol Hydrochloride (40 mg) + Hydrochlorothiazide (25 mg)TabletOralWyeth Ayerst Canada Inc.1993-12-312001-06-05Canada
Inderide-80 TabPropranolol Hydrochloride (80 mg) + Hydrochlorothiazide (25 mg)TabletOralWyeth Ayerst Canada Inc.1993-12-312001-05-22Canada
Propranolol Hydrochloride and HydrochlorothiazidePropranolol Hydrochloride (80 mg/1) + Hydrochlorothiazide (25 mg/1)TabletOralMylan Pharmaceuticals1987-04-01Not applicableUs
Propranolol Hydrochloride and HydrochlorothiazidePropranolol Hydrochloride (40 mg/1) + Hydrochlorothiazide (25 mg/1)TabletOralMylan Pharmaceuticals1987-03-04Not applicableUs00378 0731 01 nlmimage10 b60e5b62
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Propranolol ScopolaminePropranolol Hydrochloride (20 mg/20.25mg) + Scopolamine (.25 mg/20.25mg)TabletOralTPS2014-10-01Not applicableUs
Propranolol ScopolaminePropranolol Hydrochloride (40 mg/40.5mg) + Scopolamine (.5 mg/40.5mg)TabletOralTPS2014-10-01Not applicableUs
International/Other Brands
Angilol / Bedranol SR / Cardinol / Ciplar / Deralin / Dociton / Duranol / Inderal / Indobloc / INNOPRAN / Prophylux / Sumial
Categories
UNII
9Y8NXQ24VQ
CAS number
525-66-6
Weight
Average: 259.3434
Monoisotopic: 259.157228921
Chemical Formula
C16H21NO2
InChI Key
AQHHHDLHHXJYJD-UHFFFAOYSA-N
InChI
InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
IUPAC Name
1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol
SMILES
CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12

Pharmacology

Indication

For the prophylaxis of migraine.

Associated Conditions
Pharmacodynamics

Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.

Mechanism of action

Propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.

TargetActionsOrganism
ABeta-1 adrenergic receptor
antagonist
Human
UBeta-2 adrenergic receptor
antagonist
Human
UBeta-3 adrenergic receptor
antagonist
Human
U5-hydroxytryptamine receptor 1A
other/unknown
Human
U5-hydroxytryptamine receptor 1B
other/unknown
Human
Absorption

Propranolol is almost completely absorbed from the GI tract; however, plasma concentrations attained are quite variable among individuals.

Volume of distribution
  • 4 L
Protein binding

More than 90%

Metabolism

Hepatic

Route of elimination

Propranolol is extensively metabolized with most metabolites appearing in the urine.

Half life

4 hours

Clearance
Not Available
Toxicity

Symptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm. LD50=565 mg/kg (orally in mice).

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Propranolol Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
1,10-Phenanthroline1,10-Phenanthroline may increase the bradycardic activities of Propranolol.Experimental
3-isobutyl-1-methyl-7H-xanthineThe risk or severity of adverse effects can be increased when Propranolol is combined with 3-isobutyl-1-methyl-7H-xanthine.Experimental
4-MethoxyamphetamineThe therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Propranolol.Experimental, Illicit
6-O-benzylguanineThe risk or severity of adverse effects can be increased when Propranolol is combined with 6-O-benzylguanine.Investigational
7-DeazaguanineThe risk or severity of adverse effects can be increased when Propranolol is combined with 7-Deazaguanine.Experimental
7,9-DimethylguanineThe risk or severity of adverse effects can be increased when Propranolol is combined with 7,9-Dimethylguanine.Experimental
8-azaguanineThe risk or severity of adverse effects can be increased when Propranolol is combined with 8-azaguanine.Experimental
8-chlorotheophyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with 8-chlorotheophylline.Approved
9-DeazaguanineThe risk or severity of adverse effects can be increased when Propranolol is combined with 9-Deazaguanine.Experimental
9-MethylguanineThe risk or severity of adverse effects can be increased when Propranolol is combined with 9-Methylguanine.Experimental
AbediterolPropranolol may decrease the bronchodilatory activities of Abediterol.Investigational
AbemaciclibThe serum concentration of Propranolol can be increased when it is combined with Abemaciclib.Approved, Investigational
AbirateroneThe serum concentration of Propranolol can be increased when it is combined with Abiraterone.Approved
AcebutololAcebutolol may increase the hypotensive activities of Propranolol.Approved, Investigational
AceclofenacAceclofenac may decrease the antihypertensive activities of Propranolol.Approved, Investigational
AcefyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Acefylline.Experimental
AcemetacinAcemetacin may decrease the antihypertensive activities of Propranolol.Approved, Experimental, Investigational
AcepromazineThe serum concentration of Propranolol can be increased when it is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe serum concentration of Propranolol can be increased when it is combined with Aceprometazine.Approved
AcetaminophenThe serum concentration of Propranolol can be increased when it is combined with Acetaminophen.Approved
AcetohexamidePropranolol may increase the hypoglycemic activities of Acetohexamide.Approved, Investigational, Withdrawn
AcetophenazineThe serum concentration of Propranolol can be increased when it is combined with Acetophenazine.Approved
AcetylcholineThe risk or severity of adverse effects can be increased when Propranolol is combined with Acetylcholine.Approved
AcetyldigitoxinPropranolol may increase the bradycardic activities of Acetyldigitoxin.Approved
AcetyldigoxinPropranolol may increase the bradycardic activities of Acetyldigoxin.Experimental
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Propranolol.Approved, Vet Approved
AcyclovirThe risk or severity of adverse effects can be increased when Propranolol is combined with Acyclovir.Approved
AdrafinilThe therapeutic efficacy of Adrafinil can be decreased when used in combination with Propranolol.Withdrawn
AfatinibThe serum concentration of Propranolol can be increased when it is combined with Afatinib.Approved
AgmatineThe therapeutic efficacy of Agmatine can be decreased when used in combination with Propranolol.Experimental, Investigational
Agrostis gigantea pollenThe risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Propranolol.Approved
Agrostis stolonifera pollenThe risk of a hypersensitivity reaction to Agrostis stolonifera pollen is increased when it is combined with Propranolol.Approved
AlaproclateThe serum concentration of Propranolol can be increased when it is combined with Alaproclate.Experimental
AlbendazoleThe serum concentration of Propranolol can be increased when it is combined with Albendazole.Approved, Vet Approved
AlclofenacAlclofenac may decrease the antihypertensive activities of Propranolol.Approved, Withdrawn
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Propranolol.Approved
AlectinibThe serum concentration of Propranolol can be increased when it is combined with Alectinib.Approved, Investigational
AlfentanilAlfentanil may increase the bradycardic activities of Propranolol.Approved, Illicit
AlimemazineThe serum concentration of Propranolol can be increased when it is combined with Alimemazine.Approved, Vet Approved
AliskirenAliskiren may increase the hypotensive activities of Propranolol.Approved, Investigational
AlminoprofenAlminoprofen may decrease the antihypertensive activities of Propranolol.Experimental
AlosetronThe metabolism of Propranolol can be decreased when combined with Alosetron.Approved, Withdrawn
AlprenololPropranolol may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AmbenoniumAmbenonium may increase the bradycardic activities of Propranolol.Approved
AmbrisentanAmbrisentan may increase the hypotensive activities of Propranolol.Approved, Investigational
AmibegronThe therapeutic efficacy of Amibegron can be decreased when used in combination with Propranolol.Investigational
AmifostinePropranolol may increase the hypotensive activities of Amifostine.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Propranolol is combined with Amiloride.Approved
AminophenazoneAminophenazone may decrease the antihypertensive activities of Propranolol.Approved, Withdrawn
AmiodaroneThe therapeutic efficacy of Propranolol can be increased when used in combination with Amiodarone.Approved, Investigational
AmitrazThe therapeutic efficacy of Amitraz can be decreased when used in combination with Propranolol.Vet Approved
AmitriptylinePropranolol may increase the orthostatic hypotensive activities of Amitriptyline.Approved
AmlodipineThe serum concentration of Propranolol can be increased when it is combined with Amlodipine.Approved
AmobarbitalAmobarbital may increase the hypotensive activities of Propranolol.Approved, Illicit
AmodiaquineThe risk or severity of QTc prolongation can be decreased when Amodiaquine is combined with Propranolol.Approved, Investigational
AmoxapinePropranolol may increase the orthostatic hypotensive activities of Amoxapine.Approved
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Propranolol.Approved, Investigational
AmprenavirThe metabolism of Propranolol can be decreased when combined with Amprenavir.Approved, Investigational
AmsacrineThe serum concentration of Propranolol can be increased when it is combined with Amsacrine.Approved, Investigational
Amyl NitriteThe risk or severity of adverse effects can be increased when Propranolol is combined with Amyl Nitrite.Approved
AnisodamineThe therapeutic efficacy of Anisodamine can be decreased when used in combination with Propranolol.Investigational
AnnamycinThe serum concentration of Propranolol can be increased when it is combined with Annamycin.Investigational
Anthoxanthum odoratum pollenThe risk of a hypersensitivity reaction to Anthoxanthum odoratum pollen is increased when it is combined with Propranolol.Approved
AntipyrineAntipyrine may decrease the antihypertensive activities of Propranolol.Approved, Investigational
AntrafenineAntrafenine may decrease the antihypertensive activities of Propranolol.Approved
ApalutamideThe serum concentration of Propranolol can be decreased when it is combined with Apalutamide.Approved, Investigational
ApomorphineThe therapeutic efficacy of Apomorphine can be decreased when used in combination with Propranolol.Approved, Investigational
ApraclonidineThe therapeutic efficacy of Apraclonidine can be decreased when used in combination with Propranolol.Approved
AprepitantThe serum concentration of Propranolol can be increased when it is combined with Aprepitant.Approved, Investigational
ArbutaminePropranolol may decrease the bronchodilatory activities of Arbutamine.Approved
ArdeparinThe risk or severity of hyperkalemia can be increased when Ardeparin is combined with Propranolol.Approved, Investigational, Withdrawn
ArecolineThe risk or severity of adverse effects can be increased when Propranolol is combined with Arecoline.Experimental
ArformoterolPropranolol may decrease the bronchodilatory activities of Arformoterol.Approved, Investigational
Aripiprazole lauroxilPropranolol may increase the orthostatic hypotensive activities of Aripiprazole lauroxil.Approved, Investigational
ArotinololThe risk or severity of adverse effects can be increased when Arotinolol is combined with Propranolol.Investigational
Arrhenatherum elatius pollenThe risk of a hypersensitivity reaction to Arrhenatherum elatius pollen is increased when it is combined with Propranolol.Approved
Arsenic trioxideThe risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Propranolol.Approved, Investigational
AsenapinePropranolol may increase the orthostatic hypotensive activities of Asenapine.Approved
AstemizoleThe serum concentration of Propranolol can be increased when it is combined with Astemizole.Approved, Withdrawn
AsunaprevirThe metabolism of Propranolol can be decreased when combined with Asunaprevir.Approved, Investigational, Withdrawn
AtazanavirThe metabolism of Propranolol can be decreased when combined with Atazanavir.Approved, Investigational
AtenololAtenolol may increase the hypotensive activities of Propranolol.Approved
AtorvastatinThe serum concentration of Propranolol can be increased when it is combined with Atorvastatin.Approved
AvanafilAvanafil may increase the antihypertensive activities of Propranolol.Approved
AzapropazoneAzapropazone may decrease the antihypertensive activities of Propranolol.Withdrawn
AzathioprineThe risk or severity of adverse effects can be increased when Propranolol is combined with Azathioprine.Approved
AzelastineThe serum concentration of Propranolol can be increased when it is combined with Azelastine.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Propranolol is combined with Azilsartan medoxomil.Approved, Investigational
AzithromycinThe serum concentration of Propranolol can be increased when it is combined with Azithromycin.Approved
Bafilomycin A1The serum concentration of Propranolol can be increased when it is combined with Bafilomycin A1.Experimental
Bafilomycin B1The serum concentration of Propranolol can be increased when it is combined with Bafilomycin B1.Experimental
BalsalazideBalsalazide may decrease the antihypertensive activities of Propranolol.Approved, Investigational
BambuterolPropranolol may decrease the bronchodilatory activities of Bambuterol.Approved, Investigational
BamifyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Bamifylline.Experimental
BarbexacloneBarbexaclone may increase the hypotensive activities of Propranolol.Experimental
BarbitalBarbital may increase the hypotensive activities of Propranolol.Illicit
BarnidipinePropranolol may increase the antihypertensive activities of Barnidipine.Approved
BefunololThe therapeutic efficacy of Befunolol can be decreased when used in combination with Propranolol.Experimental
BemiparinThe risk or severity of hyperkalemia can be increased when Bemiparin is combined with Propranolol.Approved, Investigational
BenazeprilBenazepril may increase the hypotensive activities of Propranolol.Approved, Investigational
BenazeprilatBenazeprilat may increase the hypotensive activities of Propranolol.Experimental
BendazacBendazac may decrease the antihypertensive activities of Propranolol.Experimental
BendroflumethiazideBendroflumethiazide may increase the hypotensive activities of Propranolol.Approved
BenmoxinBenmoxin may increase the hypotensive activities of Propranolol.Withdrawn
BenorilateBenorilate may decrease the antihypertensive activities of Propranolol.Experimental
BenoxaprofenBenoxaprofen may decrease the antihypertensive activities of Propranolol.Withdrawn
BenzphetamineThe therapeutic efficacy of Benzphetamine can be decreased when used in combination with Propranolol.Approved, Illicit
BenzquinamideThe serum concentration of Propranolol can be increased when it is combined with Benzquinamide.Withdrawn
BenzydamineBenzydamine may decrease the antihypertensive activities of Propranolol.Approved
Benzyl alcoholThe serum concentration of Propranolol can be increased when it is combined with Benzyl alcohol.Approved
BepridilThe serum concentration of Propranolol can be increased when it is combined with Bepridil.Approved, Withdrawn
BeractantPropranolol may increase the bradycardic activities of Beractant.Approved
BetaxololBetaxolol may increase the hypotensive activities of Propranolol.Approved, Investigational
BethanecholThe risk or severity of adverse effects can be increased when Propranolol is combined with Bethanechol.Approved
BethanidineThe therapeutic efficacy of Bethanidine can be decreased when used in combination with Propranolol.Approved
BevantololPropranolol may increase the orthostatic hypotensive activities of Bevantolol.Approved
BicalutamideThe serum concentration of Propranolol can be increased when it is combined with Bicalutamide.Approved
BietaserpineBietaserpine may increase the hypotensive activities of Propranolol.Experimental
BimatoprostBimatoprost may increase the hypotensive activities of Propranolol.Approved, Investigational
Biricodar dicitrateThe serum concentration of Propranolol can be increased when it is combined with Biricodar dicitrate.Investigational
BisoprololBisoprolol may increase the hypotensive activities of Propranolol.Approved
BitolterolPropranolol may decrease the bronchodilatory activities of Bitolterol.Withdrawn
BL-1020The serum concentration of Propranolol can be increased when it is combined with BL-1020.Investigational
BoceprevirThe metabolism of Propranolol can be decreased when combined with Boceprevir.Approved, Withdrawn
BopindololThe risk or severity of hyperkalemia can be increased when Bopindolol is combined with Propranolol.Approved
BortezomibThe risk or severity of adverse effects can be increased when Bortezomib is combined with Propranolol.Approved, Investigational
BosentanThe serum concentration of Propranolol can be decreased when it is combined with Bosentan.Approved, Investigational
Bouteloua gracilis pollenThe risk of a hypersensitivity reaction to Bouteloua gracilis pollen is increased when it is combined with Propranolol.Approved
BQ-123BQ-123 may increase the hypotensive activities of Propranolol.Investigational
Brefeldin AThe serum concentration of Propranolol can be increased when it is combined with Brefeldin A.Experimental
BretyliumBretylium may increase the bradycardic activities of Propranolol.Approved
BrexpiprazolePropranolol may increase the orthostatic hypotensive activities of Brexpiprazole.Approved, Investigational
BrimonidineBrimonidine may increase the antihypertensive activities of Propranolol.Approved
BromfenacBromfenac may decrease the antihypertensive activities of Propranolol.Approved
BromocriptineThe therapeutic efficacy of Bromocriptine can be decreased when used in combination with Propranolol.Approved, Investigational
BromotheophyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Bromotheophylline.Approved
Bromus secalinus pollenThe risk of a hypersensitivity reaction to Bromus secalinus pollen is increased when it is combined with Propranolol.Approved
BucindololPropranolol may increase the orthostatic hypotensive activities of Bucindolol.Investigational
BufexamacBufexamac may decrease the antihypertensive activities of Propranolol.Approved, Experimental
BufuralolThe risk or severity of hyperkalemia can be increased when Propranolol is combined with Bufuralol.Experimental, Investigational
BufyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Bufylline.Experimental
BumadizoneBumadizone may decrease the antihypertensive activities of Propranolol.Experimental
BumetanideThe risk or severity of adverse effects can be increased when Propranolol is combined with Bumetanide.Approved
BunazosinPropranolol may increase the orthostatic hypotensive activities of Bunazosin.Investigational
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Propranolol.Approved, Investigational
BupranololPropranolol may increase the hypotensive activities of Bupranolol.Approved
BuprenorphineThe serum concentration of Propranolol can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Propranolol can be decreased when combined with Bupropion.Approved
BuspironeThe serum concentration of Propranolol can be increased when it is combined with Buspirone.Approved, Investigational
ButaperazineThe serum concentration of Propranolol can be increased when it is combined with Butaperazine.Experimental
CabazitaxelThe serum concentration of Propranolol can be increased when it is combined with Cabazitaxel.Approved
CabergolinePropranolol may increase the vasoconstricting activities of Cabergoline.Approved
CadralazineCadralazine may increase the hypotensive activities of Propranolol.Experimental
CafedrineThe risk or severity of adverse effects can be increased when Propranolol is combined with Cafedrine.Investigational
CaffeineThe risk or severity of adverse effects can be increased when Propranolol is combined with Caffeine.Approved
CalfactantPropranolol may increase the bradycardic activities of Calfactant.Approved
CanagliflozinThe serum concentration of Propranolol can be increased when it is combined with Canagliflozin.Approved
CandesartanCandesartan may increase the hypotensive activities of Propranolol.Experimental
Candesartan cilexetilCandesartan cilexetil may increase the hypotensive activities of Propranolol.Approved
CandoxatrilCandoxatril may increase the hypotensive activities of Propranolol.Experimental
CaptoprilThe serum concentration of Propranolol can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Propranolol can be increased when combined with Carbamazepine.Approved, Investigational
CarbamoylcholineThe risk or severity of adverse effects can be increased when Propranolol is combined with Carbamoylcholine.Approved
Carbaspirin calciumCarbaspirin calcium may decrease the antihypertensive activities of Propranolol.Experimental, Investigational
CarbetocinThe risk or severity of adverse effects can be increased when Carbetocin is combined with Propranolol.Approved, Investigational
CarbutamidePropranolol may increase the hypoglycemic activities of Carbutamide.Experimental
CaroxazoneCaroxazone may increase the hypotensive activities of Propranolol.Withdrawn
CarprofenCarprofen may decrease the antihypertensive activities of Propranolol.Approved, Vet Approved, Withdrawn
CarteololCarteolol may increase the hypotensive activities of Propranolol.Approved
CarvedilolPropranolol may increase the orthostatic hypotensive activities of Carvedilol.Approved, Investigational
CefoperazoneThe serum concentration of Propranolol can be increased when it is combined with Cefoperazone.Approved, Investigational
CeftriaxoneThe serum concentration of Propranolol can be increased when it is combined with Ceftriaxone.Approved
CelecoxibCelecoxib may decrease the antihypertensive activities of Propranolol.Approved, Investigational
CeliprololPropranolol may decrease the bronchodilatory activities of Celiprolol.Approved, Investigational
CeritinibPropranolol may increase the bradycardic activities of Ceritinib.Approved
CertoparinThe risk or severity of hyperkalemia can be increased when Certoparin is combined with Propranolol.Approved, Investigational
CevimelineThe risk or severity of adverse effects can be increased when Propranolol is combined with Cevimeline.Approved
ChloroformThe serum concentration of Propranolol can be increased when it is combined with Chloroform.Vet Approved
ChloroquineThe risk or severity of QTc prolongation can be decreased when Chloroquine is combined with Propranolol.Approved, Investigational, Vet Approved
ChlorothiazideChlorothiazide may increase the hypotensive activities of Propranolol.Approved, Vet Approved
ChlorproethazineThe serum concentration of Propranolol can be increased when it is combined with Chlorproethazine.Experimental
ChlorpromazineThe serum concentration of Propranolol can be increased when it is combined with Chlorpromazine.Approved, Investigational, Vet Approved
ChlorpropamidePropranolol may increase the hypoglycemic activities of Chlorpropamide.Approved, Investigational
ChlorprothixeneThe serum concentration of Propranolol can be increased when it is combined with Chlorprothixene.Approved, Investigational, Withdrawn
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Propranolol.Approved
CholecalciferolThe metabolism of Propranolol can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CholestyramineCholestyramine can cause a decrease in the absorption of Propranolol resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
CholineThe serum concentration of Choline can be increased when it is combined with Propranolol.Approved, Nutraceutical
Choline magnesium trisalicylateCholine magnesium trisalicylate may decrease the antihypertensive activities of Propranolol.Approved
Choline salicylateThe serum concentration of Choline salicylate can be increased when it is combined with Propranolol.Approved, Nutraceutical
CicletanineCicletanine may increase the hypotensive activities of Propranolol.Investigational
CilazaprilCilazapril may increase the hypotensive activities of Propranolol.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Cilnidipine is combined with Propranolol.Approved, Investigational
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Propranolol.Approved, Investigational
CimicoxibCimicoxib may decrease the antihypertensive activities of Propranolol.Investigational
CinacalcetThe metabolism of Propranolol can be decreased when combined with Cinacalcet.Approved
CiprofloxacinThe metabolism of Propranolol can be decreased when combined with Ciprofloxacin.Approved, Investigational
CirazolineThe therapeutic efficacy of Cirazoline can be decreased when used in combination with Propranolol.Experimental
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Propranolol.Approved
ClarithromycinThe metabolism of Propranolol can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Propranolol can be decreased when combined with Clemastine.Approved, Investigational
ClenbuterolPropranolol may decrease the bronchodilatory activities of Clenbuterol.Approved, Investigational, Vet Approved
ClevidipineThe risk or severity of adverse effects can be increased when Propranolol is combined with Clevidipine.Approved, Investigational
ClobazamThe metabolism of Propranolol can be decreased when combined with Clobazam.Approved, Illicit
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Propranolol.Approved, Investigational
ClofazimineThe serum concentration of Propranolol can be increased when it is combined with Clofazimine.Approved, Investigational
ClomipramineThe serum concentration of Propranolol can be increased when it is combined with Clomipramine.Approved, Investigational, Vet Approved
ClonidineThe therapeutic efficacy of Clonidine can be decreased when used in combination with Propranolol.Approved
ClonixinClonixin may decrease the antihypertensive activities of Propranolol.Approved
CloranololPropranolol may increase the hypotensive activities of Cloranolol.Experimental
ClotrimazoleThe metabolism of Propranolol can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapinePropranolol may increase the orthostatic hypotensive activities of Clozapine.Approved
CobicistatThe serum concentration of Propranolol can be increased when it is combined with Cobicistat.Approved
CocaineThe metabolism of Propranolol can be decreased when combined with Cocaine.Approved, Illicit
ColchicineThe serum concentration of Propranolol can be increased when it is combined with Colchicine.Approved
ColesevelamColesevelam can cause a decrease in the absorption of Propranolol resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Propranolol resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Concanamycin AThe serum concentration of Propranolol can be increased when it is combined with Concanamycin A.Experimental
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Propranolol.Approved, Investigational
CoumaphosCoumaphos may increase the bradycardic activities of Propranolol.Vet Approved
CrizotinibThe serum concentration of Propranolol can be increased when it is combined with Crizotinib.Approved
CryptenamineCryptenamine may increase the hypotensive activities of Propranolol.Approved
CurcuminThe metabolism of Propranolol can be decreased when combined with Curcumin.Approved, Investigational
CyamemazineThe serum concentration of Propranolol can be increased when it is combined with Cyamemazine.Approved
CyclopenthiazideCyclopenthiazide may increase the hypotensive activities of Propranolol.Experimental
CyclosporineThe serum concentration of Propranolol can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
CyclothiazideCyclothiazide may increase the hypotensive activities of Propranolol.Approved
CymarinPropranolol may increase the bradycardic activities of Cymarin.Experimental
Cynodon dactylon pollenThe risk of a hypersensitivity reaction to Cynodon dactylon pollen is increased when it is combined with Propranolol.Approved
Cyproterone acetateThe serum concentration of Propranolol can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
DabrafenibThe serum concentration of Propranolol can be decreased when it is combined with Dabrafenib.Approved, Investigational
DaclatasvirThe serum concentration of Propranolol can be increased when it is combined with Daclatasvir.Approved, Investigational
DactinomycinThe serum concentration of Propranolol can be increased when it is combined with Dactinomycin.Approved, Investigational
Dactylis glomerata pollenThe risk of a hypersensitivity reaction to Dactylis glomerata pollen is increased when it is combined with Propranolol.Approved
DalteparinThe risk or severity of hyperkalemia can be increased when Dalteparin is combined with Propranolol.Approved
DanaparoidThe risk or severity of hyperkalemia can be increased when Danaparoid is combined with Propranolol.Approved, Withdrawn
DanazolThe metabolism of Propranolol can be decreased when combined with Danazol.Approved
DapagliflozinThe risk or severity of adverse effects can be increased when Propranolol is combined with Dapagliflozin.Approved
DapiprazolePropranolol may increase the orthostatic hypotensive activities of Dapiprazole.Approved
DapoxetineThe serum concentration of Propranolol can be increased when it is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Propranolol can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Propranolol can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Propranolol can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Propranolol can be increased when it is combined with Daunorubicin.Approved
DebrisoquinDebrisoquin may increase the hypotensive activities of Propranolol.Approved, Investigational
DecamethoniumDecamethonium may increase the bradycardic activities of Propranolol.Approved
DeferasiroxThe serum concentration of Propranolol can be decreased when it is combined with Deferasirox.Approved, Investigational
DelaprilDelapril may increase the hypotensive activities of Propranolol.Investigational
DelavirdineThe metabolism of Propranolol can be decreased when combined with Delavirdine.Approved
DemecariumDemecarium may increase the bradycardic activities of Propranolol.Approved
DeserpidineDeserpidine may increase the hypotensive activities of Propranolol.Approved
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Propranolol.Approved
DesipramineThe serum concentration of Propranolol can be increased when it is combined with Desipramine.Approved, Investigational
DeslanosidePropranolol may increase the bradycardic activities of Deslanoside.Approved
DesmethylsertralineThe serum concentration of Propranolol can be increased when it is combined with Desmethylsertraline.Experimental
DesvenlafaxineThe serum concentration of Propranolol can be increased when it is combined with Desvenlafaxine.Approved, Investigational
DetomidineThe therapeutic efficacy of Detomidine can be decreased when used in combination with Propranolol.Vet Approved
DexamethasoneThe serum concentration of Propranolol can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexibuprofenDexibuprofen may decrease the antihypertensive activities of Propranolol.Approved, Investigational
DexketoprofenDexketoprofen may decrease the antihypertensive activities of Propranolol.Approved, Investigational
DexmedetomidineThe therapeutic efficacy of Dexmedetomidine can be decreased when used in combination with Propranolol.Approved, Vet Approved
DexniguldipineThe serum concentration of Propranolol can be increased when it is combined with Dexniguldipine.Experimental
DexverapamilThe serum concentration of Propranolol can be increased when it is combined with Dexverapamil.Experimental
DiazoxideDiazoxide may increase the hypotensive activities of Propranolol.Approved
DichlorvosDichlorvos may increase the bradycardic activities of Propranolol.Vet Approved
DiclofenacDiclofenac may decrease the antihypertensive activities of Propranolol.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Propranolol is combined with Diclofenamide.Approved, Investigational
Diethyl etherThe serum concentration of Propranolol can be increased when it is combined with Diethyl ether.Experimental
DiethylnorspermineDiethylnorspermine may increase the hypotensive activities of Propranolol.Investigational
DifenpiramideDifenpiramide may decrease the antihypertensive activities of Propranolol.Experimental
DiflunisalDiflunisal may decrease the antihypertensive activities of Propranolol.Approved, Investigational
DigitoxinPropranolol may increase the bradycardic activities of Digitoxin.Approved, Investigational
DigoxinPropranolol may increase the bradycardic activities of Digoxin.Approved
DihydralazineDihydralazine may increase the hypotensive activities of Propranolol.Approved, Investigational
DihydroergocorninePropranolol may increase the vasoconstricting activities of Dihydroergocornine.Approved
DihydroergocristinePropranolol may increase the vasoconstricting activities of Dihydroergocristine.Approved, Experimental
DihydroergocryptinePropranolol may increase the vasoconstricting activities of Dihydroergocryptine.Experimental
DihydroergotamineThe therapeutic efficacy of Dihydroergotamine can be decreased when used in combination with Propranolol.Approved, Investigational
DiltiazemDiltiazem may increase the hypotensive activities of Propranolol.Approved, Investigational
DinutuximabThe risk or severity of adverse effects can be increased when Propranolol is combined with Dinutuximab.Approved, Investigational
DiphenhydramineThe metabolism of Propranolol can be decreased when combined with Diphenhydramine.Approved, Investigational
DipivefrinPropranolol may decrease the bronchodilatory activities of Dipivefrin.Approved
DipyridamoleDipyridamole may increase the bradycardic activities of Propranolol.Approved
DisopyramideDisopyramide may increase the bradycardic activities of Propranolol.Approved
Distichlis spicata pollenThe risk of a hypersensitivity reaction to Distichlis spicata pollen is increased when it is combined with Propranolol.Approved
DistigmineDistigmine may increase the bradycardic activities of Propranolol.Experimental
DixyrazineThe serum concentration of Propranolol can be increased when it is combined with Dixyrazine.Experimental
DL-MethylephedrineThe therapeutic efficacy of DL-Methylephedrine can be decreased when used in combination with Propranolol.Approved
DobutaminePropranolol may decrease the bronchodilatory activities of Dobutamine.Approved
DofequidarThe serum concentration of Propranolol can be increased when it is combined with Dofequidar.Experimental, Investigational
DonepezilDonepezil may increase the bradycardic activities of Propranolol.Approved
DopamineThe serum concentration of Dopamine can be increased when it is combined with Propranolol.Approved
DopexamineThe therapeutic efficacy of Dopexamine can be decreased when used in combination with Propranolol.Approved, Investigational
DorzolamideDorzolamide may increase the hypotensive activities of Propranolol.Approved
DosulepinThe metabolism of Propranolol can be decreased when combined with Dosulepin.Approved
DovitinibThe serum concentration of Propranolol can be increased when it is combined with Dovitinib.Investigational
DoxazosinPropranolol may increase the orthostatic hypotensive activities of Doxazosin.Approved
DoxepinPropranolol may increase the orthostatic hypotensive activities of Doxepin.Approved, Investigational
DoxofyllineThe serum concentration of Doxofylline can be increased when it is combined with Propranolol.Approved, Investigational
DoxycyclineThe metabolism of Propranolol can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Propranolol can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneDronedarone may increase the bradycardic activities of Propranolol.Approved
DroperidolPropranolol may increase the orthostatic hypotensive activities of Droperidol.Approved, Vet Approved
DroxicamDroxicam may decrease the antihypertensive activities of Propranolol.Withdrawn
DroxidopaPropranolol may decrease the bronchodilatory activities of Droxidopa.Approved, Investigational
DuloxetinePropranolol may increase the orthostatic hypotensive activities of Duloxetine.Approved
EchothiophateEchothiophate may increase the bradycardic activities of Propranolol.Approved
EconazoleThe serum concentration of Propranolol can be increased when it is combined with Econazole.Approved
EdrophoniumEdrophonium may increase the bradycardic activities of Propranolol.Approved
EfavirenzThe metabolism of Propranolol can be decreased when combined with Efavirenz.Approved, Investigational
EfonidipineEfonidipine may increase the hypotensive activities of Propranolol.Approved, Investigational
ElacridarThe serum concentration of Propranolol can be increased when it is combined with Elacridar.Investigational
Elymus repens pollenThe risk of a hypersensitivity reaction to Elymus repens pollen is increased when it is combined with Propranolol.Approved
EmopamilThe serum concentration of Propranolol can be increased when it is combined with Emopamil.Experimental
EmpagliflozinThe risk or severity of adverse effects can be increased when Propranolol is combined with Empagliflozin.Approved
EnalaprilEnalapril may increase the hypotensive activities of Propranolol.Approved, Vet Approved
EnalaprilatEnalaprilat may increase the hypotensive activities of Propranolol.Approved
EnasidenibThe serum concentration of Propranolol can be increased when it is combined with Enasidenib.Approved, Investigational
EndralazineEndralazine may increase the hypotensive activities of Propranolol.Experimental
EnoxacinThe metabolism of Propranolol can be decreased when combined with Enoxacin.Approved, Investigational
EnoxaparinThe risk or severity of hyperkalemia can be increased when Enoxaparin is combined with Propranolol.Approved
EntecavirThe risk or severity of adverse effects can be increased when Propranolol is combined with Entecavir.Approved, Investigational
EnzalutamideThe serum concentration of Propranolol can be decreased when it is combined with Enzalutamide.Approved
EpanololEpanolol may increase the hypotensive activities of Propranolol.Experimental
EphedraPropranolol may decrease the bronchodilatory activities of Ephedra.Approved, Nutraceutical, Withdrawn
EphedrineThe therapeutic efficacy of Ephedrine can be decreased when used in combination with Propranolol.Approved
EpibatidineThe risk or severity of adverse effects can be increased when Propranolol is combined with Epibatidine.Experimental
EpinephrinePropranolol may decrease the bronchodilatory activities of Epinephrine.Approved, Vet Approved
EpirizoleEpirizole may decrease the antihypertensive activities of Propranolol.Approved
EplerenoneThe risk or severity of adverse effects can be increased when Propranolol is combined with Eplerenone.Approved
EpoprostenolEpoprostenol may increase the hypotensive activities of Propranolol.Approved
EprosartanEprosartan may increase the hypotensive activities of Propranolol.Approved
Ergoloid mesylatePropranolol may increase the vasoconstricting activities of Ergoloid mesylate.Approved
ErgonovineThe therapeutic efficacy of Ergonovine can be decreased when used in combination with Propranolol.Approved
ErgotaminePropranolol may increase the vasoconstricting activities of Ergotamine.Approved
ErlotinibThe serum concentration of Propranolol can be increased when it is combined with Erlotinib.Approved, Investigational
ErythromycinThe serum concentration of Propranolol can be increased when it is combined with Erythromycin.Approved, Investigational, Vet Approved
EsatenololEsatenolol may increase the hypotensive activities of Propranolol.Experimental
EsmololEsmolol may increase the hypotensive activities of Propranolol.Approved
EsomeprazoleThe serum concentration of Propranolol can be increased when it is combined with Esomeprazole.Approved, Investigational
EstramustineThe serum concentration of Propranolol can be increased when it is combined with Estramustine.Approved, Investigational
Etacrynic acidThe risk or severity of adverse effects can be increased when Propranolol is combined with Etacrynic acid.Approved, Investigational
EtafedrinePropranolol may decrease the bronchodilatory activities of Etafedrine.Approved
EtamiphyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Etamiphylline.Experimental
EthanolThe serum concentration of Propranolol can be decreased when it is combined with Ethanol.Approved
EthenzamideEthenzamide may decrease the antihypertensive activities of Propranolol.Experimental
EtilefrineThe therapeutic efficacy of Etilefrine can be decreased when used in combination with Propranolol.Withdrawn
EtodolacEtodolac may decrease the antihypertensive activities of Propranolol.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may decrease the antihypertensive activities of Propranolol.Approved, Investigational
EtomidateThe therapeutic efficacy of Etomidate can be decreased when used in combination with Propranolol.Approved
EtoposideThe serum concentration of Propranolol can be increased when it is combined with Etoposide.Approved
EtoricoxibEtoricoxib may decrease the antihypertensive activities of Propranolol.Approved, Investigational
EtravirineThe serum concentration of Propranolol can be decreased when it is combined with Etravirine.Approved
FelbinacFelbinac may decrease the antihypertensive activities of Propranolol.Experimental
FelodipineThe serum concentration of Propranolol can be increased when it is combined with Felodipine.Approved, Investigational
FenbufenFenbufen may decrease the antihypertensive activities of Propranolol.Approved
FenethyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Fenethylline.Approved
FenofibrateThe serum concentration of Propranolol can be increased when it is combined with Fenofibrate.Approved
FenoldopamFenoldopam may increase the hypotensive activities of Propranolol.Approved
FenoprofenFenoprofen may decrease the antihypertensive activities of Propranolol.Approved
FenoterolPropranolol may decrease the bronchodilatory activities of Fenoterol.Approved, Investigational
FentanylFentanyl may increase the bradycardic activities of Propranolol.Approved, Illicit, Investigational, Vet Approved
FenthionFenthion may increase the bradycardic activities of Propranolol.Vet Approved
FentiazacFentiazac may decrease the antihypertensive activities of Propranolol.Experimental
FeprazoneFeprazone may decrease the antihypertensive activities of Propranolol.Experimental
Ferulic acidFerulic acid may increase the hypotensive activities of Propranolol.Experimental
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Propranolol.Approved
Festuca pratensis pollenThe risk of a hypersensitivity reaction to Festuca pratensis pollen is increased when it is combined with Propranolol.Approved
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Propranolol.Approved, Investigational
FingolimodPropranolol may increase the bradycardic activities of Fingolimod.Approved, Investigational
FirocoxibFirocoxib may decrease the antihypertensive activities of Propranolol.Experimental, Vet Approved
FloctafenineThe risk or severity of adverse effects can be increased when Propranolol is combined with Floctafenine.Approved, Withdrawn
FluconazoleThe serum concentration of Propranolol can be increased when it is combined with Fluconazole.Approved, Investigational
FlunixinFlunixin may decrease the antihypertensive activities of Propranolol.Vet Approved
FlunoxaprofenFlunoxaprofen may decrease the antihypertensive activities of Propranolol.Experimental
FluoxetineThe serum concentration of Propranolol can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolPropranolol may increase the orthostatic hypotensive activities of Flupentixol.Approved, Investigational, Withdrawn
FluphenazineThe serum concentration of Propranolol can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Propranolol can be increased when it is combined with Flurazepam.Approved, Illicit, Investigational
FlurbiprofenFlurbiprofen may decrease the antihypertensive activities of Propranolol.Approved, Investigational
FluvoxamineThe serum concentration of Propranolol can be increased when it is combined with Fluvoxamine.Approved, Investigational
ForasartanThe risk or severity of hyperkalemia can be increased when Forasartan is combined with Propranolol.Experimental
FormoterolPropranolol may decrease the bronchodilatory activities of Formoterol.Approved, Investigational
FosamprenavirThe metabolism of Propranolol can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Propranolol can be increased when it is combined with Fosaprepitant.Approved
FosinoprilFosinopril may increase the hypotensive activities of Propranolol.Approved
FosinoprilatFosinoprilat may increase the hypotensive activities of Propranolol.Experimental
FosphenytoinThe metabolism of Propranolol can be increased when combined with Fosphenytoin.Approved, Investigational
FostamatinibFostamatinib may increase the antihypertensive activities of Propranolol.Approved, Investigational
FurafyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Furafylline.Experimental
FurazolidoneFurazolidone may increase the hypotensive activities of Propranolol.Approved, Investigational, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Propranolol is combined with Furosemide.Approved, Vet Approved
Fusidic AcidThe serum concentration of Propranolol can be increased when it is combined with Fusidic Acid.Approved, Investigational
GalantamineGalantamine may increase the bradycardic activities of Propranolol.Approved
Gallamine TriethiodideGallamine Triethiodide may increase the bradycardic activities of Propranolol.Approved
GallopamilThe serum concentration of Propranolol can be increased when it is combined with Gallopamil.Investigational
GanciclovirThe risk or severity of adverse effects can be increased when Propranolol is combined with Ganciclovir.Approved, Investigational
GefitinibThe serum concentration of Propranolol can be increased when it is combined with Gefitinib.Approved, Investigational
GenisteinThe serum concentration of Propranolol can be increased when it is combined with Genistein.Investigational
Ginkgo bilobaGinkgo biloba may increase the bradycardic activities of Propranolol.Approved, Investigational, Nutraceutical
GitoformatePropranolol may increase the bradycardic activities of Gitoformate.Experimental
GlecaprevirThe serum concentration of Propranolol can be increased when it is combined with Glecaprevir.Approved, Investigational
GlibornuridePropranolol may increase the hypoglycemic activities of Glibornuride.Investigational, Withdrawn
GliclazidePropranolol may increase the hypoglycemic activities of Gliclazide.Approved
GlimepiridePropranolol may increase the hypoglycemic activities of Glimepiride.Approved
GlipizidePropranolol may increase the hypoglycemic activities of Glipizide.Approved, Investigational
GliquidonePropranolol may increase the hypoglycemic activities of Gliquidone.Approved, Investigational
GlisoxepidePropranolol may increase the hypoglycemic activities of Glisoxepide.Investigational
GlyburidePropranolol may increase the hypoglycemic activities of Glyburide.Approved
GlycerinThe serum concentration of Propranolol can be increased when it is combined with Glycerin.Approved, Investigational
Glycerol PhenylbutyrateThe metabolism of Propranolol can be decreased when combined with Glycerol Phenylbutyrate.Approved
Gramicidin DThe serum concentration of Propranolol can be increased when it is combined with Gramicidin D.Approved
GTS-21The risk or severity of adverse effects can be increased when Propranolol is combined with GTS-21.Investigational
GuacetisalGuacetisal may decrease the antihypertensive activities of Propranolol.Experimental
GuanabenzThe therapeutic efficacy of Guanabenz can be decreased when used in combination with Propranolol.Approved, Investigational
GuanadrelGuanadrel may increase the hypotensive activities of Propranolol.Approved
GuanazodineGuanazodine may increase the hypotensive activities of Propranolol.Experimental
GuanethidineGuanethidine may increase the hypotensive activities of Propranolol.Approved
GuanfacineThe therapeutic efficacy of Guanfacine can be decreased when used in combination with Propranolol.Approved, Investigational
GuanineThe risk or severity of adverse effects can be increased when Propranolol is combined with Guanine.Experimental
GuanoclorGuanoclor may increase the hypotensive activities of Propranolol.Experimental
GuanoxabenzGuanoxabenz may increase the hypotensive activities of Propranolol.Experimental
GuanoxanGuanoxan may increase the hypotensive activities of Propranolol.Experimental
HaloperidolThe metabolism of Propranolol can be decreased when combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Propranolol.Approved, Vet Approved
HarmalineHarmaline may increase the hypotensive activities of Propranolol.Experimental
HeparinThe risk or severity of hyperkalemia can be increased when Heparin is combined with Propranolol.Approved, Investigational
HexamethoniumHexamethonium may increase the hypotensive activities of Propranolol.Experimental
HexobarbitalHexobarbital may increase the hypotensive activities of Propranolol.Approved
HexoprenalinePropranolol may decrease the bronchodilatory activities of Hexoprenaline.Approved, Withdrawn
HigenamineThe therapeutic efficacy of Higenamine can be decreased when used in combination with Propranolol.Investigational
HistamineThe serum concentration of Histamine can be increased when it is combined with Propranolol.Approved, Investigational
HM-30181The serum concentration of Propranolol can be increased when it is combined with HM-30181.Experimental
Holcus lanatus pollenThe risk of a hypersensitivity reaction to Holcus lanatus pollen is increased when it is combined with Propranolol.Approved
Huperzine AHuperzine A may increase the bradycardic activities of Propranolol.Approved, Investigational
HycanthoneThe serum concentration of Propranolol can be increased when it is combined with Hycanthone.Approved, Investigational
HydracarbazineHydracarbazine may increase the hypotensive activities of Propranolol.Experimental
HydralazineHydralazine may increase the hypotensive activities of Propranolol.Approved
HydrochlorothiazideHydrochlorothiazide may increase the hypotensive activities of Propranolol.Approved, Vet Approved
HydrocodoneThe serum concentration of the active metabolites of Hydrocodone can be reduced when Hydrocodone is used in combination with Propranolol resulting in a loss in efficacy.Approved, Illicit
HydroflumethiazideHydroflumethiazide may increase the hypotensive activities of Propranolol.Approved, Investigational
HydroxychloroquineThe risk or severity of QTc prolongation can be decreased when Hydroxychloroquine is combined with Propranolol.Approved
HypoxanthineThe risk or severity of adverse effects can be increased when Propranolol is combined with Hypoxanthine.Experimental
IbuprofenIbuprofen may decrease the antihypertensive activities of Propranolol.Approved
IbuproxamIbuproxam may decrease the antihypertensive activities of Propranolol.Withdrawn
IcosapentIcosapent may decrease the antihypertensive activities of Propranolol.Approved, Nutraceutical
IdelalisibThe metabolism of Propranolol can be decreased when combined with Idelalisib.Approved
IloperidonePropranolol may increase the orthostatic hypotensive activities of Iloperidone.Approved
IloprostIloprost may increase the hypotensive activities of Propranolol.Approved, Investigational
ImatinibThe serum concentration of Propranolol can be increased when it is combined with Imatinib.Approved
ImidaprilImidapril may increase the hypotensive activities of Propranolol.Investigational
Imidazole salicylateImidazole salicylate may decrease the antihypertensive activities of Propranolol.Experimental
ImipraminePropranolol may increase the orthostatic hypotensive activities of Imipramine.Approved
IndacaterolPropranolol may decrease the bronchodilatory activities of Indacaterol.Approved
IndalpineThe serum concentration of Propranolol can be increased when it is combined with Indalpine.Investigational, Withdrawn
IndapamideIndapamide may increase the hypotensive activities of Propranolol.Approved
IndenololIndenolol may increase the hypotensive activities of Propranolol.Withdrawn
IndinavirThe metabolism of Propranolol can be decreased when combined with Indinavir.Approved
IndobufenIndobufen may decrease the antihypertensive activities of Propranolol.Investigational
IndomethacinIndomethacin may decrease the antihypertensive activities of Propranolol.Approved, Investigational
IndoprofenIndoprofen may decrease the antihypertensive activities of Propranolol.Withdrawn
IndoraminPropranolol may increase the orthostatic hypotensive activities of Indoramin.Withdrawn
Insulin AspartPropranolol may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DegludecPropranolol may increase the hypoglycemic activities of Insulin Degludec.Approved
Insulin DetemirPropranolol may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlarginePropranolol may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisinePropranolol may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanPropranolol may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproPropranolol may increase the hypoglycemic activities of Insulin Lispro.Approved
Insulin peglisproPropranolol may increase the hypoglycemic activities of Insulin peglispro.Investigational
Insulin PorkPropranolol may increase the hypoglycemic activities of Insulin Pork.Approved
IpidacrineIpidacrine may increase the bradycardic activities of Propranolol.Experimental
IproniazidIproniazid may increase the hypotensive activities of Propranolol.Withdrawn
IrbesartanIrbesartan may increase the hypotensive activities of Propranolol.Approved, Investigational
IsavuconazoleThe serum concentration of Propranolol can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe serum concentration of Propranolol can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Propranolol.Approved
IsoetarinePropranolol may decrease the bronchodilatory activities of Isoetarine.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Propranolol.Approved, Vet Approved
IsoflurophateIsoflurophate may increase the bradycardic activities of Propranolol.Approved, Investigational, Withdrawn
IsomethepteneThe therapeutic efficacy of Isometheptene can be decreased when used in combination with Propranolol.Approved
IsoniazidThe metabolism of Propranolol can be decreased when combined with Isoniazid.Approved, Investigational
IsoprenalinePropranolol may decrease the bronchodilatory activities of Isoprenaline.Approved, Investigational
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Propranolol is combined with Isosorbide Dinitrate.Approved, Investigational
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Propranolol is combined with Isosorbide Mononitrate.Approved
IsoxicamIsoxicam may decrease the antihypertensive activities of Propranolol.Withdrawn
IsoxsuprineThe therapeutic efficacy of Isoxsuprine can be decreased when used in combination with Propranolol.Approved, Withdrawn
IsradipineThe serum concentration of Propranolol can be increased when it is combined with Isradipine.Approved, Investigational
ItoprideItopride may increase the bradycardic activities of Propranolol.Investigational
ItraconazoleThe metabolism of Propranolol can be decreased when combined with Itraconazole.Approved, Investigational
IvabradinePropranolol may increase the bradycardic activities of Ivabradine.Approved
IvermectinThe serum concentration of Propranolol can be increased when it is combined with Ivermectin.Approved, Investigational, Vet Approved
IvosidenibThe serum concentration of Propranolol can be increased when it is combined with Ivosidenib.Approved, Investigational
KebuzoneKebuzone may decrease the antihypertensive activities of Propranolol.Experimental
KetanserinKetanserin may increase the hypotensive activities of Propranolol.Investigational
KetoconazoleThe metabolism of Propranolol can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenKetoprofen may decrease the antihypertensive activities of Propranolol.Approved, Vet Approved
KetorolacKetorolac may decrease the antihypertensive activities of Propranolol.Approved
Koeleria macrantha pollenThe risk of a hypersensitivity reaction to Koeleria macrantha pollen is increased when it is combined with Propranolol.Approved
LabetalolPropranolol may increase the orthostatic hypotensive activities of Labetalol.Approved
LacosamidePropranolol may increase the atrioventricular blocking (AV block) activities of Lacosamide.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Propranolol.Approved, Investigational
Lanatoside CPropranolol may increase the bradycardic activities of Lanatoside C.Experimental
LandiololThe risk or severity of hyperkalemia can be increased when Propranolol is combined with Landiolol.Investigational
LaniquidarThe serum concentration of Propranolol can be increased when it is combined with Laniquidar.Investigational
LanreotidePropranolol may increase the bradycardic activities of Lanreotide.Approved
LansoprazoleThe serum concentration of Propranolol can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Propranolol can be increased when it is combined with Lapatinib.Approved, Investigational
LatanoprostLatanoprost may increase the hypotensive activities of Propranolol.Approved, Investigational
LedipasvirThe serum concentration of Propranolol can be increased when it is combined with Ledipasvir.Approved
LercanidipineLercanidipine may increase the hypotensive activities of Propranolol.Approved, Investigational
LetermovirThe serum concentration of Propranolol can be increased when it is combined with Letermovir.Approved, Investigational
LevobetaxololThe risk or severity of hyperkalemia can be increased when Propranolol is combined with Levobetaxolol.Approved, Investigational
LevobunololThe risk or severity of adverse effects can be increased when Propranolol is combined with Levobunolol.Approved
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Propranolol.Approved, Investigational
LevodopaPropranolol may increase the orthostatic hypotensive activities of Levodopa.Approved
LevofloxacinThe serum concentration of Propranolol can be increased when it is combined with Levofloxacin.Approved, Investigational
LevomilnacipranThe serum concentration of Propranolol can be increased when it is combined with Levomilnacipran.Approved, Investigational
LevosalbutamolPropranolol may decrease the bronchodilatory activities of Levosalbutamol.Approved, Investigational
LevosimendanThe risk or severity of adverse effects can be increased when Levosimendan is combined with Propranolol.Approved, Investigational
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Propranolol.Approved, Vet Approved
LinagliptinThe serum concentration of Propranolol can be increased when it is combined with Linagliptin.Approved
LinezolidLinezolid may increase the hypotensive activities of Propranolol.Approved, Investigational
LinsidomineLinsidomine may increase the hypotensive activities of Propranolol.Experimental
LisinoprilLisinopril may increase the hypotensive activities of Propranolol.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Lisofylline.Investigational
LisuridePropranolol may increase the vasoconstricting activities of Lisuride.Approved, Investigational
LobeglitazoneThe metabolism of Propranolol can be decreased when combined with Lobeglitazone.Approved, Investigational
LobelineThe risk or severity of adverse effects can be increased when Propranolol is combined with Lobeline.Investigational
LobucavirThe risk or severity of adverse effects can be increased when Propranolol is combined with Lobucavir.Investigational
LofexidineThe therapeutic efficacy of Lofexidine can be decreased when used in combination with Propranolol.Approved, Investigational
Lolium perenne pollenThe risk of a hypersensitivity reaction to Lolium perenne pollen is increased when it is combined with Propranolol.Approved
Lolium perenne subsp. multiflorum pollenThe risk of a hypersensitivity reaction to Lolium perenne subsp. multiflorum pollen is increased when it is combined with Propranolol.Approved
LomerizineThe serum concentration of Propranolol can be increased when it is combined with Lomerizine.Experimental
LomitapideThe serum concentration of Propranolol can be increased when it is combined with Lomitapide.Approved, Investigational
LonafarnibThe serum concentration of Propranolol can be increased when it is combined with Lonafarnib.Investigational
LonazolacLonazolac may decrease the antihypertensive activities of Propranolol.Experimental
LoperamideThe serum concentration of Propranolol can be increased when it is combined with Loperamide.Approved
LopinavirThe metabolism of Propranolol can be decreased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Propranolol can be increased when it is combined with Loratadine.Approved, Investigational
LorcaserinThe metabolism of Propranolol can be decreased when combined with Lorcaserin.Approved
LornoxicamLornoxicam may decrease the antihypertensive activities of Propranolol.Approved, Investigational
LorpiprazoleThe serum concentration of Propranolol can be increased when it is combined with Lorpiprazole.Approved
LosartanThe serum concentration of Propranolol can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Propranolol can be increased when it is combined with Lovastatin.Approved, Investigational
LoxapineThe serum concentration of Propranolol can be increased when it is combined with Loxapine.Approved
LoxoprofenLoxoprofen may decrease the antihypertensive activities of Propranolol.Approved, Investigational
LucinactantPropranolol may increase the bradycardic activities of Lucinactant.Approved, Investigational
LuliconazoleThe serum concentration of Propranolol can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Propranolol can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Propranolol can be decreased when combined with Lumefantrine.Approved
LumiracoxibLumiracoxib may decrease the antihypertensive activities of Propranolol.Approved, Investigational
LusutrombopagThe serum concentration of Propranolol can be increased when it is combined with Lusutrombopag.Approved, Investigational
Lysergic Acid DiethylamidePropranolol may increase the vasoconstricting activities of Lysergic Acid Diethylamide.Illicit, Investigational, Withdrawn
MacitentanMacitentan may increase the hypotensive activities of Propranolol.Approved
Magnesium salicylateMagnesium salicylate may decrease the antihypertensive activities of Propranolol.Approved
MalathionMalathion may increase the bradycardic activities of Propranolol.Approved, Investigational
ManidipineManidipine may increase the hypotensive activities of Propranolol.Approved, Investigational
MannitolThe risk or severity of adverse effects can be increased when Propranolol is combined with Mannitol.Approved, Investigational
Mannitol busulfanThe risk or severity of hyperkalemia can be increased when Propranolol is combined with Mannitol busulfan.Approved, Investigational
MebanazineMebanazine may increase the hypotensive activities of Propranolol.Withdrawn
MecamylamineMecamylamine may increase the hypotensive activities of Propranolol.Approved, Investigational
Meclofenamic acidMeclofenamic acid may decrease the antihypertensive activities of Propranolol.Approved, Vet Approved
MedetomidineThe therapeutic efficacy of Medetomidine can be decreased when used in combination with Propranolol.Vet Approved
Mefenamic acidMefenamic acid may decrease the antihypertensive activities of Propranolol.Approved
MefloquineThe risk or severity of QTc prolongation can be decreased when Mefloquine is combined with Propranolol.Approved, Investigational
Megestrol acetateThe serum concentration of Propranolol can be increased when it is combined with Megestrol acetate.Approved, Investigational, Vet Approved
MeloxicamMeloxicam may decrease the antihypertensive activities of Propranolol.Approved, Vet Approved
MemantineThe serum concentration of Memantine can be increased when it is combined with Propranolol.Approved, Investigational
MephentermineThe therapeutic efficacy of Mephentermine can be decreased when used in combination with Propranolol.Approved
MepindololThe risk or severity of hyperkalemia can be increased when Mepindolol is combined with Propranolol.Experimental
MepivacaineThe serum concentration of Mepivacaine can be increased when it is combined with Propranolol.Approved, Vet Approved
MesalazineMesalazine may decrease the antihypertensive activities of Propranolol.Approved
MesoridazineThe serum concentration of Propranolol can be increased when it is combined with Mesoridazine.Approved, Investigational
MetahexamidePropranolol may increase the hypoglycemic activities of Metahexamide.Experimental
MetamizoleMetamizole may decrease the antihypertensive activities of Propranolol.Approved, Investigational, Withdrawn
MetaraminolThe therapeutic efficacy of Metaraminol can be decreased when used in combination with Propranolol.Approved, Investigational
MetergolinePropranolol may increase the vasoconstricting activities of Metergoline.Experimental
MetforminThe serum concentration of Metformin can be increased when it is combined with Propranolol.Approved
MethacholinePropranolol may increase the bronchoconstrictory activities of Methacholine.Approved, Investigational
MethadoneThe serum concentration of Propranolol can be increased when it is combined with Methadone.Approved
MethamphetamineThe therapeutic efficacy of Methamphetamine can be decreased when used in combination with Propranolol.Approved, Illicit
Methanesulfonyl FluorideMethanesulfonyl Fluoride may increase the bradycardic activities of Propranolol.Investigational
MethazolamideThe risk or severity of adverse effects can be increased when Propranolol is combined with Methazolamide.Approved
MethohexitalMethohexital may increase the hypotensive activities of Propranolol.Approved
MethoserpidineMethoserpidine may increase the hypotensive activities of Propranolol.Experimental
MethotrimeprazineThe serum concentration of Propranolol can be increased when it is combined with Methotrimeprazine.Approved, Investigational
MethoxamineThe therapeutic efficacy of Methoxamine can be decreased when used in combination with Propranolol.Approved, Investigational
MethoxyphenamineThe therapeutic efficacy of Methoxyphenamine can be decreased when used in combination with Propranolol.Experimental
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Propranolol.Approved
MethyldopaThe therapeutic efficacy of Methyldopa can be decreased when used in combination with Propranolol.Approved
Methylene blueThe serum concentration of Propranolol can be increased when it is combined with Methylene blue.Approved, Investigational
MethylergometrinePropranolol may increase the vasoconstricting activities of Methylergometrine.Approved
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Propranolol.Approved, Investigational
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Propranolol.Approved
MethysergidePropranolol may increase the vasoconstricting activities of Methysergide.Approved
MetildigoxinPropranolol may increase the bradycardic activities of Metildigoxin.Experimental
MetipranololMetipranolol may increase the hypotensive activities of Propranolol.Approved
MetoclopramideMetoclopramide may increase the bradycardic activities of Propranolol.Approved, Investigational
MetolazoneMetolazone may increase the hypotensive activities of Propranolol.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Propranolol.Approved, Investigational
MetronidazoleThe serum concentration of Propranolol can be increased when it is combined with Metronidazole.Approved
MetyrosineMetyrosine may increase the hypotensive activities of Propranolol.Approved
MexiletineThe metabolism of Propranolol can be decreased when combined with Mexiletine.Approved, Investigational
MibefradilThe metabolism of Propranolol can be decreased when combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe serum concentration of Propranolol can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Propranolol can be increased when it is combined with Midazolam.Approved, Illicit
MidostaurinThe metabolism of Propranolol can be decreased when combined with Midostaurin.Approved, Investigational
MifepristoneThe serum concentration of Propranolol can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe serum concentration of Propranolol can be increased when it is combined with Milnacipran.Approved, Investigational
MinaprineMinaprine may increase the bradycardic activities of Propranolol.Approved
MinoxidilMinoxidil may increase the hypotensive activities of Propranolol.Approved, Investigational
MirabegronThe therapeutic efficacy of Mirabegron can be decreased when used in combination with Propranolol.Approved
MirodenafilMirodenafil may increase the antihypertensive activities of Propranolol.Investigational
MitotaneThe serum concentration of Propranolol can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Propranolol can be increased when it is combined with Mitoxantrone.Approved, Investigational
MoclobemideMoclobemide may increase the hypotensive activities of Propranolol.Approved, Investigational
ModafinilThe serum concentration of Propranolol can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilMoexipril may increase the hypotensive activities of Propranolol.Approved
MofebutazoneMofebutazone may decrease the antihypertensive activities of Propranolol.Experimental
MolsidomineMolsidomine may increase the hypotensive activities of Propranolol.Approved, Investigational
MonensinThe serum concentration of Propranolol can be increased when it is combined with Monensin.Vet Approved
MoricizineThe serum concentration of Propranolol can be increased when it is combined with Moricizine.Approved, Investigational, Withdrawn
MorniflumateMorniflumate may decrease the antihypertensive activities of Propranolol.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Propranolol.Approved, Investigational
MoxonidineThe therapeutic efficacy of Moxonidine can be decreased when used in combination with Propranolol.Approved, Investigational
MuzolimineMuzolimine may increase the hypotensive activities of Propranolol.Experimental
NabiloneThe risk or severity of adverse effects can be increased when Nabilone is combined with Propranolol.Approved, Investigational
NabumetoneNabumetone may decrease the antihypertensive activities of Propranolol.Approved
NadololPropranolol may increase the hypotensive activities of Nadolol.Approved
NadroparinThe risk or severity of hyperkalemia can be increased when Nadroparin is combined with Propranolol.Approved, Investigational
NafamostatThe serum concentration of Nafamostat can be increased when it is combined with Propranolol.Approved, Investigational
NafcillinThe serum concentration of Propranolol can be decreased when it is combined with Nafcillin.Approved, Investigational
NaftopidilNaftopidil may increase the hypotensive activities of Propranolol.Investigational
NaloxoneThe metabolism of Propranolol can be decreased when combined with Naloxone.Approved, Vet Approved
NaphazolineThe therapeutic efficacy of Naphazoline can be decreased when used in combination with Propranolol.Approved
NaproxenNaproxen may decrease the antihypertensive activities of Propranolol.Approved, Vet Approved
NebivololThe therapeutic efficacy of Nebivolol can be decreased when used in combination with Propranolol.Approved, Investigational
NefazodoneThe serum concentration of Propranolol can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Propranolol can be decreased when combined with Nelfinavir.Approved
NeostigmineNeostigmine may increase the bradycardic activities of Propranolol.Approved, Vet Approved
NepafenacNepafenac may decrease the antihypertensive activities of Propranolol.Approved, Investigational
NeratinibThe serum concentration of Propranolol can be increased when it is combined with Neratinib.Approved, Investigational
NesiritideThe risk or severity of adverse effects can be increased when Propranolol is combined with Nesiritide.Approved, Investigational
NetupitantThe serum concentration of Propranolol can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Propranolol can be increased when combined with Nevirapine.Approved
NialamideNialamide may increase the hypotensive activities of Propranolol.Withdrawn
NicardipinePropranolol may increase the orthostatic hypotensive activities of Nicardipine.Approved, Investigational
NicergolinePropranolol may increase the vasoconstricting activities of Nicergoline.Approved, Investigational
NicorandilNicorandil may increase the hypotensive activities of Propranolol.Approved, Investigational
NicotineThe risk or severity of adverse effects can be increased when Propranolol is combined with Nicotine.Approved
NifedipineThe risk or severity of congestive heart failure and hypotension can be increased when Nifedipine is combined with Propranolol.Approved
NifenazoneNifenazone may decrease the antihypertensive activities of Propranolol.Experimental
Niflumic AcidNiflumic Acid may decrease the antihypertensive activities of Propranolol.Approved
NigericinThe serum concentration of Propranolol can be increased when it is combined with Nigericin.Experimental
NiguldipinePropranolol may increase the orthostatic hypotensive activities of Niguldipine.Experimental
NilotinibThe metabolism of Propranolol can be decreased when combined with Nilotinib.Approved, Investigational
NilvadipineNilvadipine may increase the hypotensive activities of Propranolol.Approved, Investigational
NimesulideNimesulide may decrease the antihypertensive activities of Propranolol.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Propranolol can be increased when it is combined with Nimodipine.Approved, Investigational
NisoldipineThe serum concentration of Propranolol can be increased when it is combined with Nisoldipine.Approved
NitrendipineThe serum concentration of Propranolol can be increased when it is combined with Nitrendipine.Approved, Investigational
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Propranolol.Approved
NitroaspirinNitroaspirin may decrease the antihypertensive activities of Propranolol.Investigational
NitroglycerinThe risk or severity of adverse effects can be increased when Propranolol is combined with Nitroglycerin.Approved, Investigational
NitroprussideNitroprusside may increase the hypotensive activities of Propranolol.Approved, Investigational
Nitrous acidThe risk or severity of adverse effects can be increased when Nitrous acid is combined with Propranolol.Approved, Investigational
NN344Propranolol may increase the hypoglycemic activities of NN344.Investigational
NorepinephrinePropranolol may decrease the bronchodilatory activities of Norepinephrine.Approved
NorfenefrineThe therapeutic efficacy of Norfenefrine can be decreased when used in combination with Propranolol.Experimental
NortriptylinePropranolol may increase the orthostatic hypotensive activities of Nortriptyline.Approved
NS-398NS-398 may decrease the antihypertensive activities of Propranolol.Experimental
NylidrinThe therapeutic efficacy of Nylidrin can be decreased when used in combination with Propranolol.Approved
ObinutuzumabPropranolol may increase the hypotensive activities of Obinutuzumab.Approved, Investigational
OctamoxinOctamoxin may increase the hypotensive activities of Propranolol.Withdrawn
OctopamineThe therapeutic efficacy of Octopamine can be decreased when used in combination with Propranolol.Experimental
OctreotideOctreotide may increase the bradycardic activities of Propranolol.Approved, Investigational
OlanzapinePropranolol may increase the orthostatic hypotensive activities of Olanzapine.Approved, Investigational
OlaparibThe metabolism of Propranolol can be decreased when combined with Olaparib.Approved
OleandrinPropranolol may increase the bradycardic activities of Oleandrin.Experimental, Investigational
OlmesartanOlmesartan may increase the hypotensive activities of Propranolol.Approved, Investigational
OlodaterolPropranolol may decrease the bronchodilatory activities of Olodaterol.Approved
OlsalazineOlsalazine may decrease the antihypertensive activities of Propranolol.Approved
OmapatrilatOmapatrilat may increase the hypotensive activities of Propranolol.Investigational
OmeprazoleThe serum concentration of Propranolol can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
ONT-093The serum concentration of Propranolol can be increased when it is combined with ONT-093.Investigational
OrciprenalinePropranolol may decrease the bronchodilatory activities of Orciprenaline.Approved
OsimertinibThe serum concentration of Propranolol can be increased when it is combined with Osimertinib.Approved
OuabainPropranolol may increase the bradycardic activities of Ouabain.Approved
OxaliplatinThe serum concentration of Oxaliplatin can be increased when it is combined with Propranolol.Approved, Investigational
OxaprozinOxaprozin may decrease the antihypertensive activities of Propranolol.Approved
OxprenololPropranolol may increase the hypotensive activities of Oxprenolol.Approved
OxtriphyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Oxtriphylline.Approved
OxyfedrineThe therapeutic efficacy of Oxyfedrine can be decreased when used in combination with Propranolol.Experimental
OxymetazolineThe therapeutic efficacy of Oxymetazoline can be decreased when used in combination with Propranolol.Approved, Investigational
OxyphenbutazoneOxyphenbutazone may decrease the antihypertensive activities of Propranolol.Approved, Withdrawn
PaclitaxelThe serum concentration of Propranolol can be increased when it is combined with Paclitaxel.Approved, Vet Approved
PalbociclibThe serum concentration of Propranolol can be increased when it is combined with Palbociclib.Approved, Investigational
PaliperidoneThe therapeutic efficacy of Paliperidone can be decreased when used in combination with Propranolol.Approved
PanobinostatThe serum concentration of Propranolol can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe serum concentration of Propranolol can be increased when it is combined with Pantoprazole.Approved
PapaverineThe risk or severity of adverse effects can be increased when Propranolol is combined with Papaverine.Approved, Investigational
ParaoxonParaoxon may increase the bradycardic activities of Propranolol.Experimental
ParecoxibParecoxib may decrease the antihypertensive activities of Propranolol.Approved
PargylinePargyline may increase the hypotensive activities of Propranolol.Approved
ParitaprevirThe serum concentration of Propranolol can be increased when it is combined with Paritaprevir.Approved, Investigational
ParnaparinThe risk or severity of hyperkalemia can be increased when Parnaparin is combined with Propranolol.Approved, Investigational
ParoxetineThe serum concentration of Propranolol can be increased when it is combined with Paroxetine.Approved, Investigational
Pascopyrum smithii pollenThe risk of a hypersensitivity reaction to Pascopyrum smithii pollen is increased when it is combined with Propranolol.Approved
PasireotidePropranolol may increase the bradycardic activities of Pasireotide.Approved
Paspalum notatum pollenThe risk of a hypersensitivity reaction to Paspalum notatum pollen is increased when it is combined with Propranolol.Approved
Patent BlueThe risk or severity of hypersensitivity reaction can be increased when Patent Blue is combined with Propranolol.Approved
Peginterferon alfa-2bThe serum concentration of Propranolol can be decreased when it is combined with Peginterferon alfa-2b.Approved
PeldesineThe risk or severity of adverse effects can be increased when Propranolol is combined with Peldesine.Experimental, Investigational
PemetrexedThe risk or severity of adverse effects can be increased when Propranolol is combined with Pemetrexed.Approved, Investigational
PenbutololPropranolol may increase the hypotensive activities of Penbutolol.Approved, Investigational
PenciclovirThe risk or severity of adverse effects can be increased when Propranolol is combined with Penciclovir.Approved
Penicillin G Acyl-SerineThe risk or severity of hyperkalemia can be increased when Propranolol is combined with Penicillin G Acyl-Serine.Experimental
PentamidineThe risk or severity of hyperkalemia can be increased when Propranolol is combined with Pentamidine.Approved, Investigational
PentazocineThe serum concentration of Propranolol can be increased when it is combined with Pentazocine.Approved, Vet Approved
PentifyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Pentifylline.Experimental
PentobarbitalPentobarbital may increase the hypotensive activities of Propranolol.Approved, Investigational, Vet Approved
PentoliniumPentolinium may increase the hypotensive activities of Propranolol.Approved
PerazineThe serum concentration of Propranolol can be increased when it is combined with Perazine.Approved, Investigational
PergolideThe therapeutic efficacy of Pergolide can be decreased when used in combination with Propranolol.Approved, Investigational, Vet Approved, Withdrawn
PerindoprilPerindopril may increase the hypotensive activities of Propranolol.Approved
PerindoprilatPerindoprilat may increase the hypotensive activities of Propranolol.Experimental
PerphenazineThe serum concentration of Propranolol can be increased when it is combined with Perphenazine.Approved
PeruvosidePropranolol may increase the bradycardic activities of Peruvoside.Experimental
PethidineThe serum concentration of Propranolol can be increased when it is combined with Pethidine.Approved
PF-00610355Propranolol may decrease the bronchodilatory activities of PF-00610355.Investigational
Phalaris arundinacea pollenThe risk of a hypersensitivity reaction to Phalaris arundinacea pollen is increased when it is combined with Propranolol.Approved
Phalaris minor pollenThe risk of a hypersensitivity reaction to Phalaris minor pollen is increased when it is combined with Propranolol.Approved
PhendimetrazineThe therapeutic efficacy of Phendimetrazine can be decreased when used in combination with Propranolol.Approved, Illicit
PhenelzinePhenelzine may increase the hypotensive activities of Propranolol.Approved
PheniprazinePheniprazine may increase the hypotensive activities of Propranolol.Withdrawn
PhenobarbitalPhenobarbital may increase the hypotensive activities of Propranolol.Approved, Investigational
PhenoxybenzaminePropranolol may increase the orthostatic hypotensive activities of Phenoxybenzamine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Propranolol.Withdrawn
PhentolaminePropranolol may increase the orthostatic hypotensive activities of Phentolamine.Approved
PhenylbutazonePhenylbutazone may decrease the antihypertensive activities of Propranolol.Approved, Vet Approved
Phenylbutyric acidThe metabolism of Propranolol can be decreased when combined with Phenylbutyric acid.Approved, Investigational
PhenylephrineThe therapeutic efficacy of Phenylephrine can be decreased when used in combination with Propranolol.Approved
PhenylpropanolaminePropranolol may decrease the bronchodilatory activities of Phenylpropanolamine.Approved, Vet Approved, Withdrawn
PhenytoinThe metabolism of Propranolol can be increased when combined with Phenytoin.Approved, Vet Approved
Phleum pratense pollenThe risk of a hypersensitivity reaction to Phleum pratense pollen is increased when it is combined with Propranolol.Approved, Investigational
PhysostigminePhysostigmine may increase the bradycardic activities of Propranolol.Approved, Investigational
PibrentasvirThe serum concentration of Propranolol can be increased when it is combined with Pibrentasvir.Approved, Investigational
PilocarpineThe risk or severity of adverse effects can be increased when Propranolol is combined with Pilocarpine.Approved, Investigational
PimozideThe serum concentration of Propranolol can be increased when it is combined with Pimozide.Approved
PinacidilPinacidil may increase the hypotensive activities of Propranolol.Approved
PindololPropranolol may increase the hypotensive activities of Pindolol.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Propranolol.Approved, Investigational
PipotiazineThe serum concentration of Propranolol can be increased when it is combined with Pipotiazine.Approved, Investigational
PirbuterolPropranolol may decrease the bronchodilatory activities of Pirbuterol.Approved
PirlindolePirlindole may increase the hypotensive activities of Propranolol.Approved
PiroxicamPiroxicam may decrease the antihypertensive activities of Propranolol.Approved, Investigational
PirprofenPirprofen may decrease the antihypertensive activities of Propranolol.Experimental
PitolisantThe serum concentration of Pitolisant can be increased when it is combined with Propranolol.Approved, Investigational
PivhydrazinePivhydrazine may increase the hypotensive activities of Propranolol.Withdrawn
PizotifenPropranolol may increase the orthostatic hypotensive activities of Pizotifen.Approved
Poa annua pollenThe risk of a hypersensitivity reaction to Poa annua pollen is increased when it is combined with Propranolol.Approved
Poa compressa pollenThe risk of a hypersensitivity reaction to Poa compressa pollen is increased when it is combined with Propranolol.Approved
Poa pratensis pollenThe risk of a hypersensitivity reaction to Poa pratensis pollen is increased when it is combined with Propranolol.Approved
PolythiazidePolythiazide may increase the hypotensive activities of Propranolol.Approved
PonatinibThe serum concentration of Propranolol can be increased when it is combined with Ponatinib.Approved, Investigational
Poractant alfaPropranolol may increase the bradycardic activities of Poractant alfa.Approved
PosaconazoleThe metabolism of Propranolol can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
Potassium acetateThe risk or severity of hyperkalemia can be increased when Potassium acetate is combined with Propranolol.Approved, Investigational
Potassium bicarbonateThe risk or severity of hyperkalemia can be increased when Potassium bicarbonate is combined with Propranolol.Approved
Potassium cationThe risk or severity of hyperkalemia can be increased when Potassium cation is combined with Propranolol.Approved, Investigational
Potassium ChlorideThe risk or severity of hyperkalemia can be increased when Potassium Chloride is combined with Propranolol.Approved, Withdrawn
Potassium CitrateThe risk or severity of hyperkalemia can be increased when Potassium Citrate is combined with Propranolol.Approved, Investigational, Vet Approved
PractololPractolol may increase the hypotensive activities of Propranolol.Approved
PramipexoleThe serum concentration of Pramipexole can be increased when it is combined with Propranolol.Approved, Investigational
PranoprofenPranoprofen may decrease the antihypertensive activities of Propranolol.Experimental, Investigational
PrazosinPropranolol may increase the orthostatic hypotensive activities of Prazosin.Approved
PrednisoneThe serum concentration of Propranolol can be increased when it is combined with Prednisone.Approved, Vet Approved
PrenalterolThe therapeutic efficacy of Prenalterol can be decreased when used in combination with Propranolol.Experimental
PrimaquineThe risk or severity of QTc prolongation can be decreased when Primaquine is combined with Propranolol.Approved
PrimidonePrimidone may increase the hypotensive activities of Propranolol.Approved, Vet Approved
ProcaterolPropranolol may decrease the bronchodilatory activities of Procaterol.Approved, Investigational
ProchlorperazineThe serum concentration of Propranolol can be increased when it is combined with Prochlorperazine.Approved, Vet Approved
ProgesteroneThe serum concentration of Propranolol can be increased when it is combined with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may decrease the antihypertensive activities of Propranolol.Experimental
PromazineThe serum concentration of Propranolol can be increased when it is combined with Promazine.Approved, Vet Approved
PromethazineThe serum concentration of Propranolol can be increased when it is combined with Promethazine.Approved, Investigational
PropacetamolPropacetamol may decrease the antihypertensive activities of Propranolol.Approved, Investigational
PropafenoneThe serum concentration of Propranolol can be increased when it is combined with Propafenone.Approved
PropentofyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Propentofylline.Investigational
PropericiazineThe serum concentration of Propranolol can be increased when it is combined with Propericiazine.Approved, Investigational
PropiomazinePropranolol may increase the orthostatic hypotensive activities of Propiomazine.Approved
PropiopromazineThe serum concentration of Propranolol can be increased when it is combined with Propiopromazine.Vet Approved
PropiverinePropranolol may increase the orthostatic hypotensive activities of Propiverine.Approved, Investigational
PropofolThe serum concentration of Propranolol can be increased when it is combined with Propofol.Approved, Investigational, Vet Approved
PropyphenazonePropyphenazone may decrease the antihypertensive activities of Propranolol.Experimental
ProquazoneProquazone may decrease the antihypertensive activities of Propranolol.Experimental
ProscillaridinPropranolol may increase the bradycardic activities of Proscillaridin.Experimental
ProtokylolPropranolol may decrease the bronchodilatory activities of Protokylol.Approved, Vet Approved
ProtriptylineThe serum concentration of Propranolol can be increased when it is combined with Protriptyline.Approved
ProxyphyllineThe risk or severity of adverse effects can be increased when Propranolol is combined with Proxyphylline.Experimental
PseudoephedrineThe therapeutic efficacy of Pseudoephedrine can be decreased when used in combination with Propranolol.Approved
PyridostigminePyridostigmine may increase the bradycardic activities of Propranolol.Approved, Investigational
QuercetinThe serum concentration of Propranolol can be increased when it is combined with Quercetin.Experimental, Investigational
QuetiapinePropranolol may increase the orthostatic hypotensive activities of Quetiapine.Approved
QuinacrineThe serum concentration of Propranolol can be increased when it is combined with Quinacrine.Approved, Investigational
QuinaprilQuinapril may increase the hypotensive activities of Propranolol.Approved, Investigational
QuinaprilatQuinaprilat may increase the hypotensive activities of Propranolol.Experimental
QuinidineThe serum concentration of Propranolol can be increased when it is combined with Quinidine.Approved, Investigational
QuinineThe metabolism of Propranolol can be increased when combined with Quinine.Approved
RacepinephrinePropranolol may decrease the bronchodilatory activities of Racepinephrine.Approved
RactopamineThe therapeutic efficacy of Ractopamine can be decreased when used in combination with Propranolol.Vet Approved
RamiprilRamipril may increase the hypotensive activities of Propranolol.Approved
RamiprilatRamiprilat may increase the hypotensive activities of Propranolol.Experimental
RanitidineThe serum concentration of Propranolol can be increased when it is combined with Ranitidine.Approved
RasagilineRasagiline may increase the hypotensive activities of Propranolol.Approved
ReboxetineThe serum concentration of Propranolol can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibRegorafenib may increase the bradycardic activities of Propranolol.Approved
RemifentanilRemifentanil may increase the bradycardic activities of Propranolol.Approved
RemikirenRemikiren may increase the hypotensive activities of Propranolol.Approved
ReproterolThe therapeutic efficacy of Reproterol can be decreased when used in combination with Propranolol.Investigational
RescinnamineRescinnamine may increase the hypotensive activities of Propranolol.Approved
ReserpineReserpine may increase the hypotensive activities of Propranolol.Approved, Investigational
Reversin 121The serum concentration of Propranolol can be increased when it is combined with Reversin 121.Experimental
ReviparinThe risk or severity of hyperkalemia can be increased when Reviparin is combined with Propranolol.Approved, Investigational
RheinThe metabolism of Propranolol can be decreased when combined with Rhein.Experimental
RifampicinThe metabolism of Propranolol can be increased when combined with Rifampicin.Approved
RifamycinThe metabolism of Propranolol can be increased when combined with Rifamycin.Investigational
RifapentineThe metabolism of Propranolol can be increased when combined with Rifapentine.Approved, Investigational
RifaximinThe metabolism of Propranolol can be increased when combined with Rifaximin.Approved, Investigational
RilmenidineThe therapeutic efficacy of Rilmenidine can be decreased when used in combination with Propranolol.Approved, Investigational
RilpivirineThe serum concentration of Propranolol can be increased when it is combined with Rilpivirine.Approved
RimexoloneThe metabolism of Propranolol can be increased when combined with Rimexolone.Approved
RimiterolThe therapeutic efficacy of Rimiterol can be decreased when used in combination with Propranolol.Experimental
RiociguatRiociguat may increase the hypotensive activities of Propranolol.Approved
RisperidonePropranolol may increase the hypotensive activities of Risperidone.Approved, Investigational
RitanserinThe serum concentration of Propranolol can be increased when it is combined with Ritanserin.Investigational
RitobegronThe therapeutic efficacy of Ritobegron can be decreased when used in combination with Propranolol.Investigational
RitodrinePropranolol may decrease the bronchodilatory activities of Ritodrine.Approved, Investigational
RitonavirThe metabolism of Propranolol can be decreased when combined with Ritonavir.Approved, Investigational
RituximabPropranolol may increase the hypotensive activities of Rituximab.Approved
RivastigminePropranolol may increase the bradycardic activities of Rivastigmine.Approved, Investigational
RizatriptanThe serum concentration of Rizatriptan can be increased when it is combined with Propranolol.Approved
RobenacoxibRobenacoxib may decrease the antihypertensive activities of Propranolol.Experimental, Vet Approved
RofecoxibRofecoxib may decrease the antihypertensive activities of Propranolol.Approved, Investigational, Withdrawn
RolapitantThe serum concentration of Propranolol can be increased when it is combined with Rolapitant.Approved, Investigational
RomifidineThe therapeutic efficacy of Romifidine can be decreased when used in combination with Propranolol.Vet Approved
RopiniroleThe therapeutic efficacy of Ropinirole can be decreased when used in combination with Propranolol.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Propranolol.Approved
RotigotineThe risk or severity of adverse effects can be increased when Rotigotine is combined with Propranolol.Approved
RucaparibThe serum concentration of Propranolol can be increased when it is combined with Rucaparib.Approved, Investigational
RuxolitinibRuxolitinib may increase the bradycardic activities of Propranolol.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Propranolol.Approved
SafinamideSafinamide may increase the hypotensive activities of Propranolol.Approved, Investigational
SafrazineSafrazine may increase the hypotensive activities of Propranolol.Withdrawn
SalbutamolPropranolol may decrease the bronchodilatory activities of Salbutamol.Approved, Vet Approved
SalicylamideSalicylamide may decrease the antihypertensive activities of Propranolol.Approved
Salicylic acidSalicylic acid may decrease the antihypertensive activities of Propranolol.Approved, Investigational, Vet Approved
SalinomycinThe serum concentration of Propranolol can be increased when it is combined with Salinomycin.Vet Approved
SalmeterolPropranolol may decrease the bronchodilatory activities of Salmeterol.Approved
SalsalateSalsalate may decrease the antihypertensive activities of Propranolol.Approved
SaprisartanSaprisartan may increase the hypotensive activities of Propranolol.Experimental
SaquinavirThe metabolism of Propranolol can be decreased when combined with Saquinavir.Approved, Investigational
SaralasinThe risk or severity of hyperkalemia can be increased when Saralasin is combined with Propranolol.Investigational
SarilumabThe therapeutic efficacy of Propranolol can be decreased when used in combination with Sarilumab.Approved, Investigational
SC-236SC-236 may decrease the antihypertensive activities of Propranolol.Experimental, Investigational
Secale cereale pollenThe risk of a hypersensitivity reaction to Secale cereale pollen is increased when it is combined with Propranolol.Approved
SecobarbitalSecobarbital may increase the hypotensive activities of Propranolol.Approved, Vet Approved
SelegilineSelegiline may increase the hypotensive activities of Propranolol.Approved, Investigational, Vet Approved
SelexipagSelexipag may increase the hypotensive activities of Propranolol.Approved
SertralineThe serum concentration of Propranolol can be increased when it is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Propranolol.Approved, Vet Approved
SildenafilSildenafil may increase the antihypertensive activities of Propranolol.Approved, Investigational
SilodosinPropranolol may increase the orthostatic hypotensive activities of Silodosin.Approved
SiltuximabThe serum concentration of Propranolol can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Propranolol can be increased when it is combined with Simeprevir.Approved
SitaxentanSitaxentan may increase the hypotensive activities of Propranolol.Approved, Investigational, Withdrawn
SolabegronThe therapeutic efficacy of Solabegron can be decreased when used in combination with Propranolol.Investigational
SorafenibThe serum concentration of Propranolol can be increased when it is combined with Sorafenib.Approved, Investigational
Sorghum bicolor subsp. drummondii pollenThe risk of a hypersensitivity reaction to Sorghum bicolor subsp. drummondii pollen is increased when it is combined with Propranolol.Approved
Sorghum halepense pollenThe risk of a hypersensitivity reaction to Sorghum halepense pollen is increased when it is combined with Propranolol.Approved
SotalolThe risk or severity of adverse effects can be increased when Sotalol is combined with Propranolol.Approved
SpiraprilSpirapril may increase the hypotensive activities of Propranolol.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Spironolactone is combined with Propranolol.Approved
St. John's WortThe serum concentration of Propranolol can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StaurosporineThe serum concentration of Propranolol can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Propranolol can be increased when it is combined with Stiripentol.Approved
StreptokinaseThe risk or severity of adverse effects can be increased when Streptokinase is combined with Propranolol.Approved, Investigational
SuccinylcholineThe risk or severity of hyperkalemia can be increased when Propranolol is combined with Succinylcholine.Approved
SufentanilSufentanil may increase the bradycardic activities of Propranolol.Approved, Investigational
SulconazoleThe metabolism of Propranolol can be decreased when combined with Sulconazole.Approved
SulfasalazineSulfasalazine may decrease the antihypertensive activities of Propranolol.Approved
SulindacSulindac may decrease the antihypertensive activities of Propranolol.Approved, Investigational
SulodexideThe risk or severity of hyperkalemia can be increased when Sulodexide is combined with Propranolol.Approved, Investigational
SunitinibThe serum concentration of Propranolol can be increased when it is combined with Sunitinib.Approved, Investigational
SuprofenSuprofen may decrease the antihypertensive activities of Propranolol.Approved, Withdrawn
SuvorexantThe serum concentration of Propranolol can be increased when it is combined with Suvorexant.Approved, Investigational
SuxibuzoneSuxibuzone may decrease the antihypertensive activities of Propranolol.Experimental
SynephrineThe therapeutic efficacy of Synephrine can be decreased when used in combination with Propranolol.Experimental
TacrineTacrine may increase the bradycardic activities of Propranolol.Investigational, Withdrawn
TacrolimusThe serum concentration of Propranolol can be increased when it is combined with Tacrolimus.Approved, Investigational
TadalafilTadalafil may increase the antihypertensive activities of Propranolol.Approved, Investigational
TalinololTalinolol may increase the hypotensive activities of Propranolol.Investigational
TalniflumateTalniflumate may decrease the antihypertensive activities of Propranolol.Approved
TamoxifenThe serum concentration of Propranolol can be increased when it is combined with Tamoxifen.Approved
TamsulosinPropranolol may increase the orthostatic hypotensive activities of Tamsulosin.Approved, Investigational
TariquidarThe serum concentration of Propranolol can be increased when it is combined with Tariquidar.Investigational
TasosartanThe risk or severity of hyperkalemia can be increased when Tasosartan is combined with Propranolol.Approved
TelaprevirThe metabolism of Propranolol can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Propranolol can be decreased when combined with Telithromycin.Approved
TelmisartanThe serum concentration of Propranolol can be increased when it is combined with Telmisartan.Approved, Investigational
TemocaprilTemocapril may increase the hypotensive activities of Propranolol.Experimental, Investigational
TemsirolimusThe serum concentration of Propranolol can be increased when it is combined with Temsirolimus.Approved
TenidapTenidap may decrease the antihypertensive activities of Propranolol.Experimental
TenoxicamTenoxicam may decrease the antihypertensive activities of Propranolol.Approved
TepoxalinTepoxalin may decrease the antihypertensive activities of Propranolol.Vet Approved
TerazosinPropranolol may increase the orthostatic hypotensive activities of Terazosin.Approved
TerbinafineThe metabolism of Propranolol can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerbutalinePropranolol may decrease the bronchodilatory activities of Terbutaline.Approved
TerfenadineThe serum concentration of Propranolol can be increased when it is combined with Terfenadine.Approved, Withdrawn
TerguridePropranolol may increase the vasoconstricting activities of Terguride.Experimental
TeriflunomideThe serum concentration of Propranolol can be decreased when it is combined with Teriflunomide.Approved
TertatololThe risk or severity of hyperkalemia can be increased when Tertatolol is combined with Propranolol.Experimental
TesmilifeneThe serum concentration of Propranolol can be increased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Propranolol can be increased when it is combined with Testosterone.Approved, Investigational
Testosterone cypionateTestosterone cypionate may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.Approved
Testosterone enanthateThe serum concentration of Propranolol can be increased when it is combined with Testosterone enanthate.Approved
Testosterone undecanoateThe serum concentration of Propranolol can be increased when it is combined with Testosterone undecanoate.Approved, Investigational
TetraethylammoniumThe serum concentration of Tetraethylammonium can be increased when it is combined with Propranolol.Experimental, Investigational
TetrahydropalmatineTetrahydropalmatine may increase the hypotensive activities of Propranolol.Investigational
TetrandrineThe serum concentration of Propranolol can be increased when it is combined with Tetrandrine.Experimental
TetryzolineThe therapeutic efficacy of Tetryzoline can be decreased when used in combination with Propranolol.Approved
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Propranolol.Approved, Investigational, Withdrawn
TheobromineThe risk or severity of adverse effects can be increased when Propranolol is combined with Theobromine.Approved, Investigational
TheodrenalineThe risk or severity of adverse effects can be increased when Propranolol is combined with Theodrenaline.Investigational
TheophyllineTheophylline may increase the antihypertensive activities of Propranolol.Approved
ThiamylalThiamylal may increase the hypotensive activities of Propranolol.Approved, Vet Approved
ThiazinamThe serum concentration of Propranolol can be increased when it is combined with Thiazinam.Experimental
ThiethylperazineThe serum concentration of Propranolol can be increased when it is combined with Thiethylperazine.Withdrawn
ThiopentalThiopental may increase the hypotensive activities of Propranolol.Approved, Vet Approved
ThioproperazineThe serum concentration of Propranolol can be increased when it is combined with Thioproperazine.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Propranolol.Approved, Withdrawn
ThiothixeneThe metabolism of Propranolol can be decreased when combined with Thiothixene.Approved
Tiaprofenic acidTiaprofenic acid may decrease the antihypertensive activities of Propranolol.Approved
TicagrelorThe serum concentration of Propranolol can be increased when it is combined with Ticagrelor.Approved
TicrynafenTicrynafen may increase the hypotensive activities of Propranolol.Withdrawn
TimololTimolol may increase the hypotensive activities of Propranolol.Approved
TinoridineTinoridine may decrease the antihypertensive activities of Propranolol.Investigational
TinzaparinThe risk or severity of hyperkalemia can be increased when Tinzaparin is combined with Propranolol.Approved
TipifarnibThe serum concentration of Propranolol can be increased when it is combined with Tipifarnib.Investigational
TipranavirThe metabolism of Propranolol can be decreased when combined with Tipranavir.Approved, Investigational
TizanidineThe therapeutic efficacy of Tizanidine can be decreased when used in combination with Propranolol.Approved, Investigational
TocilizumabThe serum concentration of Propranolol can be decreased when it is combined with Tocilizumab.Approved
TocopherylquinoneTocopherylquinone may increase the hypotensive activities of Propranolol.Experimental, Investigational
TofacitinibTofacitinib may increase the bradycardic activities of Propranolol.Approved, Investigational
TolazamidePropranolol may increase the hypoglycemic activities of Tolazamide.Approved, Investigational
TolazolinePropranolol may increase the orthostatic hypotensive activities of Tolazoline.Approved, Vet Approved
TolbutamidePropranolol may increase the hypoglycemic activities of Tolbutamide.Approved, Investigational
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Propranolol.Approved, Withdrawn
Tolfenamic AcidTolfenamic Acid may decrease the antihypertensive activities of Propranolol.Approved, Investigational
TolmetinTolmetin may decrease the antihypertensive activities of Propranolol.Approved
TolonidineTolonidine may increase the hypotensive activities of Propranolol.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Propranolol.Approved
TolvaptanThe serum concentration of Propranolol can be increased when it is combined with Tolvaptan.Approved
TorasemideTorasemide may increase the hypotensive activities of Propranolol.Approved
ToremifeneThe serum concentration of Propranolol can be increased when it is combined with Toremifene.Approved, Investigational
TrandolaprilTrandolapril may increase the hypotensive activities of Propranolol.Approved
TranylcypromineTranylcypromine may increase the hypotensive activities of Propranolol.Approved, Investigational
TravoprostTravoprost may increase the hypotensive activities of Propranolol.Approved
TrazodoneThe serum concentration of Propranolol can be increased when it is combined with Trazodone.Approved, Investigational
TreprostinilTreprostinil may increase the hypotensive activities of Propranolol.Approved, Investigational
TretinoinThe risk or severity of adverse effects can be increased when Tretinoin is combined with Propranolol.Approved, Investigational, Nutraceutical
TretoquinolThe therapeutic efficacy of Tretoquinol can be decreased when used in combination with Propranolol.Experimental
TriamtereneThe risk or severity of adverse effects can be increased when Triamterene is combined with Propranolol.Approved
TrichlorfonTrichlorfon may increase the bradycardic activities of Propranolol.Vet Approved
TrichlormethiazideTrichlormethiazide may increase the hypotensive activities of Propranolol.Approved, Vet Approved
TrifluoperazineThe serum concentration of Propranolol can be increased when it is combined with Trifluoperazine.Approved, Investigational
TriflupromazineThe serum concentration of Propranolol can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimazosinPropranolol may increase the orthostatic hypotensive activities of Trimazosin.Experimental
TrimethaphanTrimethaphan may increase the hypotensive activities of Propranolol.Approved, Investigational
TrimethoprimThe serum concentration of Propranolol can be increased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipraminePropranolol may increase the orthostatic hypotensive activities of Trimipramine.Approved
Trolamine salicylateTrolamine salicylate may decrease the antihypertensive activities of Propranolol.Approved
TroleandomycinThe metabolism of Propranolol can be decreased when combined with Troleandomycin.Approved
TubocurarineTubocurarine may increase the bradycardic activities of Propranolol.Approved
TulobuterolThe therapeutic efficacy of Tulobuterol can be decreased when used in combination with Propranolol.Investigational
TyrothricinTyrothricin may increase the bradycardic activities of Propranolol.Approved
UbidecarenoneThe therapeutic efficacy of Ubidecarenone can be decreased when used in combination with Propranolol.Approved, Investigational, Nutraceutical
UdenafilUdenafil may increase the antihypertensive activities of Propranolol.Approved, Investigational
UnoprostoneUnoprostone may increase the hypotensive activities of Propranolol.Approved, Investigational
UrapidilPropranolol may increase the orthostatic hypotensive activities of Urapidil.Investigational
Uric AcidThe risk or severity of adverse effects can be increased when Propranolol is combined with Uric Acid.Experimental, Investigational
Urochloa mutica pollenThe risk of a hypersensitivity reaction to Urochloa mutica pollen is increased when it is combined with Propranolol.Approved
ValaciclovirThe risk or severity of adverse effects can be increased when Propranolol is combined with Valaciclovir.Approved, Investigational
ValdecoxibValdecoxib may decrease the antihypertensive activities of Propranolol.Approved, Investigational, Withdrawn
ValganciclovirThe risk or severity of adverse effects can be increased when Propranolol is combined with Valganciclovir.Approved, Investigational
ValinomycinThe serum concentration of Propranolol can be increased when it is combined with Valinomycin.Experimental
ValomaciclovirThe risk or severity of adverse effects can be increased when Propranolol is combined with Valomaciclovir.Investigational
ValsartanValsartan may increase the hypotensive activities of Propranolol.Approved, Investigational
ValspodarThe serum concentration of Propranolol can be increased when it is combined with Valspodar.Investigational
VardenafilVardenafil may increase the antihypertensive activities of Propranolol.Approved
VareniclinePropranolol may decrease the excretion rate of Varenicline which could result in a higher serum level.Approved, Investigational
VelpatasvirThe serum concentration of Propranolol can be increased when it is combined with Velpatasvir.Approved, Investigational
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Propranolol.Approved
VenlafaxineThe serum concentration of Propranolol can be increased when it is combined with Venlafaxine.Approved
VerapamilVerapamil may increase the hypotensive activities of Propranolol.Approved
VilanterolPropranolol may decrease the bronchodilatory activities of Vilanterol.Approved
VilazodoneThe metabolism of Propranolol can be decreased when combined with Vilazodone.Approved
VinblastineThe serum concentration of Propranolol can be increased when it is combined with Vinblastine.Approved
VincamineVincamine may increase the hypotensive activities of Propranolol.Experimental
VoacamineThe serum concentration of Propranolol can be increased when it is combined with Voacamine.Approved, Investigational
VorapaxarThe serum concentration of Propranolol can be increased when it is combined with Vorapaxar.Approved
VoriconazoleThe metabolism of Propranolol can be decreased when combined with Voriconazole.Approved, Investigational
VoxilaprevirThe serum concentration of Propranolol can be increased when it is combined with Voxilaprevir.Approved, Investigational
XamoterolThe therapeutic efficacy of Xamoterol can be decreased when used in combination with Propranolol.Experimental
XanthineThe risk or severity of adverse effects can be increased when Propranolol is combined with Xanthine.Experimental
XipamideXipamide may increase the hypotensive activities of Propranolol.Experimental
XylazineThe therapeutic efficacy of Xylazine can be decreased when used in combination with Propranolol.Vet Approved
XylometazolineThe therapeutic efficacy of Xylometazoline can be decreased when used in combination with Propranolol.Approved, Investigational
YohimbineYohimbine may decrease the antihypertensive activities of Propranolol.Approved, Investigational, Vet Approved
ZafirlukastThe metabolism of Propranolol can be decreased when combined with Zafirlukast.Approved, Investigational
ZaltoprofenZaltoprofen may decrease the antihypertensive activities of Propranolol.Approved, Investigational
ZileutonThe serum concentration of Propranolol can be increased when it is combined with Zileuton.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Propranolol can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidonePropranolol may increase the orthostatic hypotensive activities of Ziprasidone.Approved
ZofenoprilZofenopril may increase the hypotensive activities of Propranolol.Experimental
ZolmitriptanThe serum concentration of Zolmitriptan can be increased when it is combined with Propranolol.Approved, Investigational
ZomepiracZomepirac may decrease the antihypertensive activities of Propranolol.Withdrawn
ZosuquidarThe serum concentration of Propranolol can be increased when it is combined with Zosuquidar.Investigational
ZucapsaicinThe metabolism of Propranolol can be decreased when combined with Zucapsaicin.Approved, Investigational
ZuclopenthixolPropranolol may increase the orthostatic hypotensive activities of Zuclopenthixol.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Avoid natural licorice.
  • Take with food.

References

Synthesis Reference
US3520919
General References
  1. Brunet A, Orr SP, Tremblay J, Robertson K, Nader K, Pitman RK: Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J Psychiatr Res. 2008 May;42(6):503-6. Epub 2007 Jun 22. [PubMed:17588604]
  2. Ohnishi ST, Sadanaga KK, Katsuoka M, Weidanz WP: Effects of membrane acting-drugs on plasmodium species and sickle cell erythrocytes. Mol Cell Biochem. 1989 Nov 23-Dec 19;91(1-2):159-65. [PubMed:2695829]
  3. Singh N, Puri SK: Interaction between chloroquine and diverse pharmacological agents in chloroquine resistant Plasmodium yoelii nigeriensis. Acta Trop. 2000 Nov 2;77(2):185-93. [PubMed:11080509]
  4. Murphy SC, Harrison T, Hamm HE, Lomasney JW, Mohandas N, Haldar K: Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med. 2006 Dec;3(12):e528. [PubMed:17194200]
External Links
Human Metabolome Database
HMDB0001849
KEGG Compound
C07407
PubChem Compound
4946
PubChem Substance
46505387
ChemSpider
4777
BindingDB
25761
ChEBI
8499
ChEMBL
CHEMBL27
Therapeutic Targets Database
DAP000089
PharmGKB
PA451145
IUPHAR
564
Guide to Pharmacology
GtP Drug Page
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Propranolol
ATC Codes
C07BA05 — Propranolol and thiazidesC07AA05 — PropranololC07FA05 — Propranolol and other antihypertensives
AHFS Codes
  • 24:24.00 — Beta-adrenergic Blocking Agents
FDA label
Download (256 KB)
MSDS
Download (74.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingBasic ScienceBone, Age-related / Osteoporosis, Age-Related1
0Active Not RecruitingTreatmentPostural Tachycardia Syndrome1
0Not Yet RecruitingTreatmentGastrointestinal Cancers1
0RecruitingBasic ScienceMetabolic Syndromes / Normal Body Weight / Obese / Pre-Diabetic1
0RecruitingTreatmentAutism Spectrum Conditions/Disorders1
1Active Not RecruitingBasic ScienceCocaine Dependent Subjects1
1CompletedNot AvailableHealthy Volunteers4
1CompletedNot AvailableKidney Diseases1
1CompletedBasic ScienceAmylase / Heart Rate / Memory / Propanolol / Skin Electric Conductance1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceHealthy Volunteers / Pharmacodynamics of Mirabegron1
1CompletedBasic SciencePulmonary Disease, Chronic Obstructive1
1CompletedDiagnosticHealthy Volunteers1
1CompletedOtherTo Determine Bioequivalence Under Fed Conditions1
1CompletedTreatmentFallopian Tube Cancer / Invasive Epithelial Ovarian Cancer / Primary Peritoneal Carcinoma1
1CompletedTreatmentHealthy Volunteers2
1CompletedTreatmentHealthy Volunteers / Pulmonary Disease, Chronic Obstructive1
1CompletedTreatmentMajor Depressive Disorder (MDD)1
1CompletedTreatmentProliferative Diabetic Retinopathy (PDR)1
1CompletedTreatmentType 2 Diabetes Mellitus1
1Enrolling by InvitationTreatmentCavernous Malformations,Cerebral and/or Spinal1
1Not Yet RecruitingTreatmentPediatric Cancer1
1RecruitingTreatmentFibromyalgia Pain1
1TerminatedBasic ScienceDependence, Cocaine1
1TerminatedTreatmentSickle Cell Disorders1
1, 2Active Not RecruitingTreatmentChronic Orthostatic Intolerance / Tachycardia1
1, 2CompletedTreatmentRetinopathy of Prematurity1
1, 2Not Yet RecruitingTreatmentHemangiosarcoma1
1, 2RecruitingBasic ScienceCannabis / Post Traumatic Stress Disorder (PTSD)1
1, 2RecruitingTreatmentStage IIIC Cutaneous Melanoma AJCC v7 / Stage IV Cutaneous Melanoma AJCC v6 and v71
1, 2WithdrawnTreatmentDysautonomia / Traumatic Brain Injury (TBI)1
2Active Not RecruitingOtherCancer, Breast / Locally Advanced Malignant Neoplasm1
2Active Not RecruitingSupportive CareMultiple Myeloma (MM)1
2CompletedNot AvailableTo Determine Bioequivalence Under Fasting Conditions1
2CompletedTreatmentAlcohol Dependence / PTSD1
2CompletedTreatmentAsthma Bronchial1
2CompletedTreatmentBrain Injury / Craniocerebral Trauma / Trauma, Nervous System / Traumatic Brain Injury (TBI)1
2CompletedTreatmentCocaine-Related Disorders2
2CompletedTreatmentDependence, Cocaine1
2CompletedTreatmentHealthy Volunteers / Seasonal Affective Disorder (SAD)1
2CompletedTreatmentHemangiomas1
2CompletedTreatmentHyperalgesia1
2CompletedTreatmentInfantile Hemangiomas1
2CompletedTreatmentMinor burns / Pain1
2CompletedTreatmentPhysiology, Ocular / Regional Blood Flow1
2CompletedTreatmentPost-Traumatic Stress Disorder (PTSD)1
2CompletedTreatmentRenal Angiomyolipomas / Tuberous Sclerosis1
2CompletedTreatmentSickle Cell Disorders1
2CompletedTreatmentStress Disorders, Traumatic, Acute1
2CompletedTreatmentSyncope1
2CompletedTreatmentTemporomandibular Disorders1
2Enrolling by InvitationTreatmentObstructive Sleep Apnea (OSA)1
2Not Yet RecruitingPreventionRetinopathy of Prematurity1
2Not Yet RecruitingTreatmentAlcohol Drinking1
2Not Yet RecruitingTreatmentMalignant Soft Tissue Sarcoma1
2Not Yet RecruitingTreatmentPanic Disorders1
2Not Yet RecruitingTreatmentRenal Cell Adenocarcinoma1
2Not Yet RecruitingTreatmentRetinopathy of Prematurity1
2RecruitingOtherCerebral Cavernous Malformations1
2RecruitingTreatmentAcute Stress Reaction / Adjustment Disorders / Post-Traumatic Stress Disorder (PTSD) / Trauma and Stressor Related Disorders1
2RecruitingTreatmentCerebral Cavernous Malformations1
2RecruitingTreatmentDependence, Cocaine1
2RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
2RecruitingTreatmentInduction of Labor Affected Fetus / Newborn1
2RecruitingTreatmentKaposiform Hemangioendothelioma / Kasabach Merritt Phenomenon1
2RecruitingTreatmentLow Back Pain (LBP)1
2RecruitingTreatmentPost-Traumatic Stress Disorder (PTSD)1
2RecruitingTreatmentPrimary Lymphedema1
2RecruitingTreatmentProstate Cancer1
2RecruitingTreatmentRecurrent Neuroblastoma1
2SuspendedTreatmentStage IB Skin Melanoma / Stages II Skin Melanoma / Stages III Skin Melanoma1
2TerminatedTreatmentCancer, Breast1
2TerminatedTreatmentDysfunctional Labor1
2TerminatedTreatmentHemangiomas1
2TerminatedTreatmentHemangiomas of Infancy1
2TerminatedTreatmentMetastatic Malignant Melanoma / Unresectable Malignant Melanoma1
2TerminatedTreatmentPosttraumatic Stress Disorders1
2TerminatedTreatmentProstatic Neoplasms1
2TerminatedTreatmentTraumas1
2TerminatedTreatmentTraumatic Brain Injury (TBI)1
2Unknown StatusTreatmentAsthma Bronchial1
2Unknown StatusTreatmentFeeling Anxious1
2Unknown StatusTreatmentPosttraumatic Stress Disorders1
2Unknown StatusTreatmentSubstance Dependence1
2WithdrawnTreatmentTraumas1
2, 3Active Not RecruitingTreatmentAdjustment Disorders / Posttraumatic Stress Disorders / Trauma and Stressor Related Disorders1
2, 3CompletedPreventionHypertension Secondary to Kidney Transplant1
2, 3CompletedPreventionStrokes1
2, 3CompletedTreatmentChronic Migraine / Migraine With Aura / Migraine Without Aura1
2, 3CompletedTreatmentInfantile Hemangiomas1
2, 3CompletedTreatmentRetinopathy of Prematurity1
2, 3CompletedTreatmentMinor burns1
2, 3Not Yet RecruitingTreatmentMelanoma1
2, 3RecruitingTreatmentAge Related Macular Degeneration (ARMD)1
2, 3RecruitingTreatmentDental Anxiety1
2, 3RecruitingTreatmentLiver Cirrhosis / Portal Hypertension1
2, 3RecruitingTreatmentTardive Dyskinesia1
2, 3RecruitingTreatmentMinor burns4
2, 3TerminatedTreatmentHemangioma, Capillary1
2, 3WithdrawnTreatmentRecurrent Respiratory Papillomatosis1
3CompletedPreventionArrythmias / Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Death, Sudden,Cardiac / Heart Diseases / Myocardial Infarction / Myocardial Ischemia / Severe ventricular arrhythmias1
3CompletedPreventionCardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Infarction / Myocardial Ischemia1
3CompletedPreventionChronic Migraine1
3CompletedPreventionLiver Cirrhosis / Portal Hypertension1
3CompletedPreventionNon Cirrhotic Portal Hypertension1
3CompletedTreatmentCessation, Smoking1
3CompletedTreatmentClassic Migraine / Headaches / Migraine Without Aura / Migraines1
3CompletedTreatmentTachycardia, Supraventricular1
3RecruitingOtherAnxiety Disorders1
3RecruitingTreatmentAscites1
3RecruitingTreatmentGraves Diseases / Hyperthyroidism1
3RecruitingTreatmentHemangiomas1
3RecruitingTreatmentInfantile Hemangiomas2
3RecruitingTreatmentLiver Cirrhosis / Oesophageal varices haemorrhage / Portal Vein Thrombosis / Portal Vein, Cavernous Transformation Of1
3RecruitingTreatmentPoor; Labor1
3TerminatedPreventionLiver Cirrhosis / Varices, Esophageal1
3TerminatedTreatmentHemangiomas1
3Unknown StatusPreventionNeoplasms, Colorectal1
3WithdrawnPreventionHemorrhage, Gastrointestinal / Portal Hypertension1
4Active Not RecruitingOtherSocial Anxiety Disorder (SAD)1
4Active Not RecruitingTreatmentBrain Injuries,Traumatic1
4CompletedNot AvailableAnxiety Disorders / Posttraumatic Stress Disorders / Reconsolidation1
4CompletedBasic ScienceCortisol / Inflammatory Reaction / Stress, Psychological / Sympathetic Nervous System1
4CompletedDiagnosticOccupational; Cramp(s)1
4CompletedPreventionAscites / Hepatic Encephalopathy / Portal Hypertension Gastropathy / Spontaneous Bacterial Peritonitis (SBP) / Varices, Esophageal1
4CompletedPreventionGraves´ Disease1
4CompletedPreventionLiver Cirrhosis / Varices, Esophageal1
4CompletedPreventionPost-Traumatic Stress Disorder (PTSD)1
4CompletedTreatmentAsthma Bronchial1
4CompletedTreatmentEssential Vocal Tremor / Essential Voice Tremor / Tremor, Essential / Vocal Tremor / Voice Tremor1
4CompletedTreatmentHemangiomas1
4CompletedTreatmentHyperthyroidism1
4CompletedTreatmentMigrainous Headache1
4CompletedTreatmentNeurocardiogenic Syncope1
4CompletedTreatmentPostural Orthostatic Tachycardia Syndrome (POTS)1
4CompletedTreatmentRapid Ventricular Response Atrial Fibrillation1
4CompletedTreatmentTraumatic Brain Injury (TBI)1
4CompletedTreatmentVestibular Migraine1
4Not Yet RecruitingTreatmentHyperalgesia1
4RecruitingBasic ScienceHyperthyroidism1
4RecruitingBasic ScienceSmoking, Cigarette1
4RecruitingPreventionEsophageal and Gastric Varices / Hemorrhage / Liver Cirrhosis1
4RecruitingPreventionLiver Cirrhosis / Variceal Bleeding1
4RecruitingTreatmentVarices, Esophageal1
4SuspendedOtherObsessive-Compulsive Disorder (OCD)1
4TerminatedTreatmentHeadaches1
4TerminatedTreatmentPost-Traumatic Stress Disorder (PTSD)1
4TerminatedTreatmentPosttraumatic Stress Disorders1
4Unknown StatusTreatmentBleeding Gastric Varices / Liver Cirrhosis1
4Unknown StatusTreatmentGastroesophageal Varices Hemorrhage / Hepatocellular,Carcinoma1
4Unknown StatusTreatmentHepatocellular,Carcinoma / Liver Cirrhosis1
4Unknown StatusTreatmentHepatocellular,Carcinoma / Oesophageal varices haemorrhage1
4Unknown StatusTreatmentLiver Cirrhosis / Portal Hypertension1
4Unknown StatusTreatmentPost-Traumatic Stress Disorder (PTSD)1
Not AvailableActive Not RecruitingNot AvailableTremor, Essential / Tremors1
Not AvailableActive Not RecruitingSupportive CareCervical Cancers1
Not AvailableActive Not RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Carcinoma1
Not AvailableCompletedNot AvailableHemangiomas1
Not AvailableCompletedNot AvailableHeroin Dependence / Learning and Memory1
Not AvailableCompletedBasic ScienceHealthy Volunteers1
Not AvailableCompletedBasic SciencePain Measurement1
Not AvailableCompletedPreventionAtherosclerosis / Cardiovascular Disease (CVD) / Cerebral Arteriosclerosis / Coronary Heart Disease (CHD) / Diabetes Mellitus (DM) / Heart Diseases / High Blood Pressure (Hypertension)1
Not AvailableCompletedPreventionLiver Cirrhosis3
Not AvailableCompletedPreventionNonvalvular Atrial Fibrillation1
Not AvailableCompletedPreventionPosttraumatic Stress Disorders1
Not AvailableCompletedTreatmentArrythmias / Nonvalvular Atrial Fibrillation1
Not AvailableRecruitingBasic ScienceHypoglycemia / Type1diabetes1
Not AvailableRecruitingDiagnosticDecompensated Liver Cirrhosis / Variceal Bleeding1
Not AvailableRecruitingDiagnosticPostural Orthostatic Tachycardia Syndrome (POTS) / Tachycardia1
Not AvailableRecruitingPreventionPost-Traumatic Stress Disorder (PTSD)1
Not AvailableRecruitingTreatmentAutism, Early Infantile1
Not AvailableRecruitingTreatmentExtrusion of Tooth1
Not AvailableRecruitingTreatmentGastric Varix / Liver Cirrhoses / Portal Hypertension1
Not AvailableRecruitingTreatmentHepatic Cirrhosis / Liver Cirrhoses1
Not AvailableRecruitingTreatmentHepatocellular,Carcinoma / Male Breast Cancer / Recurrent Melanoma / Stage IV Breast Cancer / Stage IV Melanoma / Stage IV Ovarian Epithelial Cancer / Stage IV Ovarian Germ Cell Tumor / Unspecified Adult Solid Tumor, Protocol Specific1
Not AvailableRecruitingTreatmentInduction of Labor Affected Fetus / Newborn1
Not AvailableRecruitingTreatmentLiver Cirrhosis / Portal Vein Thrombosis1
Not AvailableRecruitingTreatmentPortal Hypertension2
Not AvailableRecruitingTreatmentPostpartum Hemorrhage1
Not AvailableRecruitingTreatmentRetinopathy of Prematurity1
Not AvailableRecruitingTreatmentMinor burns1
Not AvailableUnknown StatusNot AvailableArterial Hypertension / Diabetes Mellitus (DM)1
Not AvailableUnknown StatusBasic ScienceMyofascial Temporomandibular Disorders / Temporomandibular Joint Disorders1
Not AvailableUnknown StatusHealth Services ResearchMigraines1
Not AvailableUnknown StatusPreventionGastric Diseases / Migrainous Headache1
Not AvailableUnknown StatusPreventionPrimary Operable Breast Cancer1
Not AvailableUnknown StatusTreatmentDependence, Cocaine1
Not AvailableUnknown StatusTreatmentPosttraumatic Stress Disorders / Traumatic Memory1
Not AvailableWithdrawnTreatmentAutism, Early Infantile1

Pharmacoeconomics

Manufacturers
  • Akrimax pharmaceuticals llc
  • Glaxosmithkline llc
  • Actavis elizabeth llc
  • Inwood laboratories inc sub forest laboratories inc
  • Mylan pharmaceuticals inc
  • Par pharmaceutical
  • Upsher smith laboratories inc
  • Roxane laboratories inc
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia critical care
  • Bedford laboratories div ben venue laboratories inc
  • Hikma farmaceutica (portugal) sa
  • Sandoz canada inc
  • Smith and nephew solopak div smith and nephew
  • Solopak medical products inc
  • Morton grove pharmaceuticals inc
  • Wyeth ayerst laboratories
  • Clonmel healthcare ltd
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Interpharm inc
  • Ipca laboratories ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lederle laboratories div american cyanamid co
  • Mutual pharmaceutical co inc
  • Northstar healthcare holdings ltd
  • Par pharmaceutical inc
  • Pliva inc
  • Purepac pharmaceutical co
  • Sandoz inc
  • Schering corp sub schering plough corp
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Vintage pharmaceuticals
  • Warner chilcott div warner lambert co
  • Warner chilcott inc
  • Watson laboratories inc
Packagers
  • Actavis Group
  • Advanced Pharmaceutical Services Inc.
  • Akrimax Pharmaceuticals
  • Amerisource Health Services Corp.
  • Apotheca Inc.
  • APP Pharmaceuticals
  • A-S Medication Solutions LLC
  • Barr Pharmaceuticals
  • Baxter International Inc.
  • Bedford Labs
  • Ben Venue Laboratories Inc.
  • Bryant Ranch Prepack
  • Cardinal Health
  • Caremark LLC
  • Comprehensive Consultant Services Inc.
  • Dept Health Central Pharmacy
  • Direct Dispensing Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • Eurand Pharmaceuticals Inc.
  • General Injectables and Vaccines Inc.
  • GlaxoSmithKline Inc.
  • Group Health Cooperative
  • H and H Laboratories
  • H.J. Harkins Co. Inc.
  • Heartland Repack Services LLC
  • Heritage Pharmaceuticals
  • Hikma Pharmaceuticals
  • Ipca Laboratories Ltd.
  • Ivax Pharmaceuticals
  • Kaiser Foundation Hospital
  • Lake Erie Medical and Surgical Supply
  • Liberty Pharmaceuticals
  • Major Pharmaceuticals
  • Medisca Inc.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mylan
  • Northstar Rx LLC
  • Nucare Pharmaceuticals Inc.
  • Palmetto Pharmaceuticals Inc.
  • Par Pharmaceuticals
  • PCA LLC
  • PD-Rx Pharmaceuticals Inc.
  • Pharmaceutical Utilization Management Program VA Inc.
  • Pharmacy Service Center
  • Pharmedix
  • Physicians Total Care Inc.
  • Piramal Healthcare
  • Pliva Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepackage Specialists
  • Prepak Systems Inc.
  • Qualitest
  • Rebel Distributors Corp.
  • Remedy Repack
  • Resource Optimization and Innovation LLC
  • Rouses Point Pharmaceuticals LLC
  • Roxane Labs
  • Sandhills Packaging Inc.
  • Sandoz
  • Southwood Pharmaceuticals
  • Stat Rx Usa
  • Tya Pharmaceuticals
  • UDL Laboratories
  • United Research Laboratories Inc.
  • Upsher Smith Laboratories
  • Vangard Labs Inc.
  • Watson Pharmaceuticals
  • West-Ward Pharmaceuticals
  • Wyeth Pharmaceuticals
Dosage forms
FormRouteStrength
SolutionOral4.28 mg/mL
SolutionOral3.75 mg
LiquidIntravenous1 mg
Capsule, extended releaseOral160 mg/1
Capsule, extended releaseOral60 mg/1
Capsule, extended releaseOral120 mg
Capsule, extended releaseOral160 mg
Capsule, extended releaseOral60 mg
Capsule, extended releaseOral80 mg
Capsule, extended releaseOral120 mg/1
TabletOral120 mg
InjectionIntravenous1 mg/mL
Injection, solutionIntravenous1 mg/mL
SolutionOral20 mg/5mL
SolutionOral40 mg/5mL
TabletOral10 mg/1
TabletOral20 mg/1
TabletOral40 mg/1
TabletOral50 mg/1
TabletOral60 mg/1
TabletOral80 mg/1
Capsule, extended releaseOral80 mg/1
SolutionIntravenous1 mg
TabletOral10 mg/301
TabletOral
TabletOral10 mg
TabletOral20 mg
TabletOral40 mg
TabletOral80 mg
Prices
Unit descriptionCostUnit
Propranolol hcl powder11.63USD g
Propranolol 1 mg/ml vial10.0USD ml
Inderal la 160 mg capsule8.41USD capsule
Inderal LA 160 mg 24 Hour Capsule7.6USD capsule
Inderal la 160 mg capsule sa7.01USD capsule
Inderal la 120 mg capsule6.42USD capsule
Inderal LA 120 mg 24 Hour Capsule5.8USD capsule
Inderal la 120 mg capsule sa5.36USD capsule
Inderal la 80 mg capsule5.18USD capsule
Inderal LA 60 mg 24 Hour Capsule4.79USD capsule
Inderal LA 80 mg 24 Hour Capsule4.68USD capsule
Inderal la 60 mg capsule4.43USD capsule
Inderal la 80 mg capsule sa4.32USD capsule
Inderal la 60 mg capsule sa3.7USD capsule
Propranolol HCl CR 160 mg 24 Hour Capsule2.62USD capsule
InnoPran XL 80 mg 24 Hour Capsule2.5USD capsule
InnoPran XL 120 mg 24 Hour Capsule2.46USD capsule
Innopran xl 120 mg capsule2.41USD capsule
Innopran xl 80 mg capsule2.41USD capsule
Inderide 80-25 mg tablet2.17USD tablet
Propranolol HCl CR 120 mg 24 Hour Capsule2.0USD capsule
Inderide 40-25 mg tablet1.74USD tablet
Propranolol HCl CR 80 mg 24 Hour Capsule1.61USD capsule
Propranolol HCl CR 60 mg 24 Hour Capsule1.38USD capsule
Propranolol HCl 60 mg tablet1.27USD tablet
Inderal-La 160 mg Sustained-Release Capsule1.26USD capsule
Inderal-La 120 mg Sustained-Release Capsule1.07USD capsule
Inderal-La 80 mg Sustained-Release Capsule0.69USD capsule
Propranolol HCl 80 mg tablet0.66USD tablet
Propranolol-HCTZ 80-25 mg tablet0.65USD tablet
Inderal-La 60 mg Sustained-Release Capsule0.62USD capsule
Propranolol-HCTZ 40-25 mg tablet0.61USD tablet
Propranolol 80 mg tablet0.58USD tablet
Propranolol 60 mg tablet0.56USD tablet
Propranolol HCl 40 mg tablet0.53USD tablet
Propranolol 40 mg tablet0.45USD tablet
Propranolol HCl 20 mg tablet0.36USD tablet
Propranolol 20 mg tablet0.33USD tablet
Apo-Propranolol 120 mg Tablet0.32USD tablet
Propranolol HCl 10 mg tablet0.29USD tablet
Propranolol 10 mg tablet0.22USD tablet
Propranolol HCl 20 mg/5ml Solution0.11USD ml
Apo-Propranolol 80 mg Tablet0.06USD tablet
Novo-Pranol 80 mg Tablet0.06USD tablet
Pms-Propranolol 80 mg Tablet0.06USD tablet
Apo-Propranolol 20 mg Tablet0.04USD tablet
Apo-Propranolol 40 mg Tablet0.04USD tablet
Novo-Pranol 20 mg Tablet0.04USD tablet
Novo-Pranol 40 mg Tablet0.04USD tablet
Apo-Propranolol 10 mg Tablet0.02USD tablet
Novo-Pranol 10 mg Tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6500454No2001-10-042021-10-04Us
US8338489No2008-10-162028-10-16Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)96 °CPhysProp
water solubility61.7 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP3.48AVDEEF,A (1997)
Caco2 permeability-4.58ADME Research, USCD
pKa9.42SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0794 mg/mLALOGPS
logP3.03ALOGPS
logP2.58ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)14.09ChemAxon
pKa (Strongest Basic)9.67ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area41.49 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity76.83 m3·mol-1ChemAxon
Polarizability29.98 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9944
Blood Brain Barrier-0.9031
Caco-2 permeable+0.6942
P-glycoprotein substrateSubstrate0.7079
P-glycoprotein inhibitor IInhibitor0.5588
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterNon-inhibitor0.8177
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateNon-substrate0.6463
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.924
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8487
Ames testNon AMES toxic0.9392
CarcinogenicityNon-carcinogens0.9097
BiodegradationNot ready biodegradable0.9871
Rat acute toxicity2.5625 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9185
hERG inhibition (predictor II)Inhibitor0.7092
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
MS/MS Spectrum - Quattro_QQQ 10V, PositiveLC-MS/MSsplash10-03di-0090000000-f8c39664b694f5784865
MS/MS Spectrum - Quattro_QQQ 25V, PositiveLC-MS/MSsplash10-05fr-9000000000-84923a2dc3053801527a
MS/MS Spectrum - Quattro_QQQ 40V, PositiveLC-MS/MSsplash10-0fk9-2932000000-fa245a17a643ef33a0b2
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, PositiveLC-MS/MSsplash10-03di-0090000000-ee9d9c871e322202a948
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, PositiveLC-MS/MSsplash10-03di-0290000000-9f3f72a6b6b792659137
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, PositiveLC-MS/MSsplash10-0avi-5900000000-95293e6a5f843d0cc282
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, PositiveLC-MS/MSsplash10-0ab9-9700000000-6b5b9e9743cb3f7bca58
LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, PositiveLC-MS/MSsplash10-0adi-9700000000-f5825268222d45a4ce95
LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , PositiveLC-MS/MSsplash10-0159-1900000000-9872255282c6a95633aa
LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , PositiveLC-MS/MSsplash10-00di-9500000000-122203085c028de6cbe4
LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , PositiveLC-MS/MSsplash10-0aor-0900000000-39e75b6ae19b4763a0bf
LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , PositiveLC-MS/MSsplash10-004i-0900000000-b75e7bf7aa20ce854157
LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , PositiveLC-MS/MSsplash10-00di-9200000000-2f102916e2fe0f6c1f4b
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0c00-9650000000-c4a4f189be72c438d080
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0159-0910000000-d7db5bab374a7cf02fd3
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03di-0090000000-057a63162f5e674c4ce6
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03di-0190000000-87c354c205b94f5f06e1
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0cl0-4930000000-1eecec66280a12a94b9d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0ab9-4900000000-ddd58df17ce1f65a7559
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-4900000000-711c94a7c2e5c24e9e84
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a6r-3900000000-54967b29c739db5eb0d5
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03di-0090000000-057a63162f5e674c4ce6
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03di-0190000000-f4e36c8dd4e96992c94d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0830-4920000000-835447ce35e37ab07193
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0ab9-5900000000-25248a6b39724a02096d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-4900000000-5663a764e73595039671
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a6r-3900000000-20d14f48fc5615796a2d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00lr-0910000000-d51a9e2266c2de91bfaa
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-03di-0090000000-d6c29037a12e6224fc5c
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-03di-3590000000-e89d2a443f5d3480df83
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0avi-7900000000-073897b09869caa5bcdc
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0ab9-7900000000-566e620bc2a178d2a8e7
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0ab9-6900000000-21115e5f6c969e2f9e0f
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0adi-5900000000-c8d935c939307db2ee51
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03di-0090000000-ee9d9c871e322202a948
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03di-0290000000-53507ada5020c820cd0f
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0avi-5900000000-95293e6a5f843d0cc282
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0ab9-9700000000-264398d3bc59c8ced5ed
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0adi-9700000000-f5825268222d45a4ce95
LC-MS/MS Spectrum - LC-ESI-IT , positiveLC-MS/MSsplash10-0159-1900000000-63f0b6b57a76617acc2d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-060r-4900000000-c1976ec4cf413372eb24
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-05i0-4900000000-dfc2a11c8d505e07028b
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0159-0900000000-ece05c33751eecfe1c79
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00lr-0900000000-cbbd556232c991733f57
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-03di-4590000000-aaddd1419df983db1236
1H NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Naphthalenes
Sub Class
Not Available
Direct Parent
Naphthalenes
Alternative Parents
Alkyl aryl ethers / Secondary alcohols / 1,2-aminoalcohols / Dialkylamines / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
Naphthalene / Alkyl aryl ether / 1,2-aminoalcohol / Secondary alcohol / Secondary aliphatic amine / Ether / Secondary amine / Organic nitrogen compound / Organonitrogen compound / Organooxygen compound
Molecular Framework
Aromatic homopolycyclic compounds
External Descriptors
secondary amine, propanolamine, naphthalenes (CHEBI:8499)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Receptor signaling protein activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately e...
Gene Name
ADRB1
Uniprot ID
P08588
Uniprot Name
Beta-1 adrenergic receptor
Molecular Weight
51322.1 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Lewis CJ, Gong H, Brown MJ, Harding SE: Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology. Br J Pharmacol. 2004 Mar;141(5):813-24. Epub 2004 Feb 2. [PubMed:14757703]
  3. Rouget C, Barthez O, Goirand F, Leroy MJ, Breuiller-Fouche M, Rakotoniaina Z, Guerard P, Morcillo EJ, Advenier C, Sagot P, Cabrol D, Dumas M, Bardou M: Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia. Biol Reprod. 2006 Jan;74(1):209-16. Epub 2005 Sep 21. [PubMed:16177222]
  4. Horinouchi T, Morishima S, Tanaka T, Suzuki F, Tanaka Y, Koike K, Miwa S, Muramatsu I: Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. Epub 2007 Jun 16. [PubMed:17628611]
  5. Rezmann-Vitti LA, Louis SN, Nero TL, Jackman GP, Machida CA, Louis WJ: Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding. Eur J Med Chem. 2004 Jul;39(7):625-31. [PubMed:15236843]
  6. Yazawa K, Wang JW, Hao LY, Onoue Y, Kameyama M: Verrucotoxin, a stonefish venom, modulates calcium channel activity in guinea-pig ventricular myocytes. Br J Pharmacol. 2007 Aug;151(8):1198-203. Epub 2007 Jun 18. [PubMed:17572694]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately ...
Gene Name
ADRB2
Uniprot ID
P07550
Uniprot Name
Beta-2 adrenergic receptor
Molecular Weight
46458.32 Da
References
  1. Isaza C, Henao J, Ramirez E, Cuesta F, Cacabelos R: Polymorphic variants of the beta2-adrenergic receptor (ADRB2) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population. Methods Find Exp Clin Pharmacol. 2005 May;27(4):237-44. [PubMed:16082424]
  2. Rouget C, Barthez O, Goirand F, Leroy MJ, Breuiller-Fouche M, Rakotoniaina Z, Guerard P, Morcillo EJ, Advenier C, Sagot P, Cabrol D, Dumas M, Bardou M: Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia. Biol Reprod. 2006 Jan;74(1):209-16. Epub 2005 Sep 21. [PubMed:16177222]
  3. Illingworth CJ, Gooding SR, Winn PJ, Jones GA, Ferenczy GG, Reynolds CA: Classical polarization in hybrid QM/MM methods. J Phys Chem A. 2006 May 25;110(20):6487-97. [PubMed:16706406]
  4. Horinouchi T, Morishima S, Tanaka T, Suzuki F, Tanaka Y, Koike K, Miwa S, Muramatsu I: Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. Epub 2007 Jun 16. [PubMed:17628611]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Gene Name
ADRB3
Uniprot ID
P13945
Uniprot Name
Beta-3 adrenergic receptor
Molecular Weight
43518.615 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Berg T, Piercey BW, Jensen J: Role of beta1-3-adrenoceptors in blood pressure control at rest and during tyramine-induced norepinephrine release in spontaneously hypertensive rats. Hypertension. 2010 May;55(5):1224-30. doi: 10.1161/HYPERTENSIONAHA.109.149286. Epub 2010 Mar 15. [PubMed:20231523]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Other/unknown
General Function
Serotonin receptor activity
Specific Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers...
Gene Name
HTR1A
Uniprot ID
P08908
Uniprot Name
5-hydroxytryptamine receptor 1A
Molecular Weight
46106.335 Da
References
  1. Smejkal-Jagar L, Boranic M: Serotonin and serotoninergic agents affect proliferation of normal and transformed lymphoid cells. Immunopharmacol Immunotoxicol. 1995 Feb;17(1):151-62. [PubMed:7759768]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Other/unknown
General Function
Serotonin receptor activity
Specific Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive subst...
Gene Name
HTR1B
Uniprot ID
P28222
Uniprot Name
5-hydroxytryptamine receptor 1B
Molecular Weight
43567.535 Da
References
  1. Bailey SR, Elliott J: Evidence for different 5-HT1B/1D receptors mediating vasoconstriction of equine digital arteries and veins. Eur J Pharmacol. 1998 Aug 21;355(2-3):175-87. [PubMed:9760032]
  2. Choppin A, O'Connor SE: Presence of vasoconstrictor 5HT1-like receptors revealed by precontraction of rabbit isolated mesenteric artery. Br J Pharmacol. 1995 Jan;114(2):309-14. [PubMed:7881730]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Details
2. Cytochrome P450 2D6
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Yoshimoto K, Echizen H, Chiba K, Tani M, Ishizaki T: Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2. Br J Clin Pharmacol. 1995 Apr;39(4):421-31. [PubMed:7640150]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  3. Lewis DF, Modi S, Dickins M: Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82. [PubMed:11996013]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Yoshimoto K, Echizen H, Chiba K, Tani M, Ishizaki T: Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2. Br J Clin Pharmacol. 1995 Apr;39(4):421-31. [PubMed:7640150]
  2. Brosen K: Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet. 1995;29 Suppl 1:20-5. [PubMed:8846619]
  3. Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. [PubMed:19754423]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  5. Carrillo JA, Benitez J: Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet. 2000 Aug;39(2):127-53. [PubMed:10976659]
  6. Masubuchi Y, Hosokawa S, Horie T, Suzuki T, Ohmori S, Kitada M, Narimatsu S: Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos. 1994 Nov-Dec;22(6):909-15. [PubMed:7895609]
  7. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
No
General Function
Not Available
Specific Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in...
Gene Name
ORM1
Uniprot ID
P02763
Uniprot Name
Alpha-1-acid glycoprotein 1
Molecular Weight
23511.38 Da
References
  1. Ferry DG, Caplan NB, Cubeddu LX: Interaction between antidepressants and alpha 1-adrenergic receptor antagonists on the binding to alpha 1-acid glycoprotein. J Pharm Sci. 1986 Feb;75(2):146-9. [PubMed:2870173]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Quaternary ammonium group transmembrane transporter activity
Specific Function
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creat...
Gene Name
SLC22A2
Uniprot ID
O15244
Uniprot Name
Solute carrier family 22 member 2
Molecular Weight
62579.99 Da
References
  1. Dudley AJ, Bleasby K, Brown CD: The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9. [PubMed:10960071]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103]
  2. D'Emanuele A, Jevprasesphant R, Penny J, Attwood D: The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. J Control Release. 2004 Mar 24;95(3):447-53. [PubMed:15023456]

Drug created on June 13, 2005 07:24 / Updated on August 15, 2018 09:41