Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
Article Details
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Crooks PA, Kottayil SG, Al-Ghananeem AM, Byrn SR, Butterfield DA
Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. Epub 2006 Jun 13.
- PubMed ID
- 16777416 [ View in PubMed]
- Abstract
A series of 3-O-acyl-6-O-sulfate esters of morphine, dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to mu-, delta-, kappa(1)-, kappa(2)-, and kappa(3)-opiate receptors. Several compounds exhibited good affinity for the mu-opiate receptor. Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphine at the mu-opiate receptor and was the most selective compound at this receptor subtype.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Dihydromorphine Delta-type opioid receptor Protein Humans UnknownAgonistDetails Dihydromorphine Kappa-type opioid receptor Protein Humans UnknownAgonistDetails Dihydromorphine Mu-type opioid receptor Protein Humans YesAgonistDetails