Muscarinic cholinergic activation of mouse spleen cells cytotoxic to tumor cells in vitro.

Article Details

Citation

Copy to clipboard

Lane MA

Muscarinic cholinergic activation of mouse spleen cells cytotoxic to tumor cells in vitro.

J Natl Cancer Inst. 1978 Sep;61(3):923-6.

PubMed ID

29133 [ View in PubMed

]

Abstract

Carbamylcholine, acting via a pharmacologically specific receptor, had the ability to activate effector populations of spleen cells from female BALB/cfC3H and BALB/c mice; those cell populations were then significantly reactive in vitro against syngeneic tumor target cells but were only minimally reactive to normal syngeneic target tissues. The induced reactivity was inhibited by the muscarinic cholinergic antagonists atropine, scopolamine, and isopropamide, but not by the nicotinic antagonist d-tubocurare, and it appeared to involve both T-cell and non-T-cell effectors.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Isopropamide	Muscarinic acetylcholine receptor M3	Protein	Humans	Yes	Antagonist	Details
Isopropamide	Muscarinic acetylcholine receptor M4	Protein	Humans	Unknown	Antagonist	Details