Induction of CYP1A1 by GABA receptor ligands.

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Sadar MD, Westlind A, Blomstrand F, Andersson TB

Induction of CYP1A1 by GABA receptor ligands.

Biochem Biophys Res Commun. 1996 Dec 4;229(1):231-7.

PubMed ID

8954111 [ View in PubMed

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Abstract

The induction of CYP1A1 is mediated via the aromatic hydrocarbon (Ah) receptor. Studies from our laboratory show CYP1A1 induction by picrotoxin and phenobarbital which prompted us to examine if other ligands of the gamma-aminobutyric acid (GABA) receptor could also induce CYP1A1. Here we report the nuclear translocation of the Ah receptor and its DNA binding activity to radiolabeled double-stranded synthetic xenobiotic response elements (XREs) in nuclear extracts, increased accumulation of CYP1A1 mRNA, and alterations in intracellular calcium concentrations in cells exposed to GABA receptor ligands.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Phenobarbital	Cytochrome P450 1A1	Protein	Humans	Unknown	Inducer	Details
Picrotoxin	Cytochrome P450 1A1	Protein	Humans	Unknown	Inducer	Details