Teriflunomide in Patients with Relapsing-Remitting Forms of Multiple Sclerosis.
Article Details
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Chan A, de Seze J, Comabella M
Teriflunomide in Patients with Relapsing-Remitting Forms of Multiple Sclerosis.
CNS Drugs. 2016 Jan;30(1):41-51. doi: 10.1007/s40263-015-0299-y.
- PubMed ID
- 26758290 [ View in PubMed]
- Abstract
Teriflunomide is a once-daily oral agent that has been licensed in the EU since August 2013 for the treatment of adult patients with relapsing-remitting multiple sclerosis (RRMS). More recently (September 2014), the EU summary of product characteristics (SmPC) was updated to include data from patients with a first clinical demyelinating event. This review examines the EU SmPC for teriflunomide, with reference to key clinical and safety outcomes and practical considerations for prescribing physicians. In two phase III trials (TEMSO and TOWER) in patients with relapsing forms of MS, teriflunomide 14 mg significantly reduced the annualized relapse rate and the risk of confirmed disability progression sustained for at least 12 weeks. Magnetic resonance imaging (MRI) total lesion volume, gadolinium-enhancing lesions, and unique active lesions were reduced with teriflunomide treatment in TEMSO. In the TOPIC study, in patients with a first clinical demyelinating event, teriflunomide treatment significantly reduced the time to a second clinical episode (relapse). Across the clinical studies, teriflunomide was generally well tolerated; adverse events reported in >/= 10% of teriflunomide-treated patients were diarrhea, nausea, increased alanine aminotransferase, and alopecia. Data from the clinical development program support the use of teriflunomide in a broad spectrum of patients with RRMS.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Teriflunomide Cytochrome P450 1A2 Protein Humans UnknownInducerDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAcenocoumarolLeflunomide The serum concentration of Acenocoumarol can be decreased when it is combined with Leflunomide. AcetaminophenLeflunomide The serum concentration of Acetaminophen can be decreased when it is combined with Leflunomide. AcetaminophenTeriflunomide The serum concentration of Acetaminophen can be decreased when it is combined with Teriflunomide. AcyclovirLeflunomide The serum concentration of Acyclovir can be decreased when it is combined with Leflunomide. AcyclovirTeriflunomide The serum concentration of Acyclovir can be decreased when it is combined with Teriflunomide.