Docosahexaenoic acid enhances cyclooxygenase-2 induction by facilitating p44/42, but not p38, mitogen-activated protein kinase activation in rat vascular smooth muscle cells.
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Machida T, Hiramatsu M, Hamaue N, Minami M, Hirafuji M
Docosahexaenoic acid enhances cyclooxygenase-2 induction by facilitating p44/42, but not p38, mitogen-activated protein kinase activation in rat vascular smooth muscle cells.
J Pharmacol Sci. 2005 Sep;99(1):113-6. Epub 2005 Sep 1.
- PubMed ID
- 16141635 [ View in PubMed]
- Abstract
The effect of docosahexaenoic acid (DHA) on cyclooxygenase expression induced by interleukin (IL)-1beta and phorbol 12-myristate 13-acetate (PMA) in rat vascular smooth muscle cells (VSMCs) was investigated in order to clarify the cellular mechanism of cardiovascular protective effects. DHA and eicosapentaenoic acid slightly enhanced IL-1beta-induced cyclooxygenase (COX)-2, but not COX-1, expression, whereas arachidonic acid had no effect. DHA also slightly enhanced PMA-induced COX-2 expression. DHA stimulated both rapid and prolonged activation of p44/42, but not p38, mitogen-activated protein kinase (MAPK) induced by IL-1beta and PMA. These results suggest that DHA enhances the COX-2 expression by selectively facilitating p44/42 MAPK activation in VSMCs.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Icosapent Prostaglandin G/H synthase 1 Protein Humans YesInhibitorDetails Icosapent Prostaglandin G/H synthase 2 Protein Humans YesInhibitorDetails