COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.
Article Details
- CitationCopy to clipboard
Beretta C, Garavaglia G, Cavalli M
COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis.
Pharmacol Res. 2005 Oct;52(4):302-6.
- PubMed ID
- 15939622 [ View in PubMed]
- Abstract
We report on the inhibitory activity of the NSAIDs meloxicam, carprofen, phenylbutazone and flunixin, on blood cyclooxygenases in the horse using in vitro enzyme-linked assays. As expected, comparison of IC50 indicated that meloxicam and carprofen are more selective inhibitors of COX-2 than phenylbutazone and flunixin; meloxicam was the most advantageous for horses of four NSAIDs examined. However at IC80, phenylbutazone (+134.4%) and flunixin (+29.7%) had greater COX-2 selectivity than at IC50, and meloxicam (-41.2%) and carprofen (-12.9%) had lower COX-2 selectivity than at IC50. We therefore propose that the selectivity of NSAIDs should be assessed at the 80% as well as 50% inhibition level.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Carprofen Prostaglandin G/H synthase 1 Protein Humans UnknownInhibitorDetails Carprofen Prostaglandin G/H synthase 2 Protein Humans YesInhibitorDetails Phenylbutazone Prostaglandin G/H synthase 1 Protein Humans YesInhibitorDetails Phenylbutazone Prostaglandin G/H synthase 2 Protein Humans YesInhibitorDetails