Transporter-mediated Drug Interactions.
Article Details
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Tsuji A
Transporter-mediated Drug Interactions.
Drug Metab Pharmacokinet. 2002;17(4):253-74.
- PubMed ID
- 15618677 [ View in PubMed]
- Abstract
Since 1994, researchers have isolated various genes encoding transporter proteins involved in drug uptake into and efflux from tissues that play key roles in the absorption, distribution and secretion of drugs in animals and humans. The pharmacokinetic characteristics of drugs that are substrates for these transporters are expected to be influenced by coadministered drugs that work as inhibitors or enhancers of the transporter function. This review deals with recent progress in molecular and functional research on drug transporters, and then with transporter-mediated drug interactions in absorption and secretion from the intestine, secretion from the kidney and liver, and transport across the blood-brain barrier in humans. Although the participation of the particular transporters in observed drug-drug interactions can be difficult to confirm in humans, this review focuses mainly on pharmacokinetic interactions of clinically important drugs.
DrugBank Data that Cites this Article
- Drugs
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Benzylpenicillin Solute carrier family 15 member 1 Protein Humans UnknownSubstrateInhibitorDetails Cefadroxil Solute carrier family 15 member 1 Protein Humans UnknownSubstrateInhibitorDetails Cefdinir Solute carrier family 15 member 1 Protein Humans UnknownSubstrateInhibitorDetails Cefixime Solute carrier family 15 member 1 Protein Humans UnknownSubstrateInhibitorDetails Ceftibuten Solute carrier family 15 member 1 Protein Humans UnknownSubstrateInhibitorDetails Ceftizoxime Solute carrier family 15 member 1 Protein Humans UnknownSubstrateDetails Enalapril Solute carrier family 15 member 1 Protein Humans UnknownSubstrateInhibitorDetails Temocapril Solute carrier family 15 member 1 Protein Humans UnknownNot Available Details