Nucleophosmin

Details

Name
Nucleophosmin
Synonyms
  • NPM
  • Nucleolar phosphoprotein B23
  • Nucleolar protein NO38
  • Numatrin
Gene Name
NPM1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051312|Nucleophosmin
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
FDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKG
PSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
Number of residues
294
Molecular Weight
32574.765
Theoretical pI
Not Available
GO Classification
Functions
activating transcription factor binding / core promoter binding / histone binding / NF-kappaB binding / protein heterodimerization activity / protein homodimerization activity / protein kinase binding / protein kinase inhibitor activity / ribosomal large subunit binding / ribosomal small subunit binding / RNA binding / RNA polymerase II transcription coactivator activity / Tat protein binding / transcription coactivator activity / transcription factor binding / unfolded protein binding
Processes
cell aging / cellular response to UV / CENP-A containing nucleosome assembly / centrosome cycle / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / DNA repair / intracellular protein transport / negative regulation of apoptotic process / negative regulation of cell proliferation / negative regulation of centrosome duplication / negative regulation of protein kinase activity by regulation of protein phosphorylation / nucleocytoplasmic transport / nucleosome assembly / positive regulation of cell cycle G2/M phase transition / positive regulation of cell proliferation / positive regulation of NF-kappaB transcription factor activity / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / positive regulation of translation / protein localization / protein oligomerization / regulation of centriole replication / regulation of eIF2 alpha phosphorylation by dsRNA / regulation of endodeoxyribonuclease activity / regulation of endoribonuclease activity / regulation of transcription from RNA polymerase II promoter / response to stress / ribosome assembly / signal transduction / viral process
Components
centrosome / cytoplasm / cytosol / focal adhesion / intracellular ribonucleoprotein complex / membrane / nucleolus / nucleoplasm / nucleus / protein complex / protein-DNA complex / spindle pole centrosome
General Function
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).
Specific Function
Activating transcription factor binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0051313|Nucleophosmin (NPM1)
ATGGAAGATTCGATGGACATGGACATGAGCCCCCTGAGGCCCCAGAACTATCTTTTCGGT
TGTGAACTAAAGGCCGACAAAGATTATCACTTTAAGGTGGATAATGATGAAAATGAGCAC
CAGTTATCTTTAAGAACGGTCAGTTTAGGGGCTGGTGCAAAGGATGAGTTGCACATTGTT
GAAGCAGAGGCAATGAATTACGAAGGCAGTCCAATTAAAGTAACACTGGCAACTTTGAAA
ATGTCTGTACAGCCAACGGTTTCCCTTGGGGGCTTTGAAATAACACCACCAGTGGTCTTA
AGGTTGAAGTGTGGTTCAGGGCCAGTGCATATTAGTGGACAGCACTTAGTAGCTGTGGAG
GAAGATGCAGAGTCAGAAGATGAAGAGGAGGAGGATGTGAAACTCTTAAGTATATCTGGA
AAGCGGTCTGCCCCTGGAGGTGGTAGCAAGGTTCCACAGAAAAAAGTAAAACTTGCTGCT
GATGAAGATGATGACGATGATGATGAAGAGGATGATGATGAAGATGATGATGATGATGAT
TTTGATGATGAGGAAGCTGAAGAAAAAGCGCCAGTGAAGAAATCTATACGAGATACTCCA
GCCAAAAATGCACAAAAGTCAAATCAGAATGGAAAAGACTCAAAACCATCATCAACACCA
AGATCAAAAGGACAAGAATCCTTCAAGAAACAGGAAAAAACTCCTAAAACACCAAAAGGA
CCTAGTTCTGTAGAAGACATTAAAGCAAAAATGCAAGCAAGTATAGAAAAAGGTGGTTCT
CTTCCCAAAGTGGAAGCCAAATTCATCAATTATGTGAAGAATTGCTTCCGGATGACTGAC
CAAGAGGCTATTCAAGATCTCTGGCAGTGGAGGAAGTCTCTTTAA
Chromosome Location
5
Locus
5q35.1
External Identifiers
ResourceLink
UniProtKB IDP06748
UniProtKB Entry NameNPM_HUMAN
HGNC IDHGNC:7910
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails