Transient receptor potential cation channel subfamily V member 6
Details
- Name
- Transient receptor potential cation channel subfamily V member 6
- Synonyms
- Calcium transport protein 1
- CaT-L
- CaT-like
- CaT1
- ECAC2
- Epithelial calcium channel 2
- TrpV6
- Gene Name
- TRPV6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037283|Transient receptor potential cation channel subfamily V member 6 MGPLQGDGGPALGGADVAPRLSPVRVWPRPQAPKEPALHPMGLSLPKEKGLILCLWSKFC RWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGE TALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARR ASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVL HILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLM QKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLK WKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTP KDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTM VMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVV ILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYA AFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICG REYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLELGCPFSPHLSLP MPSVSRSTSRSSANWERLRQGTLRRDLRGIINRGLEDGESWEYQI
- Number of residues
- 765
- Molecular Weight
- 87284.86
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium channel activity / calmodulin bindingProcessescalcium ion transmembrane transport / calcium ion transport / ion transmembrane transport / regulation of calcium ion-dependent exocytosis / transmembrane transportComponentsextracellular exosome / integral component of plasma membrane / plasma membrane
- General Function
- Calmodulin binding
- Specific Function
- Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- 369-389 428-448 460-480 489-509 533-553 597-617
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019675|Transient receptor potential cation channel subfamily V member 6 (TRPV6) ACGGGACCTCTACAGGGAGACGGTGGGCCGGCCCTTGGGGGGGCTGATGTGGCCCCAAGG CTGAGTCCCGTCAGGGTCTGGCCTCGGCCTCAGGCCCCCAAGGAGCCGGCCCTACACCCC ATGGGTTTGTCACTGCCCAAGGAGAAAGGGCTAATTCTCTGCCTATGGAGCAAGTTCTGC AGATGGTTCCAGAGACGGGAGTCCTGGGCCCAGAGCCGAGATGAGCAGAACCTGCTGCAG CAGAAGAGGATCTGGGAGTCTCCTCTCCTTCTAGCTGCCAAAGATAATGATGTCCAGGCC CTGAACAAGTTGCTCAAGTATGAGGATTGCAAGGTGCACCAGAGAGGAGCCATGGGGGAA ACAGCGCTACACATAGCAGCCCTCTATGACAACCTGGAGGCCGCCATGGTGCTGATGGAG GCTGCCCCGGAGCTGGTCTTTGAGCCCATGACATCTGAGCTCTATGAGGGTCAGACTGCA CTGCACATCGCTGTTGTGAACCAGAACATGAACCTGGTGCGAGCCCTGCTTGCCCGCAGG GCCAGTGTCTCTGCCAGAGCCACAGGCACTGCCTTCCGCCGTAGTCCCTGCAACCTCATC TACTTTGGGGAGCACCCTTTGTCCTTTGCTGCCTGTGTGAACAGTGAGGAGATCGTGCGG CTGCTCATTGAGCATGGAGCTGACATCCGGGCCCAGGACTCCCTGGGAAACACAGTGTTA CACATCCTCATCCTCCAGCCCAACAAAACCTTTGCCTGCCAGATGTACAACCTGTTGCTG TCCTACGACAGACATGGGGACCACCTGCAGCCCCTGGACCTCGTGCCCAATCACCAGGGT CTCACCCCTTTCAAGCTGGCTGGAGTGGAGGGTAACACTGTGATGTTTCAGCACCTGATG CAGAAGCGGAAGCACACCCAGTGGACGTATGGACCACTGACCTCGACTCTCTATGACCTC ACAGAGATCGACTCCTCAGGGGATGAGCAGTCCCTGCTGGAACTTATCATCACCACCAAG AAGCGGGAGGCTCGCCAGATCCTGGACCAGACGCCGGTGAAGGAGCTGGTGAGCCTCAAG TGGAAGCGGTACGGGCGGCCGTACTTCTGCATGCTGGGTGCCATATATCTGCTGTACATC ATCTGCTTCACCATGTGCTGCATCTACCGCCCCCTCAAGCCCAGGACCAATAACCGCACG AGCCCCCGGGACAACACCCTCTTACAGCAGAAGCTACTTCAGGAAGCCTACATGACCCCT AAGGACGATATCCGGCTGGTCGGGGAGCTGGTGACTGTCATTGGGGCTATCATCATCCTG CTGGTAGAGGTTCCAGACATCTTCAGAATGGGGGTCACTCGCTTCTTTGGACAGACCATC CTTGGGGGCCCATTCCATGTCCTCATCATCACCTATGCCTTCATGGTGCTGGTGACCATG GTGATGCGGCTCATCAGTGCCAGCGGGGAGGTGGTACCCATGTCCTTTGCACTCGTGCTG GGCTGGTGCAACGTCATGTACTTCGCCCGAGGATTCCAGATGCTAGGCCCCTTCACCATC ATGATTCAGAAGATGATTTTTGGCGACCTGATGCGATTCTGCTGGCTGATGGCTGTGGTC ATCCTGGGCTTTGCTTCAGCCTTCTATATCATCTTCCAGACAGAGGACCCCGAGGAGCTA GGCCACTTCTACGACTACCCCATGGCCCTGTTCAGCACCTTCGAGCTGTTCCTTACCATC ATCGATGGCCCAGCCAACTACAACGTGGACCTGCCCTTCATGTACAGCATCACCTATGCT GCCTTTGCCATCATCGCCACACTGCTCATGCTCAACCTCCTCATTGCCATGATGGGCGAC ACTCACTGGCGAGTGGCCCATGAGCGGGATGAGCTGTGGAGGGCCCAGATTGTGGCCACC ACGGTGATGCTGGAGCGGAAGCTGCCTCGCTGCCTGTGGCCTCGCTCCGGGATCTGCGGA CGGGAGTATGGCCTGGGAGACCGCTGGTTCCTGCGGGTGGAAGACAGGCAAGATCTCAAC CGGCAGCGGATCCAACGCTACGCACAGGCCTTCCACACCCGGGGCTCTGAGGATTTGGAC AAAGACTCAGTGGAAAAACTAGAGCTGGGCTGTCCCTTCAGCCCCCACCTGTCCCTTCCT ATGCCCTCAGTGTCTCGAAGTACCTCCCGCAGCAGTGCCAATTGGGAAAGGCTTCGGCAA GGGACCCTGAGGAGAGACCTGCGTGGGATAATCAACAGGGGTCTGGAGGACGGGGAGAGC TGGGAATATCAGATCTGA
- Chromosome Location
- 7
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9H1D0 UniProtKB Entry Name TRPV6_HUMAN HGNC ID HGNC:14006 - General References
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