Sulfhydryl Compounds

Name
Sulfhydryl Compounds
Accession Number
DBCAT000316
Description

Compounds containing the -SH radical.

Drugs
DrugDrug Description
CystineAn oxidated derivative of the amino acid cysteine found in various nutritional products and creams to treat cervical injury or inflammation.
CysteineAn amino acid commonly found as a component of total parenteral nutrition and used as an antidote for acetaminophen overdose.
SuccimerA mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.
CysteamineA cystine depleting agent used to treat nephrotic cystinosis.
AzathioprineAn immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis.
MercaptopurineAn antineoplastic agent used to treat acute lymphocytic leukemia.
S-MethylcysteineNot Available
SelenocysteineA naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and...
S-PhosphocysteineNot Available
D-pantetheine 4'-phosphateNot Available
ButyrylthiocholineA sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity. [PubChem]
S-sulphocysteineNot Available
ErdosteineFro the treatment of chronic bronchitis in adults.
AlethineInvestigated for use/treatment in blood (blood forming organ disorders, unspecified), lymphoma (unspecified), and multiple myeloma.
AcetylcysteineA medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose.
DimercaprolA chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium.
Coenzyme MA uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract.
Sodium aurothiomalateA disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
PantethinePantethine is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine. It consists of two molecules of pantetheine that form a dimer...
LesinuradA uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy.
BucillamineBucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis.
MethylselenocysteineMethylselenocysteine has been used in trials studying the prevention of Prostate Carcinoma and No Evidence of Disease.
Acetylcysteine amideNot Available
MercaptoethanolNot Available
Thioglycolic acidThioglycolic acid is under investigation in clinical trial NCT03238105 (Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light).
Cysteine-S-acetamideNot Available
S-BenzylcysteineNot Available
Drugs & Drug Targets
DrugTargetType
CystineCystine/glutamate transportertarget
CystineCystinosintarget
CystineB(0,+)-type amino acid transporter 1target
CystineNeutral and basic amino acid transport protein rBATtarget
CystineMonocarboxylate transporter 10transporter
CysteineCysteine--tRNA ligase, cytoplasmictarget
CysteineGlutamate--cysteine ligase regulatory subunittarget
CysteineGlutamate--cysteine ligase catalytic subunittarget
CysteineAspartate aminotransferase, cytoplasmictarget
CysteineCystathionine gamma-lyasetarget
CysteineCystathionine beta-synthasetarget
CysteineCysteine dioxygenase type 1target
CysteineMethylated-DNA--protein-cysteine methyltransferasetarget
CysteineGlutathione synthetasetarget
CysteineProbable cysteine--tRNA ligase, mitochondrialtarget
CysteineCysteine sulfinic acid decarboxylasetarget
CysteineCysteine desulfurase, mitochondrialtarget
CysteineMonocarboxylate transporter 10transporter
SuccimerLeadtarget
SuccimerMercurytarget
SuccimerCadmiumtarget
SuccimerArsenictarget
CysteamineSomatostatintarget
CysteamineNeuropeptide Y receptor type 2target
CysteamineCystinetarget
CysteamineMyeloperoxidaseenzyme
AzathioprineThiopurine S-methyltransferaseenzyme
AzathioprineXanthine dehydrogenase/oxidaseenzyme
AzathioprineGlutathione S-transferase A1enzyme
AzathioprineGlutathione S-transferase A2enzyme
AzathioprineGlutathione S-transferase Mu 1enzyme
AzathioprineRas-related C3 botulinum toxin substrate 1target
AzathioprineCytochrome P450 1A2enzyme
AzathioprineHypoxanthine-guanine phosphoribosyltransferaseenzyme
AzathioprineNucleotide triphosphate diphosphatase NUDT15enzyme
AzathioprineEquilibrative nucleoside transporter 2transporter
AzathioprineSolute carrier family 28 member 3transporter
AzathioprineP-glycoprotein 1transporter
AzathioprineSolute carrier family 43 member 3transporter
AzathioprineSerum albumincarrier
AzathioprineInosine-5'-monophosphate dehydrogenase 1enzyme
AzathioprineInosine-5'-monophosphate dehydrogenase 2enzyme
AzathioprineGMP synthase [glutamine-hydrolyzing]enzyme
AzathioprineInosine triphosphate pyrophosphataseenzyme
MercaptopurineThiopurine S-methyltransferaseenzyme
MercaptopurineXanthine dehydrogenase/oxidaseenzyme
MercaptopurineHypoxanthine-guanine phosphoribosyltransferasetarget
MercaptopurineSolute carrier family 22 member 8transporter
MercaptopurineMultidrug resistance-associated protein 4transporter
MercaptopurineMultidrug resistance-associated protein 5transporter
MercaptopurineSodium/nucleoside cotransporter 2transporter
MercaptopurineSolute carrier family 28 member 3transporter
MercaptopurineEquilibrative nucleoside transporter 1transporter
MercaptopurineEquilibrative nucleoside transporter 2transporter
MercaptopurineAldehyde oxidaseenzyme
MercaptopurineAmidophosphoribosyltransferasetarget
MercaptopurineInosine-5'-monophosphate dehydrogenasetarget
S-MethylcysteineCathepsin Dtarget
S-MethylcysteineFatty acid-binding protein, livercarrier
S-MethylcysteineMethylated-DNA--protein-cysteine methyltransferasetarget
SelenocysteineCathelicidin antimicrobial peptidetarget
SelenocysteineNucleoside diphosphate kinase Atarget
SelenocysteineFormate dehydrogenase Htarget
SelenocysteineCysteine desulfurasetarget
S-PhosphocysteineN,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB componenttarget
S-PhosphocysteineEnamine/imine deaminasetarget
D-pantetheine 4'-phosphatePhosphopantetheine adenylyltransferasetarget
D-pantetheine 4'-phosphatePhosphopantetheine adenylyltransferasetarget
D-pantetheine 4'-phosphatePhosphopantetheine adenylyltransferasetarget
ButyrylthiocholineCholinesterasetarget
ButyrylthiocholineCholinesteraseenzyme
ErdosteineAdenosine deaminaseenzyme
AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
AcetylcysteineSolute carrier family 22 member 6transporter
AcetylcysteineAminoacylase-1target
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
AcetylcysteineGlutathione synthetasetarget
AcetylcysteineCystine/glutamate transportertarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
DimercaprolArsenictarget
DimercaprolCadmiumtarget
DimercaprolMercurytarget
DimercaprolAmyloid beta A4 proteintarget
Coenzyme MGlutathione reductase, mitochondrialenzyme
Sodium aurothiomalateUDP-glucuronosyltransferase 1-1enzyme
LesinuradSolute carrier family 22 member 12target
LesinuradSolute carrier family 22 member 11target
LesinuradCytochrome P450 2C9enzyme
LesinuradCytochrome P450 3A4enzyme
MercaptoethanolLysozymetarget
MercaptoethanolLactoylglutathione lyasetarget
MercaptoethanolPyridoxine-5'-phosphate oxidasetarget
MercaptoethanolGlucose--fructose oxidoreductasetarget
MercaptoethanolAlpha-1-antitrypsintarget
MercaptoethanolPyridoxine/pyridoxamine 5'-phosphate oxidasetarget
MercaptoethanolGalectin-1target
MercaptoethanolProtein ninBtarget
MercaptoethanolPolycomb protein SCMH1target
MercaptoethanolEndonuclease IIItarget
Cysteine-S-acetamideRibonuclease pancreatictarget
Cysteine-S-acetamide2'-5'-oligoadenylate synthase 1target
S-BenzylcysteineMethylated-DNA--protein-cysteine methyltransferasetarget