Sulfhydryl Compounds

Compounds containing the -SH radical.
DrugDrug NameDrug Indication
DB00138CystineIt has been claimed that L-cysteine has anti-inflammatory properties, that it can protect against various toxins, and that it might be helpful in osteoarthritis and rheumatoid arthritis. More research will have to be done before L-cysteine can be indicated for any of these conditions. Research to date has mostly been in animal models.
DB00151L-CysteineFor the prevention of liver damage and kidney damage associated with overdoses of acetaminophen
DB00566SuccimerFor the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.
DB00763MethimazoleFor the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
DB00847CysteamineGiven intravenously or orally to treat radiation sickness. The bitartrate salts (Cystagon® and Procysbi) have been used for the oral treatment of nephropathic cystinosis and cystinurea. The hydrochloride salt (Cystaran™) is indicated for the treatment of corneal cystine crystal accumulation in cystinosis patients.
DB00993AzathioprineFor use in rheumatoid arthritis, preventing renal transplant rejection, Crohn's disease, and colitis.
DB01033MercaptopurineFor remission induction and maintenance therapy of acute lymphatic leukemia.
DB02216S-MethylcysteineNot Available
DB02345SelenocysteineNot Available
DB03544S-PhosphocysteineNot Available
DB039124'-PhosphopantetheineNot Available
DB04250ButyrylthiocholineNot Available
DB04339CarbocisteineUsed to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis.
DB04370S-sulphocysteineNot Available
DB05057ErdosteineFro the treatment of chronic bronchitis in adults.
DB05800AlethineInvestigated for use/treatment in blood (blood forming organ disorders, unspecified), lymphoma (unspecified), and multiple myeloma.
DB06151AcetylcysteineAcetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.
DB06782DimercaprolFor the treatment of arsenic, gold and mercury poisoning. Indicated in acute lead poisoning when used concomitantly with edetate calcium disodium (DB00974).
DB09110Coenzyme MMesna is a uroprotective agent and is used prophylactically to reduce ifosfamide and cyclophosphamide induced hemorrhagic cystitis.[A18572]
DB09276Sodium aurothiomalateA disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
DB11190PantethineNot Available
DB11560LesinuradFor use, in combination with a xanthine oxidase inhibitor, for the treatment of hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone.
DB12160BucillamineNot Available
DB12430BC-3781Not Available
DB12697MethylselenocysteineNot Available
DB14089Dimercaptosuccinic acidNot Available
DB14479Acetylcysteine zincNot Available
DB14480Acetylcysteine amideNot Available
DB03345MercaptoethanolNot Available
DB15429Thioglycolic acidNot Available
DrugDrug NameTargetType
DB00138CystineCystine/glutamate transportertarget
DB00138CystineCystinosintarget
DB00138CystineB(0,+)-type amino acid transporter 1target
DB00138CystineNeutral and basic amino acid transport protein rBATtarget
DB00138CystineMonocarboxylate transporter 10transporter
DB00151L-CysteineCysteine--tRNA ligase, cytoplasmictarget
DB00151L-CysteineGlutamate--cysteine ligase regulatory subunittarget
DB00151L-CysteineGlutamate--cysteine ligase catalytic subunittarget
DB00151L-CysteineAspartate aminotransferase, cytoplasmictarget
DB00151L-CysteineCystathionine gamma-lyasetarget
DB00151L-CysteineCystathionine beta-synthasetarget
DB00151L-CysteineCysteine dioxygenase type 1target
DB00151L-CysteineMethylated-DNA--protein-cysteine methyltransferasetarget
DB00151L-CysteineGlutathione synthetasetarget
DB00151L-CysteineThiamine transporter 2target
DB00151L-CysteineProbable cysteine--tRNA ligase, mitochondrialtarget
DB00151L-CysteineCysteine sulfinic acid decarboxylasetarget
DB00151L-CysteineCysteine desulfurase, mitochondrialtarget
DB00151L-CysteineMonocarboxylate transporter 10transporter
DB00566SuccimerLeadtarget
DB00566SuccimerMercurytarget
DB00566SuccimerCadmiumtarget
DB00566SuccimerArsenictarget
DB00763MethimazoleThyroid peroxidasetarget
DB00763MethimazoleCytochrome P450 1A2enzyme
DB00763MethimazoleCytochrome P450 2A6enzyme
DB00763MethimazoleCytochrome P450 2B6enzyme
DB00763MethimazoleCytochrome P450 2C19enzyme
DB00763MethimazoleCytochrome P450 2C9enzyme
DB00763MethimazoleCytochrome P450 2D6enzyme
DB00763MethimazoleCytochrome P450 2E1enzyme
DB00763MethimazoleCytochrome P450 3A4enzyme
DB00847CysteamineSomatostatintarget
DB00847CysteamineNeuropeptide Y receptor type 2target
DB00847CysteamineCystinetarget
DB00847CysteamineMyeloperoxidaseenzyme
DB00993AzathioprineHypoxanthine-guanine phosphoribosyltransferasetarget
DB00993AzathioprineThiopurine S-methyltransferaseenzyme
DB00993AzathioprineXanthine dehydrogenase/oxidaseenzyme
DB00993AzathioprineGlutathione S-transferase A1enzyme
DB00993AzathioprineGlutathione S-transferase A2enzyme
DB00993AzathioprineGlutathione S-transferase Mu 1enzyme
DB00993AzathioprineRas-related C3 botulinum toxin substrate 1target
DB00993AzathioprineCytochrome P450 1A2enzyme
DB01033MercaptopurineThiopurine S-methyltransferaseenzyme
DB01033MercaptopurineXanthine dehydrogenase/oxidaseenzyme
DB01033MercaptopurineHypoxanthine-guanine phosphoribosyltransferasetarget
DB01033MercaptopurineSolute carrier family 22 member 8transporter
DB01033MercaptopurineMultidrug resistance-associated protein 4transporter
DB01033MercaptopurineMultidrug resistance-associated protein 5transporter
DB01033MercaptopurineSodium/nucleoside cotransporter 2transporter
DB01033MercaptopurineSolute carrier family 28 member 3transporter
DB01033MercaptopurineEquilibrative nucleoside transporter 1transporter
DB01033MercaptopurineEquilibrative nucleoside transporter 2transporter
DB01033MercaptopurineAldehyde oxidaseenzyme
DB01033MercaptopurineAmidophosphoribosyltransferasetarget
DB01033MercaptopurineInosine-5'-monophosphate dehydrogenasetarget
DB02216S-MethylcysteineCathepsin Dtarget
DB02216S-MethylcysteineFatty acid-binding protein, livercarrier
DB02216S-MethylcysteineMethylated-DNA--protein-cysteine methyltransferasetarget
DB02345SelenocysteineCathelicidin antimicrobial peptidetarget
DB02345SelenocysteineNucleoside diphosphate kinase Atarget
DB02345SelenocysteineFormate dehydrogenase Htarget
DB02345SelenocysteineCysteine desulfurasetarget
DB03544S-PhosphocysteineN,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB componenttarget
DB03544S-PhosphocysteineEnamine/imine deaminasetarget
DB039124'-PhosphopantetheinePhosphopantetheine adenylyltransferasetarget
DB039124'-PhosphopantetheinePhosphopantetheine adenylyltransferasetarget
DB039124'-PhosphopantetheinePhosphopantetheine adenylyltransferasetarget
DB04250ButyrylthiocholineCholinesterasetarget
DB04250ButyrylthiocholineCholinesteraseenzyme
DB04339CarbocisteineGlutathione S-transferase Ptarget
DB05057ErdosteineAdenosine deaminaseenzyme
DB06151AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
DB06151AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
DB06151AcetylcysteineSolute carrier family 22 member 6transporter
DB06151AcetylcysteineAminoacylase-1target
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB06151AcetylcysteineGlutathione synthetasetarget
DB06151AcetylcysteineCystine/glutamate transportertarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
DB06782DimercaprolArsenictarget
DB06782DimercaprolCadmiumtarget
DB06782DimercaprolMercurytarget
DB06782DimercaprolAmyloid beta A4 proteintarget
DB09110Coenzyme MGlutathione reductase, mitochondrialenzyme
DB09276Sodium aurothiomalateUDP-glucuronosyltransferase 1-1enzyme
DB11560LesinuradSolute carrier family 22 member 12target
DB11560LesinuradSolute carrier family 22 member 11target
DB11560LesinuradCytochrome P450 2C9enzyme
DB03345MercaptoethanolLysozymetarget
DB03345MercaptoethanolLactoylglutathione lyasetarget
DB03345MercaptoethanolPyridoxine-5'-phosphate oxidasetarget
DB03345MercaptoethanolGlucose--fructose oxidoreductasetarget
DB03345MercaptoethanolAlpha-1-antitrypsintarget
DB03345MercaptoethanolPyridoxine/pyridoxamine 5'-phosphate oxidasetarget
DB03345MercaptoethanolGalectin-1target
DB03345MercaptoethanolProtein ninBtarget
DB03345MercaptoethanolPolycomb protein SCMH1target
DB03345MercaptoethanolEndonuclease IIItarget