Imino Acids

DrugDrug NameDrug Indication
DB00172ProlineL-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.
DB00492FosinoprilFor treating mild to moderate hypertension, use as an adjunct in treating congestive heart failure, and may be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
DB01197CaptoprilFor the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy.
DB02543Pyrrole-2-CarboxylateNot Available
DB02595Bulgecin ANot Available
DB03088Pidolic AcidThere is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in a variety of non-prescription, over-the-counter dietary supplement products for cognitive or memory enhancement, there are many studies that suggest that such products or such supplementation do not elicit any kind of cognitive benefit to users [A32981, A32982]. In fact, the general suggestion for any such pidolic acid product is to exercise caution in their recommendation as much more research is necessary [A32981]. Pidolic acid and sodium pidolic acid are, however, used to some extent in skin and hair conditioning agents owing to their humectant characteristics [F53].
DB03360N-AcetylprolineNot Available
DB04284L-proline betaineNot Available
DB08847HydroxyprolineUsed in France as a combination product for the treatment of small, superficial wounds.
DB08873BoceprevirBoceprevir, when used in combination with [DB00811], [DB00008], and [DB00022] is indicated for use in the treatment of chronic HCV genotype 1 infection in adults [FDA Label].
DB09164Technetium Tc-99m disofeninTechnetium Tc99m Disofenin is indicated as a hepatobiliary imaging agent. Hepatolite is indicated in the diagnosis of acute cholecystitis as well as to rule out the occurrence of acute cholecystitis in suspected patients with right upper quadrant pain, fever, jaundice, right upper quadrant tenderness and mass or rebound tenderness, but not limited to these signs and symptoms.
DB09230AzelnidipineFor the treatment of hypertension.
DB11364PidotimodFor use as immunostimulant therapy for treatment of cell-mediated immunosuppression with respiratory or urinary infections [L929].
DB11706RaxatrigineNot Available
DB11821DanegaptideNot Available
DB12224Oxothiazolidinecarboxylic acidNot Available
DB13166ZofenoprilNot Available
DB13363OxaceprolNot Available
DB14207FosinoprilatNot Available
DB08766ZofenoprilatNot Available
DB06111AB192Investigated for use/treatment in diabetes mellitus type 2.
DB020321-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidNot Available
DrugDrug NameTargetType
DB00172ProlinePyrroline-5-carboxylate reductase 1, mitochondrialtarget
DB00172ProlineBifunctional glutamate/proline--tRNA ligasetarget
DB00172ProlineSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)target
DB00172ProlineSodium-dependent proline transportertarget
DB00172ProlinePyrroline-5-carboxylate reductase 2target
DB00172ProlineProlyl 4-hydroxylase subunit alpha-2target
DB00172ProlineProline dehydrogenase 1, mitochondrialtarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Htarget
DB00172ProlineProline synthase co-transcribed bacterial homolog proteintarget
DB00172ProlineProlyl 4-hydroxylase subunit alpha-1target
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Btarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Ctarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Atarget
DB00172ProlinePeptidyl-prolyl cis-trans isomerase Gtarget
DB00172ProlineProlyl 3-hydroxylase 1target
DB00172ProlinePyrroline-5-carboxylate reductasetarget
DB00172ProlineProbable proline--tRNA ligase, mitochondrialtarget
DB00172ProlineProlyl 3-hydroxylase 2target
DB00172ProlineProlyl 3-hydroxylase 3target
DB00172ProlinePyrroline-5-carboxylate reductase 3target
DB00172ProlineTrans-L-3-hydroxyproline dehydratasetarget
DB00172ProlineProline dehydrogenase 1, mitochondrialenzyme
DB00172ProlineMonocarboxylate transporter 10transporter
DB00492FosinoprilAngiotensin-converting enzymetarget
DB00492FosinoprilSolute carrier family 15 member 1transporter
DB00492FosinoprilSolute carrier family 15 member 2transporter
DB01197CaptoprilAngiotensin-converting enzymetarget
DB01197CaptoprilCytochrome P450 2D6enzyme
DB01197CaptoprilSerum albumincarrier
DB01197Captopril72 kDa type IV collagenasetarget
DB01197CaptoprilMatrix metalloproteinase-9target
DB01197CaptoprilMultidrug resistance protein 1transporter
DB01197CaptoprilSolute carrier family 15 member 1transporter
DB01197CaptoprilSolute carrier family 22 member 6transporter
DB01197CaptoprilLeukotriene A-4 hydrolasetarget
DB01197CaptoprilB1 bradykinin receptortarget
DB02543Pyrrole-2-CarboxylateMonomeric sarcosine oxidasetarget
DB02595Bulgecin AMembrane-bound lytic murein transglycosylase Btarget
DB02595Bulgecin ASoluble lytic murein transglycosylasetarget
DB03088Pidolic AcidAlpha-amylase 2Btarget
DB03088Pidolic AcidAngiogenintarget
DB03088Pidolic AcidChondroitinase-Btarget
DB03088Pidolic AcidAlpha-amylase 1target
DB03088Pidolic AcidVascular endothelial growth factor Atarget
DB03088Pidolic AcidPancreatic alpha-amylasetarget
DB03088Pidolic AcidIg lambda-1 chain C regionstarget
DB03088Pidolic AcidIg lambda chain V-II region MGCtarget
DB03088Pidolic AcidTrefoil factor 2target
DB03088Pidolic AcidCytochrome c2target
DB03088Pidolic AcidDisintegrin and metalloproteinase domain-containing protein 28target
DB03088Pidolic AcidEndo-1,4-beta-xylanasetarget
DB03088Pidolic AcidDissimilatory copper-containing nitrite reductasetarget
DB03088Pidolic AcidKeratin-associated protein 5-2target
DB03088Pidolic AcidOrexintarget
DB03088Pidolic AcidC-C motif chemokine 8target
DB03088Pidolic AcidCytochrome c'target
DB03088Pidolic AcidPancreatic alpha-amylaseenzyme
DB03360N-Acetylproline(5R)-carbapenem-3-carboxylate synthasetarget
DB04284L-proline betaineGlycine betaine-binding periplasmic proteintarget
DB08847HydroxyprolineProton-coupled amino acid transporter 1transporter
DB08873BoceprevirCytochrome P450 3A4enzyme
DB08873BoceprevirCytochrome P450 3A5enzyme
DB08873BoceprevirMultidrug resistance protein 1transporter
DB08873BoceprevirNS3/4A proteintarget
DB09230AzelnidipineCytochrome P450 3A4enzyme
DB09230AzelnidipineVoltage-dependent L-type calcium channel subunit beta-1target
DB13166ZofenoprilAngiotensin-converting enzymetarget
DB08766ZofenoprilatCytosol aminopeptidasetarget
DB06111AB192Myeloperoxidaseenzyme
DB020321-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidAngiotensin-converting enzymetarget
DB020321-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidFEZ-1 proteintarget
DB020321-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidCarbapenem-hydrolyzing beta-lactamase BlaB-1target
DB020321-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidMetallo-beta-lactamase L1target
DB020321-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidBeta-lactamasetarget
DB020321-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidOrganic hydroperoxide resistance protein, putativetarget