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Identification
NameBoceprevir
Accession NumberDB08873
TypeSmall Molecule
GroupsApproved
DescriptionBoceprevir is a direct acting protease inhibitor for the treatment of hepatitis C. It also has two isomers in which the S isomer is more active than the R-isomer. FDA approved on May 13, 2011.
Structure
Thumb
Synonyms
SCH 503034
Victrelis
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
VictrelisCapsule200 mg/1OralMerck Sharp & Dohme Corp.2011-05-13Not applicableUs
VictrelisCapsule200 mgOralMerck Canada Inc2011-08-02Not applicableCanada
VictrelisCapsule200 mgOralMerck Sharp & Dohme Ltd2011-07-18Not applicableEu
VictrelisCapsule200 mgOralMerck Sharp & Dohme Ltd2011-07-18Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Victrelis TripleMerck Canada Inc
SaltsNot Available
Categories
UNII89BT58KELH
CAS number394730-60-0
WeightAverage: 519.6767
Monoisotopic: 519.342069575
Chemical FormulaC27H45N5O5
InChI KeyLHHCSNFAOIFYRV-DOVBMPENSA-N
InChI
InChI=1S/C27H45N5O5/c1-25(2,3)20(30-24(37)31-26(4,5)6)23(36)32-13-15-17(27(15,7)8)18(32)22(35)29-16(19(33)21(28)34)12-14-10-9-11-14/h14-18,20H,9-13H2,1-8H3,(H2,28,34)(H,29,35)(H2,30,31,37)/t15-,16?,17-,18-,20+/m0/s1
IUPAC Name
3-{[(1R,2S,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-yl]formamido}-4-cyclobutyl-2-oxobutanamide
SMILES
[H][C@]12CN([[email protected]](C(=O)NC(CC3CCC3)C(=O)C(N)=O)[C@@]1([H])C2(C)C)C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C
Pharmacology
IndicationTreatment of chronic hepatitis C genotype 1 in patients that have a compensated liver (as a result of liver diseases like cirrhosis) and are previously untreated or therapy with peginterferon alfa and ribavirin has failed.
Structured Indications
PharmacodynamicsTelaprevir is a direct-acting antiviral agent (DAA) against the hepatitis C virus.
Mechanism of actionBoceprevir inhibits replication of the hepatitis C virus by binding reversibly to nonstructural protein 3/4a (NS3 and NS4A respectively) serine protease. NS4A is a cofactor that works with NS3 for viral replication.
TargetKindPharmacological actionActionsOrganismUniProt ID
Genome polyproteinProteinyes
inhibitor
Hepatitis C virusB0B3C9 details
Related Articles
AbsorptionFood increases exposure of boceprevir by up to 65% relative to fasting state. However, type of food and time of meal does not affect bioavailability of boceprevir and thus can be taken without regards to food. Tmax = 2 hours; Time to steady state, three times a day dosing = 1 day; Cmax, 400 mg single dose, healthy subject = 557 ng/mL; AUC ∞, healthy subject = 2020 ng · h/mL;
Volume of distribution

~722 L

Protein binding~75%
Metabolism

Hepatically metabolized by the aldo-ketoreductase pathway into inactive metabolites via reduction. To a lesser extent, CYP3A4 and CYP3A5 is also involved in the metabolism of boceprevir (oxidative process).

Route of eliminationRemoved via feces (79%) and urine (9%) which suggest some degree of hepatic excretion.
Half lifeMean plasma half-life = 3.4 hours
Clearance

Mean total body clearance (Cl/F) = 161 L/h

ToxicityNot Available
Affected organisms
  • Hepatitis C virus, RSV and other RNA/DNA viruses
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe serum concentration of 1,10-Phenanthroline can be decreased when it is combined with Boceprevir.Experimental
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Boceprevir.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Boceprevir.Experimental, Illicit
3,4-DichloroisocoumarinThe serum concentration of 3,4-Dichloroisocoumarin can be decreased when it is combined with Boceprevir.Experimental
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE can be decreased when it is combined with Boceprevir.Experimental
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Boceprevir.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Boceprevir.Experimental, Illicit
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Boceprevir.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Boceprevir.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Boceprevir.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Boceprevir.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Boceprevir.Approved
AfatinibThe serum concentration of Boceprevir can be increased when it is combined with Afatinib.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Boceprevir.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Boceprevir.Approved
AldosteroneThe serum concentration of Boceprevir can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Boceprevir can be increased when it is combined with Alectinib.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Boceprevir.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Boceprevir.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Boceprevir.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Boceprevir.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Boceprevir.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Boceprevir.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Boceprevir.Approved, Withdrawn
Alpha-1-proteinase inhibitorThe serum concentration of Alpha-1-proteinase inhibitor can be decreased when it is combined with Boceprevir.Approved
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Boceprevir.Approved, Illicit, Investigational
AmantadineThe serum concentration of Boceprevir can be increased when it is combined with Amantadine.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Boceprevir.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Boceprevir.Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Boceprevir.Experimental
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Boceprevir.Approved
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Boceprevir.Illicit, Withdrawn
Aminohippuric acidThe serum concentration of Boceprevir can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Boceprevir.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Boceprevir.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Boceprevir.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Boceprevir.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Boceprevir.Approved
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Boceprevir.Approved
AmsacrineThe serum concentration of Boceprevir can be increased when it is combined with Amsacrine.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Boceprevir.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Boceprevir.Approved
Antithrombin III humanThe serum concentration of Antithrombin III human can be decreased when it is combined with Boceprevir.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Boceprevir.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Boceprevir.Approved, Investigational
AprepitantThe serum concentration of Boceprevir can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe serum concentration of Aprotinin can be decreased when it is combined with Boceprevir.Approved, Withdrawn
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Boceprevir.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Boceprevir.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Boceprevir.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Boceprevir.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Boceprevir.Approved, Withdrawn
AsunaprevirThe serum concentration of Asunaprevir can be decreased when it is combined with Boceprevir.Approved, Investigational
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Boceprevir.Approved, Investigational
AtenololThe serum concentration of Boceprevir can be increased when it is combined with Atenolol.Approved
AtomoxetineThe metabolism of Boceprevir can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Boceprevir.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Boceprevir.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Boceprevir.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Boceprevir.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Boceprevir.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Boceprevir.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Boceprevir.Approved
BatimastatThe serum concentration of Batimastat can be decreased when it is combined with Boceprevir.Experimental
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Boceprevir.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Boceprevir.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Boceprevir.Approved
BenazeprilThe serum concentration of Benazepril can be decreased when it is combined with Boceprevir.Approved, Investigational
BenzamidineThe serum concentration of Benzamidine can be decreased when it is combined with Boceprevir.Experimental
BenzocaineThe serum concentration of Boceprevir can be increased when it is combined with Benzocaine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Boceprevir.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Boceprevir.Approved
BepridilThe serum concentration of Bepridil can be increased when it is combined with Boceprevir.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Boceprevir.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Boceprevir.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Boceprevir.Approved
Bi201335The serum concentration of Bi201335 can be decreased when it is combined with Boceprevir.Investigational
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Boceprevir.Approved
BiperidenThe serum concentration of Boceprevir can be increased when it is combined with Biperiden.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Boceprevir.Approved
BivalirudinThe serum concentration of Bivalirudin can be decreased when it is combined with Boceprevir.Approved, Investigational
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Boceprevir.Approved, Investigational
BosentanThe serum concentration of Boceprevir can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Boceprevir.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Boceprevir.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Boceprevir.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Boceprevir.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Boceprevir.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Boceprevir.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Boceprevir.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Boceprevir.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Boceprevir.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Boceprevir.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Boceprevir.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Boceprevir.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Boceprevir.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Boceprevir.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Boceprevir.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Boceprevir.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Boceprevir.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Boceprevir.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Boceprevir.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Boceprevir.Approved
CandesartanThe serum concentration of Boceprevir can be increased when it is combined with Candesartan.Approved
CandoxatrilThe serum concentration of Candoxatril can be decreased when it is combined with Boceprevir.Experimental
CandoxatrilatThe serum concentration of Candoxatrilat can be decreased when it is combined with Boceprevir.Experimental
CaptoprilThe serum concentration of Captopril can be decreased when it is combined with Boceprevir.Approved
CarbamazepineThe serum concentration of Boceprevir can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Boceprevir.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Boceprevir.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Boceprevir.Approved, Investigational
CaspofunginThe serum concentration of Boceprevir can be increased when it is combined with Caspofungin.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Boceprevir.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Boceprevir.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Boceprevir.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Boceprevir.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Boceprevir.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Boceprevir.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Boceprevir.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Boceprevir.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Boceprevir.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Boceprevir.Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Boceprevir.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Boceprevir.Approved, Vet Approved
ChlorpropamideThe serum concentration of Boceprevir can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Boceprevir can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Boceprevir.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Boceprevir.Approved, Nutraceutical
CholesterolThe serum concentration of Boceprevir can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Boceprevir can be decreased when it is combined with Cholic Acid.Approved
ChymostatinThe serum concentration of Chymostatin can be decreased when it is combined with Boceprevir.Experimental
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Boceprevir.Approved, Investigational
CilastatinThe serum concentration of Cilastatin can be decreased when it is combined with Boceprevir.Approved
CilazaprilThe serum concentration of Cilazapril can be decreased when it is combined with Boceprevir.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Boceprevir.Approved
CimetidineThe serum concentration of Boceprevir can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Boceprevir.Approved
CiprofloxacinThe serum concentration of Boceprevir can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Boceprevir.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be decreased when combined with Boceprevir.Approved
ClarithromycinThe serum concentration of Boceprevir can be increased when it is combined with Clarithromycin.Approved
ClemastineThe metabolism of Boceprevir can be decreased when combined with Clemastine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Boceprevir.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Boceprevir.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Boceprevir.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Boceprevir.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Boceprevir.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Boceprevir.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Boceprevir.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Boceprevir.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Boceprevir.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Boceprevir.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Boceprevir.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Boceprevir.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Boceprevir.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Boceprevir.Approved, Illicit
ClotrimazoleThe metabolism of Boceprevir can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Boceprevir.Approved
CobicistatThe serum concentration of Boceprevir can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Boceprevir.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Boceprevir.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Boceprevir.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Boceprevir.Approved
ColforsinThe serum concentration of Boceprevir can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Boceprevir.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Boceprevir.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Boceprevir.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Boceprevir.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Boceprevir.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Boceprevir is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Boceprevir.Approved, Investigational, Vet Approved
CyclosporineThe serum concentration of Boceprevir can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Boceprevir.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Boceprevir.Approved
DabrafenibThe serum concentration of Boceprevir can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Boceprevir.Approved
DactinomycinThe serum concentration of Boceprevir can be increased when it is combined with Dactinomycin.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Boceprevir.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Boceprevir.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Boceprevir.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Boceprevir.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Boceprevir.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Boceprevir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Boceprevir.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Boceprevir.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Boceprevir.Approved
DeferasiroxThe serum concentration of Boceprevir can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Boceprevir.Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Boceprevir.Approved
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Boceprevir.Approved
DesloratadineThe serum concentration of Boceprevir can be increased when it is combined with Desloratadine.Approved, Investigational
DesogestrelThe serum concentration of Desogestrel can be increased when it is combined with Boceprevir.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Boceprevir.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Boceprevir.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Boceprevir.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Boceprevir.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Boceprevir.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Boceprevir.Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Boceprevir.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Boceprevir.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Boceprevir.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Boceprevir.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Boceprevir.Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Boceprevir.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Boceprevir.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Boceprevir.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Boceprevir.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Boceprevir.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Boceprevir.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Boceprevir.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Boceprevir.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Boceprevir.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Boceprevir.Approved
DipyridamoleThe serum concentration of Boceprevir can be increased when it is combined with Dipyridamole.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Boceprevir.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Boceprevir.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Boceprevir.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Boceprevir.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Boceprevir.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Boceprevir.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Boceprevir.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Boceprevir.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Boceprevir.Approved
DoxazosinThe serum concentration of Doxazosin can be increased when it is combined with Boceprevir.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Boceprevir.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Boceprevir.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Boceprevir.Approved, Investigational
DoxycyclineThe metabolism of Boceprevir can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Boceprevir.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Boceprevir.Approved
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Boceprevir.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Boceprevir.Approved, Investigational
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Boceprevir.Approved
EcabetThe serum concentration of Ecabet can be decreased when it is combined with Boceprevir.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Boceprevir.Approved
EfavirenzThe serum concentration of Boceprevir can be decreased when it is combined with Efavirenz.Approved, Investigational
ElafinThe serum concentration of Elafin can be decreased when it is combined with Boceprevir.Investigational
ElbasvirThe serum concentration of Boceprevir can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Boceprevir.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Boceprevir.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Boceprevir.Approved
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Boceprevir.Approved, Vet Approved
EnalaprilatThe serum concentration of Enalaprilat can be decreased when it is combined with Boceprevir.Approved
EnalkirenThe serum concentration of Enalkiren can be decreased when it is combined with Boceprevir.Experimental
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Boceprevir.Approved, Investigational
EnzalutamideThe serum concentration of Boceprevir can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Boceprevir.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Boceprevir.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Boceprevir.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Boceprevir.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Boceprevir.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Boceprevir.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Boceprevir.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Boceprevir.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Boceprevir.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Boceprevir.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Boceprevir.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Boceprevir can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Boceprevir.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Boceprevir.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Boceprevir.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Boceprevir.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Boceprevir.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Boceprevir.Approved
EstriolThe serum concentration of Boceprevir can be decreased when it is combined with Estriol.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Boceprevir.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Boceprevir.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Boceprevir.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Boceprevir.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Boceprevir.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Boceprevir.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Boceprevir.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Boceprevir.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be increased when it is combined with Boceprevir.Approved
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Boceprevir.Approved
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Boceprevir.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Boceprevir.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Boceprevir.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Boceprevir.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Boceprevir.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Boceprevir.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Boceprevir.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Boceprevir.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Boceprevir.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Boceprevir.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Boceprevir.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Boceprevir.Approved
FexofenadineThe serum concentration of Boceprevir can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Boceprevir can be increased when it is combined with Fidaxomicin.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Boceprevir.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Boceprevir.Approved, Investigational
FlecainideThe serum concentration of Flecainide can be increased when it is combined with Boceprevir.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Boceprevir.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Boceprevir.Investigational
FluconazoleThe metabolism of Boceprevir can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Boceprevir.Approved
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Boceprevir.Approved, Vet Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Boceprevir.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Boceprevir.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Boceprevir.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Boceprevir.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Boceprevir.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Boceprevir.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Boceprevir.Approved, Vet Approved
FlupentixolThe serum concentration of Boceprevir can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Boceprevir can be increased when it is combined with Fluphenazine.Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Boceprevir.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Boceprevir.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Boceprevir.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Boceprevir.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Boceprevir.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Boceprevir.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Boceprevir.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Boceprevir.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Boceprevir.Approved
FluvoxamineThe metabolism of Boceprevir can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Boceprevir.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Boceprevir.Approved
FosaprepitantThe serum concentration of Boceprevir can be increased when it is combined with Fosaprepitant.Approved
FosinoprilThe serum concentration of Fosinopril can be decreased when it is combined with Boceprevir.Approved
FosphenytoinThe serum concentration of Boceprevir can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Boceprevir.Approved, Investigational
Fusidic AcidThe serum concentration of Boceprevir can be increased when it is combined with Fusidic Acid.Approved
GabexateThe serum concentration of Gabexate can be decreased when it is combined with Boceprevir.Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Boceprevir.Approved
GarlicThe serum concentration of Boceprevir can be decreased when it is combined with Garlic.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Boceprevir.Approved, Investigational
GeldanamycinThe serum concentration of Geldanamycin can be decreased when it is combined with Boceprevir.Experimental
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Boceprevir.Approved
GenisteinThe serum concentration of Boceprevir can be increased when it is combined with Genistein.Investigational
GestodeneThe serum concentration of Gestodene can be increased when it is combined with Boceprevir.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Boceprevir.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Boceprevir.Approved
GlycerolThe serum concentration of Boceprevir can be increased when it is combined with Glycerol.Experimental
GM6001The serum concentration of GM6001 can be decreased when it is combined with Boceprevir.Experimental
Gramicidin DThe serum concentration of Boceprevir can be increased when it is combined with Gramicidin D.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Boceprevir.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Boceprevir.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Boceprevir.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Boceprevir.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Boceprevir.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Boceprevir.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Boceprevir.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Boceprevir.Withdrawn
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Boceprevir.Approved
HirulogThe serum concentration of Hirulog can be decreased when it is combined with Boceprevir.Experimental
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Boceprevir.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Boceprevir.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Boceprevir.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Boceprevir.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Boceprevir.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Boceprevir.Approved
IdelalisibThe serum concentration of Boceprevir can be increased when it is combined with Idelalisib.Approved
idraparinuxThe serum concentration of idraparinux can be decreased when it is combined with Boceprevir.Investigational
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Boceprevir resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Boceprevir.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Boceprevir.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Boceprevir.Approved
ImidaprilThe serum concentration of Imidapril can be decreased when it is combined with Boceprevir.Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Boceprevir.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Boceprevir.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Boceprevir.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Boceprevir.Approved
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Boceprevir.Approved
IndomethacinThe serum concentration of Boceprevir can be increased when it is combined with Indomethacin.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Boceprevir.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Boceprevir.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Boceprevir.Approved, Investigational
IsoflurophateThe serum concentration of Isoflurophate can be decreased when it is combined with Boceprevir.Approved, Withdrawn
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Boceprevir.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Boceprevir.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Boceprevir.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Boceprevir.Investigational
ItraconazoleThe serum concentration of Boceprevir can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Boceprevir.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Boceprevir.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Boceprevir.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Boceprevir.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Boceprevir.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Boceprevir.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Boceprevir.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Boceprevir.Approved
KetoconazoleThe serum concentration of Boceprevir can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoconazoleThe metabolism of Boceprevir can be decreased when combined with Ketoconazole.Approved, Investigational
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Boceprevir.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Boceprevir.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Boceprevir.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Boceprevir.Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Boceprevir.Approved
LepirudinThe serum concentration of Lepirudin can be decreased when it is combined with Boceprevir.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Boceprevir.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Boceprevir.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Boceprevir.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Boceprevir.Approved
LevofloxacinThe serum concentration of Boceprevir can be increased when it is combined with Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Boceprevir.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Boceprevir.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Boceprevir.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Boceprevir.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Boceprevir.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Boceprevir.Approved
LiothyronineThe serum concentration of Boceprevir can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Boceprevir can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Lisinopril can be decreased when it is combined with Boceprevir.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Boceprevir.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Boceprevir.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Boceprevir.Approved
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Boceprevir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Boceprevir.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Boceprevir.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Boceprevir.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Boceprevir.Approved, Investigational
LuliconazoleThe serum concentration of Boceprevir can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Boceprevir can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Boceprevir.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Boceprevir.Approved
LynestrenolThe serum concentration of Lynestrenol can be increased when it is combined with Boceprevir.Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Boceprevir.Approved
MaprotilineThe serum concentration of Boceprevir can be increased when it is combined with Maprotiline.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Boceprevir.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Boceprevir.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Boceprevir.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Boceprevir.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Boceprevir.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Boceprevir.Approved
Megestrol acetateThe serum concentration of Boceprevir can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Boceprevir.Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Boceprevir.Approved, Vet Approved
MeprobamateThe serum concentration of Boceprevir can be increased when it is combined with Meprobamate.Approved, Illicit
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Boceprevir.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Boceprevir.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Boceprevir.Experimental
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Boceprevir.Illicit, Withdrawn
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Boceprevir.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Boceprevir.Approved, Vet Approved
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Boceprevir.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Boceprevir.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Boceprevir.Approved
MetoprololThe serum concentration of Boceprevir can be increased when it is combined with Metoprolol.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Boceprevir.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Boceprevir.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Boceprevir.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Boceprevir.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Boceprevir.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Boceprevir.Approved, Illicit
MifepristoneThe serum concentration of Boceprevir can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Boceprevir.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Boceprevir.Approved
MitomycinThe serum concentration of Boceprevir can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Boceprevir can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Boceprevir can be decreased when it is combined with Mitoxantrone.Approved, Investigational
ModafinilThe metabolism of Modafinil can be decreased when combined with Boceprevir.Approved, Investigational
MoexiprilThe serum concentration of Moexipril can be decreased when it is combined with Boceprevir.Approved
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Boceprevir.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Boceprevir.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Boceprevir.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Boceprevir.Approved, Investigational
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline can be decreased when it is combined with Boceprevir.Experimental
NafamostatThe serum concentration of Nafamostat can be decreased when it is combined with Boceprevir.Investigational
NafcillinThe serum concentration of Boceprevir can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Boceprevir.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Boceprevir.Approved, Vet Approved
NaltrexoneThe serum concentration of Boceprevir can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Boceprevir can be increased when it is combined with Naringenin.Experimental
NateglinideThe metabolism of Nateglinide can be decreased when combined with Boceprevir.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Boceprevir.Investigational
NCX 4016The serum concentration of NCX 4016 can be decreased when it is combined with Boceprevir.Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Boceprevir.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Boceprevir.Approved
NeostigmineThe serum concentration of Boceprevir can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Boceprevir can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Boceprevir can be decreased when it is combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Boceprevir.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Boceprevir.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Boceprevir.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Boceprevir.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Boceprevir.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Boceprevir.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Boceprevir.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Boceprevir.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Boceprevir.Approved
NitroaspirinThe serum concentration of Nitroaspirin can be decreased when it is combined with Boceprevir.Investigational
NorelgestrominThe serum concentration of Norelgestromin can be increased when it is combined with Boceprevir.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Boceprevir.Approved
NorgestimateThe serum concentration of Norgestimate can be increased when it is combined with Boceprevir.Approved
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Boceprevir.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Boceprevir.Approved
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Boceprevir.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Boceprevir.Investigational
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Boceprevir.Approved
OmapatrilatThe serum concentration of Omapatrilat can be decreased when it is combined with Boceprevir.Investigational
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Boceprevir.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Boceprevir.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Boceprevir.Investigational
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Boceprevir.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Boceprevir.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Boceprevir.Approved
OtamixabanThe serum concentration of Otamixaban can be decreased when it is combined with Boceprevir.Investigational
OxazepamThe metabolism of Oxazepam can be decreased when combined with Boceprevir.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Boceprevir.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Boceprevir is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Boceprevir.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Boceprevir can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Boceprevir.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Boceprevir.Approved
Palmitic AcidThe serum concentration of Boceprevir can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Boceprevir.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Boceprevir.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Boceprevir.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Boceprevir.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Boceprevir.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Boceprevir.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Boceprevir.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Boceprevir.Approved
ParoxetineThe serum concentration of Boceprevir can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Boceprevir.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Boceprevir.Approved
PentobarbitalThe serum concentration of Boceprevir can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Boceprevir.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Boceprevir.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Boceprevir.Approved
PerindoprilThe serum concentration of Perindopril can be decreased when it is combined with Boceprevir.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Boceprevir.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Boceprevir.Approved
PethidineThe risk or severity of adverse effects can be increased when Boceprevir is combined with Pethidine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Boceprevir.Withdrawn
PhenobarbitalThe serum concentration of Boceprevir can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Boceprevir.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Boceprevir.Approved
PhenytoinThe serum concentration of Boceprevir can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Phosphoramidon can be decreased when it is combined with Boceprevir.Experimental
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Boceprevir.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Boceprevir.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Boceprevir.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Boceprevir.Withdrawn
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Boceprevir.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Boceprevir.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Boceprevir.Approved
Platelet Activating FactorThe serum concentration of Boceprevir can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe metabolism of Podofilox can be decreased when combined with Boceprevir.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Boceprevir.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Boceprevir.Approved
PosaconazoleThe serum concentration of Boceprevir can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Boceprevir.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Boceprevir.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Boceprevir resulting in a loss in efficacy.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Boceprevir.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Boceprevir.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Boceprevir.Approved, Vet Approved
PrazosinThe serum concentration of Boceprevir can be increased when it is combined with Prazosin.Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Boceprevir.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Boceprevir.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Boceprevir.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Boceprevir.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Boceprevir.Experimental
PrimaquineThe metabolism of Primaquine can be decreased when combined with Boceprevir.Approved
PrimidoneThe serum concentration of Boceprevir can be decreased when it is combined with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Prinomastat can be decreased when it is combined with Boceprevir.Investigational
ProbenecidThe serum concentration of Boceprevir can be increased when it is combined with Probenecid.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Boceprevir.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Boceprevir.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Boceprevir.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Boceprevir.Approved, Vet Approved
PromethazineThe serum concentration of Boceprevir can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Boceprevir.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Boceprevir.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Boceprevir.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Boceprevir.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Boceprevir.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Boceprevir.Approved, Illicit
QuercetinThe serum concentration of Boceprevir can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Boceprevir.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Boceprevir.Approved
QuinaprilThe serum concentration of Quinapril can be decreased when it is combined with Boceprevir.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Boceprevir.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Boceprevir.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Boceprevir.Approved, Investigational
RacecadotrilThe serum concentration of Racecadotril can be decreased when it is combined with Boceprevir.Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Boceprevir.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Boceprevir.Approved, Investigational
RamiprilThe serum concentration of Ramipril can be decreased when it is combined with Boceprevir.Approved
RanitidineThe serum concentration of Boceprevir can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Boceprevir.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Boceprevir.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Boceprevir.Approved
RemikirenThe serum concentration of Remikiren can be decreased when it is combined with Boceprevir.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Boceprevir.Approved, Investigational
ReserpineThe serum concentration of Boceprevir can be decreased when it is combined with Reserpine.Approved
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Boceprevir.Approved
RifabutinThe serum concentration of Boceprevir can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Boceprevir can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Boceprevir can be decreased when it is combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Boceprevir.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Boceprevir.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Boceprevir.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Boceprevir.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Boceprevir.Approved, Investigational
RitonavirThe serum concentration of Boceprevir can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Boceprevir.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Boceprevir.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Boceprevir.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Boceprevir.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Boceprevir.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Boceprevir.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Boceprevir.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Boceprevir.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Boceprevir.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Boceprevir.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Boceprevir.Approved
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Boceprevir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Boceprevir.Approved
ScopolamineThe serum concentration of Boceprevir can be increased when it is combined with Scopolamine.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Boceprevir.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Boceprevir.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Boceprevir.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Boceprevir.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Boceprevir.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Boceprevir.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Boceprevir.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Boceprevir.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Boceprevir.Approved
SiltuximabThe serum concentration of Boceprevir can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Boceprevir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Boceprevir.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Boceprevir.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Boceprevir.Approved, Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Boceprevir.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Boceprevir.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Boceprevir.Approved, Investigational
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Boceprevir.Approved
SpiraprilThe serum concentration of Spirapril can be decreased when it is combined with Boceprevir.Approved
SpironolactoneThe serum concentration of Boceprevir can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Boceprevir can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Boceprevir can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Boceprevir can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Boceprevir can be decreased when it is combined with Streptozocin.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Boceprevir.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Boceprevir.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Boceprevir.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Boceprevir.Approved
SulfisoxazoleThe metabolism of Boceprevir can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Boceprevir can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Boceprevir.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Boceprevir.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Boceprevir.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Boceprevir.Approved
TacrineThe serum concentration of Boceprevir can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Boceprevir.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Boceprevir.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Boceprevir.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Boceprevir.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Boceprevir.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Boceprevir.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Boceprevir.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Boceprevir.Experimental
Taurocholic AcidThe serum concentration of Boceprevir can be increased when it is combined with Taurocholic Acid.Experimental
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Boceprevir.Approved
TelithromycinThe metabolism of Boceprevir can be decreased when combined with Telithromycin.Approved
TelmisartanThe serum concentration of Boceprevir can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Boceprevir.Approved
TemocaprilThe serum concentration of Temocapril can be decreased when it is combined with Boceprevir.Experimental, Investigational
TemsirolimusThe risk or severity of adverse effects can be increased when Boceprevir is combined with Temsirolimus.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Boceprevir.Approved
TerazosinThe serum concentration of Boceprevir can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Boceprevir.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Boceprevir.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Boceprevir.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Boceprevir.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Boceprevir.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Boceprevir.Approved
ThiorphanThe serum concentration of Thiorphan can be decreased when it is combined with Boceprevir.Experimental
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Boceprevir.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Boceprevir.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Boceprevir.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Boceprevir resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Boceprevir.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Boceprevir.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Boceprevir.Approved
TipranavirThe serum concentration of Boceprevir can be decreased when it is combined with Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Boceprevir.Approved
TocilizumabThe serum concentration of Boceprevir can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Boceprevir.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Boceprevir.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Boceprevir.Approved
ToremifeneThe risk or severity of adverse effects can be increased when Boceprevir is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Boceprevir.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Boceprevir.Approved, Investigational
TrandolaprilThe serum concentration of Trandolapril can be decreased when it is combined with Boceprevir.Approved
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Boceprevir.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Boceprevir.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Boceprevir.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Boceprevir.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Boceprevir.Approved
TrifluoperazineThe serum concentration of Boceprevir can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Boceprevir can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Boceprevir.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Boceprevir.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Boceprevir.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Boceprevir.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Boceprevir.Approved
UbenimexThe serum concentration of Ubenimex can be decreased when it is combined with Boceprevir.Experimental
UdenafilThe metabolism of Udenafil can be decreased when combined with Boceprevir.Approved, Investigational
UlinastatinThe serum concentration of Ulinastatin can be decreased when it is combined with Boceprevir.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Boceprevir.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Boceprevir.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Boceprevir.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Boceprevir.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Boceprevir.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Boceprevir.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Boceprevir.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Boceprevir.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Boceprevir.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Boceprevir.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Boceprevir.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Boceprevir.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Boceprevir.Approved
VildagliptinThe serum concentration of Vildagliptin can be decreased when it is combined with Boceprevir.Approved, Investigational
VinblastineThe metabolism of Vinblastine can be decreased when combined with Boceprevir.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Boceprevir.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Boceprevir.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Boceprevir.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Boceprevir.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Boceprevir.Approved
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Boceprevir.Approved
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Boceprevir.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Boceprevir.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Boceprevir.Approved
XimelagatranThe serum concentration of Ximelagatran can be decreased when it is combined with Boceprevir.Approved, Investigational, Withdrawn
Ym150The serum concentration of Ym150 can be decreased when it is combined with Boceprevir.Investigational
YohimbineThe metabolism of Yohimbine can be decreased when combined with Boceprevir.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Boceprevir.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Boceprevir.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Boceprevir.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Boceprevir.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Boceprevir.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Boceprevir can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Boceprevir.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Boceprevir.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Boceprevir.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Boceprevir.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Boceprevir.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Boceprevir.Approved, Investigational
Food Interactions
  • Food increases the exposure of boceprevir by up to 65%. However, bioavailability is not affected and thus can be taken without regards to meals.
References
Synthesis Reference

James Lalonde, Tao Li, Jack Liang, Benjamin Mijts, Roger Sheldon, George S.K. Wong, Aleksey Zaks, “Substantially Stereomerically Pure Fused Bicyclic Proline Compounds and Processes for Preparing Boceprevir.” U.S. Patent US20120289709, issued November 15, 2012.

US20120289709
General References
  1. Kiser JJ, Flexner C: Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49. doi: 10.1146/annurev-pharmtox-011112-140254. Epub 2012 Nov 5. [PubMed:23140245 ]
  2. Treitel M, Marbury T, Preston RA, Triantafyllou I, Feely W, O'Mara E, Kasserra C, Gupta S, Hughes EA: Single-dose pharmacokinetics of boceprevir in subjects with impaired hepatic or renal function. Clin Pharmacokinet. 2012 Sep 1;51(9):619-28. doi: 10.2165/11633440-000000000-00000. [PubMed:22799589 ]
  3. Wilby KJ, Partovi N, Ford JA, Greanya E, Yoshida EM: Review of boceprevir and telaprevir for the treatment of chronic hepatitis C. Can J Gastroenterol. 2012 Apr;26(4):205-10. [PubMed:22506260 ]
External Links
ATC CodesJ05AE12
AHFS Codes
  • 8:18.40
PDB EntriesNot Available
FDA labelDownload (710 KB)
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6781
Blood Brain Barrier-0.8805
Caco-2 permeable-0.6532
P-glycoprotein substrateSubstrate0.8394
P-glycoprotein inhibitor IInhibitor0.671
P-glycoprotein inhibitor IIInhibitor0.6377
Renal organic cation transporterNon-inhibitor0.8188
CYP450 2C9 substrateNon-substrate0.7965
CYP450 2D6 substrateNon-substrate0.7996
CYP450 3A4 substrateSubstrate0.621
CYP450 1A2 substrateNon-inhibitor0.7987
CYP450 2C9 inhibitorNon-inhibitor0.7265
CYP450 2D6 inhibitorNon-inhibitor0.87
CYP450 2C19 inhibitorNon-inhibitor0.6908
CYP450 3A4 inhibitorNon-inhibitor0.9659
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8434
Ames testNon AMES toxic0.662
CarcinogenicityNon-carcinogens0.8555
BiodegradationReady biodegradable0.5913
Rat acute toxicity2.6263 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9828
hERG inhibition (predictor II)Non-inhibitor0.7092
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
CapsuleOral200 mg/1
CapsuleOral200 mg
Capsule; powder, for solutionOral; Subcutaneous
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7772178 No2007-11-112027-11-11Us
US8119602 No2007-03-172027-03-17Us
USRE43298 No2002-02-222022-02-22Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0234 mg/mLALOGPS
logP1.93ALOGPS
logP1.78ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)12.44ChemAxon
pKa (Strongest Basic)-0.91ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area150.7 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity138.2 m3·mol-1ChemAxon
Polarizability56.78 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentHybrid peptides
Alternative Parents
Substituents
  • Hybrid peptide
  • N-carbamoyl-alpha-amino acid or derivatives
  • Alpha-amino acid amide
  • Piperidinecarboxylic acid
  • Piperidinecarboxamide
  • 2-piperidinecarboxamide
  • N-acyl-piperidine
  • Pyrrolidine-2-carboxamide
  • Pyrrolidine carboxylic acid or derivatives
  • N-acylpyrrolidine
  • Fatty acyl
  • Piperidine
  • Fatty amide
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Alpha-aminoketone
  • Urea
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Primary carboxylic acid amide
  • Ketone
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Hepatitis C virus
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type peptidase activity
Specific Function:
Not Available
Gene Name:
NS3/4A
Uniprot ID:
B0B3C9
Molecular Weight:
72789.28 Da
References
  1. Ali A, Aydin C, Gildemeister R, Romano KP, Cao H, Ozen A, Soumana D, Newton A, Petropoulos CJ, Huang W, Schiffer CA: Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance. ACS Chem Biol. 2013 Jul 19;8(7):1469-78. doi: 10.1021/cb400100g. Epub 2013 May 1. [PubMed:23594083 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Kiser JJ, Flexner C: Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49. doi: 10.1146/annurev-pharmtox-011112-140254. Epub 2012 Nov 5. [PubMed:23140245 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Kiser JJ, Flexner C: Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49. doi: 10.1146/annurev-pharmtox-011112-140254. Epub 2012 Nov 5. [PubMed:23140245 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Kiser JJ, Flexner C: Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49. doi: 10.1146/annurev-pharmtox-011112-140254. Epub 2012 Nov 5. [PubMed:23140245 ]
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Drug created on May 11, 2013 22:45 / Updated on December 11, 2016 02:43