Name
Thiazides
Accession Number
DBCAT000576  (DBCAT002240, DBCAT002241)
Description

Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.

ATC Classification
Drugs
DrugDrug Description
MethyclothiazideA diuretic drug used to treat hypertension and edema caused by heart failure, renal conditions, treatment with corticosteroids, and estrogen therapy.
BendroflumethiazideA diuretic used to suppress lactation and to treat hypertension and edema.
BenzthiazideFor the treatment of high blood pressure and management of edema.
CyclothiazideCyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either...
HydroflumethiazideA thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis.
ChlorothiazideA thiazide diuretic used to treat hypertension and edema in congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
HydrochlorothiazideA thiazide diuretic used to treat edema associated with a number of conditions, and hypertension.
TrichlormethiazideUsed in the treatment of oedema (including that associated with heart failure) and hypertension.
PolythiazideA thiazide diuretic used in the management of hypertension and treatment of edema.
MebutizideNot Annotated
CyclopenthiazideCyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients...
Drugs & Drug Targets
DrugTargetType
MethyclothiazideSolute carrier family 12 member 1target
MethyclothiazideCarbonic anhydrase 4target
MethyclothiazideCarbonic anhydrase 2target
MethyclothiazideCarbonic anhydrase 1target
BendroflumethiazideSolute carrier family 12 member 3target
BendroflumethiazideCarbonic anhydrase 1target
BendroflumethiazideCarbonic anhydrase 2target
BendroflumethiazideCarbonic anhydrase 4target
BendroflumethiazideCalcium-activated potassium channel subunit alpha-1target
BendroflumethiazideThiopurine S-methyltransferaseenzyme
BenzthiazideSolute carrier family 12 member 3target
BenzthiazideCarbonic anhydrase 1target
BenzthiazideCarbonic anhydrase 2target
BenzthiazideCarbonic anhydrase 4target
BenzthiazideCarbonic anhydrase 9target
BenzthiazideCarbonic anhydrase 12target
BenzthiazideCarbonic anhydrasetarget
CyclothiazideSodium/potassium-transporting ATPase subunit gammatarget
CyclothiazideCarbonic anhydrase 1target
CyclothiazideCarbonic anhydrase 2target
CyclothiazideSolute carrier family 22 member 6transporter
CyclothiazideSecreted frizzled-related protein 4target
CyclothiazideCarbonic anhydrasetarget
HydroflumethiazideSolute carrier family 12 member 1target
HydroflumethiazideSodium/potassium-transporting ATPase subunit alpha-1target
HydroflumethiazideCarbonic anhydrase 4target
HydroflumethiazideCalcium-activated potassium channel subunit alpha-1target
HydroflumethiazideCarbonic anhydrase 2target
HydroflumethiazideCarbonic anhydrase 1target
HydroflumethiazideCarbonic anhydrase 9target
HydroflumethiazideCarbonic anhydrase 12target
HydroflumethiazideSerum albumincarrier
HydroflumethiazideSolute carrier family 22 member 6transporter
HydroflumethiazideSolute carrier family 22 member 8transporter
HydroflumethiazideCarbonic anhydrase 7target
ChlorothiazideSolute carrier family 12 member 3target
ChlorothiazideCarbonic anhydrase 1target
ChlorothiazideCarbonic anhydrase 2target
ChlorothiazideSolute carrier family 22 member 6transporter
HydrochlorothiazideSolute carrier family 12 member 3target
HydrochlorothiazideSolute carrier family 22 member 6transporter
HydrochlorothiazideCalcium-activated potassium channel subunit alpha-1target
HydrochlorothiazideSerum albumincarrier
HydrochlorothiazideSolute carrier family 22 member 11transporter
HydrochlorothiazideMultidrug resistance-associated protein 4transporter
HydrochlorothiazideSolute carrier family 22 member 8transporter
TrichlormethiazideSolute carrier family 12 member 3target
TrichlormethiazideSodium/potassium-transporting ATPase subunit alpha-1target
TrichlormethiazideCarbonic anhydrase 4target
TrichlormethiazideCarbonic anhydrase 2target
TrichlormethiazideCarbonic anhydrase 1target
TrichlormethiazideThiopurine S-methyltransferaseenzyme
PolythiazideSolute carrier family 12 member 3target
PolythiazideSolute carrier family 22 member 6transporter
PolythiazideSolute carrier family 22 member 8transporter
PolythiazideSerum albumincarrier