Identification

Name
Hydrochlorothiazide
Accession Number
DB00999  (APRD00092)
Type
Small Molecule
Groups
Approved, Vet approved
Description

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

Structure
Thumb
Synonyms
  • HCTZ
External IDs
NSC-53477 / SU-5879
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Hydro Tab 100mgTablet100 mgOralApotex Corporation1988-12-31Not applicableCanada
Apo Hydro Tab 25mgTablet25 mgOralApotex Corporation1975-12-31Not applicableCanada
Apo Hydro Tab 50mgTablet50 mgOralApotex Corporation1974-12-31Not applicableCanada
Diuchlor H Tab 50mgTablet50 mgOralMedic Laboratory LtÉe1964-12-311996-09-09Canada
EsidrixTablet25 mg/1OralNovartis1959-02-122008-08-04Us
EsidrixTablet50 mg/1OralNovartis1959-02-122008-08-04Us
HydrochlorothiazideTablet25 mgOralSanis Health Inc2011-02-08Not applicableCanada
HydrochlorothiazideTablet50 mgOralSobio Pharmaceutical Canada Inc.Not applicableNot applicableCanada
HydrochlorothiazideCapsule, gelatin coated12.5 mg/1OralCardinal Health1996-12-272012-10-31Us
HydrochlorothiazideTablet25 mgOralSobio Pharmaceutical Canada Inc.Not applicableNot applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-hydroTablet12.5 mgOralApotex Corporation2009-07-02Not applicableCanada
Ava-hydrochlorothiazideTablet50 mgOralAvanstra Inc2011-10-112014-08-21Canada
Ava-hydrochlorothiazideTablet12.5 mgOralAvanstra Inc2011-10-112014-08-21Canada
Ava-hydrochlorothiazideTablet25 mgOralAvanstra Inc2011-10-112014-08-21Canada
Bio-hydrochlorothiazideTablet25 mgOralBiomed Pharma2003-04-11Not applicableCanada
Bio-hydrochlorothiazideTablet100 mgOralBiomed PharmaNot applicableNot applicableCanada
Bio-hydrochlorothiazideTablet50 mgOralBiomed Pharma2003-04-11Not applicableCanada
Dom-hydrochlorothiazideTablet25 mgOralBiomed Pharma2004-02-062013-08-02Canada
Dom-hydrochlorothiazideTablet12.5 mgOralDominion Pharmacal2006-08-022007-11-02Canada
Dom-hydrochlorothiazideTablet50 mgOralBiomed Pharma2004-02-062013-08-02Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Accel-candesartan/hctzHydrochlorothiazide (12.5 mg) + Candesartan cilexetil (32 mg)TabletOralAccel Pharma Inc2017-12-27Not applicableCanada
Accel-candesartan/hctzHydrochlorothiazide (25 mg) + Candesartan cilexetil (32 mg)TabletOralAccel Pharma Inc2017-12-27Not applicableCanada
Accel-candesartan/hctzHydrochlorothiazide (12.5 mg) + Candesartan cilexetil (16 mg)TabletOralAccel Pharma Inc2017-12-27Not applicableCanada
AccureticHydrochlorothiazide (12.5 mg/1) + Quinapril Hydrochloride (10 mg/1)Tablet, film coatedOralParke Davis Div Of Pfizer Inc1999-12-28Not applicableUs
AccureticHydrochlorothiazide (12.5 mg/1) + Quinapril Hydrochloride (20 mg/1)Tablet, film coatedOralParke Davis Div Of Pfizer Inc1999-12-28Not applicableUs
AccureticHydrochlorothiazide (25 mg/1) + Quinapril Hydrochloride (20 mg/1)Tablet, film coatedOralParke Davis Div Of Pfizer Inc1999-12-28Not applicableUs
Accuretic 10/12.5 mgHydrochlorothiazide (12.5 mg) + Quinapril (10 mg)TabletOralPfizer1998-10-01Not applicableCanada
Accuretic 20/12.5 mgHydrochlorothiazide (12.5 mg) + Quinapril (20 mg)TabletOralPfizer1998-10-01Not applicableCanada
Accuretic 20/25 mgHydrochlorothiazide (25 mg) + Quinapril (20 mg)TabletOralPfizer2003-06-02Not applicableCanada
Ach-olmesartan HctzHydrochlorothiazide (12.5 mg) + Olmesartan medoxomil (20 mg)TabletOralAccord Healthcare LimitedNot applicableNot applicableCanada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Benazepril Hydrochloride and HydrochlorothiazideHydrochlorothiazide (12.5 mg/1) + Benazepril hydrochloride (10 mg/1)Tablet, film coatedOralSandoz Inc.2007-09-242007-09-24Us0185 020420180913 8702 1x7wy52
Benazepril Hydrochloride and HydrochlorothiazideHydrochlorothiazide (6.25 mg/1) + Benazepril hydrochloride (5 mg/1)Tablet, film coatedOralSandoz Inc.2007-09-242007-09-24Us0185 012420180913 8702 txzrab
Bisoprolol Fumarate HydrochlorothiazideHydrochlorothiazide (6.25 mg/1) + Bisoprolol Fumarate (10 mg/1)Tablet, film coatedOralWatson Pharmaceuticals2006-11-27Not applicableUs
Bisoprolol Fumarate HydrochlorothiazideHydrochlorothiazide (6.25 mg/1) + Bisoprolol Fumarate (2.5 mg/1)Tablet, film coatedOralWatson Pharmaceuticals2006-11-27Not applicableUs
Bisoprolol Fumarate HydrochlorothiazideHydrochlorothiazide (6.25 mg/1) + Bisoprolol Fumarate (5 mg/1)Tablet, film coatedOralWatson Pharmaceuticals2006-11-27Not applicableUs
CapozideHydrochlorothiazide (15 mg/1) + Captopril (25 mg/1)TabletOralPhysicians Total Care, Inc.1996-05-142011-05-31Us
CapozideHydrochlorothiazide (25 mg/1) + Captopril (50 mg/1)TabletOralPhysicians Total Care, Inc.1997-01-032002-06-30Us
Fosinopril Sodium and HydrochlorothiazideHydrochlorothiazide (12.5 mg/1) + Fosinopril sodium (20 mg/1)TabletOralAndrx Pharmaceuticals, Inc.2007-05-112007-05-11Us
Fosinopril Sodium and HydrochlorothiazideHydrochlorothiazide (12.5 mg/1) + Fosinopril sodium (10 mg/1)TabletOralAndrx Pharmaceuticals, Inc.2009-01-28Not applicableUs
Fosinopril Sodium and HydrochlorothiazideHydrochlorothiazide (12.5 mg/1) + Fosinopril sodium (10 mg/1)TabletOralAndrx Pharmaceuticals, Inc.2007-05-112007-05-11Us
International/Other Brands
Dichlotride (M & H) / Esidrex (Novartis) / Esidrix / Hydrodiuril (Merck) / HydroDIURIL (Merck) / Microzide
Categories
UNII
0J48LPH2TH
CAS number
58-93-5
Weight
Average: 297.739
Monoisotopic: 296.964474846
Chemical Formula
C7H8ClN3O4S2
InChI Key
JZUFKLXOESDKRF-UHFFFAOYSA-N
InChI
InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
IUPAC Name
6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide
SMILES
NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1

Pharmacology

Indication

For the treatment of high blood pressure and management of edema.

Associated Conditions
Pharmacodynamics

Thiazides such as hydrochlorothiazide promote water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Mechanism of action

Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining the distal convoluted tubule. The energy for this is provided by a sodium gradient established by sodium-potassium ATPases on the basolateral membrane. Once sodium has entered the cell, it is transported out into the basolateral interstitium via the sodium-potassium ATPase, causing an increase in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. By blocking the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the nephron.

TargetActionsOrganism
ASolute carrier family 12 member 3
inhibitor
Human
UCarbonic anhydrase 1
inhibitor
Human
UCarbonic anhydrase 2
inhibitor
Human
ACalcium-activated potassium channel subunit alpha-1
inhibitor
Human
Absorption

50-60%

Volume of distribution
Not Available
Protein binding

67.9%

Metabolism

Hydrochlorothiazide is not metabolized.

Route of elimination

Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney. Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.

Half life

5.6 and 14.8 hours

Clearance
Not Available
Toxicity

The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The oral LD50 of hydrochlorothiazide is greater than 10 g/kg in the mouse and rat.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Hydrochlorothiazide Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(2-benzhydryloxyethyl)diethyl-methylammonium iodideThe serum concentration of Hydrochlorothiazide can be increased when it is combined with (2-benzhydryloxyethyl)diethyl-methylammonium iodide.
(R)-warfarinThe therapeutic efficacy of (R)-warfarin can be increased when used in combination with Hydrochlorothiazide.
(S)-WarfarinThe therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Hydrochlorothiazide.
1alpha-Hydroxyvitamin D5The risk or severity of hypercalcemia can be increased when Hydrochlorothiazide is combined with 1alpha-Hydroxyvitamin D5.
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Hydrochlorothiazide.
4-hydroxycoumarinThe therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Hydrochlorothiazide.
AbediterolAbediterol may increase the hypokalemic activities of Hydrochlorothiazide.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Hydrochlorothiazide.
AcebutololHydrochlorothiazide may increase the hypotensive activities of Acebutolol.
AceclofenacThe therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Aceclofenac.
Food Interactions
  • Avoid alcohol.
  • Avoid excess salt/sodium unless otherwise instructed by your physician.
  • Avoid natural licorice.
  • Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
  • Increase potassium intake; add a banana or orange juice; unless instructed otherwise.
  • Take with food.

References

Synthesis Reference

Frederic J. Nugent, John K. C. Yen, "Process for preparing the combination products of triamterene and hydrochlorothiazide." U.S. Patent US4804540, issued July, 1987.

US4804540
General References
  1. Significant Drug–Drug Interactions with Antineoplastics [Link]
  2. Thiazide-Induced Vasodilation in Humans Is Mediated by Potassium Channel Activation [File]
External Links
Human Metabolome Database
HMDB0001928
KEGG Drug
D00340
KEGG Compound
C07041
PubChem Compound
3639
PubChem Substance
46504440
ChemSpider
3513
BindingDB
13076
ChEBI
5778
ChEMBL
CHEMBL435
Therapeutic Targets Database
DAP000750
PharmGKB
PA449899
HET
HCZ
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Hydrochlorothiazide
ATC Codes
C03AB03 — Hydrochlorothiazide and potassiumC09DX01 — Valsartan, amlodipine and hydrochlorothiazideC09XA52 — Aliskiren and hydrochlorothiazideC09DX03 — Olmesartan medoxomil, amlodipine and hydrochlorothiazideC03EA01 — Hydrochlorothiazide and potassium-sparing agentsC03AX01 — Hydrochlorothiazide, combinationsG01AE10 — Combinations of sulfonamidesC03AA03 — HydrochlorothiazideC09XA54 — Aliskiren, amlodipine and hydrochlorothiazide
AHFS Codes
  • 40:28.20 — Thiazide Diuretics
PDB Entries
3ijx / 3ik6
MSDS
Download (72.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedNot AvailableHealthy Volunteers1
0TerminatedHealth Services ResearchHigh Blood Pressure (Hypertension) / Proteinuria / Type 2 Diabetes Mellitus1
1CompletedNot AvailableHealthy Volunteers10
1CompletedNot AvailableHypertension,Essential2
1CompletedNot AvailableKidney Diseases1
1CompletedBasic ScienceHealthy Volunteers4
1CompletedSupportive CareHealthy Volunteers1
1CompletedTreatmentFasting1
1CompletedTreatmentHealthy Volunteers12
1CompletedTreatmentHigh Blood Pressure (Hypertension)5
1CompletedTreatmentType 2 Diabetes Mellitus3
1Unknown StatusTreatmentHealthy Volunteers1
1, 2RecruitingBasic ScienceHypertension,Essential1
2CompletedBasic ScienceType 2 Diabetes Mellitus1
2CompletedTreatmentAging / Cognitive Impairments / High Blood Pressure (Hypertension)1
2CompletedTreatmentBMI >30 kg/m2 / High Blood Pressure (Hypertension)1
2CompletedTreatmentHigh Blood Pressure (Hypertension)3
2CompletedTreatmentHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
2CompletedTreatmentHypertension,Essential1
2CompletedTreatmentMild Hypertension1
2Not Yet RecruitingTreatmentCritical Illness / Hypernatremia1
2RecruitingPreventionAging / High Blood Pressure (Hypertension) / Sedentary Lifestyle1
2RecruitingTreatmentAutosomal Dominant Hypocalcemia / Autosomal Dominant Hypocalcemia or OR Primary Hypoparathyroidism Related to Other Cause But Complicated by Hypercalciuria Under Treatment1
2RecruitingTreatmentBMI >30 kg/m2 / High Blood Pressure (Hypertension) / Prehypertension1
2RecruitingTreatmentHigh Blood Pressure (Hypertension)1
2TerminatedTreatmentHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
2TerminatedTreatmentNon-diabetic Nephropathy1
2TerminatedTreatmentPre-Diabetic / Pre-Hypertension1
2WithdrawnTreatmentDiabetes Mellitus (DM) / High Blood Pressure (Hypertension)1
2, 3CompletedTreatmentGrade I or II Essential Hypertension1
2, 3TerminatedTreatmentCalcium Nephrolithiasis / Dent's Disease1
3CompletedNot AvailableCardiovascular Disease (CVD) / Death, Sudden,Cardiac / Heart Arrest / Heart Diseases / High Blood Pressure (Hypertension)1
3CompletedDiagnosticHigh Blood Pressure (Hypertension)1
3CompletedPreventionAtherosclerosis / Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Diabetes Mellitus (DM) / High Blood Cholesterol Level / High Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
3CompletedTreatmentAtherosclerotic Cardiovascular Diseases / Hypertension,Essential1
3CompletedTreatmentChronic Kidney Disease (CKD) / High Blood Pressure (Hypertension)1
3CompletedTreatmentHigh Blood Pressure (Hypertension)35
3CompletedTreatmentHigh Blood Pressure (Hypertension) / Metabolic Disorders1
3CompletedTreatmentHigh Blood Pressure (Hypertension) / Obesity, Abdominal1
3CompletedTreatmentHypertension,Essential11
3CompletedTreatmentHypertension; Hypertrophy, Left Ventricular1
3CompletedTreatmentSafety1
3Not Yet RecruitingTreatmentArterial Hypertension1
3Not Yet RecruitingTreatmentEssential Arterial Hypertension1
3Not Yet RecruitingTreatmentHigh Blood Pressure (Hypertension)2
3RecruitingPreventionCalcium Nephrolithiasis1
3RecruitingPreventionGestational Hypertension / Hypertension, Pregnancy-Induced / Postpartum Preeclampsia / Postpartum Pregnancy-Induced Hypertension / Prophylaxis of preeclampsia / Superimposed Pre-Eclampsia1
3RecruitingTreatmentHigh Blood Pressure (Hypertension)1
3TerminatedTreatmentCardiovascular Events1
3WithdrawnTreatmentEssential Arterial Hypertension2
4Active Not RecruitingTreatmentObstructive Sleep Apnea (OSA)1
4CompletedDiagnosticHigh Blood Pressure (Hypertension)2
4CompletedDiagnosticHypertension,Essential1
4CompletedPreventionNonvalvular Atrial Fibrillation1
4CompletedTreatmentAlbuminuria / High Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
4CompletedTreatmentBMI >30 kg/m2 / High Blood Pressure (Hypertension)1
4CompletedTreatmentChronic Kidney Disease (CKD)1
4CompletedTreatmentCoronary Artery Disease / High Blood Pressure (Hypertension)1
4CompletedTreatmentDiabetes Mellitus (DM) / High Blood Pressure (Hypertension)1
4CompletedTreatmentDiabetes Mellitus (DM) / Type 2 Diabetes Mellitus1
4CompletedTreatmentEssential Hypertension ( Mild to Moderate)1
4CompletedTreatmentHigh Blood Pressure (Hypertension)34
4CompletedTreatmentHigh Blood Pressure (Hypertension) / Impaired Renal Function1
4CompletedTreatmentHigh Blood Pressure (Hypertension) / Left Ventricle Hypertrophy1
4CompletedTreatmentHigh Blood Pressure (Hypertension) / Metabolic Syndromes2
4CompletedTreatmentHigh Blood Pressure (Hypertension) / Metabolic Syndromes / Obesity, Abdominal1
4CompletedTreatmentHigh Blood Pressure (Hypertension) / Pharmacogenetics1
4CompletedTreatmentHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus3
4CompletedTreatmentHypertension, Dyslypidaemia1
4CompletedTreatmentHypokalaemia1
4CompletedTreatmentStage 2 Systolic Hypertension1
4CompletedTreatmentStage II Hypertension1
4Not Yet RecruitingTreatmentBlood Pressures / Cardiovascular Risk Factors / Prehypertension / Strokes / Type 2 Diabetes Mellitus1
4Not Yet RecruitingTreatmentChronic Kidney Disease (CKD)1
4Not Yet RecruitingTreatmentHigh Blood Pressure (Hypertension)1
4Not Yet RecruitingTreatmentHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
4Not Yet RecruitingTreatmentHypertension,Essential1
4Not Yet RecruitingTreatmentBone destruction / Postmenopausal Osteoporosis (PMO)1
4Not Yet RecruitingTreatmentType 2 Diabetes Mellitus1
4RecruitingBasic ScienceFeeling Anxious / High Blood Pressure (Hypertension)1
4RecruitingPreventionBlood Pressures / High Blood Pressure (Hypertension) / Strokes1
4RecruitingTreatmentCerebral Small Vessels Disease1
4RecruitingTreatmentChronic Kidney Disease (CKD)1
4RecruitingTreatmentHeart Failure, Unspecified1
4RecruitingTreatmentHigh Blood Pressure (Hypertension)3
4RecruitingTreatmentPediatric Hypertension1
4RecruitingTreatmentType 2 Diabetes Mellitus1
4SuspendedTreatmentEnd Stage Renal Disease (ESRD) / High Blood Pressure (Hypertension) / Proteinuria1
4TerminatedTreatmentAtherosclerosis1
4Unknown StatusPreventionDiabetic Nephropathies1
4Unknown StatusTreatmentBlood Pressures1
4Unknown StatusTreatmentDiuresis Preserved / Hemodialysis Treatment / Kidney Insufficiency, Chronic1
4Unknown StatusTreatmentHigh Blood Pressure (Hypertension)4
4Unknown StatusTreatmentHypertension, Resistant to Conventional Therapy / Hypertension,Essential1
4Unknown StatusTreatmentLipotoxicity / Metabolic Syndromes1
4WithdrawnTreatmentHigh Blood Pressure (Hypertension)3
4WithdrawnTreatmentHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
Not AvailableCompletedNot AvailableAging / High Blood Pressure (Hypertension)1
Not AvailableCompletedNot AvailableCardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / High Blood Pressure (Hypertension) / Myocardial Infarction1
Not AvailableCompletedNot AvailableCardiovascular Disease (CVD) / Heart Diseases / High Blood Pressure (Hypertension)1
Not AvailableCompletedNot AvailableHealthy Normotensive Participants3
Not AvailableCompletedNot AvailableHealthy Volunteers4
Not AvailableCompletedNot AvailableHigh Blood Pressure (Hypertension)9
Not AvailableCompletedNot AvailableHypertension,Essential1
Not AvailableCompletedDiagnosticArterial Hypertension1
Not AvailableCompletedDiagnosticGitelman's syndrome1
Not AvailableCompletedDiagnosticHigh Blood Pressure (Hypertension)1
Not AvailableCompletedTreatmentAlbuminuria / Diabetes Mellitus (DM) / Endothelial Dysfunction1
Not AvailableCompletedTreatmentHigh Blood Pressure (Hypertension)8
Not AvailableCompletedTreatmentHigh Blood Pressure (Hypertension) / Hypertension Treatment / Hypertension, Grade 1 / N of 1 Study Design1
Not AvailableCompletedTreatmentHigh Blood Pressure (Hypertension) / Plasma Renin Activity1
Not AvailableCompletedTreatmentHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
Not AvailableCompletedTreatmentHypertension,Essential1
Not AvailableCompletedTreatmentNephrogenic Diabetes Insipidus1
Not AvailableCompletedTreatmentNocturia1
Not AvailableCompletedTreatmentType 2 Diabetes Mellitus / Vascular Diseases1
Not AvailableRecruitingNot AvailableHypertension,Essential1
Not AvailableRecruitingPreventionChronic Kidney Disease (CKD) / Hyperparathyroidism, Secondary1
Not AvailableRecruitingPreventionRenal Stones1
Not AvailableRecruitingTreatmentCritical Care / Fluid Shifts1
Not AvailableTerminatedPreventionMetabolic Syndromes1
Not AvailableTerminatedTreatmentHigh Blood Pressure (Hypertension) / Microvascular Angina1
Not AvailableUnknown StatusNot AvailableArterial Hypertension / Diabetes Mellitus (DM)1

Pharmacoeconomics

Manufacturers
  • Apotex inc
  • Aurobindo pharma ltd
  • Cadista pharmaceuticals inc
  • Ipca laboratories ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Unichem laboratories ltd
  • Vintage pharmaceuticals inc
  • West ward pharmaceutical corp
  • Watson laboratories inc
  • Morton grove pharmaceuticals inc
  • Roxane laboratories inc
  • Novartis pharmaceuticals corp
  • Abc holding corp
  • Actavis elizabeth llc
  • Alra laboratories inc
  • Ascot hosp pharmaceuticals inc div travenol laboratories inc
  • Barr laboratories inc
  • Caraco pharmaceutical laboratories ltd
  • Dava pharmaceuticals inc
  • Elkins sinn div ah robins co inc
  • Excellium pharmaceutical inc
  • Heather drug co inc
  • Heritage pharmaceuticals inc
  • Impax laboratories inc
  • Inwood laboratories inc sub forest laboratories inc
  • Lannett holdings inc
  • Mm mast and co
  • Mutual pharmaceutical co inc
  • Private formulations inc
  • Sandoz inc
  • Solvay pharmaceuticals
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Tg united labs llc
  • Usl pharma inc
  • Vangard laboratories inc div midway medical co
  • Warner chilcott div warner lambert co
  • Whiteworth towne paulsen inc
  • Halsey drug co inc
  • Merck and co inc
  • Abbott laboratories pharmaceutical products div
Packagers
  • Abbott Laboratories Ltd.
  • Actavis Group
  • Advanced Pharmaceutical Services Inc.
  • Aidarex Pharmacuticals LLC
  • Amerisource Health Services Corp.
  • Apotex Inc.
  • Apotheca Inc.
  • A-S Medication Solutions LLC
  • AstraZeneca Inc.
  • Atlantic Biologicals Corporation
  • Aurobindo Pharma Ltd.
  • Barr Pharmaceuticals
  • Boehringer Ingelheim Ltd.
  • Bristol-Myers Squibb Co.
  • Bryant Ranch Prepack
  • BTA Pharmaceuticals
  • C.O. Truxton Inc.
  • Cadista Pharmaceuticals Inc.
  • Calvin Scott and Co. Inc.
  • Caraco Pharmaceutical Labs
  • Cardinal Health
  • Carlisle Laboratories Inc.
  • Central Texas Community Health Centers
  • Ciba Geigy Ltd.
  • Comprehensive Consultant Services Inc.
  • Corepharma LLC
  • Coupler Enterprises Inc.
  • Darby Dental Supply Co. Inc.
  • DAVA Pharmaceuticals
  • Dee Stevens and Son Feeder
  • DHHS Program Support Center Supply Service Center
  • Direct Dispensing Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • Doctor Reddys Laboratories Ltd.
  • Duramed
  • E.R. Squibb and Sons LLC
  • Endo Pharmaceuticals Inc.
  • Eon Labs
  • Excellium Pharmaceutical Inc.
  • Genpharm LP
  • Glenmark Generics Ltd.
  • Golden State Medical Supply Inc.
  • Goldline Laboratories Inc.
  • Greenstone LLC
  • Group Health Cooperative
  • H and H Laboratories
  • H.J. Harkins Co. Inc.
  • Heartland Repack Services LLC
  • Heritage Pharmaceuticals
  • International Laboratories Inc.
  • Ipca Laboratories Ltd.
  • Ivax Pharmaceuticals
  • Kaiser Foundation Hospital
  • Kraft Pharmaceutical Co. Inc.
  • Lake Erie Medical and Surgical Supply
  • Lannett Co. Inc.
  • Liberty Pharmaceuticals
  • Major Pharmaceuticals
  • Mckesson Corp.
  • Medisca Inc.
  • Medvantx Inc.
  • Merck & Co.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mylan
  • Novartis AG
  • Nucare Pharmaceuticals Inc.
  • Ohm Laboratories Inc.
  • Palmetto Pharmaceuticals Inc.
  • Par Pharmaceuticals
  • Patheon Inc.
  • PCA LLC
  • PD-Rx Pharmaceuticals Inc.
  • Pharmaceutical Utilization Management Program VA Inc.
  • Pharmedix
  • Pharmpak Inc.
  • Physicians Total Care Inc.
  • Pliva Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepackage Specialists
  • Prepak Systems Inc.
  • Qualitest
  • Quality Research Pharmaceutical Inc.
  • Ranbaxy Laboratories
  • Rebel Distributors Corp.
  • Remedy Repack
  • Resource Optimization and Innovation LLC
  • Roxane Labs
  • Sandoz
  • Solvay Pharmaceuticals
  • Southwood Pharmaceuticals
  • Stat Rx Usa
  • Stat Scripts LLC
  • Talbert Medical Management Corp.
  • Taro Pharmaceuticals USA
  • Teva Pharmaceutical Industries Ltd.
  • UDL Laboratories
  • Unichem Laboratories Ltd.
  • United Research Laboratories Inc.
  • Va Cmop Dallas
  • Vangard Labs Inc.
  • Vintage Pharmaceuticals Inc.
  • Watson Pharmaceuticals
  • West-Ward Pharmaceuticals
Dosage forms
FormRouteStrength
TabletOral50 mg
TabletOral
TabletOral12.5 mg
CapsuleOral
CapsuleOral12.5 mg/1
Capsule, gelatin coatedOral12.5 mg/1
TabletOral12.5 mg/1
TabletOral25 mg/1
TabletOral25 mg/25mg
TabletOral50 mg/50mg
TabletOral50 mg/1
TabletOral25 mg
TabletOral100 mg
Tablet, film coatedOral
Tablet, coatedOral
Prices
Unit descriptionCostUnit
Niferex-150 Forte 100 80-70 mg capsule Box109.86USD box
Niferex 100 mg/5ml Elixir 236ml Bottle80.55USD bottle
Niferex 100 40-20 mg capsule Box77.99USD box
Capozide 50-25 mg tablet3.63USD tablet
Ziac 10-6.25 mg tablet3.6USD tablet
Ziac 2.5-6.25 mg tablet3.6USD tablet
Ziac 5-6.25 mg tablet3.6USD tablet
Capozide 50-15 tablet3.49USD tablet
Capozide 50-25 tablet3.49USD tablet
Capozide 50-15 mg tablet2.59USD tablet
Lotensin 20 mg tablet2.25USD tablet
Lotensin 10 mg tablet2.09USD tablet
Lotensin 40 mg tablet2.09USD tablet
Lotensin 5 mg tablet2.09USD tablet
Accuretic 20-12.5 mg tablet2.04USD tablet
Capozide 25-15 tablet2.03USD tablet
Capozide 25-25 tablet2.03USD tablet
Accuretic 10-12.5 mg tablet2.0USD tablet
Accuretic 20-25 mg tablet2.0USD tablet
Lotensin HCT 20-12.5 mg tablet1.97USD tablet
Lotensin HCT 10-12.5 mg tablet1.95USD tablet
Lotensin HCT 20-25 mg tablet1.94USD tablet
Lotensin hct 10-12.5 tablet1.9USD tablet
Lotensin hct 20-12.5 tablet1.9USD tablet
Lotensin hct 20-25 tablet1.9USD tablet
Lotensin hct 5-6.25 tablet1.9USD tablet
Niferex-150 150-50-50 mg capsule1.62USD capsule
Capozide 25-15 mg tablet1.51USD tablet
Lotensin HCT 5-6.25 mg tablet1.31USD tablet
Hydrochlorothiazide powder1.1USD g
Hydrochlorothiazide 12.5 mg tablet0.82USD tablet
Moduretic 5-50 mg tablet0.68USD tablet
Hydrochlorothiazide 12.5 mg capsule0.5USD capsule
Hydrochlorothiazide 50 mg tablet0.16USD tablet
Apo-Hydro 100 mg Tablet0.13USD tablet
Hydrochlorothiazide 25 mg tablet0.11USD tablet
Apo-Hydro 50 mg Tablet0.06USD tablet
Novo-Hydrazide 50 mg Tablet0.06USD tablet
Apo-Hydro 25 mg Tablet0.04USD tablet
Novo-Hydrazide 25 mg Tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6294197Yes1997-12-182017-12-18Us
US6358986No2000-01-102020-01-10Us
US5559111Yes1999-01-212019-01-21Us
US5616599Yes1996-10-252016-10-25Us
US8618172No2008-07-132028-07-13Us
US6878703Yes2002-05-192022-05-19Us
US8101599No2003-05-162023-05-16Us
US8475839Yes2003-11-162023-11-16Us
US8618174No2001-11-152021-11-15Us
US8183295No2003-05-162023-05-16Us
US5994348Yes1995-12-072015-12-07Us
US9023893No2002-03-032022-03-03Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)266-268U.S. Patent 3,163,645.
water solubility722 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-0.07HANSCH,C ET AL. (1995)
logS-2.62ADME Research, USCD
Caco2 permeability-6.06ADME Research, USCD
pKa7.9SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility2.24 mg/mLALOGPS
logP-0.16ALOGPS
logP-0.58ChemAxon
logS-2.1ALOGPS
pKa (Strongest Acidic)9.09ChemAxon
pKa (Strongest Basic)-2.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area118.36 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity63.11 m3·mol-1ChemAxon
Polarizability25.35 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9202
Blood Brain Barrier-0.9659
Caco-2 permeable-0.8956
P-glycoprotein substrateNon-substrate0.6533
P-glycoprotein inhibitor INon-inhibitor0.8624
P-glycoprotein inhibitor IINon-inhibitor0.8688
Renal organic cation transporterNon-inhibitor0.8416
CYP450 2C9 substrateNon-substrate0.7664
CYP450 2D6 substrateNon-substrate0.8333
CYP450 3A4 substrateNon-substrate0.6217
CYP450 1A2 substrateNon-inhibitor0.9401
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9252
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9569
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9036
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.7986
BiodegradationNot ready biodegradable0.9964
Rat acute toxicity2.0666 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9576
hERG inhibition (predictor II)Non-inhibitor0.9135
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (11.5 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-00r2-6490000000-3f5d9320308b823c6489
MS/MS Spectrum - Quattro_QQQ 10V, PositiveLC-MS/MSsplash10-052b-0090000000-aaa48e4702874457ae26
MS/MS Spectrum - Quattro_QQQ 25V, PositiveLC-MS/MSsplash10-0r6r-0920000000-b129acf72e7dde12441e
MS/MS Spectrum - Quattro_QQQ 40V, PositiveLC-MS/MSsplash10-0a4i-1900000000-67f803f38aed0bd12ade
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-014i-0090000000-7906a6e4cfb51dce1396
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0090000000-c44dbed5084dc5df03d8
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0090000000-976dcb246a2272b22565
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0uxr-1090000000-16e563e592e4a566424d
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0fb9-9580000000-3c9227e3df8ed6dc9ae9
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-004i-9720000000-12525bfcb83ea1611970
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-004i-9200000000-df37b796b59f084b0229
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0090000000-220666bc28231ad387e8
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0090000000-f434c5d8ee94540ec0d2
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0uxr-1090000000-8a3c270e0fb285b26f15
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0fb9-9480000000-5f6c5ed1d291d71a0aae
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-004i-9520000000-679def33e8239c1382f3
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-004i-9400000000-c9b80274d62fda64c531
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-014i-0090000000-0a962453b9e31eec3822
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0002-0090000000-ac2b5d07eaacba87a181
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0gb9-1090000000-8649018477d708cb6bd7
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-004i-9400000000-266cd4efe3deeebe29f3
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-014i-0090000000-bc85dd2515151e4fec03
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0090000000-f8a0765b6023cbf47593
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0090000000-ca679180c1ca0c54141e
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0090000000-5aee0df6931c521ae675
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0390000000-2d94b79cdd59fb180851
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0f79-0920000000-a3852b5fd8f817191c39
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0900000000-017f1f0aa88d206d3790
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-05br-1900000000-9adb8f34fa45627894bb
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0090000000-49e6e4b4d7de4164fea3
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0090000000-eba848023908f7d51e1a
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0490000000-09360a196ae79b28c238
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0f79-0920000000-f620823c599998180372
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-1900000000-bb4b565d2cab86e56d75
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-052r-2900000000-67c9a5ba10fd79140b7d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-001i-0090000000-de56ae9572cecd0e3bce
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-00lr-0090000000-6ec2b0c4b0ea116fd154
MS/MS Spectrum - , positiveLC-MS/MSsplash10-001i-0490000000-86abfe4bae6e32f1189a
1H NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Thiadiazines
Sub Class
Benzothiadiazines
Direct Parent
1,2,4-benzothiadiazine-1,1-dioxides
Alternative Parents
Secondary alkylarylamines / Organosulfonamides / Benzenoids / Aryl chlorides / Aminosulfonyl compounds / Azacyclic compounds / Organopnictogen compounds / Organochlorides / Organic oxides / Hydrocarbon derivatives
Substituents
1,2,4-benzothiadiazine-1,1-dioxide / Secondary aliphatic/aromatic amine / Aryl chloride / Aryl halide / Organosulfonic acid amide / Benzenoid / Organic sulfonic acid or derivatives / Organosulfonic acid or derivatives / Aminosulfonyl compound / Sulfonyl
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
sulfonamide, organochlorine compound, benzothiadiazine (CHEBI:5778)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Transporter activity
Specific Function
Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption.
Gene Name
SLC12A3
Uniprot ID
P55017
Uniprot Name
Solute carrier family 12 member 3
Molecular Weight
113138.04 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Ran XW, Wang C, Dai F, Jiang JJ, Tong NW, Li XJ, Liang JZ: [A case of Gitelman's syndrome presenting with severe hypocalcaemia and hypokalemic periodic paralysis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jul;36(4):583-7. [PubMed:16078592]
  3. Turner ST, Schwartz GL, Chapman AB, Boerwinkle E: WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic. Hypertension. 2005 Oct;46(4):758-65. Epub 2005 Sep 19. [PubMed:16172412]
  4. Abuladze N, Yanagawa N, Lee I, Jo OD, Newman D, Hwang J, Uyemura K, Pushkin A, Modlin RL, Kurtz I: Peripheral blood mononuclear cells express mutated NCCT mRNA in Gitelman's syndrome: evidence for abnormal thiazide-sensitive NaCl cotransport. J Am Soc Nephrol. 1998 May;9(5):819-26. [PubMed:9596079]
  5. Barry EL, Gesek FA, Kaplan MR, Hebert SC, Friedman PA: Expression of the sodium-chloride cotransporter in osteoblast-like cells: effect of thiazide diuretics. Am J Physiol. 1997 Jan;272(1 Pt 1):C109-16. [PubMed:9038817]
  6. Kurschat C, Heering P, Grabensee B: [Gitelman's syndrome: an important differential diagnosis of hypokalemia]. Dtsch Med Wochenschr. 2003 May 30;128(22):1225-8. [PubMed:12772080]
  7. Monroy A, Plata C, Hebert SC, Gamba G: Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol. 2000 Jul;279(1):F161-9. [PubMed:10894798]
  8. Significant Drug–Drug Interactions with Antineoplastics [Link]
Details
2. Carbonic anhydrase 1
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Zinc ion binding
Specific Function
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.
Gene Name
CA1
Uniprot ID
P00915
Uniprot Name
Carbonic anhydrase 1
Molecular Weight
28870.0 Da
References
  1. Puscas I, Coltau M, Baican M, Domuta G, Hecht A: Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. [PubMed:10713865]
Details
3. Carbonic anhydrase 2
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Zinc ion binding
Specific Function
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion in...
Gene Name
CA2
Uniprot ID
P00918
Uniprot Name
Carbonic anhydrase 2
Molecular Weight
29245.895 Da
References
  1. Schaeffer P, Vigne P, Frelin C, Lazdunski M: Identification and pharmacological properties of binding sites for the atypical thiazide diuretic, indapamide. Eur J Pharmacol. 1990 Jul 17;182(3):503-8. [PubMed:2226620]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Voltage-gated potassium channel activity
Specific Function
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activati...
Gene Name
KCNMA1
Uniprot ID
Q12791
Uniprot Name
Calcium-activated potassium channel subunit alpha-1
Molecular Weight
137558.115 Da
References
  1. Thiazide-Induced Vasodilation in Humans Is Mediated by Potassium Channel Activation [File]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one ...
Gene Name
SLC22A6
Uniprot ID
Q4U2R8
Uniprot Name
Solute carrier family 22 member 6
Molecular Weight
61815.78 Da
References
  1. Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. [PubMed:10049739]
  2. Uwai Y, Saito H, Hashimoto Y, Inui KI: Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther. 2000 Oct;295(1):261-5. [PubMed:10991988]

Drug created on June 13, 2005 07:24 / Updated on September 21, 2018 20:42