Renal Agents

Name
Renal Agents
Accession Number
DBCAT000629
Description

Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.

Drugs
DrugDrug Description
CycloserineA broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).
TrimethoprimAn antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract.
FurazolidoneFor the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.
SulfacetamideA corticosteroid used to treat inflammatory ocular conditions and acne vulgaris.
SulfametopyrazineFor the treatment of urinary tract infection and chronic bronchitis.
NitrofurantoinAn antibiotic used to treat urinary tract infections.
ProbenecidA medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia.
LevofloxacinA fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague.
SulfinpyrazoneA platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout .
AmdinocillinUsed in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms.
OfloxacinAn antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
SulfadoxineA long acting sulfonamide used for the treatment or prevention of malaria.
NitroxolineNitroxoline is an antibiotic agent.
PivmecillinamA prodrug of the beta lactam antibiotic mecillinam, indicated for the treatment of uncomplicated urinary tract infections (UTIs).
Tienilic acidFor the treatment of hypertension.
MethenamineA urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy.
SulfameterLong acting sulfonamide used in leprosy, urinary, and respiratory tract infections.
AzapropazoneNot Available
FlumequineFlumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections.
SulfachlorpyridazineA sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.
LesinuradA uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy.
BenzbromaroneBenzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney Disease, Abnormal Renal Function, and Gout and Asymptomatic Hyperuricemia.
BenziodaroneBenziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France...
FurazidinNot Annotated
CarfecillinNot Annotated
Oxolinic acidNot Annotated
NifurtoinolNot Annotated
Piromidic acidNot Annotated
Pipemidic acidNot Annotated
FinafloxacinFinafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1...
Drugs & Drug Targets
DrugTargetType
CycloserineD-alanine--D-alanine ligase Atarget
CycloserineAlanine racemasetarget
CycloserineAromatic-L-amino-acid decarboxylaseenzyme
CycloserineProton-coupled amino acid transporter 2transporter
TrimethoprimDihydrofolate reductasetarget
TrimethoprimCytochrome P450 2C8enzyme
TrimethoprimCytochrome P450 3A4enzyme
TrimethoprimP-glycoprotein 1transporter
TrimethoprimCytochrome P450 2C9enzyme
TrimethoprimCytochrome P450 1A2enzyme
TrimethoprimMultidrug and toxin extrusion protein 1transporter
TrimethoprimMultidrug and toxin extrusion protein 2transporter
FurazolidoneDNAtarget
FurazolidoneAmine oxidase [flavin-containing] Benzyme
FurazolidoneAmine oxidase [flavin-containing] Aenzyme
SulfacetamideDihydropteroate synthasetarget
SulfacetamideDihydropteroate synthase type-1target
SulfacetamideFolic acid synthesis protein FOL1target
SulfametopyrazineDihydropteroate synthetasetarget
Nitrofurantoin30S ribosomal protein S10target
NitrofurantoinOxygen-insensitive NADPH nitroreductasetarget
NitrofurantoinProbable pyruvate-flavodoxin oxidoreductasetarget
NitrofurantoinATP-binding cassette sub-family G member 2transporter
NitrofurantoinNADPH--cytochrome P450 reductaseenzyme
NitrofurantoinBile salt export pumptransporter
NitrofurantoinP-glycoprotein 1transporter
NitrofurantoinCanalicular multispecific organic anion transporter 1transporter
ProbenecidSolute carrier family 22 member 8target
ProbenecidSolute carrier family 22 member 11target
ProbenecidSerum albumincarrier
ProbenecidSolute carrier family 22 member 2transporter
ProbenecidSolute carrier family 22 member 1transporter
ProbenecidCanalicular multispecific organic anion transporter 2transporter
ProbenecidMultidrug resistance-associated protein 4transporter
ProbenecidMultidrug resistance-associated protein 5transporter
ProbenecidMonocarboxylate transporter 2transporter
ProbenecidSolute carrier family 22 member 5transporter
ProbenecidMultidrug resistance-associated protein 6transporter
ProbenecidMultidrug resistance-associated protein 1transporter
ProbenecidSolute carrier organic anion transporter family member 1A2transporter
ProbenecidMonocarboxylate transporter 1transporter
ProbenecidSodium/bile acid cotransportertransporter
ProbenecidSolute carrier family 22 member 6transporter
ProbenecidSolute carrier family 22 member 10transporter
ProbenecidSolute carrier family 22 member 8transporter
ProbenecidCanalicular multispecific organic anion transporter 1transporter
ProbenecidATP-binding cassette sub-family C member 11transporter
ProbenecidSolute carrier family 22 member 11transporter
ProbenecidSolute carrier organic anion transporter family member 1C1transporter
ProbenecidSolute carrier family 22 member 7transporter
ProbenecidSolute carrier family 22 member 6target
ProbenecidPannexin-1target
ProbenecidCytochrome P450 2C8enzyme
ProbenecidCytochrome P450 3A4enzyme
ProbenecidSolute carrier family 22 member 12transporter
ProbenecidSolute carrier family 2, facilitated glucose transporter member 9transporter
ProbenecidTaste receptor type 2 member 16target
ProbenecidUDP-glucuronosyltransferase 1-1enzyme
ProbenecidCytochrome P450 2C9enzyme
LevofloxacinDNA gyrase subunit Atarget
LevofloxacinDNA topoisomerase 4 subunit Atarget
LevofloxacinCytochrome P450 1A2enzyme
LevofloxacinSolute carrier family 22 member 2transporter
LevofloxacinP-glycoprotein 1transporter
LevofloxacinSolute carrier family 22 member 4transporter
LevofloxacinMultidrug and toxin extrusion protein 1transporter
LevofloxacinMultidrug and toxin extrusion protein 2transporter
LevofloxacinCytochrome P450 2C9enzyme
LevofloxacinSerum albumincarrier
LevofloxacinSolute carrier organic anion transporter family member 4C1transporter
LevofloxacinSolute carrier family 22 member 1transporter
LevofloxacinSolute carrier organic anion transporter family member 1A2transporter
SulfinpyrazoneMultidrug resistance-associated protein 1target
SulfinpyrazoneCanalicular multispecific organic anion transporter 1target
SulfinpyrazoneFatty acid-binding protein, intestinalcarrier
SulfinpyrazoneCytochrome P450 2C9enzyme
SulfinpyrazoneCanalicular multispecific organic anion transporter 2transporter
SulfinpyrazoneMultidrug resistance-associated protein 4transporter
SulfinpyrazoneMultidrug resistance-associated protein 5transporter
SulfinpyrazoneMultidrug resistance-associated protein 6transporter
SulfinpyrazoneMultidrug resistance-associated protein 1transporter
SulfinpyrazoneCanalicular multispecific organic anion transporter 1transporter
SulfinpyrazoneCytochrome P450 3A4enzyme
SulfinpyrazoneCytochrome P450 2B6enzyme
SulfinpyrazoneCytochrome P450 2C8enzyme
SulfinpyrazoneSolute carrier family 22 member 12target
SulfinpyrazoneNuclear receptor subfamily 1 group I member 2target
SulfinpyrazoneBile salt export pumptransporter
AmdinocillinPenicillin-binding protein 2target
AmdinocillinPenicillin-binding protein 2atarget
AmdinocillinPenicillin-binding protein 3target
AmdinocillinPenicillin-binding protein 1Atarget
AmdinocillinPenicillin-binding protein 2Btarget
AmdinocillinPenicillin-binding protein 1btarget
OfloxacinDNA gyrase subunit Atarget
OfloxacinDNA topoisomerase 4 subunit Atarget
OfloxacinDNA topoisomerase 2-alphatarget
OfloxacinCytochrome P450 1A2enzyme
OfloxacinSolute carrier family 22 member 5transporter
OfloxacinMultidrug resistance-associated protein 1transporter
OfloxacinSolute carrier family 22 member 6transporter
OfloxacinCanalicular multispecific organic anion transporter 1transporter
OfloxacinSolute carrier family 22 member 4transporter
OfloxacinBile salt export pumptransporter
SulfadoxineDihydropteroate synthetasetarget
SulfadoxineBifunctional dihydrofolate reductase-thymidylate synthasetarget
NitroxolineMethionine aminopeptidase 2target
NitroxolineMagnesium cationtarget
NitroxolineManganese cationtarget
PivmecillinamPenicillin-binding protein 1Atarget
Tienilic acidCytochrome P450 2C9enzyme
SulfameterDihydropteroate synthasetarget
AzapropazoneSerum albumincarrier
FlumequineCytochrome P450 1A2enzyme
LesinuradSolute carrier family 22 member 12target
LesinuradSolute carrier family 22 member 11target
LesinuradCytochrome P450 2C9enzyme
LesinuradCytochrome P450 3A4enzyme
BenzbromaroneCytochrome P450 2C9target
BenzbromaroneCytochrome P450 2C19target
BenzbromaroneSolute carrier organic anion transporter family member 1B1transporter
BenzbromaroneSolute carrier organic anion transporter family member 2B1transporter
BenzbromaroneBile salt export pumptransporter
BenzbromaroneCytochrome P450 2C19enzyme
Oxolinic acidCytochrome P450 1A2enzyme
Pipemidic acidCytochrome P450 1A2enzyme
FinafloxacinDNA gyrase subunit Atarget
FinafloxacinDNA topoisomerase 4 subunit Atarget
FinafloxacinDNA topoisomerase 2-alphatarget