Glycoside Hydrolase Inhibitors

Name
Glycoside Hydrolase Inhibitors
Accession Number
DBCAT000670
Description

Compounds that inhibit or block the activity of GLYCOSIDE HYDROLASES such as ALPHA-AMYLASES and APHA-GLUCOSIDASES.

ATC Classification
Drugs
DrugDrug Description
AcarboseAn alpha-glucosidase inhibitor used in conjunction with diet and exercise for management of type II diabetes mellitus.
MiglitolAn oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates.
VogliboseFor the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications.
MiglustatA glucosylceramide synthase inhibitor used for the management of mild to moderate type I Gaucher disease for patients who are not candidates for whole enzyme replacement.
CastanospermineNot Available
Drugs & Drug Targets
DrugTargetType
AcarboseMaltase-glucoamylase, intestinaltarget
AcarboseLysosomal alpha-glucosidasetarget
AcarboseSucrase-isomaltase, intestinaltarget
AcarbosePancreatic alpha-amylasetarget
MiglitolMaltase-glucoamylase, intestinaltarget
MiglitolPancreatic alpha-amylaseenzyme
MiglitolLysosomal alpha-glucosidasetarget
MiglitolNeutral alpha-glucosidase ABtarget
MiglitolNeutral alpha-glucosidase Ctarget
VogliboseMaltase-glucoamylase, intestinaltarget
MiglustatCeramide glucosyltransferasetarget
CastanospermineGlucan 1,3-beta-glucosidasetarget