Serotonin 5-HT1 Receptor Agonists

Name
Serotonin 5-HT1 Receptor Agonists
Accession Number
DBCAT000734
Description

Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.

Drugs
DrugDrug Description
ZolmitriptanA member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults.
SumatriptanA serotonin receptor agonist used to treat migraines and cluster headaches.
NaratriptanA 5-HT1B/1D receptor agonist used to treat migraines.
NaluzotanInvestigated for use/treatment in anxiety disorders and depression.
VilazodoneAn antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors.
VortioxetineAn atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD).
DihydroergotamineAn ergot alkaloid used in the acute treatment of migraine headache and cluster headache.
AlmotriptanA 5-HT1B/1D receptor agonist used to treat migraines.
RizatriptanA 5-HT1B/1D receptor agonist used to treat migraines.
FrovatriptanA 5-HT1B/1D receptor agonist used to treat migraines.
ErgotamineA alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches.
LisurideFor the management of Parkinson's Disease
CabergolineA dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes.
ZiprasidoneAn atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia.
FlibanserinA 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD).
RotigotineA non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome.
CinitaprideIt is indicated to treat gastrointestinal disorders associated with motility disturbances like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia and delayed gastric emptying.
BrexpiprazoleA serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia.
CariprazineAn atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder.
5-methoxy-N,N-dimethyltryptamine5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug,...
TetrahydrocannabivarinTHCV does not currently have any FDA, Health Canada, or EMA approved indications.
PiclozotanPiclozotan has been investigated for the treatment of Parkinson's Disease.
CannabidiolAn active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer.
EletriptanA triptan used for the treatment of migraines.
AripiprazoleAn atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
Drugs & Drug Targets
DrugTargetType
Zolmitriptan5-hydroxytryptamine receptor 1Dtarget
Zolmitriptan5-hydroxytryptamine receptor 1Btarget
Zolmitriptan5-hydroxytryptamine receptor 1Ftarget
ZolmitriptanCytochrome P450 1A2enzyme
ZolmitriptanAmine oxidase [flavin-containing] Aenzyme
Zolmitriptan5-hydroxytryptamine receptor 1Atarget
ZolmitriptanP-glycoprotein 1transporter
Zolmitriptan5-hydroxytryptamine receptor 7target
Zolmitriptan5-hydroxytryptamine receptor 2Atarget
Zolmitriptan5-hydroxytryptamine receptor 2Btarget
Zolmitriptan5-hydroxytryptamine receptor 1Etarget
Sumatriptan5-hydroxytryptamine receptor 1Dtarget
Sumatriptan5-hydroxytryptamine receptor 1Btarget
Sumatriptan5-hydroxytryptamine receptor 1Ftarget
SumatriptanAmine oxidase [flavin-containing] Aenzyme
Sumatriptan5-hydroxytryptamine receptor 1Atarget
SumatriptanSolute carrier organic anion transporter family member 1A2transporter
SumatriptanP-glycoprotein 1transporter
SumatriptanATP-binding cassette sub-family G member 2transporter
SumatriptanSolute carrier organic anion transporter family member 1B1transporter
Naratriptan5-hydroxytryptamine receptor 1Dtarget
Naratriptan5-hydroxytryptamine receptor 1Btarget
Naratriptan5-hydroxytryptamine receptor 1Ftarget
Naratriptan5-hydroxytryptamine receptor 1Atarget
NaratriptanAmine oxidase [flavin-containing] Aenzyme
Naluzotan5-hydroxytryptamine receptor 1Atarget
Vilazodone5-hydroxytryptamine receptor 1Atarget
VilazodoneCytochrome P450 3A4enzyme
VilazodoneCytochrome P450 2D6enzyme
VilazodoneSodium-dependent serotonin transportertarget
VilazodoneCytochrome P450 2C19enzyme
VortioxetineSodium-dependent serotonin transportertarget
Vortioxetine5-hydroxytryptamine receptor 3Atarget
Vortioxetine5-hydroxytryptamine receptor 7target
Vortioxetine5-hydroxytryptamine receptor 1Btarget
Vortioxetine5-hydroxytryptamine receptor 1Atarget
VortioxetineBeta-1 adrenergic receptortarget
VortioxetineSodium-dependent noradrenaline transportertarget
VortioxetineCytochrome P450 2D6enzyme
VortioxetineCytochrome P450 3A4enzyme
VortioxetineCytochrome P450 3A5enzyme
VortioxetineCytochrome P450 2C19enzyme
VortioxetineCytochrome P450 2C9enzyme
VortioxetineCytochrome P450 2A6enzyme
VortioxetineCytochrome P450 2C8enzyme
VortioxetineCytochrome P450 2B6enzyme
Dihydroergotamine5-hydroxytryptamine receptor 1Dtarget
Dihydroergotamine5-hydroxytryptamine receptor 1Btarget
DihydroergotamineCytochrome P450 3A4enzyme
DihydroergotamineAlpha-2A adrenergic receptortarget
Dihydroergotamine5-hydroxytryptamine receptor 2Btarget
DihydroergotamineP-glycoprotein 1transporter
Almotriptan5-hydroxytryptamine receptor 1Dtarget
Almotriptan5-hydroxytryptamine receptor 1Btarget
AlmotriptanCytochrome P450 3A4enzyme
AlmotriptanCytochrome P450 2D6enzyme
AlmotriptanAmine oxidase [flavin-containing] Aenzyme
AlmotriptanDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
AlmotriptanCytochrome P450 2C19enzyme
AlmotriptanCytochrome P450 2E1enzyme
AlmotriptanCytochrome P450 2C8enzyme
Rizatriptan5-hydroxytryptamine receptor 1Dtarget
Rizatriptan5-hydroxytryptamine receptor 1Btarget
Rizatriptan5-hydroxytryptamine receptor 1Ftarget
RizatriptanAmine oxidase [flavin-containing] Aenzyme
Frovatriptan5-hydroxytryptamine receptor 1Dtarget
Frovatriptan5-hydroxytryptamine receptor 1Btarget
FrovatriptanCytochrome P450 1A2enzyme
ErgotamineAlpha-1A adrenergic receptortarget
Ergotamine5-hydroxytryptamine receptor 1Dtarget
Ergotamine5-hydroxytryptamine receptor 1Btarget
Ergotamine5-hydroxytryptamine receptor 2Atarget
ErgotamineAlpha-2A adrenergic receptortarget
ErgotamineDopamine D2 receptortarget
ErgotamineAlpha-2B adrenergic receptortarget
ErgotamineCytochrome P450 3A4enzyme
ErgotamineAlpha-1B adrenergic receptortarget
ErgotamineAlpha-1D adrenergic receptortarget
ErgotamineP-glycoprotein 1transporter
ErgotamineD(1) dopamine receptortarget
Ergotamine5-hydroxytryptamine receptor 1Atarget
Ergotamine5-hydroxytryptamine receptor 1Ftarget
Ergotamine5-hydroxytryptamine receptor 2Ctarget
Ergotamine5-hydroxytryptamine receptor 2Btarget
LisurideDopamine D1 receptortarget
Lisuride5-hydroxytryptamine receptor 1Atarget
LisurideDopamine D2 receptortarget
LisurideAlpha-2A adrenergic receptortarget
LisurideAlpha-2B adrenergic receptortarget
LisurideAlpha-2C adrenergic receptortarget
LisurideDopamine D3 receptortarget
Lisuride5-hydroxytryptamine receptor 1Dtarget
Lisuride5-hydroxytryptamine receptor 2Btarget
Lisuride5-hydroxytryptamine receptor 2Atarget
LisurideDopamine D4 receptortarget
Lisuride5-hydroxytryptamine receptor 2Ctarget
LisurideDopamine D5 receptortarget
Lisuride5-hydroxytryptamine receptor 1Btarget
LisurideCytochrome P450 3A4enzyme
Lisuride5-hydroxytryptamine receptor 7target
CabergolineDopamine D2 receptortarget
Cabergoline5-hydroxytryptamine receptor 2Btarget
CabergolineDopamine D3 receptortarget
Cabergoline5-hydroxytryptamine receptor 2Atarget
CabergolineAlpha-2B adrenergic receptortarget
Cabergoline5-hydroxytryptamine receptor 1Dtarget
CabergolineDopamine D4 receptortarget
CabergolineAlpha-2A adrenergic receptortarget
Cabergoline5-hydroxytryptamine receptor 1Atarget
CabergolineAlpha-2C adrenergic receptortarget
CabergolineDopamine D5 receptortarget
CabergolineDopamine D1 receptortarget
Cabergoline5-hydroxytryptamine receptor 1Btarget
Cabergoline5-hydroxytryptamine receptor 2Ctarget
CabergolineCytochrome P450 3A4enzyme
Cabergoline5-hydroxytryptamine receptor 7target
CabergolineAlpha-1A adrenergic receptortarget
CabergolineAlpha-1B adrenergic receptortarget
CabergolineAlpha-1D adrenergic receptortarget
CabergolineBeta-1 adrenergic receptortarget
CabergolineBeta-2 adrenergic receptortarget
CabergolineD(1) dopamine receptortarget
CabergolineP-glycoprotein 1transporter
ZiprasidoneAlpha-1A adrenergic receptortarget
ZiprasidoneDopamine D2 receptortarget
Ziprasidone5-hydroxytryptamine receptor 2Ctarget
ZiprasidoneDopamine D3 receptortarget
Ziprasidone5-hydroxytryptamine receptor 1Atarget
Ziprasidone5-hydroxytryptamine receptor 1Dtarget
ZiprasidoneHistamine H1 receptortarget
Ziprasidone5-hydroxytryptamine receptor 2Atarget
ZiprasidoneDopamine D4 receptortarget
Ziprasidone5-hydroxytryptamine receptor 7target
ZiprasidoneCytochrome P450 3A4enzyme
ZiprasidoneAlpha-2A adrenergic receptortarget
ZiprasidoneAlpha-1B adrenergic receptortarget
ZiprasidoneAlpha-2B adrenergic receptortarget
ZiprasidoneAlpha-2C adrenergic receptortarget
ZiprasidoneDopamine D1 receptortarget
ZiprasidoneDopamine D5 receptortarget
ZiprasidoneMuscarinic acetylcholine receptor M1target
ZiprasidoneMuscarinic acetylcholine receptor M2target
ZiprasidoneMuscarinic acetylcholine receptor M3target
ZiprasidoneMuscarinic acetylcholine receptor M4target
ZiprasidoneMuscarinic acetylcholine receptor M5target
Ziprasidone5-hydroxytryptamine receptor 1Btarget
Ziprasidone5-hydroxytryptamine receptor 1Etarget
Ziprasidone5-hydroxytryptamine receptor 6target
ZiprasidoneAldehyde oxidaseenzyme
ZiprasidoneSerum albumincarrier
ZiprasidoneP-glycoprotein 1transporter
ZiprasidoneAlpha-1-acid glycoprotein 1carrier
Ziprasidone5-hydroxytryptamine 3 receptortarget
Ziprasidone5-hydroxytryptamine receptor 5Atarget
Flibanserin5-hydroxytryptamine receptor 1Atarget
Flibanserin5-hydroxytryptamine receptor 2Atarget
FlibanserinDopamine D4 receptortarget
FlibanserinCytochrome P450 3A4enzyme
FlibanserinP-glycoprotein 1transporter
RotigotineDopamine D3 receptortarget
RotigotineDopamine D5 receptortarget
RotigotineDopamine D4 receptortarget
RotigotineDopamine D2 receptortarget
Rotigotine5-hydroxytryptamine receptor 1Atarget
RotigotineDopamine D1 receptortarget
RotigotineCytochrome P450 2D6enzyme
RotigotineCytochrome P450 3A4enzyme
RotigotineAlpha-2B adrenergic receptortarget
Cinitapride5-hydroxytryptamine receptor 1Atarget
Cinitapride5-hydroxytryptamine receptor 4target
Cinitapride5-hydroxytryptamine receptor 2Atarget
BrexpiprazoleCytochrome P450 2D6enzyme
BrexpiprazoleCytochrome P450 3A4enzyme
Brexpiprazole5-hydroxytryptamine receptor 1Atarget
BrexpiprazoleDopamine D2 receptortarget
Brexpiprazole5-hydroxytryptamine receptor 2Atarget
BrexpiprazoleAlpha-2C adrenergic receptortarget
BrexpiprazoleAlpha-1B adrenergic receptortarget
CariprazineDopamine D3 receptortarget
CariprazineDopamine D2 receptortarget
CariprazineCytochrome P450 3A4enzyme
CariprazineCytochrome P450 2D6enzyme
Cariprazine5-hydroxytryptamine receptor 1Atarget
Cariprazine5-hydroxytryptamine receptor 2Btarget
Cariprazine5-hydroxytryptamine receptor 2Atarget
CariprazineHistamine H1 receptortarget
5-methoxy-N,N-dimethyltryptamine5-hydroxytryptamine receptor 1Atarget
5-methoxy-N,N-dimethyltryptamine5-hydroxytryptamine receptor 2Atarget
5-methoxy-N,N-dimethyltryptamineCytochrome P450 2D6enzyme
TetrahydrocannabivarinCannabinoid receptor 1target
TetrahydrocannabivarinCannabinoid receptor 2target
TetrahydrocannabivarinG-protein coupled receptor 55target
Tetrahydrocannabivarin5-hydroxytryptamine receptor 1Atarget
TetrahydrocannabivarinTransient receptor potential cation channel subfamily V member 2target
TetrahydrocannabivarinTransient receptor potential cation channel subfamily M member 8target
TetrahydrocannabivarinTransient receptor potential cation channel subfamily A member 1target
CannabidiolCytochrome P450 2C9enzyme
CannabidiolCytochrome P450 2C19enzyme
CannabidiolCytochrome P450 2D6enzyme
CannabidiolCytochrome P450 3A4enzyme
CannabidiolCannabinoid receptor 1target
CannabidiolCannabinoid receptor 2target
CannabidiolG-protein coupled receptor 12target
CannabidiolGlycine receptor subunit alpha-1target
CannabidiolGlycine receptor (alpha-1/beta)target
CannabidiolGlycine receptor subunit alpha-3target
CannabidiolN-arachidonyl glycine receptortarget
CannabidiolG-protein coupled receptor 55target
Cannabidiol5-hydroxytryptamine receptor 1Atarget
Cannabidiol5-hydroxytryptamine receptor 2Atarget
CannabidiolNeuronal acetylcholine receptor subunit alpha-7target
CannabidiolDelta-type opioid receptortarget
CannabidiolMu-type opioid receptortarget
CannabidiolPeroxisome proliferator-activated receptor gammatarget
CannabidiolCytochrome P450 3A5enzyme
CannabidiolArylalkylamine N-acetyltransferaseenzyme
CannabidiolCytochrome P450 1A1enzyme
CannabidiolFatty-acid amide hydrolase 1enzyme
CannabidiolArachidonate 5-lipoxygenaseenzyme
CannabidiolArachidonate 15-lipoxygenaseenzyme
CannabidiolQuinone oxidoreductaseenzyme
CannabidiolMultidrug resistance-associated protein 1transporter
CannabidiolATP-binding cassette sub-family G member 2transporter
CannabidiolEquilibrative nucleoside transporter 1transporter
CannabidiolTransient receptor potential cation channel subfamily V member 1target
CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Htarget
CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Itarget
CannabidiolTransient receptor potential cation channel subfamily A member 1target
CannabidiolTransient receptor potential cation channel subfamily M member 8target
CannabidiolTransient receptor potential cation channel subfamily V member 2target
CannabidiolTransient receptor potential cation channel subfamily V member 3target
CannabidiolTransient receptor potential cation channel subfamily V member 4target
CannabidiolVoltage-dependent anion-selective channel protein 1target
Cannabidiol5-hydroxytryptamine receptor 3Atarget
CannabidiolAdenosine receptor A1target
CannabidiolProstaglandin G/H synthase 1target
CannabidiolProstaglandin G/H synthase 2target
CannabidiolAcetyl-CoA acetyltransferase, mitochondrialtarget
CannabidiolSteroid 17-alpha-hydroxylase/17,20 lyasetarget
Cannabidiol3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
CannabidiolGlutathione reductase, mitochondrialtarget
CannabidiolGlutathione peroxidase 1target
CannabidiolIndoleamine 2,3-dioxygenase 1target
CannabidiolCytochrome P450 1B1target
CannabidiolNAD(P)H dehydrogenase [quinone] 1target
CannabidiolCatalasetarget
CannabidiolCytochrome P450 3A5target
CannabidiolCytochrome P450 2D6target
CannabidiolSuperoxide dismutase [Cu-Zn]target
CannabidiolCytochrome P450 1A2target
CannabidiolCytochrome P450 3A7target
CannabidiolArylalkylamine N-acetyltransferasetarget
CannabidiolN-acylethanolamine-hydrolyzing acid amidasetarget
Eletriptan5-hydroxytryptamine receptor 1Dtarget
Eletriptan5-hydroxytryptamine receptor 1Atarget
Eletriptan5-hydroxytryptamine receptor 1Ftarget
Eletriptan5-hydroxytryptamine receptor 1Btarget
EletriptanCytochrome P450 3A4enzyme
EletriptanCytochrome P450 2D6enzyme
EletriptanCytochrome P450 2C9enzyme
EletriptanCytochrome P450 2C19enzyme
EletriptanProstaglandin G/H synthase 1enzyme
EletriptanCytochrome P450 2A6enzyme
EletriptanP-glycoprotein 1transporter
AripiprazoleDopamine D2 receptortarget
Aripiprazole5-hydroxytryptamine receptor 1Atarget
Aripiprazole5-hydroxytryptamine receptor 2Atarget
AripiprazoleCytochrome P450 3A4enzyme
AripiprazoleCytochrome P450 2D6enzyme
Aripiprazole5-hydroxytryptamine receptor 1Btarget
Aripiprazole5-hydroxytryptamine receptor 1Dtarget
Aripiprazole5-hydroxytryptamine receptor 1Etarget
AripiprazoleDopamine D1 receptortarget
AripiprazoleDopamine D5 receptortarget
AripiprazoleDopamine D3 receptortarget
AripiprazoleDopamine D4 receptortarget
Aripiprazole5-hydroxytryptamine receptor 2Ctarget
Aripiprazole5-hydroxytryptamine receptor 3Atarget
Aripiprazole5-hydroxytryptamine receptor 6target
Aripiprazole5-hydroxytryptamine receptor 7target
AripiprazoleHistamine H1 receptortarget
AripiprazoleAlpha-1A adrenergic receptortarget
AripiprazoleAlpha-1B adrenergic receptortarget
AripiprazoleAlpha-2A adrenergic receptortarget
AripiprazoleAlpha-2B adrenergic receptortarget
AripiprazoleAlpha-2C adrenergic receptortarget
AripiprazoleCytochrome P450 3A5enzyme
AripiprazoleCytochrome P450 3A7enzyme
AripiprazoleSerum albumincarrier
Aripiprazole5-hydroxytryptamine receptor 2Btarget
Aripiprazole5-hydroxytryptamine receptor 5Atarget
AripiprazoleBeta-1 adrenergic receptortarget
AripiprazoleBeta-2 adrenergic receptortarget
AripiprazoleHistamine H2 receptortarget
AripiprazoleHistamine H3 receptortarget
AripiprazoleHistamine H4 receptortarget
AripiprazoleMuscarinic acetylcholine receptor M1target
AripiprazoleMuscarinic acetylcholine receptor M2target
AripiprazoleMuscarinic acetylcholine receptor M3target
AripiprazoleMuscarinic acetylcholine receptor M4target
AripiprazoleMuscarinic acetylcholine receptor M5target
AripiprazoleKappa-type opioid receptortarget
AripiprazoleMu-type opioid receptortarget
AripiprazoleDelta-type opioid receptortarget
AripiprazoleGlutamate (NMDA) receptortarget
AripiprazoleSodium-dependent dopamine transportertarget
AripiprazoleSodium-dependent serotonin transportertarget