Alkanesulfonic Acids

Sulfonic acid derivatives that are substituted with an aliphatic hydrocarbon group.
DrugDrug NameDrug Indication
DB00464Sodium Tetradecyl SulfateFor the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.
DB00659AcamprosateFor the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation
DB00815Sodium lauryl sulfateSLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.
DB01008BusulfanFor use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases.
DB03309N-cyclohexyltaurineNot Available
DB03635Ethanesulfonic AcidNot Available
DB03967Dodecyl sulfateNot Available
DB04348Taurocholic AcidNot Available
DB06527TramiprosateInvestigated for use/treatment in strokes and alzheimer's disease.
DB06536TesaglitazarInvestigated for use/treatment in diabetes mellitus type 2.
DB06633N-chlorotaurineInvestigated for use/treatment in eye disorders/infections.
DB08833Taurochenodeoxycholic acidTaurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy.
DB08834Tauroursodeoxycholic acidUsed in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
DB09110Coenzyme MMesna is a uroprotective agent and is used prophylactically to reduce ifosfamide and cyclophosphamide induced hemorrhagic cystitis.[A18572]
DB11678TreosulfanNot Available
DB12197AuricloseneNot Available
DB12473TaurolidineNot Available
DB13321MethiodalNot Available
DB13334MannosulfanNot Available
DB01956TaurineThe use of diet supplements containing taurine is indicated for the nutritional support of infants and young pediatric patients requiring total parenteral nutrition via central or peripheral routes. The usage of diet supplements containing taurine prevents nitrogen and weight loss or to treat negative nitrogen balance in pediatric patients where the alimentary tract cannot be done through oral, gastrostomy or jejunostomy administration, there is impaired gastrointestinal absorption or protein requirements are substantially increased.[FDA label]
DB14779LGD-6972Not Available
DrugDrug NameTargetType
DB00464Sodium Tetradecyl SulfateVitamin K-dependent protein Ctarget
DB00464Sodium Tetradecyl SulfateVitamin K-dependent protein Starget
DB00659AcamprosateMetabotropic glutamate receptor 5target
DB00659AcamprosateProton-coupled amino acid transporter 1transporter
DB00659AcamprosateGABA-A receptor (anion channel)target
DB00659AcamprosateGlutamate (NMDA) receptortarget
DB00815Sodium lauryl sulfateSerum albumincarrier
DB01008BusulfanDNAtarget
DB01008BusulfanCytochrome P450 3A4enzyme
DB01008BusulfanGlutathione S-transferase A2enzyme
DB01008BusulfanGlutathione S-transferase A1enzyme
DB01008BusulfanGlutathione S-transferase Mu 1enzyme
DB01008BusulfanGlutathione S-transferase Penzyme
DB01008BusulfanMicrosomal glutathione S-transferase 2enzyme
DB03309N-cyclohexyltaurineSulfotransferase family cytosolic 2B member 1target
DB03309N-cyclohexyltaurineNitrite reductasetarget
DB03309N-cyclohexyltaurineHomeobox protein engrailed-2target
DB03309N-cyclohexyltaurineRibonuclease PHtarget
DB03309N-cyclohexyltaurineCyanovirin-Ntarget
DB03309N-cyclohexyltaurinePhosphoproteintarget
DB03635Ethanesulfonic AcidPlatelet basic proteintarget
DB03635Ethanesulfonic AcidPhosphonoacetaldehyde hydrolasetarget
DB03967Dodecyl sulfateLysozyme Ctarget
DB03967Dodecyl sulfateLipid A palmitoyltransferase PagPtarget
DB04348Taurocholic AcidBile salt-activated lipasetarget
DB04348Taurocholic AcidGastrotropintarget
DB04348Taurocholic AcidBile salt export pumptransporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB04348Taurocholic AcidIleal sodium/bile acid cotransportertransporter
DB04348Taurocholic AcidCanalicular multispecific organic anion transporter 1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1B1transporter
DB04348Taurocholic AcidCanalicular multispecific organic anion transporter 2transporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 4transporter
DB04348Taurocholic AcidMultidrug resistance protein 1transporter
DB04348Taurocholic AcidSolute carrier family 22 member 6transporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 7transporter
DB04348Taurocholic AcidSolute carrier family 22 member 8transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 4A1transporter
DB04348Taurocholic AcidATP-binding cassette sub-family C member 11transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1C1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 3A1transporter
DB04348Taurocholic AcidATP-binding cassette sub-family G member 2transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 2B1transporter
DB04348Taurocholic AcidMonocarboxylate transporter 1transporter
DB04348Taurocholic AcidSodium/bile acid cotransportertransporter
DB04348Taurocholic AcidOrganic solute transporter subunit alphatransporter
DB04348Taurocholic AcidOrganic solute transporter subunit betatransporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1B3transporter
DB04348Taurocholic AcidCystine/glutamate transportertransporter
DB04348Taurocholic AcidBile acid receptortarget
DB06536TesaglitazarPeroxisome proliferator-activated receptor alphatarget
DB06536TesaglitazarPeroxisome proliferator-activated receptor gammatarget
DB08833Taurochenodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08833Taurochenodeoxycholic acidCystine/glutamate transportertransporter
DB08833Taurochenodeoxycholic acidCytochrome P450 3A4enzyme
DB08834Tauroursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08834Tauroursodeoxycholic acidCystine/glutamate transportertransporter
DB08834Tauroursodeoxycholic acidCytochrome P450 3A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 3A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B9enzyme
DB09110Coenzyme MGlutathione reductase, mitochondrialenzyme
DB01956TaurineAlpha-ketoglutarate-dependent taurine dioxygenasetarget
DB01956TaurineCholoylglycine hydrolasetarget
DB01956TaurineGlycine receptor subunit alpha-1target
DB01956TaurineProton-coupled amino acid transporter 1transporter
DB01956TaurineSodium- and chloride-dependent taurine transportertransporter
DB01956TaurineSolute carrier family 15 member 1transporter
DB01956TaurineProtein-glutamine gamma-glutamyltransferase 6enzyme
DB01956TaurineBile acid-CoA:amino acid N-acyltransferaseenzyme
DB01956TaurineGlutamate receptor ionotropic, NMDA 2Btarget
DB01956TaurineGlycine receptor subunit alpha-2target
DB01956TaurineGlycine receptor subunit alpha-3target
DB01956TaurineGABA-A receptor (anion channel)target
DB01956TaurineGamma-aminobutyric acid type B receptor subunit 1target