17-Ketosteroids

Steroids that contain a ketone group at position 17.
DrugDrug NameDrug Description
DB00655EstroneAn estrogen used to treat perimenopausal and postmenopausal symptoms.
DB0143419-norandrostenedioneThe claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated.
DB014565-androstenedione5-androstenedione is a prohormone of testosterone. In the United States, the Controlled Substance Act is inclusive to anabolic steroids and their precursors. Thus 5-androstenedione is a controlled substance, and its...
DB01536AndrostenedioneA delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as...
DB01708PrasteroneA steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy.
DB02187EquilinFor the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and...
DB03515EquileninAn estrogenic steroid produced by HORSES. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the URINE of pregnant...
DB04574Estrone sulfateAn estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders.
DB04870Oleoyl-estroneFor the treatment of obesity.
DB0510716-BromoepiandrosteroneInvestigated for use/treatment in cystic fibrosis, HIV infection, hepatitis (viral, B), and malaria.
DB05212HE3286For the treatment of rheumatoid arthritis and type 2 diabetes.
DB05804Prasterone sulfateInvestigated for use/treatment in asthma and burns and burn infections.
DB06157IstaroximeInvestigated for use/treatment in heart disease.
DB06250FluasteroneInvestigated for use/treatment in psoriasis and psoriatic disorders, hyperlipidemia, metabolic disease, cancer/tumors (unspecified), and obesity.
DB08905FormestaneFor the treatment of estrogen-receptor positive breast cancer in post-menopausal women.
DB12194AtamestaneAtamestane has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasms, Hormone-Dependent.
DrugDrug NameTargetType
DB00655EstroneEstrogen receptor alphatarget
DB00655EstroneCytochrome P450 1A2enzyme
DB00655EstroneCytochrome P450 1A1enzyme
DB00655EstroneSerum albumincarrier
DB00655EstroneSolute carrier organic anion transporter family member 2B1transporter
DB00655EstroneP-glycoprotein 1transporter
DB00655EstroneSolute carrier organic anion transporter family member 1A2transporter
DB00655EstroneATP-binding cassette sub-family G member 2transporter
DB00655EstroneSolute carrier organic anion transporter family member 1B1transporter
DB00655EstroneCytochrome P450 3A4enzyme
DB00655EstroneCytochrome P450 1B1enzyme
DB00655EstroneCytochrome P450 2B6enzyme
DB00655EstroneCytochrome P450 2C9enzyme
DB00655EstroneCytochrome P450 2E1enzyme
DB00655EstroneCytochrome P450 3A5enzyme
DB00655EstroneEstrogen receptor betatarget
DB00655EstroneAndrogen receptortarget
DB00655EstroneCytochrome P450 19A1target
DB00655EstroneSex hormone-binding globulintarget
DB00655EstroneSolute carrier family 22 member 8transporter
DB014565-androstenedioneCytochrome P450 3A4enzyme
DB01536AndrostenedioneAldo-keto reductase family 1 member C3target
DB01536AndrostenedioneEstradiol 17-beta-dehydrogenase 1target
DB01536Androstenedione6-deoxyerythronolide B hydroxylasetarget
DB01536Androstenedione3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB01536AndrostenedioneCytochrome P450 3A4enzyme
DB01708PrasteroneSteroid Delta-isomerasetarget
DB01708PrasteroneBile salt sulfotransferasetarget
DB01708PrasteroneCholesterol oxidasetarget
DB01708PrasteroneEstradiol 17-beta-dehydrogenase 1target
DB01708PrasteroneSulfotransferase family cytosolic 2B member 1target
DB01708PrasteroneCytochrome P450 3A7enzyme
DB01708PrasteronePeroxisome proliferator-activated receptor alphatarget
DB01708PrasteroneEstrogen receptor alphatarget
DB01708PrasteroneSigma non-opioid intracellular receptor 1target
DB01708PrasteroneEstrogen receptor betatarget
DB01708PrasteroneNuclear receptor subfamily 1 group I member 2target
DB01708PrasteroneNuclear receptor subfamily 1 group I member 3target
DB01708PrasteroneGABA-A receptor (anion channel)target
DB01708PrasteroneNMDA receptortarget
DB01708PrasteroneAndrogen receptortarget
DB02187EquilinEstradiol 17-beta-dehydrogenase 1target
DB02187EquilinEstrogen receptor alphatarget
DB02187EquilinCytochrome P450 3A4enzyme
DB03515EquileninSteroid Delta-isomerasetarget
DB03515EquileninSteroid Delta-isomerasetarget
DB03515EquileninCytochrome P450 3A4enzyme
DB04574Estrone sulfateCytochrome P450 1A2enzyme
DB04574Estrone sulfateCytochrome P450 3A4enzyme
DB04574Estrone sulfateEstrogen receptor alphatarget
DB04574Estrone sulfateEstrogen receptor betatarget
DB04574Estrone sulfateSex hormone-binding globulincarrier
DB04574Estrone sulfateSerum albumincarrier
DB04574Estrone sulfateCytochrome P450 2C9enzyme
DB04574Estrone sulfateMultidrug and toxin extrusion protein 1transporter
DB04574Estrone sulfateMultidrug and toxin extrusion protein 2transporter
DB0510716-BromoepiandrosteroneGlucose-6-phosphate 1-dehydrogenasetarget
DB05212HE3286Nuclear factor NF-kappa-B p105 subunittarget
DB05212HE3286Nuclear factor NF-kappa-B p100 subunittarget
DB05212HE3286Cytochrome P450 3A4enzyme
DB05804Prasterone sulfateCytochrome P450 19A1enzyme
DB05804Prasterone sulfateCytochrome P450 3A7enzyme
DB05804Prasterone sulfateProstaglandin G/H synthase 2enzyme
DB05804Prasterone sulfateSolute carrier family 22 member 8transporter
DB05804Prasterone sulfateSolute carrier organic anion transporter family member 1A2transporter
DB05804Prasterone sulfateSolute carrier organic anion transporter family member 1B1transporter
DB05804Prasterone sulfateSolute carrier organic anion transporter family member 1B3transporter
DB05804Prasterone sulfateSolute carrier organic anion transporter family member 2B1transporter
DB05804Prasterone sulfateSolute carrier family 10 member 6transporter
DB05804Prasterone sulfateBile salt export pumptransporter
DB06157IstaroximeSarcoplasmic/endoplasmic reticulum calcium ATPase 2target
DB06157IstaroximeSodium/potassium-transporting ATPase subunit alpha-1target
DB08905FormestaneCytochrome P450 3A4enzyme