Histone Deacetylase Inhibitors

Name
Histone Deacetylase Inhibitors
Accession Number
DBCAT001486  (DBCAT001790)
Description

Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.

Drugs
DrugDrug Description
VorinostatA histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies.
BelinostatA histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).
PanobinostatA non-selective histone deacetylase inhibitor used to treat multiple myeloma in combination with other antineoplastic agents.
PracinostatFor the treatment of various forms of cancer.
TucidinostatInvestigated for use/treatment in cancer/tumors (unspecified).
MocetinostatMocetinostat has been used in trials studying the treatment of Lymphoma, Urothelial Carcinoma, Relapsed and Refractory, Myelodysplastic Syndrome, and Metastatic Leiomyosarcoma, among others.
EntinostatEntinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic...
CUDC-907CUDC-907 has been used in trials studying the treatment of Lymphoma, Solid Tumors, BREAST CANCER, Multiple Myeloma, and NUT Midline Carcinoma, among others.
CUDC-101CUDC-101 has been used in trials studying the treatment of Cancer, Tumors, Liver Cancer, Breast Cancer, and Gastric Cancer, among others.
CG-200745Cg200745 has been used in trials studying the treatment of Solid Tumour.
OBP-801OBP-801 has been used in trials studying the treatment of Solid Tumor.
RicolinostatRicolinostat is under investigation for the treatment of Breast Carcinoma and Metastatic Breast Cancer.
R-306465R306465 has been used in trials studying the treatment of Neoplasms.
AbexinostatAbexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase...
GivinostatGivinostat has been used in trials studying the treatment of Polycythemia Vera, Juvenile Idiopathic Arthritis, Duchenne Muscular Dystrophy (DMD), Chronic Myeloproliferative Neoplasms, and Polyarticular Course Juvenile Idiopathic Arthritis.
RomidepsinA histone deacetylase (HDAC) inhibitor used to treat cutaneous and peripheral T-cell lymphoma.
Valproic acidAn anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
BufexamacAn NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses.
TefinostatTefinostat is under investigation in clinical trial NCT02759601 (Dose Escalation Trial of Tefinostat for Cancer Associated Inflamation in Hepatocellular Carcinoma (HCC)).
NanatinostatNanatinostat is under investigation in clinical trial NCT00697879 (Safety Study of the Histone Deacetylase Inhibitor, CHR-3996, in Patients With Advanced Solid Tumours).
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamideNot Available
Trichostatin ANot Available
Drugs & Drug Targets
DrugTargetType
VorinostatHistone deacetylase 1target
VorinostatHistone deacetylase 2target
VorinostatHistone deacetylase 3target
VorinostatHistone deacetylase 6target
VorinostatHistone deacetylase 8target
VorinostatAcetoin utilization proteintarget
BelinostatHistone deacetylasetarget
BelinostatCytochrome P450 1A2enzyme
BelinostatUDP-glucuronosyltransferase 1-4enzyme
BelinostatCytochrome P450 2C8enzyme
BelinostatCytochrome P450 2C9enzyme
BelinostatP-glycoprotein 1transporter
PanobinostatCytochrome P450 2D6enzyme
PanobinostatCytochrome P450 3A4enzyme
PanobinostatP-glycoprotein 1transporter
PanobinostatHistone deacetylasetarget
PracinostatHistone deacetylase 1target
PracinostatHistone deacetylase 2target
PracinostatHistone deacetylase 3target
PracinostatHistone deacetylase 6target
MocetinostatHistone deacetylase 1target
MocetinostatHistone deacetylase 3target
MocetinostatHistone deacetylase 2target
AbexinostatHistone deacetylase 1target
RomidepsinCytochrome P450 3A4enzyme
RomidepsinCytochrome P450 3A5enzyme
RomidepsinP-glycoprotein 1transporter
RomidepsinSolute carrier organic anion transporter family member 1B3transporter
RomidepsinCytochrome P450 1A1enzyme
RomidepsinCytochrome P450 2B6enzyme
RomidepsinCytochrome P450 2C19enzyme
RomidepsinHistone deacetylase 1target
RomidepsinHistone deacetylase 2target
RomidepsinHistone deacetylase 4target
RomidepsinHistone deacetylase 6target
RomidepsinMultidrug resistance-associated protein 1target
Valproic acidHistone deacetylase 9target
Valproic acidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
Valproic acidCytochrome P450 2A6enzyme
Valproic acidCytochrome P450 2B6enzyme
Valproic acidCytochrome P450 2C9enzyme
Valproic acidSolute carrier family 22 member 5transporter
Valproic acidSolute carrier family 22 member 6transporter
Valproic acidSolute carrier family 22 member 8transporter
Valproic acidMonocarboxylate transporter 1transporter
Valproic acidSolute carrier family 22 member 7transporter
Valproic acidCytochrome P450 3A5enzyme
Valproic acidUDP-glucuronosyltransferase 1-9enzyme
Valproic acidProstaglandin G/H synthase 1enzyme
Valproic acidCytochrome P450 1A2enzyme
Valproic acidCytochrome P450 2C19enzyme
Valproic acidCytochrome P450 3A4enzyme
Valproic acidUDP-glucuronosyltransferase 1-4enzyme
Valproic acidUDP-glucuronosyltransferase 1-8enzyme
Valproic acidUDP-glucuronosyltransferase 1-10enzyme
Valproic acidUDP-glucuronosyltransferase 1-6enzyme
Valproic acidUDP-glucuronosyltransferase 1-3enzyme
Valproic acidUDP-glucuronosyltransferase 2B7enzyme
Valproic acidUDP-glucuronosyltransferase 2B15enzyme
Valproic acid2-oxoglutarate dehydrogenase, mitochondrialtarget
Valproic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
Valproic acidSodium channel proteintarget
Valproic acidHistone deacetylase 2target
Valproic acidPeroxisome proliferator-activated receptor alphatarget
Valproic acidPeroxisome proliferator-activated receptor deltatarget
Valproic acidPeroxisome proliferator-activated receptor gammatarget
Valproic acidSerum albumincarrier
Valproic acidUDP-glucuronosyltransferase 1-1enzyme
Valproic acidSolute carrier organic anion transporter family member 2B1transporter
BufexamacProstaglandin G/H synthase 1target
BufexamacProstaglandin G/H synthase 2target
BufexamacHistone deacetylase 6target
BufexamacHistone deacetylase 10target
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamideHistone deacetylase 8target
Trichostatin AHistone deacetylase 8target
Trichostatin AAcetoin utilization proteintarget
Trichostatin AHistone deacetylase 7target