Vitamin K Antagonists

Name
Vitamin K Antagonists
Accession Number
DBCAT002267
Description
Not Available
ATC Classification
Drugs
DrugDrug Description
WarfarinA vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction.
DicoumarolFor decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis.
PhenindioneFor the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
PhenprocoumonUsed for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation...
AcenocoumarolAn anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction.
Ethyl biscoumacetateEthyl biscoumacetate is a courmarin that is used as an anticoagulant. It has actions similar to those of Warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)
FluindioneFluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for...
ClorindioneClorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans.
DiphenadioneNot Annotated
TioclomarolNot Annotated
4-hydroxycoumarinNot Available
(R)-warfarinWarfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in...
(S)-WarfarinWarfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in...
CoumarinNot Available
Drugs & Drug Targets
DrugTargetType
WarfarinVitamin K epoxide reductase complex subunit 1target
WarfarinCytochrome P450 2C8enzyme
WarfarinCytochrome P450 1A2enzyme
WarfarinCytochrome P450 2C9enzyme
WarfarinAlpha-1-acid glycoprotein 1carrier
WarfarinSerum albumincarrier
WarfarinCytochrome P450 2C19enzyme
WarfarinCytochrome P450 3A4enzyme
WarfarinCytochrome P450 2C18enzyme
WarfarinNuclear receptor subfamily 1 group I member 2target
DicoumarolVitamin K epoxide reductase complex subunit 1target
DicoumarolNAD(P)H dehydrogenase [quinone] 1target
DicoumarolQuinone oxidoreductasetarget
DicoumarolCytochrome P450 2C9enzyme
DicoumarolSerum albumincarrier
DicoumarolCytochrome P450 2C6enzyme
DicoumarolCytochrome P450 2C11enzyme
PhenindioneVitamin K epoxide reductase complex subunit 1target
PhenprocoumonVitamin K epoxide reductase complex subunit 1target
PhenprocoumonAlpha-1-acid glycoprotein 1carrier
PhenprocoumonSerum albumincarrier
PhenprocoumonCytochrome P450 2C9enzyme
PhenprocoumonCytochrome P450 3A4enzyme
PhenprocoumonCytochrome P450 2C8enzyme
AcenocoumarolVitamin K epoxide reductase complex subunit 1target
AcenocoumarolCytochrome P450 2C9enzyme
AcenocoumarolCytochrome P450 1A2enzyme
AcenocoumarolSerum albumincarrier
AcenocoumarolAlpha-1-acid glycoprotein 1carrier
AcenocoumarolCytochrome P450 2C19enzyme
AcenocoumarolCytochrome P450 3A4enzyme
AcenocoumarolP-glycoprotein 1transporter
Ethyl biscoumacetateGlutamine synthetaseenzyme
Ethyl biscoumacetateCytochrome P450 3A4enzyme
FluindioneCytochrome P450 2C9enzyme
FluindioneCytochrome P450 3A4enzyme
ClorindioneCytochrome P450 3A4enzyme
DiphenadioneCytochrome P450 3A4enzyme
4-hydroxycoumarinMajor NAD(P)H-flavin oxidoreductasetarget
4-hydroxycoumarinCytochrome P450 3A4enzyme
(R)-warfarinSerum albumincarrier
(R)-warfarinCytochrome P450 2C8enzyme
(R)-warfarinCytochrome P450 2C9enzyme
(R)-warfarinCytochrome P450 2C18enzyme
(R)-warfarinCytochrome P450 2C19enzyme
(R)-warfarinCytochrome P450 1A2enzyme
(R)-warfarinCytochrome P450 1A1enzyme
(R)-warfarinCytochrome P450 3A4enzyme
(S)-WarfarinCytochrome P450 3A4enzyme
(S)-WarfarinCytochrome P450 2C8enzyme
(S)-WarfarinCytochrome P450 2C9enzyme
(S)-WarfarinCytochrome P450 2C18enzyme
(S)-WarfarinCytochrome P450 2C19enzyme
CoumarinCytochrome P450 2A6target
CoumarinCytochrome P450 2C9enzyme