Decongestants and Antiallergics

DrugDrug NameDrug Description
DB00751EpinastineAn H1 receptor antagonist used to prevent itching in allergic conjunctivitis.
DB00935OxymetazolineAn alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea.
DB01084EmedastineA selective H1-receptor antagonist used topically to manage symptoms of allergic conjunctivitis.
DB01106LevocabastineA selective histamine H1 receptor antagonist indicated for the management of seasonal allergic conjunctivitis symptoms.
DB06694XylometazolineA direct acting sympathomimetic agent used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.
DB06766AlcaftadineA H1 histamine receptor antagonist for ophthalmic use to prevent itching associated with allergic conjunctivitis.
DB06794LodoxamideAn ophthalmic agent used for the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
DB08835Spaglumic AcidUsed in patients with allergic conjunctivitis.
DB09203SynephrineSynephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer...
DB00388PhenylephrineAn alpha-1 adrenergic antagonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
DB00716NedocromilA pyrano quinoline used to treat allergic conjunctivitis.
DB00768OlopatadineA histamine H1 antagonist used to treat allergic conjunctivitis and rhinitis.
DB00920KetotifenA histamine H1 receptor blocker used to treat mild asthma and allergic conjunctivitis.
DB00972AzelastineA histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis.
DB01003Cromoglicic acidA medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions.
DB06711NaphazolineA sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.
DB06764TetryzolineAn alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations.
DrugDrug NameTargetType
DB00751EpinastineHistamine H1 receptortarget
DB00751EpinastineHistamine H2 receptortarget
DB00751EpinastineAlpha-1A adrenergic receptortarget
DB00751EpinastineAlpha-2A adrenergic receptortarget
DB00751Epinastine5-hydroxytryptamine receptor 2Atarget
DB00751Epinastine5-hydroxytryptamine receptor 7target
DB00751EpinastineP-glycoprotein 1transporter
DB00751EpinastineCytochrome P450 2B6enzyme
DB00751EpinastineCytochrome P450 2D6enzyme
DB00751EpinastineCytochrome P450 3A4enzyme
DB00935OxymetazolineAlpha-1A adrenergic receptortarget
DB00935OxymetazolineAlpha-2A adrenergic receptortarget
DB00935OxymetazolineAlpha-2C adrenergic receptortarget
DB00935OxymetazolineAlpha-2B adrenergic receptortarget
DB00935OxymetazolineAlpha-1B adrenergic receptortarget
DB00935OxymetazolineAlpha-1D adrenergic receptortarget
DB01084EmedastineHistamine H1 receptortarget
DB01106LevocabastineNeurotensin receptor type 2target
DB01106LevocabastineHistamine H1 receptortarget
DB06694XylometazolineAlpha-2A adrenergic receptortarget
DB06694XylometazolineAlpha-1A adrenergic receptortarget
DB06694XylometazolineAlpha-1B adrenergic receptortarget
DB06694XylometazolineAlpha-1D adrenergic receptortarget
DB06694XylometazolineAlpha-2B adrenergic receptortarget
DB06694XylometazolineAlpha-2C adrenergic receptortarget
DB06766AlcaftadineHistamine H1 receptortarget
DB08835Spaglumic AcidProton-coupled amino acid transporter 1transporter
DB08835Spaglumic AcidGlutamate carboxypeptidase 2target
DB09203SynephrineAlpha-1 adrenergic receptorstarget
DB00388PhenylephrineAlpha-1A adrenergic receptortarget
DB00388PhenylephrineAlpha-1B adrenergic receptortarget
DB00388PhenylephrineAmine oxidase [flavin-containing] Aenzyme
DB00388PhenylephrineAlpha-1D adrenergic receptortarget
DB00388PhenylephrineCytochrome P450 1A2enzyme
DB00388PhenylephrineSulfotransferase 1A3/1A4enzyme
DB00388PhenylephrineAmine oxidase [flavin-containing] Benzyme
DB00716NedocromilCysteinyl leukotriene receptor 1target
DB00716NedocromilCysteinyl leukotriene receptor 2target
DB00716NedocromilProstaglandin D2 receptortarget
DB00716NedocromilfMet-Leu-Phe receptortarget
DB00716NedocromilHeat shock protein HSP 90-alphatarget
DB00768OlopatadineHistamine H1 receptortarget
DB00768OlopatadineProtein S100-A1target
DB00768OlopatadineProtein S100-A12target
DB00768OlopatadineProtein S100-Btarget
DB00768OlopatadineProtein S100-A13target
DB00768OlopatadineProtein S100-A2target
DB00768OlopatadineCytochrome P450 3A4enzyme
DB00768OlopatadineSerum albumincarrier
DB00768OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00768OlopatadineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00768OlopatadineP-glycoprotein 1transporter
DB00768OlopatadineHistamine H2 receptortarget
DB00768OlopatadineHistamine H3 receptortarget
DB00920KetotifenHistamine H1 receptortarget
DB00920Ketotifen6-phosphogluconate dehydrogenase, decarboxylatingtarget
DB00972AzelastineHistamine H1 receptortarget
DB00972AzelastineCytochrome P450 1A2enzyme
DB00972AzelastineCytochrome P450 2D6enzyme
DB00972AzelastineCytochrome P450 3A4enzyme
DB00972AzelastineCytochrome P450 2C19enzyme
DB00972AzelastineCytochrome P450 1A1enzyme
DB00972AzelastineCytochrome P450 3A5enzyme
DB00972AzelastineCytochrome P450 2C9enzyme
DB00972AzelastineCytochrome P450 2C8enzyme
DB00972AzelastineP-glycoprotein 1transporter
DB00972AzelastineCytochrome P450 2A6enzyme
DB00972AzelastineCytochrome P450 2E1enzyme
DB00972AzelastineHistamine H2 receptortarget
DB00972AzelastinePhospholipase A2target
DB00972AzelastineLeukotriene C4 synthasetarget
DB00972AzelastineCytochrome P450 2B6enzyme
DB01003Cromoglicic acidCalcium-activated potassium channel subunit alpha-1target
DB01003Cromoglicic acidProtein S100-Ptarget
DB06711NaphazolineAlpha-1A adrenergic receptortarget
DB06711NaphazolineAlpha-2A adrenergic receptortarget
DB06764TetryzolineAlpha-1A adrenergic receptortarget