First-Generation Cephalosporins

DrugDrug NameDrug Indication
DB00456CefalotinUsed to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.
DB00567CephalexinCephalexin is indicated for the treatment of certain infections caused by susceptible bacteria.[Label,L6550,L6553] These infections include respiratory tract infections, otitis media, skin and skin structure infections, bone infections, and genitourinary tract infections.[Label,L6550,L6553]
DB01139CefapirinFor treatment of infections caused by susceptible bacteria.
DB01140CefadroxilFor the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes
DB01327CefazolinMainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
DB01333CefradineNot Available
DB01414CefacetrileCefacetrile is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections.
DB09008CefaloridineNot Available
DB11367CefroxadineWas used for the treatment of bacterial infections.
DB13266CefatrizineNot Available
DB13778CefazedoneNot Available
DB13821CeftezoleNot Available
DrugDrug NameTargetType
DB00456CefalotinPenicillin-binding protein 1Atarget
DB00456CefalotinD-alanyl-D-alanine carboxypeptidasetarget
DB00456CefalotinBeta-lactamasetarget
DB00456CefalotinSolute carrier family 22 member 5transporter
DB00456CefalotinSolute carrier family 15 member 1transporter
DB00456CefalotinSolute carrier family 15 member 2transporter
DB00456CefalotinSolute carrier family 22 member 6transporter
DB00456CefalotinSolute carrier family 22 member 8transporter
DB00456CefalotinSolute carrier family 22 member 11transporter
DB00456CefalotinSolute carrier family 22 member 7transporter
DB00456CefalotinPenicillin-binding protein 1Atarget
DB00456CefalotinPenicillin-binding protein 1btarget
DB00456CefalotinPenicillin-binding protein 3target
DB00456CefalotinPenicillin-binding protein 2atarget
DB00456CefalotinPenicillin-binding protein 2Btarget
DB00456CefalotinSerum albumincarrier
DB00567CephalexinSerum albumincarrier
DB00567CephalexinSolute carrier family 22 member 5transporter
DB00567CephalexinSolute carrier family 15 member 1transporter
DB00567CephalexinSolute carrier family 15 member 2transporter
DB00567CephalexinSolute carrier family 22 member 6transporter
DB00567CephalexinSolute carrier family 22 member 8transporter
DB00567CephalexinMultidrug and toxin extrusion protein 1transporter
DB00567CephalexinPenicillin-binding protein 3target
DB00567CephalexinPenicillin-binding protein 2atarget
DB00567CephalexinPenicillin-binding protein 1btarget
DB00567CephalexinPenicillin-binding protein 1Atarget
DB00567CephalexinPenicillin-binding protein 2Btarget
DB01139CefapirinPenicillin-binding protein 1Atarget
DB01140CefadroxilSolute carrier family 22 member 5transporter
DB01140CefadroxilSolute carrier family 15 member 1transporter
DB01140CefadroxilSolute carrier family 15 member 2transporter
DB01140CefadroxilSolute carrier family 22 member 6transporter
DB01140CefadroxilSolute carrier family 22 member 8transporter
DB01140CefadroxilPenicillin-binding protein 3target
DB01140CefadroxilPenicillin-binding protein 1Atarget
DB01140CefadroxilPenicillin-binding protein 1btarget
DB01140CefadroxilPenicillin-binding protein 2Btarget
DB01327CefazolinSerum paraoxonase/arylesterase 1target
DB01327CefazolinSerum albumincarrier
DB01327CefazolinSolute carrier family 22 member 6transporter
DB01327CefazolinSolute carrier family 22 member 8transporter
DB01327CefazolinSolute carrier family 22 member 11transporter
DB01327CefazolinPenicillin-binding protein 1Atarget
DB01327CefazolinPenicillin-binding protein 1Btarget
DB01327CefazolinPenicillin-binding protein 2target
DB01327CefazolinPenicillin-binding protein 1Ctarget
DB01327CefazolinPeptidoglycan synthase FtsItarget
DB01327CefazolinMultidrug resistance-associated protein 4transporter
DB01327CefazolinThiopurine S-methyltransferaseenzyme
DB01327CefazolinInterleukin-15target
DB01327CefazolinInterleukin-2target
DB01333CefradineSolute carrier family 22 member 5transporter
DB01333CefradineSolute carrier family 15 member 1transporter
DB01333CefradineSolute carrier family 15 member 2transporter
DB01333CefradineSolute carrier family 22 member 6transporter
DB01333CefradinePenicillin-binding protein 1Atarget
DB01333CefradineCytochrome P450 3A4enzyme
DB01333CefradineMultidrug and toxin extrusion protein 1transporter
DB01414CefacetrilePenicillin-binding protein 1Atarget
DB01414CefacetrilePenicillin-binding protein 1Btarget
DB01414CefacetrileSolute carrier family 22 member 6transporter
DB01414CefacetrileSolute carrier family 22 member 8transporter
DB09008CefaloridineSolute carrier family 22 member 6transporter
DB09008CefaloridineSolute carrier family 22 member 8transporter
DB11367CefroxadineBeta-lactamaseenzyme
DB11367CefroxadinePenicillin-binding protein 1Btarget