Cefatrizine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Cefatrizine
Accession Number
DB13266
Type
Small Molecule
Groups
Experimental
Description
Not Available
Structure
Thumb
Synonyms
  • cefatrizina
  • céfatrizine
  • cefatrizinum
External IDs
antibiotic BL-S 640 / BL-S 640 / BL-S640 / BLS 640 / S-640P / SKF 60771
Product Ingredients
IngredientUNIICASInChI Key
Cefatrizine propylene glycolate3731IA5GI964217-62-5CKOIKOHDEYTLFR-PFBPGKLMSA-N
Categories
UNII
8P4W949T8K
CAS number
51627-14-6
Weight
Average: 462.5
Monoisotopic: 462.078010052
Chemical Formula
C18H18N6O5S2
InChI Key
UOCJDOLVGGIYIQ-PBFPGSCMSA-N
InChI
InChI=1S/C18H18N6O5S2/c19-12(8-1-3-10(25)4-2-8)15(26)21-13-16(27)24-14(18(28)29)9(7-31-17(13)24)6-30-11-5-20-23-22-11/h1-5,12-13,17,25H,6-7,19H2,(H,21,26)(H,28,29)(H,20,22,23)/t12-,13-,17-/m1/s1
IUPAC Name
(6R,7R)-7-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-3-[(1H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SMILES
[H][C@@]1(NC(=O)[C@H](N)C2=CC=C(O)C=C2)C(=O)N2C(C(O)=O)=C(CSC3=CNN=N3)CS[C@]12[H]

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe risk or severity of bleeding can be increased when Cefatrizine is combined with (R)-warfarin.
(S)-WarfarinThe risk or severity of bleeding can be increased when Cefatrizine is combined with (S)-Warfarin.
4-hydroxycoumarinThe risk or severity of bleeding can be increased when Cefatrizine is combined with 4-hydroxycoumarin.
AbacavirCefatrizine may decrease the excretion rate of Abacavir which could result in a higher serum level.
AcarboseCefatrizine may decrease the excretion rate of Acarbose which could result in a higher serum level.
AceclofenacCefatrizine may decrease the excretion rate of Aceclofenac which could result in a higher serum level.
AcemetacinThe risk or severity of nephrotoxicity can be increased when Cefatrizine is combined with Acemetacin.
AcenocoumarolThe risk or severity of bleeding can be increased when Cefatrizine is combined with Acenocoumarol.
AcetaminophenCefatrizine may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Acetylsalicylic acidThe risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefatrizine.
Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Drug
D02406
ChemSpider
4918615
ChEBI
131730
ChEMBL
CHEMBL1095284
Wikipedia
Cefatrizine
ATC Codes
J01DB07 — Cefatrizine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.149 mg/mLALOGPS
logP-0.28ALOGPS
logP-2.2ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)2.92ChemAxon
pKa (Strongest Basic)7.22ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area174.53 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity115.69 m3·mol-1ChemAxon
Polarizability42.34 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as cephalosporins. These are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid moiety or a derivative thereof.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Lactams
Sub Class
Beta lactams
Direct Parent
Cephalosporins
Alternative Parents
N-acyl-alpha amino acids and derivatives / Alpha amino acid amides / Phenylacetamides / 1-hydroxy-2-unsubstituted benzenoids / Alkylarylthioethers / Aralkylamines / 1,3-thiazines / Triazoles / Tertiary carboxylic acid amides / Heteroaromatic compounds
show 14 more
Substituents
Cephalosporin / N-acyl-alpha amino acid or derivatives / Alpha-amino acid amide / Phenylacetamide / Alpha-amino acid or derivatives / Aryl thioether / Phenol / Alkylarylthioether / Aralkylamine / 1-hydroxy-2-unsubstituted benzenoid
show 33 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on June 23, 2017 14:38 / Updated on November 02, 2018 09:14