Tetracyclines

Name
Tetracyclines
Accession Number
DBCAT002418  (DBCAT000616, DBCAT003308, DBCAT003374, DBCAT003384)
Description

Closely congeneric derivatives of the polycyclic naphthacenecarboxamide. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1117)

ATC Classification
Drugs
DrugDrug Description
LymecyclineFor the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia....
MetacyclineFor the treatment of acute bacterial exacerbations of chronic bronchitis
RolitetracyclineA broad-spectrum tetracycline antibiotic used in cases needing high concentrations or when oral administration is impractical.
ClomocyclineFor the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
TigecyclineA glycylcycline antibiotic used to treat a number of susceptible bacterial infections.
DoxycyclineA tetracycline antibiotic used to treat a wide variety of bacterial infections.
MinocyclineA tetracycline analog used to treat a wide variety of infections in the body.
DemeclocyclineA tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
ChlortetracyclineThe first tetracycline antibiotic most commonly used for veterinary purposes.
PenimepicyclinePenimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients . In the classification...
OxytetracyclineA tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
TetracyclineAn antibiotic used to treat a wide variety of susceptible infections.
SarecyclineA tetracycline antibiotic used to treat inflammatory lesions of non-nodular moderate to severe acne vulgaris.
OmadacyclineA tetracycline antibiotic used to treat community acquired bacterial pneumonia.
MeclocyclineCurrently under investigation for the topical treatment of ulcerative oral mucositis
EravacyclineA tetracycline antibiotic used to treat complicated intra-abdominal infections.
Drugs & Drug Targets
DrugTargetType
Lymecycline30S ribosomal protein S4target
Lymecycline30S ribosomal protein S9target
MetacyclineSerum albumincarrier
Metacycline16S ribosomal RNAtarget
Rolitetracycline30S ribosomal protein S9target
Rolitetracycline16S ribosomal RNAtarget
Clomocycline30S ribosomal protein S4target
Clomocycline30S ribosomal protein S9target
Clomocycline16S ribosomal RNAtarget
Tigecycline30S ribosomal protein S9target
Tigecycline16S ribosomal RNAtarget
Tigecycline30S ribosomal protein S14target
Tigecycline30S ribosomal protein S13target
Tigecycline30S ribosomal protein S19target
Tigecycline30S ribosomal protein S12target
Doxycycline16S ribosomal RNAtarget
DoxycyclineSolute carrier family 22 member 6transporter
DoxycyclineCytochrome P450 3A4enzyme
DoxycyclineATP-binding cassette sub-family B member 5transporter
Minocycline30S ribosomal protein S4target
Minocycline30S ribosomal protein S9target
Minocycline16S ribosomal RNAtarget
MinocyclineInterleukin-1 betatarget
MinocyclineArachidonate 5-lipoxygenasetarget
MinocyclineMatrix metalloproteinase-9target
MinocyclineVascular endothelial growth factor Atarget
MinocyclineCaspase-1target
MinocyclineCaspase-3target
MinocyclineCytochrome ctarget
MinocyclineSolute carrier family 22 member 6transporter
MinocyclineSolute carrier family 22 member 7transporter
MinocyclineOuter membrane protein Ftransporter
MinocyclineOuter membrane porin Ctransporter
MinocyclineMitogen-activated Protein Kinasestarget
MinocyclineNitric oxide synthase, inducibletarget
Demeclocycline30S ribosomal protein S4target
Demeclocycline30S ribosomal protein S9target
Chlortetracycline16S ribosomal RNAtarget
ChlortetracyclineSerum albumincarrier
Chlortetracycline30S ribosomal protein S3target
Chlortetracycline30S ribosomal protein S8target
Chlortetracycline30S ribosomal protein S19target
Chlortetracycline30S ribosomal protein S14target
Chlortetracycline30S ribosomal protein S7target
Oxytetracycline30S ribosomal protein S4target
Oxytetracycline30S ribosomal protein S9target
Oxytetracycline16S ribosomal RNAtarget
OxytetracyclineSolute carrier family 22 member 6transporter
OxytetracyclineSolute carrier family 22 member 8transporter
OxytetracyclineSolute carrier family 22 member 11transporter
OxytetracyclineSolute carrier family 22 member 7transporter
OxytetracyclineSerum albumincarrier
Tetracycline16S ribosomal RNAtarget
TetracyclineMajor prion proteintarget
TetracyclineSerum albumincarrier
TetracyclineCytochrome P450 3A4enzyme
TetracyclineSolute carrier family 22 member 6transporter
TetracyclineSolute carrier family 22 member 8transporter
TetracyclineSolute carrier family 22 member 11transporter
TetracyclineSolute carrier family 22 member 7transporter
Tetracycline30S ribosomal protein S3target
Tetracycline30S ribosomal protein S8target
Tetracycline30S ribosomal protein S19target
Tetracycline30S ribosomal protein S14target
Tetracycline30S ribosomal protein S7target
TetracyclineMultidrug translocase MdfAtarget
TetracyclineProtein-arginine deiminase type-4target
TetracyclineSolute carrier organic anion transporter family member 2B1transporter
SarecyclineP-glycoprotein 1transporter
OmadacyclineP-glycoprotein 1transporter
Omadacycline30S ribosomal protein S3target
Omadacycline30S ribosomal protein S7target
Omadacycline30S ribosomal protein S8target
Omadacycline30S ribosomal protein S19target
Omadacycline30S ribosomal protein S14target
Omadacycline16S ribosomal RNAtarget
OmadacyclineSerum albumincarrier
MeclocyclineOuter membrane protein Ftransporter
MeclocyclineOuter membrane porin Ctransporter
Meclocycline30S ribosomal protein S7target
MeclocyclineTetX family tetracycline inactivation enzymeenzyme
EravacyclineCytochrome P450 3A4enzyme
EravacyclineAmine oxidase [flavin-containing] Aenzyme
Eravacycline30S ribosomal protein S4target