Identification
NameDoxycycline
Accession NumberDB00254  (APRD00597)
TypeSmall Molecule
GroupsApproved, Investigational, Vet Approved
Description

A synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum).

Structure
Thumb
Synonyms
5-hydroxy-α-6-deoxytetracycline
6-alpha-deoxy-5-oxytetracycline
6alpha-deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
Anhydrous doxycycline
Doxiciclina
Doxycyclin
Doxycycline (anhydrous)
Doxycyclinum
External IDs Not Available
Product Ingredients
IngredientUNIICASInChI KeyDetails
Doxycycline calcium8ZL07I20SB 94088-85-4IYECPECUTCOMMD-QFWOMMJSSA-NDetails
Doxycycline hyclate19XTS3T51U 24390-14-5HALQELOKLVRWRI-VDBOFHIQSA-NDetails
Doxycycline hydrochloride4182Z6T2ET 10592-13-9RUYHIJHUVHIMIR-CVHRZJFOSA-NDetails
Doxycycline monohydrateN12000U13O 17086-28-1XQTWDDCIUJNLTR-CVHRZJFOSA-NDetails
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ActiclateTablet, coated75 mg/1OralAqua Pharmaceuticals2014-07-28Not applicableUs
ActiclateTablet, coated150 mg/1OralAqua Pharmaceuticals2014-07-28Not applicableUs
Alti-doxycycline - Tab 100mgTablet100 mgOralAltimed Pharma Inc.1995-12-312001-09-05Canada
Alti-doxycycline-cap 100mgCapsule100 mgOralAltimed Pharma Inc.1995-12-312001-09-05Canada
Apprilon40 mgOralGalderma2012-11-29Not applicableCanada
AtridoxKitOralTolmar Inc1998-09-03Not applicableUs
AtridoxKit44 mgOralTolmar Inc2001-01-31Not applicableCanada
AtridoxKitOralDen Mat Holdings, Llc2016-12-01Not applicableUs
Dom-doxycyclineTablet100 mgOralDominion Pharmacal2008-04-162016-10-25Canada
Dom-doxycyclineCapsule100 mgOralDominion Pharmacal2008-04-162016-10-25Canada
DoryxTablet, delayed release200 mg/1OralWarner Chilcott2013-07-012016-04-30Us00430 0114 20 nlmimage10 1a3a0d30
DoryxTablet, delayed release50 mg/1OralMayne Pharma2015-05-26Not applicableUs
DoryxTablet, delayed release150 mg/1OralWarner Chilcott2011-09-21Not applicableUs00430 0115 20 nlmimage10 e63af317
DoryxTablet, delayed release200 mg/1OralMayne Pharma2015-04-13Not applicableUs
Doryx 100mg CapCapsule, extended release100 mgOralParke Davis Division, Warner Lambert Canada Inc.1991-12-311998-09-14Canada
Doryx MpcTablet, delayed release60 mg/1OralMayne Pharma2016-07-01Not applicableUs
Doryx MpcTablet, delayed release120 mg/1OralMayne Pharma2016-07-01Not applicableUs
Doxycin Cap 100mgCapsule100 mgOralLaboratoire Riva Inc1989-12-31Not applicableCanada
Doxycin Tab 100mgTablet100 mgOralLaboratoire Riva Inc1989-12-31Not applicableCanada
DoxycyclineCapsule100 mg/1OralGreenstone, Llc2015-05-01Not applicableUs
DoxycyclineCapsule40 mg/1OralPrasco, Laboratories2015-04-01Not applicableUs
DoxycyclineCapsule40 mg/1OralOwen Laboratories2010-05-14Not applicableUs
Doxycycline CapsulesCapsule100 mgOralSanis Health Inc2010-06-15Not applicableCanada
Doxycycline HyclateTablet, film coated150 mg/1OralActavis Pharma Company2017-06-19Not applicableUs
Doxycycline HyclateTablet, delayed release150 mg/1OralMayne Pharma2013-07-08Not applicableUs
Doxycycline HyclateTablet, film coated75 mg/1OralActavis Pharma Company2017-06-19Not applicableUs
Doxycycline HyclateTablet, delayed release75 mg/1OralMayne Pharma2013-07-08Not applicableUs
Doxycycline HyclateTablet, delayed release50 mg/1OralMayne Pharma2016-05-26Not applicableUs
Doxycycline HyclateTablet, delayed release100 mg/1OralMayne Pharma2013-07-08Not applicableUs
Doxycycline HyclateTablet, delayed release200 mg/1OralMayne Pharma2016-02-01Not applicableUs
Doxycycline MonohydrateCapsule100 mg/1OralPhysicians Total Care, Inc.2010-10-22Not applicableUs00591 0411 50 nlmimage10 db056deb
Doxycycline MonohydrateCapsule100 mg/1OralActavis Pharma Company2005-02-07Not applicableUs
Doxycycline MonohydrateCapsule100 mg/1Oralbryant ranch prepack2005-02-07Not applicableUs
Doxycycline MonohydrateCapsule75 mg/1OralActavis Pharma Company2011-02-07Not applicableUs
Doxycycline MonohydrateCapsule50 mg/1OralActavis Pharma Company2005-02-07Not applicableUs00591 0410 01 nlmimage10 383e9c64
Doxycycline MonohydrateCapsule100 mg/1OralPd Rx Pharmaceuticals, Inc.2005-02-07Not applicableUs
Doxycycline TabletsTablet100 mgOralSanis Health Inc2010-06-15Not applicableCanada
Doxycycline-100 Cap 100mg USPCapsule100 mgOralPro Doc Limitee1987-12-312010-07-13Canada
Doxytab 100mgTablet100 mgOralPro Doc Limitee1990-12-31Not applicableCanada
MonodoxCapsule75 mg/1OralAqua Pharmaceuticals2007-01-31Not applicableUs16110 0075 01 nlmimage10 d21fe93f
MonodoxCapsule100 mg/1OralAqua Pharmaceuticals1989-12-29Not applicableUs16110 0259 04 nlmimage10 4515a2cd
MonodoxCapsule50 mg/1OralAqua Pharmaceuticals1992-02-10Not applicableUs
Ntp-doxycycline CapsulesCapsule100 mgOralTevaNot applicableNot applicableCanada
Ntp-doxycycline TabletsTablet100 mgOralTevaNot applicableNot applicableCanada
Nu-doxycycline Cap 100mgCapsule100 mgOralNu Pharm Inc1993-12-312012-09-04Canada
Nu-doxycycline Tab 100mgTablet100 mgOralNu Pharm Inc1993-12-312012-09-04Canada
OraceaCapsule40 mg/1OralGalderma2010-05-14Not applicableUs
Penta-doxycycline TabletsTablet100 mgOralPentapharm Ltd.Not applicableNot applicableCanada
PeriostatCapsule20 mgOralPendopharm Division Of De Pharmascience Inc2003-09-03Not applicableCanada
PHL-doxycyclineTablet100 mgOralPharmel Inc2007-07-272016-10-25Canada
PHL-doxycyclineCapsule100 mgOralPharmel Inc2007-07-272016-10-25Canada
PMS-doxycyclineTablet100 mgOralPharmascience Inc2007-04-12Not applicableCanada
PMS-doxycyclineCapsule100 mgOralPharmascience Inc2007-04-12Not applicableCanada
Ratio-doxycyclineCapsule100 mgOralRatiopharm Inc Division Of Teva Canada Limited1994-12-312008-08-01Canada
Ratio-doxycyclineTablet100 mgOralRatiopharm Inc Division Of Teva Canada Limited1994-12-312008-08-01Canada
Rho-doxycin - Cap 100mgCapsule100 mgOralRhodiapharm Inc1995-12-311996-09-09Canada
Rho-doxycin Tabs - 100mgTablet100 mgOralRhodiapharm Inc1995-12-311996-09-09Canada
Rho-doxycycline - Cap 100mgCapsule100 mgOralRhodiapharm Inc1996-02-021998-08-05Canada
Rho-doxycycline - Tab 100mgTablet100 mgOralRhodiapharm Inc1996-12-311998-08-05Canada
Teva-doxycyclineTablet100 mgOralTeva1995-12-31Not applicableCanada
Teva-doxycyclineCapsule100 mgOralTeva1989-12-31Not applicableCanada
Vibra-tabsTablet100 mgOralPfizer1986-12-312014-04-04Canada
Vibramycin CalciumSyrup50 mg/5mLOralPfizer Laboratories Div Pfizer Inc.1974-09-23Not applicableUs
Vibramycin Cap 100mgCapsule100 mgOralPfizer1969-12-312016-04-04Canada
Vibramycin HyclateCapsule100 mg/1OralPfizer Laboratories Div Pfizer Inc.1967-12-05Not applicableUs
Vibramycin InjPowder100 mgIntravenousPfizer1997-07-252000-07-26Canada
Vibramycin MonohydratePowder, for suspension25 mg/5mLOralPfizer Laboratories Div Pfizer Inc.1967-12-06Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AdoxaCapsule150 mg/1OralPharma Derm, A Division Of Fougera Pharmaceuticals Inc.2011-06-01Not applicableUs10337 0815 06 nlmimage10 7203b95d
AlodoxTablet20 mg/1OralO Cu Soft, Inc.2008-10-01Not applicableUs
Apo-doxy Cap 100mgCapsule100 mgOralApotex Corporation1987-12-31Not applicableCanada
Apo-doxy Tabs 100mgTablet100 mgOralApotex Corporation1990-12-31Not applicableCanada
Doxy 100Injection, powder, lyophilized, for solution100 mg/10mLIntravenousGeneral Injectables & Vaccines2012-02-22Not applicableUs
Doxy 100Injection, powder, lyophilized, for solution100 mg/10mLIntravenousFresenius Kabi2000-10-17Not applicableUs
Doxycyclate HyclateCapsule100 mg/1OralWest Ward Pharmaceutical1990-09-01Not applicableUs00143 9803 50 nlmimage10 1d458ebc
Doxycyclate HyclateCapsule100 mg/1OralGolden State Medical Supply2002-12-092016-02-22Us00143 3142 05 nlmimage10 e005702b
Doxycyclate HyclateCapsule100 mg/1OralLiberty Pharmaceuticals, Inc.1990-09-01Not applicableUs
Doxycyclate HyclateCapsule50 mg/1OralGolden State Medical Supply2002-12-092016-02-22Us
DoxycyclineTablet, coated100 mg/1OralAmerincan Health Packaging2013-03-01Not applicableUs
DoxycyclineCapsule100 mg/1OralRemedy Repack2013-11-152017-03-02Us
DoxycyclineInjection, powder, lyophilized, for solution100 mg/10mLIntravenousMylan Institutional2012-08-21Not applicableUs
DoxycyclineTablet150 mg/1OralHeritage2012-01-05Not applicableUs
DoxycyclineInjection, powder, lyophilized, for solution100 mg/10mLIntravenousPfizer Laboratories Div Pfizer Inc.2012-08-21Not applicableUs
DoxycyclineCapsule75 mg/1OralAlembic Pharmaceuticals Limited2017-07-31Not applicableUs
DoxycyclineTablet, coated100 mg/1OralMesource Pharmaceuticals2003-07-02Not applicableUs
DoxycyclineTablet, coated100 mg/1OralMajor2003-07-02Not applicableUs
DoxycyclineCapsule100 mg/1OralDirectrx2016-03-17Not applicableUs
DoxycyclineTablet, film coated75 mg/1OralMylan Pharmaceuticals2006-11-17Not applicableUs
DoxycyclineCapsule75 mg/1OralLupin Pharmaceuticals2014-04-14Not applicableUs
DoxycyclineCapsule50 mg/1OralRanbaxy Inc.2000-12-26Not applicableUs
DoxycyclineFor suspension25 mg/5mLOralLupin Pharmaceuticals2013-06-04Not applicableUs
DoxycyclineCapsule100 mg/1Oralbryant ranch prepack2000-12-01Not applicableUs
DoxycyclineTablet, coated100 mg/1OralBlenheim Pharmacal, Inc.2012-05-09Not applicableUs
DoxycyclineTablet, coated100 mg/1OralBlu Pharmceuticals Llc2010-05-012016-10-13Us
DoxycyclineTablet, film coated50 mg/1OralRanbaxy Inc.2006-10-05Not applicableUs
DoxycyclineTablet, coated100 mg/1OralCardinal Health2004-08-03Not applicableUs
DoxycyclineCapsule75 mg/1OralNovel Laboratories, Inc.2015-05-28Not applicableUs
DoxycyclinePowder, for suspension25 mg/5mLOralCipla Limited2008-07-16Not applicableUs
DoxycyclineCapsule100 mg/1OralPar Pharmaceutical2000-12-01Not applicableUs
DoxycyclineTablet100 mg/1OralPar Pharmaceutical2000-12-152020-08-31Us49884 0093 03 nlmimage10 ee05777b
DoxycyclineTablet, film coated50 mg/1OralLannett Company, Inc.2005-12-08Not applicableUs00527 1335 01 nlmimage10 d0346803
DoxycyclineTablet, film coated150 mg/1OralRanbaxy Inc.2006-10-05Not applicableUs
DoxycyclineTablet, coated100 mg/1OralA S Medication Solutions2003-07-02Not applicableUs
DoxycyclineTablet, coated100 mg/1OralGolden State Medical Supply2003-07-022016-02-22Us
DoxycyclineTablet, coated100 mg/1OralKeltman Pharmaceuticals Inc.2011-01-10Not applicableUs
DoxycyclineCapsule75 mg/1OralZydus Pharmaceuticals Usa, Inc.2016-03-14Not applicableUs
DoxycyclineTablet, coated100 mg/1OralSt. Marys Medical Park Pharmacy2003-07-02Not applicableUs
DoxycyclineTablet100 mg/1OralA S Medication Solutions2012-05-012017-06-20Us
DoxycyclineCapsule100 mg/1OralCadila Pharnmaceuticals2016-03-14Not applicableUs
DoxycyclineCapsule150 mg/1OralImpax Generics2011-02-17Not applicableUs
DoxycyclineCapsule100 mg/1OralAlembic Pharmaceuticals Limited2017-07-31Not applicableUs
DoxycyclineCapsule100 mg/1OralRemedy Repack2013-04-292017-02-03Us49884 0727 03 nlmimage10 a339d1fe
DoxycyclinePowder, for suspension25 mg/5mLOralChartwell Governmental and Specialty RX LLC2008-07-16Not applicableUs
DoxycyclineTablet, coated100 mg/1OralLake Erie Medical &Surgical Supply Dba Quality Care Products Llc2011-12-07Not applicableUs
DoxycyclineCapsule100 mg/1OralRemedy Repack2017-01-31Not applicableUs
DoxycyclineCapsule50 mg/1OralPd Rx Pharmaceuticals, Inc.2016-04-29Not applicableUs
DoxycyclineCapsule100 mg/1OralProficient Rx LP2016-03-14Not applicableUs
DoxycyclineCapsule75 mg/1OralGw Pharmaceuticals Ltd.2016-04-29Not applicableUs
DoxycyclineCapsule100 mg/1OralRemedy Repack2016-07-18Not applicableUs
DoxycyclineCapsule150 mg/1OralMylan Pharmaceuticals2012-06-12Not applicableUs
DoxycyclineTablet, coated100 mg/1OralRebel Distributors2003-07-02Not applicableUs
DoxycyclineTablet, coated100 mg/1OralDirectrx2015-12-17Not applicableUs
DoxycyclineCapsule100 mg/1OralGavis Pharmaceuticals, LLC.2015-07-08Not applicableUs
DoxycyclineTablet75 mg/1OralHeritage2012-01-05Not applicableUs
DoxycyclineTablet, film coated150 mg/1OralLannett Company, Inc.2008-08-25Not applicableUs00527 1537 30 nlmimage10 2215915c
DoxycyclineCapsule150 mg/1OralPar Pharmaceutical2011-06-01Not applicableUs
DoxycyclineTablet50 mg/1OralPar Pharmaceutical2000-12-152020-03-31Us
DoxycyclineTablet, film coated100 mg/1OralElorac, Inc.2005-12-08Not applicableUs
DoxycyclineTablet, film coated75 mg/1OralRanbaxy Inc.2006-10-05Not applicableUs
DoxycyclineCapsule100 mg/1OralCardinal Health2000-12-01Not applicableUs
DoxycyclineCapsule50 mg/1OralCadila Pharnmaceuticals2016-03-14Not applicableUs
DoxycyclineCapsule100 mg/1OralAlembic Pharmaceuticals Limited2017-07-31Not applicableUs
DoxycyclineTablet100 mg/1OralRemedy Repack2016-12-05Not applicableUs
DoxycyclineCapsule100 mg/1OralAmerincan Health Packaging2014-05-12Not applicableUs
DoxycyclineTablet, coated100 mg/1OralLiberty Pharmaceuticals, Inc.2003-07-02Not applicableUs
DoxycyclineCapsule100 mg/1OralAidarex Pharmaceuticals LLC2014-04-14Not applicableUs
DoxycyclineTablet, film coated100 mg/1OralMylan Pharmaceuticals2006-11-17Not applicableUs
DoxycyclineCapsule100 mg/1OralLupin Pharmaceuticals2014-04-14Not applicableUs
DoxycyclineCapsule50 mg/1OralPd Rx Pharmaceuticals, Inc.2015-07-08Not applicableUs
DoxycyclineCapsule75 mg/1OralRanbaxy Inc.2000-12-26Not applicableUs
DoxycyclineCapsule100 mg/1OralRemedy Repack2017-02-10Not applicableUs
DoxycyclineTablet, coated100 mg/1OralLegacy Pharmaceutical Packaging2010-05-01Not applicableUs
DoxycyclineCapsule100 mg/1Oralbryant ranch prepack2014-04-14Not applicableUs
DoxycyclineTablet50 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2012-01-05Not applicableUs
DoxycyclineCapsule100 mg/1OralNovel Laboratories, Inc.2015-05-28Not applicableUs
DoxycyclineCapsule50 mg/1OralGavis Pharmaceuticals, LLC.2015-07-08Not applicableUs
DoxycyclineCapsule100 mg/1Oralbryant ranch prepack2014-04-14Not applicableUs
DoxycyclineCapsule100 mg/1OralRemedy Repack2016-04-082016-10-13Us
DoxycyclineTablet150 mg/1OralPar Pharmaceutical2000-12-152020-06-30Us49884 0236 11 nlmimage10 ff057feb
DoxycyclineTablet, film coated100 mg/1OralLannett Company, Inc.2005-12-08Not applicableUs
DoxycyclineCapsule100 mg/1OralZydus Pharmaceuticals Usa, Inc.2016-03-14Not applicableUs
DoxycyclineCapsule100 mg/1OralA S Medication Solutions2000-12-012017-06-20Us
DoxycyclineCapsule100 mg/1OralA S Medication Solutions2016-04-292017-06-20Us
DoxycyclineTablet, film coated100 mg/1OralKaiser Foundations Hospitals2013-03-14Not applicableUs
DoxycyclineCapsule100 mg/1OralGw Pharmaceuticals Ltd.2016-04-29Not applicableUs
DoxycyclineCapsule100 mg/1OralRemedy Repack2016-08-222017-03-08Us
DoxycyclineTablet, coated100 mg/1OralCardinal Health2013-03-22Not applicableUs
DoxycyclineTablet, film coated50 mg/1OralMylan Pharmaceuticals2006-11-17Not applicableUs
DoxycyclineCapsule50 mg/1OralLupin Pharmaceuticals2014-04-14Not applicableUs
DoxycyclineInjection, powder, lyophilized, for solution100 mg/100mgIntravenousGeneral Injectables & Vaccines2010-08-012017-01-28Us
DoxycyclineCapsule100 mg/1OralProficient Rx LP2000-12-01Not applicableUs
DoxycyclineTablet100 mg/1OralHeritage2012-01-05Not applicableUs
DoxycyclineCapsule100 mg/1OralRed Pharm Drug, Inc.2014-04-14Not applicableUs
DoxycyclineCapsule100 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2000-12-01Not applicableUs
DoxycyclineCapsule100 mg/1OralPd Rx Pharmaceuticals, Inc.2015-07-08Not applicableUs
DoxycyclineCapsule100 mg/1OralRanbaxy Inc.2000-12-26Not applicableUs
DoxycyclinePowder, for suspension25 mg/5mLOralHarris Pharmaceutical, Inc.2008-07-16Not applicableUs
DoxycyclineCapsule100 mg/1OralRemedy Repack2017-02-14Not applicableUs
DoxycyclineCapsule50 mg/1OralPar Pharmaceutical2000-12-01Not applicableUs49884 0726 01 nlmimage10 38349c24
DoxycyclineTablet, coated100 mg/1OralCardinal Health2003-07-02Not applicableUs
DoxycyclineTablet, coated100 mg/1OralAidarex Pharmaceuticals LLC2003-07-02Not applicableUs
DoxycyclineTablet75 mg/1OralPar Pharmaceutical2000-12-152020-03-31Us
DoxycyclineTablet, film coated100 mg/1OralRanbaxy Inc.2006-10-05Not applicableUs
DoxycyclineTablet, coated100 mg/1OralPd Rx Pharmaceuticals, Inc.2003-07-02Not applicableUs
DoxycyclineCapsule75 mg/1OralCadila Pharnmaceuticals2016-03-14Not applicableUs
DoxycyclineCapsule75 mg/1OralAlembic Pharmaceuticals Limited2017-07-31Not applicableUs
DoxycyclineTablet, coated100 mg/1OralWest Ward Pharmaceutical2003-07-02Not applicableUs
DoxycyclineCapsule100 mg/1OralRed Pharm Drug, Inc.2016-03-14Not applicableUs
DoxycyclineCapsule100 mg/1OralPd Rx Pharmaceuticals, Inc.2016-04-29Not applicableUs
DoxycyclineTablet, film coated150 mg/1OralMylan Pharmaceuticals2007-06-08Not applicableUs
DoxycyclineCapsule50 mg/1OralNovel Laboratories, Inc.2015-05-28Not applicableUs
DoxycyclineTablet100 mg/1OralKaiser Foundations Hospitals2014-04-28Not applicableUs
DoxycyclineTablet, coated100 mg/1OralA S Medication Solutions2003-07-022017-06-20Us
DoxycyclineTablet, coated100 mg/1OralRemedy Repack2013-05-102017-01-18Us
DoxycyclineTablet100 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2012-01-05Not applicableUs
DoxycyclineTablet, film coated50 mg/1OralDirectrx2015-01-01Not applicableUs
DoxycyclineCapsule75 mg/1OralGavis Pharmaceuticals, LLC.2015-07-08Not applicableUs
DoxycyclineTablet50 mg/1OralHeritage2012-01-05Not applicableUs
DoxycyclineCapsule100 mg/1OralProficient Rx LP2014-04-14Not applicableUs
DoxycyclineTablet, film coated75 mg/1OralLannett Company, Inc.2008-08-25Not applicableUs00527 1535 01 nlmimage10 20471008
DoxycyclineTablet100 mg/1OralDirectrx2015-01-01Not applicableUs23155 0135 25 nlmimage10 2e3a1750
DoxycyclineCapsule50 mg/1OralZydus Pharmaceuticals Usa, Inc.2016-03-14Not applicableUs
DoxycyclineCapsule50 mg/1OralGw Pharmaceuticals Ltd.2016-04-29Not applicableUs
DoxycyclineTablet, film coated100 mg/1OralA S Medication Solutions2005-12-082017-06-20Us
Doxycycline HyclateCapsule100 mg/1OralA S Medication Solutions1986-07-10Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralHarris Pharmaceutical, Inc.1984-09-11Not applicableUs
Doxycycline HyclateTablet, film coated20 mg/1OralBurke Therapeutics, LLC2014-09-292016-10-13Us
Doxycycline HyclateTablet, film coated100 mg/1OralNucare Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralDepartment Of State Health Services, Pharmacy Branch1986-07-10Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralNucare Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralPreferreed Pharmaceuticals Inc.2015-04-21Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralA S Medication Solutions1986-07-102017-06-20Us
Doxycycline HyclateTablet, delayed release200 mg/1OralSolco healthcare U.S., LLC2016-11-28Not applicableUs
Doxycycline HyclateCapsule, gelatin coated50 mg/1OralA S Medication Solutions1984-11-07Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralChartwell Rx, Llc1984-09-11Not applicableUs
Doxycycline HyclateTablet100 mg/1OralActavis Pharma Company1983-02-02Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralAv Pak2014-06-05Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralLiberty Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralPreferreed Pharmaceuticals Inc.2011-06-09Not applicableUs
Doxycycline HyclateTablet, coated100 mg/1OralHHS/Program Support Center/Supply Service Center2003-07-02Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralPhysicians Total Care, Inc.1994-08-01Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralDirectrx2014-01-01Not applicableUs
Doxycycline HyclateTablet, film coated20 mg/1OralAidarex Pharmaceuticals LLC2005-11-10Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralPd Rx Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralA S Medication Solutions1984-05-072017-06-20Us
Doxycycline HyclateCapsule50 mg/1OralA S Medication Solutions2016-06-272017-06-20Us
Doxycycline HyclateTablet, film coated100 mg/1OralLegacy Pharmaceutical Packaging2011-02-09Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralH.J. Harkins Company1984-11-07Not applicableUs
Doxycycline HyclateTablet, film coated150 mg/1OralMayne Pharma2017-06-14Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralCardinal Health1982-01-01Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralCitron Pharma LLC1984-09-11Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralCarilion Materials Management1984-05-07Not applicableUs
Doxycycline HyclateTablet, delayed release150 mg/1OralMylan Pharmaceuticals2012-04-30Not applicableUs00378 3030 01 nlmimage10 093984bc
Doxycycline HyclateCapsule100 mg/1OralAv Kare, Inc.2013-07-232017-02-10Us
Doxycycline HyclateCapsule100 mg/1OralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Doxycycline HyclateTablet100 mg/1OralC.O. Truxton, Inc.2013-11-25Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralSun Pharmaceutical Industries Limited1986-07-10Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralStat Rx USA1984-05-07Not applicableUs
Doxycycline HyclateTablet, delayed release150 mg/1OralSolco healthcare U.S., LLC2016-11-28Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralAmerincan Health Packaging2015-06-01Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralActavis Pharma Company1982-10-13Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralAphena Pharma Solutions Tennessee, Inc.1986-07-10Not applicableUs
Doxycycline HyclateTablet, film coated20 mg/1OralCore Pharma, Llc2005-12-122016-03-15Us64720 0152 10 nlmimage10 2615930c
Doxycycline HyclateCapsule100 mg/1OralAv Pak2014-06-05Not applicableUs53489 0119 02 nlmimage10 333499b4
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralNucare Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralChartwell Governmental and Specialty RX LLC1984-09-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Doxycycline HyclateCapsule, gelatin coated50 mg/1Oralbryant ranch prepack1984-11-07Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralLife Line Home Care Services2012-02-08Not applicableUs
Doxycycline HyclateTablet100 mg/1OralPhysicians Total Care, Inc.1994-03-24Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralHHS/Program Support Center/Supply Service Center2011-06-17Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralA S Medication Solutions1986-07-102017-06-20Us
Doxycycline HyclateCapsule100 mg/1OralAidarex Pharmaceuticals LLC1984-05-07Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralPd Rx Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralMesource Pharmaceuticals1986-07-10Not applicableUs
Doxycycline HyclateTablet, delayed release50 mg/1OralMylan Pharmaceuticals2016-05-23Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralMHC Pharma, LLC1984-09-11Not applicableUs
Doxycycline HyclateTablet, film coated75 mg/1OralMayne Pharma2017-06-14Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralAmneal Pharmaceuticals2016-06-28Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralAlvogen, Inc.2016-06-27Not applicableUs
Doxycycline HyclateTablet100 mg/1OralMylan Pharmaceuticals1983-02-15Not applicableUs
Doxycycline HyclateTablet100 mg/1OralA S Medication Solutions1984-09-112017-06-20Us
Doxycycline HyclateCapsule100 mg/1OralLake Erie Medical Dba Quality Care Produts Llc1984-09-11Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralHarris Pharmaceutical, Inc.1984-09-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralRemedy Repack2012-10-012017-01-11Us
Doxycycline HyclateTablet, film coated100 mg/1OralChartwell Rx, Llc1984-09-11Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralClinical Solutions Wholsesale1984-09-11Not applicableUs
Doxycycline HyclateTablet100 mg/1OralPreferreed Pharmaceuticals Inc.2013-12-17Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralUnit Dose Services1984-09-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralA S Medication Solutions1984-09-112017-06-20Us
Doxycycline HyclateCapsule50 mg/1OralA S Medication Solutions1986-07-102017-06-20Us
Doxycycline HyclateCapsule100 mg/1OralRemedy Repack2013-05-202017-01-10Us
Doxycycline HyclateCapsule100 mg/1OralA S Medication Solutions1977-02-142017-06-20Us
Doxycycline HyclateCapsule50 mg/1OralCitron Pharma LLC1984-09-11Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralAv Kare, Inc.2013-06-062017-02-10Us
Doxycycline HyclateCapsule50 mg/1OralDispensing Solutions, Inc.1986-07-10Not applicableUs53489 0118 02 nlmimage10 fa34fd77
Doxycycline HyclateCapsule100 mg/1OralCipla Limited1984-09-11Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralRemedy Repack2017-03-09Not applicableUs
Doxycycline HyclateCapsule, gelatin coated50 mg/1OralPd Rx Pharmaceuticals, Inc.1984-11-07Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1Oralbryant ranch prepack1984-05-07Not applicableUs
Doxycycline HyclateCapsule, gelatin coated50 mg/1OralWest Ward Pharmaceutical1984-11-07Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralPar Pharmaceutical1984-09-112020-06-30Us
Doxycycline HyclateCapsule100 mg/1OralBlenheim Pharmacal, Inc.2013-01-14Not applicableUs
Doxycycline HyclateTablet100 mg/1OralCardinal Health1983-02-02Not applicableUs
Doxycycline HyclateTablet100 mg/1OralPutney, Inc.2015-02-20Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralClinical Solutions Wholsesale1984-05-072017-06-29Us
Doxycycline HyclateTablet, delayed release75 mg/1OralMylan Pharmaceuticals2010-12-30Not applicableUs
Doxycycline HyclateTablet, delayed release75 mg/1OralActavis Pharma Company2013-10-28Not applicableUs
Doxycycline HyclateTablet20 mg/1OralLarken Laboratories, Inc.2010-11-15Not applicableUs
Doxycycline HyclateTablet, film coated20 mg/1OralLannett Company, Inc.2005-11-10Not applicableUs
Doxycycline HyclateTablet100 mg/1OralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation1983-02-02Not applicableUs
Doxycycline HyclateTablet, film coated20 mg/1OralE5 Pharma, Llc.2017-05-15Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralMHC Pharma, LLC1984-09-11Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralNorthwind Pharmaceuticals2017-03-14Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralPreferreed Pharmaceuticals Inc.2016-07-25Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralPreferreed Pharmaceuticals Inc.2015-08-19Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralMylan Pharmaceuticals1982-03-29Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralA S Medication Solutions1984-09-112017-06-20Us
Doxycycline HyclateTablet, delayed release75 mg/1OralGlobal Pharmaceuticals, Division of Impax Laboratories, Inc.2011-04-112016-11-29Us
Doxycycline HyclateTablet, film coated100 mg/1OralSafecor Health, LLC1986-07-10Not applicableUs53489 0120 02 nlmimage10 d4346a13
Doxycycline HyclateCapsule100 mg/1OralApotheca, Inc.1984-09-11Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralEpic Pharma, LLC2016-10-01Not applicableUs
Doxycycline HyclateTablet100 mg/1OralNorthwind Pharmaceuticals2014-09-15Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralSun Pharmaceutical Industries Limited1986-07-10Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralHHS/Program Support Center/Supply Service Center2011-06-17Not applicableUs
Doxycycline HyclateTablet, film coated20 mg/1OralPhysicians Total Care, Inc.2005-04-20Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralAidarex Pharmaceuticals LLC1982-10-13Not applicableUs00591 5535 50 nlmimage10 331599cc
Doxycycline HyclateTablet100 mg/1OralGolden State Medical Supply2014-02-12Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralA S Medication Solutions1986-07-102017-06-20Us
Doxycycline HyclateCapsule, gelatin coated100 mg/1Oralbryant ranch prepack1984-05-07Not applicableUs
Doxycycline HyclateTablet100 mg/1OralAphena Pharma Solutions (Formerly Test Pak)2011-07-14Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2012-04-16Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralRemedy Repack2013-02-092017-02-22Us
Doxycycline HyclateTablet100 mg/1OralA S Medication Solutions1983-02-022017-06-20Us
Doxycycline HyclateCapsule, gelatin coated50 mg/1OralMajor1984-11-01Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralStat Rx USA1984-11-07Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralVersa Pharm Incorporated1998-04-01Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralTYA Pharmaceuticals1977-02-14Not applicableUs00591 5440 50 nlmimage10 b834dc76
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralProficient Rx LP1984-05-07Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralChartwell Governmental and Specialty RX LLC1984-09-11Not applicableUs
Doxycycline HyclateTablet, delayed release200 mg/1OralSolbuiomix2017-06-202017-07-14Us
Doxycycline HyclateTablet, film coated100 mg/1OralA S Medication Solutions1986-07-10Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralGolden State Medical Supply2015-03-16Not applicableUs
Doxycycline HyclateTablet100 mg/1OralLiberty Pharmaceuticals, Inc.1983-02-02Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralNucare Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralNucare Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralWest Ward Pharmaceutical1984-05-07Not applicableUs
Doxycycline HyclateTablet100 mg/1OralPar Pharmaceutical1984-09-112020-08-31Us67253 0391 50 nlmimage10 81404092
Doxycycline HyclateCapsule100 mg/1OralA S Medication Solutions2016-06-27Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralChartwell Rx, Llc1984-09-11Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralPd Rx Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralA S Medication Solutions1984-05-072017-02-10Us
Doxycycline HyclateTablet, film coated50 mg/1OralA S Medication Solutions2016-06-272017-06-20Us
Doxycycline HyclateTablet100 mg/1OralA S Medication Solutions1983-02-022017-06-20Us00591 5553 50 nlmimage10 dd346e93
Doxycycline HyclateCapsule100 mg/1OralBlenheim Pharmacal, Inc.2011-11-15Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralRemedy Repack2012-01-122017-03-09Us
Doxycycline HyclateCapsule100 mg/1OralCitron Pharma LLC1984-09-11Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralAv Kare, Inc.2013-07-232017-02-10Us
Doxycycline HyclateCapsule100 mg/1OralContract Pharmacy Services Pa2010-03-10Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralCipla Limited1984-09-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralActavis Pharma Company1977-02-14Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralAv Pak2014-06-05Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralChartwell Governmental and Specialty RX LLC1984-09-11Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralAphena Pharma Solutions New Jersey, Llc1986-07-10Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1Oralbryant ranch prepack1986-07-10Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralPhysicians Total Care, Inc.1993-06-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralBlenheim Pharmacal, Inc.2009-12-22Not applicableUs
Doxycycline HyclateTablet, delayed release100 mg/1OralMylan Pharmaceuticals2010-12-30Not applicableUs00378 4532 01 nlmimage10 613f30b9
Doxycycline HyclateTablet, film coated100 mg/1OralApothecary Shop Wholesale Inc.2011-07-01Not applicableUs
Doxycycline HyclateTablet, delayed release100 mg/1OralActavis Pharma Company2013-10-28Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralAmerincan Health Packaging2015-03-312017-04-27Us
Doxycycline HyclateTablet, film coated100 mg/1OralA S Medication Solutions1986-07-10Not applicableUs
Doxycycline HyclateTablet, delayed release200 mg/1OralMylan Pharmaceuticals2016-05-19Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralProficient Rx LP1984-09-11Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralMHC Pharma, LLC1984-09-11Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralAlvogen, Inc.2016-06-27Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralNucare Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralPreferreed Pharmaceuticals Inc.2016-08-22Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralAlvogen, Inc.2016-06-27Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralMylan Pharmaceuticals1982-03-29Not applicableUs
Doxycycline HyclateTablet, film coated20 mg/1OralSun Pharmaceutical Industries Limited2005-05-13Not applicableUs53489 0647 01 nlmimage10 2815945c
Doxycycline HyclateTablet, delayed release100 mg/1OralGlobal Pharmaceuticals, Division of Impax Laboratories, Inc.2011-04-112016-11-29Us
Doxycycline HyclateTablet100 mg/1OralPura Cap Pharmaceutical Llc.2013-11-25Not applicableUs24658 0312 05 nlmimage10 2b491588
Doxycycline HyclateTablet, film coated100 mg/1OralHarris Pharmaceutical, Inc.1984-09-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralRemedy Repack2012-03-292017-03-09Us
Doxycycline HyclateCapsule100 mg/1OralNucare Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralRemedy Repack2013-02-272016-10-13Us
Doxycycline HyclateCapsule50 mg/1OralProficient Rx LP1984-09-11Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralC.O. Truxton, Inc.2013-01-14Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralSun Pharmaceutical Industries Limited1986-07-10Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralApace Packaging1984-05-07Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralRemedy Repack2016-11-15Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralCambridge Therapeutics Technologies, Llc1984-09-11Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralUnit Dose Services1984-05-07Not applicableUs
Doxycycline HyclateTablet20 mg/1OralSTI Pharma2010-11-15Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralLake Erie Medical Dba Quality Care Produts Llc2017-01-13Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralA S Medication Solutions1986-07-102017-06-20Us
Doxycycline HyclateCapsule100 mg/1OralMajor2008-08-05Not applicableUs
Doxycycline HyclateCapsule100 mg/1OralRebel Distributors1984-11-07Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralRebel Distributors1984-11-07Not applicableUs
Doxycycline HyclateTablet, film coated100 mg/1OralMed Vantx, Inc.1984-09-11Not applicableUs00172 3626 48 nlmimage10 4832a425
Doxycycline HyclateCapsule50 mg/1OralCipla Limited1984-09-11Not applicableUs
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralNucare Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline HyclateTablet100 mg/1OralAvera Mc Kennan Hospital2015-03-09Not applicableUs
Doxycycline HyclateTablet100 mg/1OralUnit Dose Services1983-02-02Not applicableUs
Doxycycline HyclateCapsule50 mg/1OralPar Pharmaceutical1984-09-112019-07-31Us
Doxycycline HyclateCapsule, gelatin coated100 mg/1OralPd Rx Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline Hyclate CapsulesCapsule50 mg/1OralHikma Pharmaceutical1990-09-01Not applicableUs
Doxycycline Hyclate CapsulesCapsule100 mg/1OralHikma Pharmaceutical1990-09-01Not applicableUs
Doxycycline Hyclate Delayed releaseTablet, delayed release100 mg/1OralHeritage2013-04-30Not applicableUs
Doxycycline Hyclate Delayed releaseTablet, delayed release150 mg/1OralHeritage2013-04-30Not applicableUs
Doxycycline Hyclate Delayed releaseTablet, delayed release75 mg/1OralHeritage2013-04-30Not applicableUs
Doxycycline MonohydrateTablet100 mg/1OralAmerincan Health Packaging2014-12-152018-08-31Us
MondoxyneCapsule50 mg/50mgOralOculus Innovative Scicences2015-05-28Not applicableUs
MondoxyneCapsule75 mg/75mgOralOculus Innovative Scicences2015-05-28Not applicableUs
Mondoxyne NL 100mgCapsule100 mg/100mgOralOculus Innovative Scicences2015-05-28Not applicableUs
MonodoxCapsule100 mg/1OralDierct Rx2016-05-27Not applicableUs
MorgidoxCapsule100 mg/1OralMedimetriks Pharmaceuticals2011-03-15Not applicableUs
MorgidoxCapsule50 mg/1OralMedimetriks Pharmaceuticals1984-11-07Not applicableUs
MorgidoxCapsule100 mg/1OralMedimetriks Pharmaceuticals2011-03-15Not applicableUs
MorgidoxKitMedimetriks Pharmaceuticals1984-11-07Not applicableUs
MorgidoxCapsule100 mg/1OralMedimetriks Pharmaceuticals2011-03-15Not applicableUs
MorgidoxCapsule100 mg/1OralMedimetriks Pharmaceuticals2011-03-15Not applicableUs
OcudoxCapsule50 mg/1OralO Cu Soft, Inc.2011-04-01Not applicableUs
OraceaCapsule, delayed release pellets40 mg/1OralPhysicians Total Care, Inc.2006-09-29Not applicableUs
TargadoxTablet50 mg/1OralJourney Medical Corporation2016-08-29Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
DoxyGalpharma
DoxycinLaboratoire Riva
DoxylinActavis
JenacyclinNot Available
MicrodoxMicro Labs
NicAzelDoxyKitNot Available
Nu-DoxycyclineNu-Pharm
SupracyclinGrünenthal
VibramycinPfizer
Brand mixturesNot Available
Categories
UNII334895S862
CAS number564-25-0
WeightAverage: 444.4346
Monoisotopic: 444.153265754
Chemical FormulaC22H24N2O8
InChI KeyJBIWCJUYHHGXTC-AKNGSSGZSA-N
InChI
InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1
IUPAC Name
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
SMILES
[H][[email protected]@]12[[email protected]@H](C)C3=C(C(O)=CC=C3)C(=O)C1=C(O)[[email protected]]1(O)C(=O)C(C(N)=O)=C(O)[[email protected]@H](N(C)C)[[email protected]]1([H])[[email protected]]2O
Pharmacology
Indication

Doxycycline is indicated for use in respiratory tract infections caused by Mycoplasma pneumoniae, Haemophilus influenzae, Streptococcus pneumoniae, Legionella spp., or Klebsiella spp. It is also used for prophylaxis of malaria. Doxycycline is indicated for a variety of bacterial infections, from Mycobacterium fortuitum and M. marinum, to susceptible E. coli and Brucella spp. It can be used as an alternative to treating plague, tetanus, Campylobacter fetus

Structured Indications
Pharmacodynamics

Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.

Mechanism of action

Doxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria. Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis. Doxycycline prevents the normal function of the apicoplast of Plasmodium falciparum, a malaria causing organism.

TargetKindPharmacological actionActionsOrganismUniProt ID
30S ribosomal protein S4Proteinyes
inhibitor
Escherichia coli (strain K12)P0A7V8 details
30S ribosomal protein S9Proteinyes
inhibitor
Escherichia coli (strain K12)P0A7X3 details
16S rRNANucleotideyes
inhibitor
Enteric bacteria and other eubacterianot applicabledetails
Protein-arginine deiminase type-4ProteinunknownNot AvailableHumanQ9UM07 details
Beta-2-microglobulinProteinunknownNot AvailableHumanP61769 details
Related Articles
Absorption

Completely absorbed following oral administration.

Volume of distributionNot Available
Protein binding

>90%

Metabolism

Hepatic

Route of elimination

They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form.

Half life

18-22 hours

ClearanceNot Available
Toxicity

Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg (I.P. in rat).

Affected organisms
  • Enteric bacteria and other eubacteria
  • Treponema pallidum
  • Leptospira interrogans
  • Clostridium perfringens
  • Borrelia burgdorferi
  • Brucella abortus
  • Brucella canis
  • Chlamydia pneumoniae
  • Chlamydia trachomatis
  • Helicobacter pylori
  • Mycoplasma pneumoniae
  • Neisseria gonorrhoeae
  • Rickettsia rickettsii
  • Vibrio cholerae
  • Yersinia pestis
  • Chlamydia psittaci
Pathways
PathwayCategorySMPDB ID
Doxycycline Action PathwayDrug actionSMP00291
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Doxycycline.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Doxycycline.Approved
AcepromazineThe serum concentration of Acepromazine can be increased when it is combined with Doxycycline.Approved, Vet Approved
AceprometazineThe serum concentration of Aceprometazine can be increased when it is combined with Doxycycline.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Doxycycline.Approved
AcitretinThe risk or severity of adverse effects can be increased when Doxycycline is combined with Acitretin.Approved
AdapaleneThe risk or severity of adverse effects can be increased when Doxycycline is combined with Adapalene.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Doxycycline.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Doxycycline.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Doxycycline.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Doxycycline.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Doxycycline.Approved, Investigational
AlimemazineThe serum concentration of Alimemazine can be increased when it is combined with Doxycycline.Approved, Vet Approved
AliskirenThe metabolism of Aliskiren can be decreased when combined with Doxycycline.Approved, Investigational
AlitretinoinThe risk or severity of adverse effects can be increased when Doxycycline is combined with Alitretinoin.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Doxycycline.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Doxycycline.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Doxycycline.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Doxycycline.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Doxycycline.Approved, Illicit, Investigational
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Doxycycline.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Doxycycline.Approved
AmdinocillinThe therapeutic efficacy of Amdinocillin can be decreased when used in combination with Doxycycline.Withdrawn
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Doxycycline.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Doxycycline.Approved
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Doxycycline.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Doxycycline.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Doxycycline.Approved
AmobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Amobarbital.Approved, Illicit
AmoxicillinThe therapeutic efficacy of Amoxicillin can be decreased when used in combination with Doxycycline.Approved, Vet Approved
AmpicillinThe therapeutic efficacy of Ampicillin can be decreased when used in combination with Doxycycline.Approved, Vet Approved
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Doxycycline.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Doxycycline.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Doxycycline.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Doxycycline.Approved, Investigational
AprepitantThe metabolism of Aprepitant can be decreased when combined with Doxycycline.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Doxycycline.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Doxycycline.Approved, Investigational
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Doxycycline.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Doxycycline.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Doxycycline.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Doxycycline.Approved, Investigational
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Doxycycline.Approved
Atracurium besylateDoxycycline may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Doxycycline.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Doxycycline.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Doxycycline.Approved
AzidocillinThe therapeutic efficacy of Azidocillin can be decreased when used in combination with Doxycycline.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Doxycycline.Approved
AzlocillinThe therapeutic efficacy of Azlocillin can be decreased when used in combination with Doxycycline.Approved
BacampicillinThe therapeutic efficacy of Bacampicillin can be decreased when used in combination with Doxycycline.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Doxycycline.Investigational
BarbexacloneThe serum concentration of Doxycycline can be decreased when it is combined with Barbexaclone.Experimental
BarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Barbital.Illicit
BCG vaccineThe therapeutic efficacy of Bcg can be decreased when used in combination with Doxycycline.Investigational
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Doxycycline.Approved
Benzathine benzylpenicillinThe therapeutic efficacy of Benzathine benzylpenicillin can be decreased when used in combination with Doxycycline.Approved, Vet Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Doxycycline.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Doxycycline.Approved
BenzylpenicillinThe therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Doxycycline.Approved, Vet Approved
Benzylpenicilloyl PolylysineThe therapeutic efficacy of Benzylpenicilloyl Polylysine can be decreased when used in combination with Doxycycline.Approved
BexaroteneThe risk or severity of adverse effects can be increased when Doxycycline is combined with Bexarotene.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Doxycycline.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Doxycycline.Approved
Bismuth SubcitrateThe serum concentration of Doxycycline can be decreased when it is combined with Bismuth Subcitrate.Approved
Bismuth SubsalicylateThe serum concentration of Doxycycline can be decreased when it is combined with Bismuth Subsalicylate.Approved, Vet Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Doxycycline.Approved
BL-1020The serum concentration of BL-1020 can be increased when it is combined with Doxycycline.Investigational
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Doxycycline.Withdrawn
BortezomibThe metabolism of Bortezomib can be decreased when combined with Doxycycline.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Doxycycline.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Doxycycline.Approved
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Doxycycline.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Doxycycline.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Doxycycline.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Doxycycline.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Doxycycline.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Doxycycline.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Doxycycline.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Doxycycline.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Doxycycline.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Doxycycline.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Doxycycline.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Doxycycline.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Doxycycline.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Doxycycline.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Doxycycline.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Doxycycline.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Doxycycline.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Doxycycline.Approved, Nutraceutical
CalciumThe serum concentration of Doxycycline can be decreased when it is combined with Calcium.Nutraceutical
Calcium AcetateThe serum concentration of Doxycycline can be decreased when it is combined with Calcium Acetate.Approved
Calcium CarbonateCalcium carbonate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Calcium ChlorideThe serum concentration of Doxycycline can be decreased when it is combined with Calcium Chloride.Approved
Calcium CitrateThe serum concentration of Doxycycline can be decreased when it is combined with Calcium citrate.Approved
Calcium glubionateThe serum concentration of Doxycycline can be decreased when it is combined with Calcium glubionate.Approved
Calcium GluceptateThe serum concentration of Doxycycline can be decreased when it is combined with Calcium Gluceptate.Approved
Calcium gluconateThe serum concentration of Doxycycline can be decreased when it is combined with Calcium gluconate.Approved, Vet Approved
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Doxycycline.Approved
CarbamazepineThe serum concentration of Doxycycline can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbenicillinThe therapeutic efficacy of Carbenicillin can be decreased when used in combination with Doxycycline.Approved
Carbenicillin indanylThe therapeutic efficacy of Carindacillin can be decreased when used in combination with Doxycycline.Approved
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Doxycycline.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Doxycycline.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Doxycycline.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Doxycycline.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Doxycycline.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Doxycycline.Approved, Vet Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Doxycycline.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Doxycycline.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Doxycycline.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Doxycycline.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Doxycycline.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Doxycycline.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Doxycycline.Approved, Vet Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Doxycycline.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Doxycycline.Approved, Nutraceutical
CholestyramineCholestyramine can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Doxycycline.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Doxycycline.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Doxycycline.Approved
CisaprideThe metabolism of Cisapride can be decreased when combined with Doxycycline.Approved, Investigational, Withdrawn
Cisatracurium besylateDoxycycline may increase the neuromuscular blocking activities of Cisatracurium besylate.Approved
CitalopramThe metabolism of Citalopram can be decreased when combined with Doxycycline.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Doxycycline.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Doxycycline.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Doxycycline.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Doxycycline.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Doxycycline.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Doxycycline.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Doxycycline.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Doxycycline.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Doxycycline.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Doxycycline.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Doxycycline.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Doxycycline.Approved, Illicit
CloxacillinThe therapeutic efficacy of Cloxacillin can be decreased when used in combination with Doxycycline.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Doxycycline.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Doxycycline.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Doxycycline.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Doxycycline.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Doxycycline.Approved
ColesevelamColesevelam can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Doxycycline.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Doxycycline.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Doxycycline.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Doxycycline.Approved
CyclacillinThe therapeutic efficacy of Cyclacillin can be decreased when used in combination with Doxycycline.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Doxycycline.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Doxycycline.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Doxycycline.Approved, Investigational
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Doxycycline.Approved
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Doxycycline.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Doxycycline.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Doxycycline.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Doxycycline.Investigational
DapsoneThe risk or severity of adverse effects can be increased when Doxycycline is combined with Dapsone.Approved, Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Doxycycline.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Doxycycline.Approved, Investigational
DarunavirThe metabolism of Darunavir can be decreased when combined with Doxycycline.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Doxycycline.Approved
DasatinibThe metabolism of Dasatinib can be decreased when combined with Doxycycline.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Doxycycline.Approved
DecamethoniumDoxycycline may increase the neuromuscular blocking activities of Decamethonium.Approved
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Doxycycline.Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Doxycycline.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Doxycycline.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Doxycycline.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Doxycycline.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Doxycycline.Approved, Vet Approved
DicloxacillinThe therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Doxycycline.Approved, Vet Approved
DicoumarolDoxycycline may increase the anticoagulant activities of Dicoumarol.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Doxycycline.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Doxycycline.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Doxycycline.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Doxycycline.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Doxycycline.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Doxycycline.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Doxycycline.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Doxycycline.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Doxycycline.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Doxycycline.Approved
Domoic AcidDoxycycline may increase the neuromuscular blocking activities of Domoic Acid.Experimental
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Doxycycline.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Doxycycline.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Doxycycline.Approved
Doxacurium chlorideDoxycycline may increase the neuromuscular blocking activities of Doxacurium chloride.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Doxycycline.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Doxycycline.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Doxycycline.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Doxycycline.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Doxycycline.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Doxycycline.Approved, Investigational
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Doxycycline.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Doxycycline.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Doxycycline.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Doxycycline.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Doxycycline.Approved, Vet Approved
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Doxycycline.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Doxycycline.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Doxycycline.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Doxycycline.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Doxycycline.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Doxycycline.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Doxycycline.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Doxycycline.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Doxycycline.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Doxycycline.Approved, Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Doxycycline.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Doxycycline.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Doxycycline.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Doxycycline.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Doxycycline.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Doxycycline.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Doxycycline.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Doxycycline.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Doxycycline.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Doxycycline.Approved
Ethyl biscoumacetateDoxycycline may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Doxycycline.Approved, Illicit
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Doxycycline.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Doxycycline.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Doxycycline.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Doxycycline.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Doxycycline.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Doxycycline.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Doxycycline.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Doxycycline.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Doxycycline.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Doxycycline.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Doxycycline.Approved, Illicit, Investigational, Vet Approved
Ferric CarboxymaltoseDoxycycline can cause a decrease in the absorption of Ferric Carboxymaltose resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Ferric CitrateDoxycycline can cause a decrease in the absorption of Ferric Citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Ferric pyrophosphateDoxycycline can cause a decrease in the absorption of Ferric pyrophosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Doxycycline.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Doxycycline.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Doxycycline.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Doxycycline.Approved
FlucloxacillinThe therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Doxycycline.Approved
FluindioneDoxycycline may increase the anticoagulant activities of Fluindione.Investigational
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Doxycycline.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Doxycycline.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Doxycycline.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Doxycycline.Approved, Vet Approved
FluphenazineThe serum concentration of Fluphenazine can be increased when it is combined with Doxycycline.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Doxycycline.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Doxycycline.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Doxycycline.Approved
Fluticasone propionateThe metabolism of Fluticasone Propionate can be decreased when combined with Doxycycline.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Doxycycline.Approved
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Doxycycline.Approved
FosphenytoinThe serum concentration of Doxycycline can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Doxycycline.Approved, Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Doxycycline.Approved
Gallamine TriethiodideDoxycycline may increase the neuromuscular blocking activities of Gallamine Triethiodide.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Doxycycline.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Doxycycline.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Doxycycline.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Doxycycline.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Doxycycline.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Doxycycline.Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Doxycycline.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Doxycycline.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Doxycycline.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Doxycycline.Approved, Vet Approved
HexobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Hexobarbital.Approved
HistamineThe metabolism of Histamine Phosphate can be decreased when combined with Doxycycline.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Doxycycline.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Doxycycline.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Doxycycline.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Doxycycline.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Doxycycline.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Doxycycline resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Doxycycline.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Doxycycline.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Doxycycline.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Doxycycline.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Doxycycline.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Doxycycline.Approved
IndinavirThe metabolism of Indinavir can be decreased when combined with Doxycycline.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Doxycycline.Approved
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Doxycycline.Approved, Investigational
IronDoxycycline can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Iron DextranDoxycycline can cause a decrease in the absorption of Iron Dextran resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Vet Approved
Iron saccharateThe serum concentration of Doxycycline can be decreased when it is combined with Iron saccharate.Approved
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Doxycycline.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Doxycycline.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Doxycycline.Approved
IsotretinoinThe risk or severity of adverse effects can be increased when Doxycycline is combined with Isotretinoin.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Doxycycline.Approved
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Doxycycline.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Doxycycline.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Doxycycline.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Doxycycline.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Doxycycline.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Doxycycline.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Doxycycline.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Doxycycline.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Doxycycline.Approved
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Doxycycline.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Doxycycline.Approved, Investigational
Lanthanum carbonateThe serum concentration of Doxycycline can be decreased when it is combined with Lanthanum carbonate.Approved
LapatinibThe metabolism of Lapatinib can be decreased when combined with Doxycycline.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Doxycycline.Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Doxycycline.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Doxycycline.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Doxycycline.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Doxycycline.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Doxycycline.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Doxycycline.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Doxycycline.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Doxycycline.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Doxycycline.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Doxycycline.Approved, Vet Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Doxycycline.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Doxycycline.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Doxycycline.Approved
LopinavirThe metabolism of Lopinavir can be decreased when combined with Doxycycline.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Doxycycline.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Doxycycline.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Doxycycline.Approved
LovastatinThe metabolism of Lovastatin can be decreased when combined with Doxycycline.Approved, Investigational
LumefantrineThe risk or severity of adverse effects can be increased when Doxycycline is combined with Lumefantrine.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Doxycycline.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Doxycycline.Approved
MagaldrateMagaldrate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
Magnesium carbonateMagnesium carbonate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium HydroxideMagnesium hydroxide can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium oxideMagnesium oxide can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium salicylateMagnesium salicylate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium SulfateMagnesium Sulfate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Vet Approved
Magnesium TrisilicateMagnesium Trisilicate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Doxycycline.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Doxycycline.Approved, Vet Approved
MecamylamineDoxycycline may increase the neuromuscular blocking activities of Mecamylamine.Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Doxycycline.Approved, Investigational
MefloquineThe metabolism of Mefloquine can be decreased when combined with Doxycycline.Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Doxycycline.Approved, Vet Approved
MesoridazineThe serum concentration of Mesoridazine can be increased when it is combined with Doxycycline.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Doxycycline.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Doxycycline.Illicit, Withdrawn
MethohexitalThe serum concentration of Doxycycline can be decreased when it is combined with Methohexital.Approved
MethotrimeprazineThe serum concentration of Methotrimeprazine can be increased when it is combined with Doxycycline.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Doxycycline.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Doxycycline.Approved, Vet Approved
Methylene blueThe serum concentration of Methylene blue can be increased when it is combined with Doxycycline.Investigational
MethylphenobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Methylphenobarbital.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Doxycycline.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Doxycycline.Approved
MeticillinThe therapeutic efficacy of Meticillin can be decreased when used in combination with Doxycycline.Approved
MetocurineDoxycycline may increase the neuromuscular blocking activities of Metocurine.Approved
Metocurine IodideDoxycycline may increase the neuromuscular blocking activities of Metocurine Iodide.Withdrawn
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Doxycycline.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Doxycycline.Approved
MezlocillinThe therapeutic efficacy of Mezlocillin can be decreased when used in combination with Doxycycline.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Doxycycline.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Doxycycline.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Doxycycline.Approved, Illicit
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Doxycycline.Approved, Investigational
MipomersenDoxycycline may increase the hepatotoxic activities of Mipomersen.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Doxycycline.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Doxycycline.Approved
MivacuriumDoxycycline may increase the neuromuscular blocking activities of Mivacurium.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Doxycycline.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Doxycycline.Approved
MoricizineThe serum concentration of Moricizine can be increased when it is combined with Doxycycline.Approved, Withdrawn
MorphineThe metabolism of Morphine can be decreased when combined with Doxycycline.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Doxycycline.Approved, Investigational
NafcillinThe therapeutic efficacy of Nafcillin can be decreased when used in combination with Doxycycline.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Doxycycline.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Doxycycline.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Doxycycline.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Doxycycline.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Doxycycline.Approved
NeosaxitoxinDoxycycline may increase the neuromuscular blocking activities of Neosaxitoxin.Investigational
NevirapineThe metabolism of Nevirapine can be decreased when combined with Doxycycline.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Doxycycline.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Doxycycline.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Doxycycline.Approved
NilotinibThe metabolism of Nilotinib can be decreased when combined with Doxycycline.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Doxycycline.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Doxycycline.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Doxycycline.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Doxycycline.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Doxycycline.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Doxycycline.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Doxycycline.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Doxycycline.Approved
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Doxycycline.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Doxycycline.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Doxycycline.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Doxycycline.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Doxycycline.Approved
OxacillinThe therapeutic efficacy of Oxacillin can be decreased when used in combination with Doxycycline.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Doxycycline.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Doxycycline.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Doxycycline is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Doxycycline.Approved, Vet Approved
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Doxycycline.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Doxycycline.Approved, Investigational
PancuroniumDoxycycline may increase the neuromuscular blocking activities of Pancuronium.Approved
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Doxycycline.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Doxycycline.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Doxycycline.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Doxycycline.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Doxycycline.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Doxycycline.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Doxycycline.Approved
PazopanibThe metabolism of Pazopanib can be decreased when combined with Doxycycline.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Doxycycline.Approved
PentobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Doxycycline.Approved
PerazineThe serum concentration of Perazine can be increased when it is combined with Doxycycline.Investigational
PergolideThe metabolism of Pergolide can be decreased when combined with Doxycycline.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Doxycycline.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Doxycycline.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Doxycycline.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Doxycycline.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Doxycycline.Withdrawn
PhenindioneDoxycycline may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Doxycycline.Approved
PhenoxymethylpenicillinThe therapeutic efficacy of Phenoxymethylpenicillin can be decreased when used in combination with Doxycycline.Approved, Vet Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Doxycycline.Approved
PhenytoinThe serum concentration of Doxycycline can be decreased when it is combined with Phenytoin.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Doxycycline.Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Doxycycline.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Doxycycline.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Doxycycline.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Doxycycline.Withdrawn
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Doxycycline.Approved, Investigational
PipecuroniumDoxycycline may increase the neuromuscular blocking activities of Pipecuronium.Approved
PiperacillinThe therapeutic efficacy of Piperacillin can be decreased when used in combination with Doxycycline.Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Doxycycline.Approved
PivampicillinThe therapeutic efficacy of Pivampicillin can be decreased when used in combination with Doxycycline.Approved
PivmecillinamThe therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Doxycycline.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Doxycycline.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Doxycycline.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Doxycycline.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Doxycycline.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Doxycycline.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Doxycycline.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Doxycycline.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Doxycycline.Approved, Vet Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Doxycycline.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Doxycycline.Approved, Vet Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Doxycycline.Approved
PrimidoneThe serum concentration of Doxycycline can be decreased when it is combined with Primidone.Approved, Vet Approved
Procaine benzylpenicillinThe therapeutic efficacy of Procaine benzylpenicillin can be decreased when used in combination with Doxycycline.Approved, Vet Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Doxycycline.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Doxycycline.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Doxycycline.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Doxycycline.Approved, Vet Approved
PromethazineThe serum concentration of Promethazine can be increased when it is combined with Doxycycline.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Doxycycline.Approved
PropiopromazineThe serum concentration of Propiopromazine can be increased when it is combined with Doxycycline.Vet Approved
PropofolThe metabolism of Propofol can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Doxycycline.Approved, Investigational
PyrantelDoxycycline may increase the neuromuscular blocking activities of Pyrantel.Approved, Vet Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Doxycycline.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Doxycycline.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Doxycycline.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Doxycycline.Approved
QuinaprilThe serum concentration of Doxycycline can be decreased when it is combined with Quinapril.Approved, Investigational
QuinidineThe metabolism of Quinidine can be decreased when combined with Doxycycline.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Doxycycline.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Doxycycline.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Doxycycline.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Doxycycline.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Doxycycline.Approved, Investigational
RapacuroniumDoxycycline may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Doxycycline.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Doxycycline.Approved
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Doxycycline.Approved, Investigational
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Doxycycline.Approved
RifabutinThe metabolism of Rifabutin can be decreased when combined with Doxycycline.Approved
RifampicinThe serum concentration of Doxycycline can be decreased when it is combined with Rifampicin.Approved
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Doxycycline.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Doxycycline.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Doxycycline.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Doxycycline.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Doxycycline.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Doxycycline.Approved
RocuroniumDoxycycline may increase the neuromuscular blocking activities of Rocuronium.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Doxycycline.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Doxycycline.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Doxycycline.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Doxycycline.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Doxycycline.Approved
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Doxycycline.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Doxycycline.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Doxycycline.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Doxycycline.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Doxycycline.Approved
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Doxycycline.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Doxycycline.Approved
SecobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Secobarbital.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Doxycycline.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Doxycycline.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Doxycycline.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Doxycycline.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Doxycycline.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Doxycycline.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be decreased when combined with Doxycycline.Approved, Investigational
SilodosinThe metabolism of Silodosin can be decreased when combined with Doxycycline.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Doxycycline.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Doxycycline.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Doxycycline.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Doxycycline.Approved, Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Doxycycline.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Doxycycline.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Doxycycline.Approved, Investigational
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Doxycycline.Approved
Strontium ranelateThe serum concentration of Doxycycline can be decreased when it is combined with Strontium ranelate.Approved
SuccinylcholineDoxycycline may increase the neuromuscular blocking activities of Succinylcholine.Approved
SucralfateSucralfate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Doxycycline.Approved, Investigational
SulbactamThe therapeutic efficacy of Sulbactam can be decreased when used in combination with Doxycycline.Approved
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Doxycycline.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Doxycycline.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Doxycycline.Approved
SultamicillinThe therapeutic efficacy of Sultamicillin can be decreased when used in combination with Doxycycline.Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Doxycycline.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Doxycycline.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Doxycycline.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Doxycycline.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Doxycycline.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Doxycycline.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Doxycycline.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Doxycycline.Approved, Investigational
TasosartanThe metabolism of Tasosartan can be decreased when combined with Doxycycline.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Doxycycline.Experimental
TazobactamThe therapeutic efficacy of Tazobactam can be decreased when used in combination with Doxycycline.Approved
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Doxycycline.Withdrawn
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Doxycycline.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Doxycycline.Approved
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Doxycycline.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Doxycycline.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Doxycycline.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Doxycycline.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Doxycycline.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Doxycycline.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Doxycycline.Approved
ThiamylalThe serum concentration of Doxycycline can be decreased when it is combined with Thiamylal.Approved, Vet Approved
ThiethylperazineThe serum concentration of Thiethylperazine can be increased when it is combined with Doxycycline.Withdrawn
ThiopentalThe serum concentration of Doxycycline can be decreased when it is combined with Thiopental.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Doxycycline.Withdrawn
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Doxycycline.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Doxycycline.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Doxycycline.Approved
TicarcillinThe therapeutic efficacy of Ticarcillin can be decreased when used in combination with Doxycycline.Approved, Vet Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Doxycycline.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Doxycycline.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Doxycycline.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Doxycycline.Approved, Investigational
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Doxycycline.Approved, Investigational
TolterodineThe metabolism of Tolterodine can be decreased when combined with Doxycycline.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Doxycycline.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Doxycycline.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Doxycycline.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Doxycycline.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Doxycycline.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Doxycycline.Approved, Investigational
TretinoinThe risk or severity of adverse effects can be increased when Doxycycline is combined with Tretinoin.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Doxycycline.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Doxycycline.Approved
TrifluoperazineThe serum concentration of Trifluoperazine can be increased when it is combined with Doxycycline.Approved
TriflupromazineThe serum concentration of Triflupromazine can be increased when it is combined with Doxycycline.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Doxycycline.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Doxycycline.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Doxycycline.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Doxycycline.Withdrawn
TubocurarineDoxycycline may increase the neuromuscular blocking activities of Tubocurarine.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Doxycycline.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Doxycycline.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Doxycycline.Investigational, Withdrawn
VandetanibThe metabolism of Vandetanib can be decreased when combined with Doxycycline.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Doxycycline.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Doxycycline.Approved
VecuroniumDoxycycline may increase the neuromuscular blocking activities of Vecuronium.Approved
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Doxycycline.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Doxycycline.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Doxycycline.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Doxycycline.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Doxycycline.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Doxycycline.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Doxycycline.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Doxycycline.Approved
VincristineThe metabolism of Vincristine can be decreased when combined with Doxycycline.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Doxycycline.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Doxycycline.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Doxycycline.Approved
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Doxycycline.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Doxycycline.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Doxycycline.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Doxycycline.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Doxycycline.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Doxycycline.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Doxycycline.Approved, Illicit, Investigational
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Doxycycline.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Doxycycline.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Doxycycline.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Doxycycline.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Doxycycline.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Doxycycline.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Doxycycline.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Doxycycline.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take with a full glass of water Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
References
Synthesis Reference

Dai-Wu Seol, "DNA cassette for the production of secretable recombinant trimeric TRAIL proteins, tetracycline/ doxycycline-inducible adeno-associated virus vector, their combination and use in gene therapy." U.S. Patent US20020128438, issued September 12, 2002.

US20020128438
General References
  1. Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ: Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep;50(9):3124-31. [PubMed:16940111 ]
  2. Hoerauf A, Mand S, Fischer K, Kruppa T, Marfo-Debrekyei Y, Debrah AY, Pfarr KM, Adjei O, Buttner DW: Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol. 2003 Nov;192(4):211-6. Epub 2003 Mar 5. [PubMed:12684759 ]
  3. Taylor MJ, Makunde WH, McGarry HF, Turner JD, Mand S, Hoerauf A: Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet. 2005 Jun 18-24;365(9477):2116-21. [PubMed:15964448 ]
External Links
ATC CodesA01AB22 — DoxycyclineJ01AA20 — Combinations of tetracyclinesJ01AA02 — Doxycycline
AHFS Codes
  • 08:12.24
  • 52:04.04
PDB Entries
FDA labelDownload (48.1 KB)
MSDSDownload (73.4 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0Not Yet RecruitingPreventionSexually Transmitted Infections (STIs) / Syphilis1
0RecruitingTreatmentOsteomyelitis1
1CompletedNot AvailableHealthy Volunteers4
1CompletedNot AvailableTo Determine Bioequivalence Under Fasting Conditions3
1CompletedNot AvailableTo Determine Bioequivalence Under Fed Conditions2
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceHealthy Volunteers / Infections, Bacterial / Infections, Fungal1
1CompletedPreventionArteriovenous Malformations / Brain Aneurysms / Cavernous Angiomas1
1CompletedTreatmentAneurysms / Arteriovenous Malformations1
1RecruitingPreventionCardiorenal Syndrome / Chronic Kidney Disease (CKD)1
1RecruitingTreatmentColorectal Cancers / Head and Neck Carcinoma1
1TerminatedTreatmentAnthrax1
1, 2Active Not RecruitingHealth Services ResearchAcne Vulgaris1
1, 2Active Not RecruitingTreatmentAmyloidosis; Heart (Manifestation) / Senile Cardiac Amyloidosis1
1, 2CompletedTreatmentAutoimmune Diseases / Endocrine System Diseases / Eye Diseases / Eye Diseases, Hereditary / Graves Diseases / Graves Ophthalmopathy / Hyperthyroidism / Immune System Diseases / Thyroid Diseases1
1, 2TerminatedTreatmentDiabetic Foot Ulcers (DFU)1
1, 2TerminatedTreatmentMelanoma1
1, 2Unknown StatusTreatmentAcne Vulgaris1
2Active Not RecruitingSupportive CareDermatologic Complications / Neoplasms, Malignant1
2Active Not RecruitingTreatmentAneurysms1
2Active Not RecruitingTreatmentCystic Fibrosis (CF)1
2Active Not RecruitingTreatmentMarginal Zone Lymphoma of Ocular Adnexal1
2Active Not RecruitingTreatmentPain1
2CompletedNot AvailableEye Dryness1
2CompletedBasic ScienceAortic Aneurysm, Abdominal1
2CompletedPreventionCo-Infection / Mansonella Perstans Infection / Mycobacterium marinum infection / Tuberculosis1
2CompletedPreventionRas-wildtype Colorectal Cancer1
2CompletedPreventionRash Due to Epidermal Growth Factor Receptor Inhibitors1
2CompletedTreatmentAcne Vulgaris1
2CompletedTreatmentChronic Rhinosinusitis / Polyps, Nasal1
2CompletedTreatmentDiabetic Foot Ulcers (DFU)1
2CompletedTreatmentBacterial blepharitis / Eye Dryness / Meibomianitis1
2CompletedTreatmentLeft Ventricular Remodeling / Myocardial Infarction (MI)1
2CompletedTreatmentMansonella Perstans Infection / Mp Microfilaremia1
2CompletedTreatmentNon-Hodgkin's Lymphoma (NHL)1
2CompletedTreatmentNon-Small-Cell Lung Carcinoma (NSCLC)1
2CompletedTreatmentPelvic Inflammatory Disease (PID)1
2CompletedTreatmentPeriodontal Diseases / Periodontitis1
2CompletedTreatmentPosterior Blepharitis1
2CompletedTreatmentRetinopathy, Diabetic2
2CompletedTreatmentProphylaxis of cardiomyopathy / Transthyretin Amyloidosis1
2CompletedTreatmentUrethritis1
2Not Yet RecruitingTreatmentCutaneous T-Cell Lymphoma (CTCL) / Mycosis Fungoides (MF) / Sezary Syndrome1
2RecruitingTreatmentAneurysm, Coronary / Mucocutaneous Lymph Node Syndrome1
2RecruitingTreatmentCarcinoma, Breast / Endometrial Clear Cell Adenocarcinoma / Endometrial Serous Adenocarcinoma / Uterine Corpus Cancer / Uterine Corpus Carcinosarcoma1
2RecruitingTreatmentChronic Periodontitis1
2RecruitingTreatmentLarynx / LIP / Oral Cavity / Pharynx1
2RecruitingTreatmentMalignant Pleural Effusions1
2RecruitingTreatmentPrimary Systemic Amyloidosis1
2RecruitingTreatmentResectable Pancreatic Cancers1
2RecruitingTreatmentSeizures1
2RecruitingTreatmentTuberculosis1
2RecruitingTreatmentUlcerative Colitis (UC)1
2RecruitingTreatmentModerate, refractory Atopic dermatitis1
2TerminatedTreatmentAdult Diffuse Large B-Cell Lymphoma / Chronic Lymphocytic Leukaemia (CLL) / Follicular Lymphoma (FL) / Malignant Lymphoma - Lymphoplasmacytic / Mantle Cell Lymphoma Recurrent / Marginal Zone B-Cell Lymphoma / Small Lymphocytic Lymphoma (SLL) / T-Cell Lymphomas / Waldenstrom's Macroglobulinemia (WM)1
2TerminatedTreatmentMinor Intra-uterine Abnormalities1
2TerminatedTreatmentNon-ischaemic Cardiomyopathy / Systolic Heart Failure (NYHA II-III)1
2Unknown StatusPreventionMucositis1
2Unknown StatusTreatmentAcne1
2Unknown StatusTreatmentAutoimmune Diseases / Endocrine System Diseases / Eye Diseases / Eye Diseases, Hereditary / Graves Diseases / Graves Ophthalmopathy / Hyperthyroidism / Immune System Diseases / Thyroid Diseases1
2Unknown StatusTreatmentCrohn's Disease (CD)1
2Unknown StatusTreatmentPlague1
2, 3Active Not RecruitingTreatmentAcute Myocardial Infarction (AMI) / Cardiovascular Disease (CVD) / Vascular Diseases1
2, 3CompletedNot AvailableJarisch Herxheimer Reaction / Relapsing Fever, Tick-Borne1
2, 3CompletedTreatmentDiabetes Mellitus With Periodontal Disease1
2, 3RecruitingTreatmentDry Macular Degeneration1
2, 3Unknown StatusTreatmentAcne / Inflammatory Reaction1
2, 3Unknown StatusTreatmentEye Burns1
3CompletedNot AvailableMycoplasma Infections / Persian Gulf Syndrome1
3CompletedDiagnosticLyme Neuroborreliosis1
3CompletedSupportive CareMetastatic Cancers1
3CompletedTreatmentAcne1
3CompletedTreatmentAndrogen Excess / Menstrual Irregularities / Polycystic Ovarian Syndrome (PCOS)1
3CompletedTreatmentChlamydial Infections1
3CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
3CompletedTreatmentChronic Periodontitis1
3CompletedTreatmentLyme Disease2
3CompletedTreatmentPeriodontitis1
3CompletedTreatmentReactive Arthritis / Reiter's Disease1
3CompletedTreatmentRosaceas1
3CompletedTreatmentSevere Acne Vulgaris1
3CompletedTreatmentSyphilis1
3CompletedTreatmentUrethritis1
3CompletedTreatmentUrogential Chlamydia Trachomatis Infection1
3CompletedTreatmentUterine Hemorrhage1
3CompletedTreatmentSynovitis of osteoarthritis1
3Enrolling by InvitationTreatmentNeuroborreliosis, Borrelia Burgdorferi1
3Not Yet RecruitingTreatmentFilariasis / Lymphatic Filariasis / Lymphedema of the extremities3
3RecruitingTreatmentCancers / Overall Survival / Quality of Life1
3RecruitingTreatmentESI-related Bleeding1
3RecruitingTreatmentIndigestion1
3Unknown StatusNot AvailableChronic Obstructive Pulmonary Disease (COPD)1
3Unknown StatusTreatmentAlzheimer's Disease (AD)2
3Unknown StatusTreatmentMetastatic Colorectal Cancers / Skin Toxicities1
3Unknown StatusTreatmentScrub Typhus1
4Active Not RecruitingTreatmentAcne Vulgaris1
4CompletedBasic ScienceInfections, Bacterial1
4CompletedPreventionPregnancy Termination / Vomiting1
4CompletedSupportive CareRosaceas1
4CompletedTreatmentAcne1
4CompletedTreatmentAcne Vulgaris2
4CompletedTreatmentBMI >30 kg/m2 / Type 2 Diabetes Mellitus1
4CompletedTreatmentBorrelia Infection / Lyme Disease1
4CompletedTreatmentBorreliosis / Early Lyme Disease / Erythema Chronicum Migrans / Lyme Disease1
4CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4CompletedTreatmentCoxiella Infection / Fatigue Syndrome, Chronic / Q Fever1
4CompletedTreatmentCystic Fibrosis (CF)1
4CompletedTreatmentErythema Chronicum Migrans / Post-Lyme Disease Symptoms1
4CompletedTreatmentFilarial; Infestation1
4CompletedTreatmentLymphangioleiomyomatosis / Tuberous Sclerosis1
4CompletedTreatmentOver Active Bladder1
4CompletedTreatmentPapulopustular Rosacea2
4CompletedTreatmentPeriodontal Diseases / Type 2 Diabetes Mellitus1
4CompletedTreatmentRosaceas3
4CompletedTreatmentSinusitis1
4Not Yet RecruitingTreatmentBacterial Infection Due to Helicobacter Pylori (H. Pylori)1
4Not Yet RecruitingTreatmentDry Eye Syndromes / Meibomian Gland Dysfunction (MGD)1
4RecruitingPreventionRabies1
4RecruitingTreatmentBacterial Infection Due to Helicobacter Pylori (H. Pylori)1
4TerminatedTreatmentBladder Pain Syndrome / Chronic Pelvic Pain Syndrome (CPPS)1
4TerminatedTreatmentPeriodontitis1
4TerminatedTreatmentSeptic Abortion1
4Unknown StatusTreatmentCervicitis / Chlamydia Trachomatis / Genital Mycoplasma Infection / Urethritis1
4Unknown StatusTreatmentChronic Obstructive Pulmonary Disease (COPD) / Inflammatory Reaction / Pulmonary Emphysema1
4Unknown StatusTreatmentEndometrial Bleeding / Periodontal Diseases1
4Unknown StatusTreatmentLyme Neuroborreliosis1
4Unknown StatusTreatmentBacterial blepharitis1
4WithdrawnPreventionCardiovascular Disease (CVD)1
4WithdrawnTreatmentPulmonary Disease, Chronic Obstructive1
Not AvailableCompletedNot AvailableErythema Chronicum Migrans1
Not AvailableCompletedNot AvailableHealthy Volunteers2
Not AvailableCompletedNot AvailableLyme Neuroborreliosis1
Not AvailableCompletedNot AvailableMycoplasma Pneumoniae1
Not AvailableCompletedNot AvailablePeriodontal Diseases / Psoriatic Arthritis / Rheumatoid Arthritis1
Not AvailableCompletedBasic ScienceCognitive Dysfunctions / Paresis / Paresthesia / Radicular Pain / Tiredness1
Not AvailableCompletedPreventionFirst Trimester Abortion1
Not AvailableCompletedPreventionMethicillin Resistant Staphylococcus Aureus Skin Infections1
Not AvailableCompletedPreventionSyphilis1
Not AvailableCompletedPreventionSynovitis of osteoarthritis1
Not AvailableCompletedTreatmentAortic Aneurysms1
Not AvailableCompletedTreatmentCardiopulmonary Bypass / Coronary Artery Bypass Grafting (CABG) Surgery / Reperfusion Injury1
Not AvailableCompletedTreatmentCystic Fibrosis (CF)1
Not AvailableCompletedTreatmentDiabetes Mellitus With Periodontal Disease1
Not AvailableCompletedTreatmentGastritis1
Not AvailableCompletedTreatmentOral Contraceptives (OC)1
Not AvailableCompletedTreatmentPolyp of Nasal Sinus1
Not AvailableCompletedTreatmentUlcerative Colitis (UC)1
Not AvailableEnrolling by InvitationPreventionPropionibacterium1
Not AvailableNot Yet RecruitingPreventionMotility Disorders / Staphylococcus Aureus1
Not AvailableRecruitingNot AvailableBullous Pemphigoid (BP)1
Not AvailableRecruitingTreatmentChronic Obstructive Pulmonary Disease (COPD) / Emphysema / HIV Disease1
Not AvailableRecruitingTreatmentMethicillin-Resistant Staphylococcus Aureus (MRSA)1
Not AvailableRecruitingTreatmentMultiple Erythema Migrans1
Not AvailableRecruitingTreatmentTick-borne Encephalitis (TBE)1
Not AvailableTerminatedTreatmentAdvanced Cancers / Malignant Pleural Effusions1
Not AvailableTerminatedTreatmentUlcerative Colitis (UC)1
Not AvailableUnknown StatusTreatmentBreakthrough Bleeding1
Not AvailableUnknown StatusTreatmentLateral Epicondylalgia (Tennis Elbow)1
Not AvailableUnknown StatusTreatmentRosaceas1
Not AvailableUnknown StatusTreatmentScrub Typhus1
Not AvailableUnknown StatusTreatmentSuspected Early Lyme Neuroborreliosis1
Not AvailableWithdrawnPreventionSeroma1
Not AvailableWithdrawnSupportive CareNon-Small-Cell Lung Carcinoma (NSCLC)1
Not AvailableWithdrawnTreatmentHeadache Disorders, Primary / Migraine Disorders / Migraine With Aura / Migraine Without Aura / Migraines / Migrainous Headache1
Not AvailableWithdrawnTreatmentRotator Cuff Injury1
Pharmacoeconomics
Manufacturers
  • Mylan pharmaceuticals inc
  • Par pharmaceutical inc
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Watson laboratories inc
  • Watson pharmaceuticals inc
  • Galderma laboratories lp
  • Rachelle laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Pfizer laboratories div pfizer inc
  • Lannett holdings inc
  • Mutual pharmaceutical co inc
  • Pliva inc
  • Mayne pharma international faulding pharm
  • Warner chilcott bermuda ltd
  • Medicis pharmaceutical corp
  • Halsey drug co inc
  • Heather drug co inc
  • Interpharm inc
  • Private formulations inc
  • Ranbaxy pharmaceuticals inc
  • Superpharm corp
  • Warner chilcott div warner lambert co
  • West ward pharmaceutical corp
  • Teva pharmaceuticals usa inc
  • Collagenex inc
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Tolmar inc
  • Corepharma llc
  • Larken laboratories inc
  • Mutual pharmacal co
  • Truxton inc
  • Vintage pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
Tablet, coatedOral150 mg/1
Tablet, coatedOral75 mg/1
TabletOral20 mg/1
KitOral
KitOral44 mg
Tablet, delayed releaseOral150 mg/1
Tablet, delayed releaseOral200 mg/1
Tablet, delayed releaseOral50 mg/1
Capsule, extended releaseOral100 mg
Tablet, delayed releaseOral120 mg/1
Tablet, delayed releaseOral60 mg/1
TabletOral100 mg
CapsuleOral100 mg/1
CapsuleOral150 mg/1
For suspensionOral25 mg/5mL
Injection, powder, lyophilized, for solutionIntravenous100 mg/10mL
Injection, powder, lyophilized, for solutionIntravenous100 mg/100mg
Powder, for suspensionOral25 mg/5mL
TabletOral100 mg/1
TabletOral150 mg/1
TabletOral50 mg/1
TabletOral75 mg/1
Tablet, coatedOral100 mg/1
Tablet, film coatedOral100 mg/1
Tablet, film coatedOral150 mg/1
Tablet, film coatedOral50 mg/1
Tablet, film coatedOral75 mg/1
Capsule, gelatin coatedOral100 mg/1
Capsule, gelatin coatedOral50 mg/1
Tablet, delayed releaseOral100 mg/1
Tablet, delayed releaseOral75 mg/1
Tablet, film coatedOral20 mg/1
CapsuleOral50 mg/1
CapsuleOral75 mg/1
CapsuleOral50 mg/50mg
CapsuleOral75 mg/75mg
CapsuleOral100 mg/100mg
Kit
CapsuleOral40 mg/1
Capsule, delayed release pelletsOral40 mg/1
CapsuleOral20 mg
CapsuleOral100 mg
SyrupOral50 mg/5mL
PowderIntravenous100 mg
Prices
Unit descriptionCostUnit
Vibramycin 25 mg/5ml Suspension 60ml Bottle36.29USD bottle
Adoxa pak 1-150 mg tablet19.93USD tablet
Doryx 150 mg Enteric Coated Tabs17.51USD tab
Doryx dr 150 mg tablet16.83USD tablet
Doxycycline hyc 100 mg vial14.16USD vial
Adoxa 100 mg tablet13.86USD tablet
Monodox 100 mg capsule13.46USD capsule
Adoxa 75 mg tablet12.77USD tablet
Oracea 40 mg Delayed Release Capsule12.44USD capsule
Oracea 40 mg capsule11.96USD capsule
Avidoxy 100 mg tablet11.52USD tablet
Monodox 75 mg capsule11.02USD capsule
Doryx 100 mg Enteric Coated Tabs10.31USD tab
Doryx dr 100 mg tablet9.91USD tablet
Adoxa pak 1-100 mg tablet9.88USD tablet
Doxycycline Monohydrate 150 mg tablet9.51USD tablet
Adoxa 50 mg tablet9.29USD tablet
Doxycycline mono 150 mg tablet9.13USD tablet
Doryx 75 mg Enteric Coated Tabs8.76USD tab
Doryx dr 75 mg tablet8.42USD tablet
Vibramycin 100 mg capsule6.67USD capsule
Vibra-tabs 100 mg tablet6.67USD tablet
Monodox 50 mg capsule6.0USD capsule
Doxycycline mono 100 mg tablet5.98USD tablet
Periostat 20 mg tablet5.75USD tablet
Doxycycline mono 75 mg tablet5.74USD tablet
Doxycycline Monohydrate 100 mg tablet5.12USD tablet
Doxycycline mono 50 mg tablet4.17USD tablet
Doxycycline Monohydrate 50 mg tablet3.0USD tablet
Doxycycline hyclate powder2.56USD g
Vibramycin 50 mg capsule2.41USD capsule
Doxycycline Monohydrate 100 mg capsule2.22USD capsule
Vibramycin 100 mg Capsule1.91USD capsule
Doxycycline Monohydrate 50 mg capsule1.51USD capsule
Doxycycline hyclate 100 mg tablet1.28USD tablet
Doxycycline hyclate 20 mg tablet1.28USD tablet
Doxycycline Hyclate 100 mg capsule1.18USD capsule
Doxycycline Hyclate 50 mg capsule0.76USD capsule
Vibramycin 50 mg/5ml Syrup0.67USD ml
Vibramycin 50 mg/5 ml syrup0.64USD ml
Apo-Doxy 100 mg Capsule0.61USD capsule
Apo-Doxy 100 mg Tablet0.61USD tablet
Doxycin 100 mg Capsule0.61USD capsule
Doxycin 100 mg Tablet0.61USD tablet
Novo-Doxylin 100 mg Capsule0.61USD capsule
Novo-Doxylin 100 mg Tablet0.61USD tablet
Nu-Doxycycline 100 mg Capsule0.61USD capsule
Pms-Doxycycline 100 mg Capsule0.61USD capsule
Pms-Doxycycline 100 mg Tablet0.61USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6958161 No2002-12-152022-12-15Us
US8715724 No2008-02-032028-02-03Us
US7211267 No2002-04-052022-04-05Us
US7232572 No2002-04-052022-04-05Us
US7749532 No2007-12-192027-12-19Us
US8206740 No2005-12-242025-12-24Us
US8394405 No2004-04-072024-04-07Us
US8394406 No2004-04-072024-04-07Us
US8470364 No2004-04-072024-04-07Us
US8603506 No2002-04-052022-04-05Us
US5789395 No1996-08-302016-08-30Us
US5919775 No1996-08-302016-08-30Us
US8709478 No2004-04-072024-04-07Us
US9241946 No2002-04-052022-04-05Us
US9511031 No2014-10-232034-10-23Us
US9446057 No2014-12-232034-12-23Us
US9295652 No2014-10-232034-10-23Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)201 °CNot Available
water solubility630 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-0.02SANGSTER (1994)
logS-2.87ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.63 mg/mLALOGPS
logP-0.72ALOGPS
logP-3.4ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)-2.2ChemAxon
pKa (Strongest Basic)7.75ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area181.62 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity113.89 m3·mol-1ChemAxon
Polarizability42.88 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.85
Blood Brain Barrier-0.9881
Caco-2 permeable-0.8706
P-glycoprotein substrateSubstrate0.699
P-glycoprotein inhibitor INon-inhibitor0.8038
P-glycoprotein inhibitor IINon-inhibitor0.8628
Renal organic cation transporterNon-inhibitor0.9562
CYP450 2C9 substrateNon-substrate0.8008
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6551
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9144
CYP450 2D6 inhibitorNon-inhibitor0.9293
CYP450 2C19 inhibitorNon-inhibitor0.9099
CYP450 3A4 inhibitorNon-inhibitor0.8567
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8086
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8632
BiodegradationNot ready biodegradable0.9941
Rat acute toxicity2.3159 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9946
hERG inhibition (predictor II)Non-inhibitor0.7466
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MSNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tetracyclines. These are polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassTetracyclines
Sub ClassNot Available
Direct ParentTetracyclines
Alternative ParentsNaphthacenes / Anthracenecarboxylic acids and derivatives / Tetralins / Aryl ketones / 1-hydroxy-2-unsubstituted benzenoids / 1-hydroxy-4-unsubstituted benzenoids / Aralkylamines / Cyclohexenones / Tertiary alcohols / Vinylogous acids
SubstituentsTetracycline / Naphthacene / Tetracene / Anthracene carboxylic acid or derivatives / Tetralin / Aryl ketone / 1-hydroxy-4-unsubstituted benzenoid / 1-hydroxy-2-unsubstituted benzenoid / Cyclohexenone / Aralkylamine
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptorstetracyclines (CHEBI:50845 ) / Linear tetracyclines (C06973 ) / Linear tetracyclines (LMPK07000001 )

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Translation repressor activity, nucleic acid binding
Specific Function:
One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity muta...
Gene Name:
rpsD
Uniprot ID:
P0A7V8
Uniprot Name:
30S ribosomal protein S4
Molecular Weight:
23468.915 Da
References
  1. Griffin MO, Fricovsky E, Ceballos G, Villarreal F: Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. doi: 10.1152/ajpcell.00047.2010. Epub 2010 Jun 30. [PubMed:20592239 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Trna binding
Specific Function:
The C-terminal tail plays a role in the affinity of the 30S P site for different tRNAs. Mutations that decrease this affinity are suppressed in the 70S ribosome.
Gene Name:
rpsI
Uniprot ID:
P0A7X3
Uniprot Name:
30S ribosomal protein S9
Molecular Weight:
14856.105 Da
References
  1. Griffin MO, Fricovsky E, Ceballos G, Villarreal F: Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. doi: 10.1152/ajpcell.00047.2010. Epub 2010 Jun 30. [PubMed:20592239 ]
3. 16S rRNA
Kind
Nucleotide
Organism
Enteric bacteria and other eubacteria
Pharmacological action
yes
Actions
inhibitor
References
  1. Pringle M, Fellstrom C, Johansson KE: Decreased susceptibility to doxycycline associated with a 16S rRNA gene mutation in Brachyspira hyodysenteriae. Vet Microbiol. 2007 Jul 20;123(1-3):245-8. Epub 2007 Feb 25. [PubMed:17428623 ]
  2. Kumar S, Kutlin A, Roblin P, Kohlhoff S, Bodetti T, Timms P, Hammerschlag MR: Isolation and antimicrobial susceptibilities of Chlamydial isolates from Western barred bandicoots. J Clin Microbiol. 2007 Feb;45(2):392-4. Epub 2006 Nov 22. [PubMed:17122017 ]
  3. Ross JI, Eady EA, Cove JH, Cunliffe WJ: 16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium. Antimicrob Agents Chemother. 1998 Jul;42(7):1702-5. [PubMed:9661007 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein-arginine deiminase activity
Specific Function:
Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as...
Gene Name:
PADI4
Uniprot ID:
Q9UM07
Uniprot Name:
Protein-arginine deiminase type-4
Molecular Weight:
74078.65 Da
References
  1. Knuckley B, Luo Y, Thompson PR: Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bioorg Med Chem. 2008 Jan 15;16(2):739-45. Epub 2007 Oct 13. [PubMed:17964793 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Identical protein binding
Specific Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Gene Name:
B2M
Uniprot ID:
P61769
Uniprot Name:
Beta-2-microglobulin
Molecular Weight:
13714.43 Da
References
  1. Giorgetti S, Raimondi S, Pagano K, Relini A, Bucciantini M, Corazza A, Fogolari F, Codutti L, Salmona M, Mangione P, Colombo L, De Luigi A, Porcari R, Gliozzi A, Stefani M, Esposito G, Bellotti V, Stoppini M: Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils. J Biol Chem. 2011 Jan 21;286(3):2121-31. doi: 10.1074/jbc.M110.178376. Epub 2010 Nov 10. [PubMed:21068391 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Uniprot Name:
Cytochrome P450 3A4
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Zhao XJ, Ishizaki T: A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (Ki) and type of inhibition. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):272-8. [PubMed:10716067 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Uniprot Name:
Solute carrier family 22 member 6
Molecular Weight:
61815.78 Da
References
  1. Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. [PubMed:11855680 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Uniprot Name:
Solute carrier family 22 member 8
Molecular Weight:
59855.585 Da
References
  1. Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. [PubMed:11855680 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.
Gene Name:
SLC22A11
Uniprot ID:
Q9NSA0
Uniprot Name:
Solute carrier family 22 member 11
Molecular Weight:
59970.945 Da
References
  1. Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. [PubMed:11855680 ]
Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:25