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Identification
NameSphingosine
Accession NumberDB03203  (EXPT02945)
TypeSmall Molecule
GroupsExperimental
DescriptionAn amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)
Structure
Thumb
SynonymsNot Available
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIINGZ37HRE42
CAS number123-78-4
WeightAverage: 299.4919
Monoisotopic: 299.282429433
Chemical FormulaC18H37NO2
InChI KeyWWUZIQQURGPMPG-BXDGKWANSA-N
InChI
InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14-/t17-,18+/m1/s1
IUPAC Name
(2R,3S,4Z)-2-aminooctadec-4-ene-1,3-diol
SMILES
[H][C@@](N)(CO)[C@@]([H])(O)\C=C/CCCCCCCCCCCCC
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
Glycolipid transfer proteinProteinunknownNot AvailableHumanQ9NZD2 details
Genome polyproteinProteinunknownNot AvailablePoliovirus type 1 (strain Mahoney)P03300 details
Genome polyproteinProteinunknownNot AvailableHRV-14P03303 details
Genome polyproteinProteinunknownNot AvailableSVDVP13900 details
Genome polyproteinProteinunknownNot AvailablePoliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)P03302 details
Poliovirus receptorProteinunknownNot AvailableHumanP15151 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcetaminophenThe serum concentration of Sphingosine can be increased when it is combined with Acetaminophen.Approved
AfatinibThe serum concentration of Sphingosine can be increased when it is combined with Afatinib.Approved
AlbendazoleThe serum concentration of Sphingosine can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Sphingosine can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Sphingosine can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Sphingosine can be increased when it is combined with Alfentanil.Approved, Illicit
AmantadineThe serum concentration of Sphingosine can be increased when it is combined with Amantadine.Approved
Aminohippuric acidThe serum concentration of Sphingosine can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe serum concentration of Sphingosine can be decreased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Sphingosine can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Sphingosine can be increased when it is combined with Amlodipine.Approved
AmprenavirThe serum concentration of Sphingosine can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Sphingosine can be increased when it is combined with Amsacrine.Approved
AstemizoleThe serum concentration of Sphingosine can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Sphingosine can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Sphingosine can be increased when it is combined with Atenolol.Approved
AtorvastatinThe serum concentration of Sphingosine can be increased when it is combined with Atorvastatin.Approved
AzelastineThe serum concentration of Sphingosine can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Sphingosine can be increased when it is combined with Azithromycin.Approved
BenzocaineThe serum concentration of Sphingosine can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Sphingosine can be increased when it is combined with Bepridil.Approved, Withdrawn
BiperidenThe serum concentration of Sphingosine can be increased when it is combined with Biperiden.Approved
BosutinibThe serum concentration of Sphingosine can be increased when it is combined with Bosutinib.Approved
BromocriptineThe serum concentration of Sphingosine can be increased when it is combined with Bromocriptine.Approved, Investigational
BuprenorphineThe serum concentration of Sphingosine can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Sphingosine can be increased when it is combined with Buspirone.Approved, Investigational
CabazitaxelThe serum concentration of Sphingosine can be increased when it is combined with Cabazitaxel.Approved
CaffeineThe serum concentration of Sphingosine can be increased when it is combined with Caffeine.Approved
CanagliflozinThe serum concentration of Sphingosine can be increased when it is combined with Canagliflozin.Approved
CandesartanThe serum concentration of Sphingosine can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Sphingosine can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Sphingosine can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarvedilolThe serum concentration of Sphingosine can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Sphingosine can be increased when it is combined with Caspofungin.Approved
ChloroquineThe serum concentration of Sphingosine can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Sphingosine can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Sphingosine can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Sphingosine can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
CholesterolThe serum concentration of Sphingosine can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Sphingosine can be decreased when it is combined with Cholic Acid.Approved
CilazaprilThe serum concentration of Sphingosine can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Sphingosine can be decreased when it is combined with Cimetidine.Approved
CiprofloxacinThe serum concentration of Sphingosine can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CitalopramThe serum concentration of Sphingosine can be increased when it is combined with Citalopram.Approved
ClarithromycinThe serum concentration of Sphingosine can be increased when it is combined with Clarithromycin.Approved
ClofazimineThe serum concentration of Sphingosine can be increased when it is combined with Clofazimine.Approved, Investigational
ClomipramineThe serum concentration of Sphingosine can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClotrimazoleThe serum concentration of Sphingosine can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
CobicistatThe serum concentration of Sphingosine can be increased when it is combined with Cobicistat.Approved
ColchicineThe serum concentration of Sphingosine can be increased when it is combined with Colchicine.Approved
ColforsinThe serum concentration of Sphingosine can be increased when it is combined with Colforsin.Experimental
CrizotinibThe serum concentration of Sphingosine can be increased when it is combined with Crizotinib.Approved
CyclophosphamideThe serum concentration of Sphingosine can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Sphingosine can be decreased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
DaclatasvirThe serum concentration of Sphingosine can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Sphingosine can be increased when it is combined with Dactinomycin.Approved
DasatinibThe serum concentration of Sphingosine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Sphingosine can be decreased when it is combined with Daunorubicin.Approved
DesipramineThe serum concentration of Sphingosine can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Sphingosine can be increased when it is combined with Desloratadine.Approved, Investigational
DexamethasoneThe serum concentration of Sphingosine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Sphingosine can be increased when it is combined with Dextromethorphan.Approved
DiclofenacThe serum concentration of Sphingosine can be increased when it is combined with Diclofenac.Approved, Vet Approved
DigoxinThe serum concentration of Sphingosine can be decreased when it is combined with Digoxin.Approved
DihydroergotamineThe serum concentration of Sphingosine can be increased when it is combined with Dihydroergotamine.Approved
DiltiazemThe serum concentration of Sphingosine can be increased when it is combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Sphingosine can be increased when it is combined with Dipyridamole.Approved
DoxazosinThe serum concentration of Sphingosine can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Sphingosine can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Sphingosine can be decreased when it is combined with Doxorubicin.Approved, Investigational
DronabinolThe serum concentration of Sphingosine can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe serum concentration of Sphingosine can be increased when it is combined with Dronedarone.Approved
ElbasvirThe serum concentration of Sphingosine can be increased when it is combined with Elbasvir.Approved
EnalaprilThe serum concentration of Sphingosine can be increased when it is combined with Enalapril.Approved, Vet Approved
EnzalutamideThe serum concentration of Sphingosine can be increased when it is combined with Enzalutamide.Approved
ErgonovineThe serum concentration of Sphingosine can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Sphingosine can be increased when it is combined with Ergotamine.Approved
ErythromycinThe serum concentration of Sphingosine can be decreased when it is combined with Erythromycin.Approved, Vet Approved
EstramustineThe serum concentration of Sphingosine can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Sphingosine can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Sphingosine can be decreased when it is combined with Estrone.Approved
EtoposideThe serum concentration of Sphingosine can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of Sphingosine can be increased when it is combined with Etravirine.Approved
FelodipineThe serum concentration of Sphingosine can be increased when it is combined with Felodipine.Approved, Investigational
FentanylThe serum concentration of Sphingosine can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe serum concentration of Sphingosine can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Sphingosine can be increased when it is combined with Fidaxomicin.Approved
FluconazoleThe serum concentration of Sphingosine can be increased when it is combined with Fluconazole.Approved
FluoxetineThe serum concentration of Sphingosine can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Sphingosine can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Sphingosine can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Sphingosine can be increased when it is combined with Flurazepam.Approved, Illicit
FluvoxamineThe serum concentration of Sphingosine can be increased when it is combined with Fluvoxamine.Approved, Investigational
GefitinibThe serum concentration of Sphingosine can be increased when it is combined with Gefitinib.Approved, Investigational
GenisteinThe serum concentration of Sphingosine can be increased when it is combined with Genistein.Investigational
GlyburideThe serum concentration of Sphingosine can be increased when it is combined with Glyburide.Approved
GlycerolThe serum concentration of Sphingosine can be increased when it is combined with Glycerol.Experimental
Gramicidin DThe serum concentration of Sphingosine can be increased when it is combined with Gramicidin D.Approved
GrepafloxacinThe serum concentration of Sphingosine can be increased when it is combined with Grepafloxacin.Withdrawn
HaloperidolThe serum concentration of Sphingosine can be increased when it is combined with Haloperidol.Approved
HydrocortisoneThe serum concentration of Sphingosine can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
IdelalisibThe serum concentration of Sphingosine can be increased when it is combined with Idelalisib.Approved
ImatinibThe serum concentration of Sphingosine can be increased when it is combined with Imatinib.Approved
ImipramineThe serum concentration of Sphingosine can be increased when it is combined with Imipramine.Approved
IndinavirThe serum concentration of Sphingosine can be decreased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Sphingosine can be increased when it is combined with Indomethacin.Approved, Investigational
IsavuconazoniumThe serum concentration of Sphingosine can be increased when it is combined with Isavuconazonium.Approved, Investigational
ItraconazoleThe serum concentration of Sphingosine can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Sphingosine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Sphingosine can be increased when it is combined with Ivermectin.Approved, Vet Approved
KetamineThe serum concentration of Sphingosine can be increased when it is combined with Ketamine.Approved, Vet Approved
KetoconazoleThe serum concentration of Sphingosine can be increased when it is combined with Ketoconazole.Approved, Investigational
LansoprazoleThe serum concentration of Sphingosine can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Sphingosine can be increased when it is combined with Lapatinib.Approved, Investigational
LevofloxacinThe serum concentration of Sphingosine can be increased when it is combined with Levofloxacin.Approved, Investigational
LevothyroxineThe serum concentration of Sphingosine can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Sphingosine can be increased when it is combined with Lidocaine.Approved, Vet Approved
LiothyronineThe serum concentration of Sphingosine can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Sphingosine can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Sphingosine can be increased when it is combined with Lisinopril.Approved, Investigational
LomitapideThe serum concentration of Sphingosine can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Sphingosine can be increased when it is combined with Loperamide.Approved
LopinavirThe serum concentration of Sphingosine can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Sphingosine can be increased when it is combined with Loratadine.Approved
LosartanThe serum concentration of Sphingosine can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Sphingosine can be increased when it is combined with Lovastatin.Approved, Investigational
LumacaftorThe serum concentration of Sphingosine can be decreased when it is combined with Lumacaftor.Approved
MaprotilineThe serum concentration of Sphingosine can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Sphingosine can be increased when it is combined with Mebendazole.Approved, Vet Approved
MefloquineThe serum concentration of Sphingosine can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Sphingosine can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeprobamateThe serum concentration of Sphingosine can be increased when it is combined with Meprobamate.Approved, Illicit
MethadoneThe serum concentration of Sphingosine can be increased when it is combined with Methadone.Approved
MetoprololThe serum concentration of Sphingosine can be increased when it is combined with Metoprolol.Approved, Investigational
MibefradilThe serum concentration of Sphingosine can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Sphingosine can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Sphingosine can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Sphingosine can be decreased when it is combined with Mifepristone.Approved, Investigational
MitomycinThe serum concentration of Sphingosine can be increased when it is combined with Mitomycin.Approved
MitoxantroneThe serum concentration of Sphingosine can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MorphineThe serum concentration of Sphingosine can be increased when it is combined with Morphine.Approved, Investigational
NaltrexoneThe serum concentration of Sphingosine can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Sphingosine can be increased when it is combined with Naringenin.Experimental
NefazodoneThe serum concentration of Sphingosine can be decreased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Sphingosine can be decreased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Sphingosine can be increased when it is combined with Neostigmine.Approved, Vet Approved
NicardipineThe serum concentration of Sphingosine can be increased when it is combined with Nicardipine.Approved
NifedipineThe serum concentration of Sphingosine can be decreased when it is combined with Nifedipine.Approved
NilotinibThe serum concentration of Sphingosine can be increased when it is combined with Nilotinib.Approved, Investigational
NisoldipineThe serum concentration of Sphingosine can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Sphingosine can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Sphingosine can be increased when it is combined with Nitrendipine.Approved
NorethisteroneThe serum concentration of Sphingosine can be decreased when it is combined with Norethisterone.Approved
OmeprazoleThe serum concentration of Sphingosine can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Sphingosine can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Sphingosine can be increased when it is combined with Paclitaxel.Approved, Vet Approved
Palmitic AcidThe serum concentration of Sphingosine can be increased when it is combined with Palmitic Acid.Experimental
PantoprazoleThe serum concentration of Sphingosine can be increased when it is combined with Pantoprazole.Approved
ParoxetineThe serum concentration of Sphingosine can be increased when it is combined with Paroxetine.Approved, Investigational
PerindoprilThe serum concentration of Sphingosine can be increased when it is combined with Perindopril.Approved
PhenobarbitalThe serum concentration of Sphingosine can be decreased when it is combined with Phenobarbital.Approved
PimozideThe serum concentration of Sphingosine can be increased when it is combined with Pimozide.Approved
Platelet Activating FactorThe serum concentration of Sphingosine can be decreased when it is combined with Platelet Activating Factor.Experimental
PonatinibThe serum concentration of Sphingosine can be increased when it is combined with Ponatinib.Approved
PosaconazoleThe serum concentration of Sphingosine can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Sphingosine can be increased when it is combined with Pravastatin.Approved
PrazosinThe serum concentration of Sphingosine can be increased when it is combined with Prazosin.Approved
PrednisoneThe serum concentration of Sphingosine can be increased when it is combined with Prednisone.Approved, Vet Approved
ProbenecidThe serum concentration of Sphingosine can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Sphingosine can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Sphingosine can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Sphingosine can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Sphingosine can be increased when it is combined with Propranolol.Approved, Investigational
ProtriptylineThe serum concentration of Sphingosine can be increased when it is combined with Protriptyline.Approved
QuercetinThe serum concentration of Sphingosine can be increased when it is combined with Quercetin.Experimental
QuinacrineThe serum concentration of Sphingosine can be increased when it is combined with Quinacrine.Approved
QuinidineThe serum concentration of Sphingosine can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Sphingosine can be increased when it is combined with Quinine.Approved
RanitidineThe serum concentration of Sphingosine can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Sphingosine can be increased when it is combined with Ranolazine.Approved, Investigational
ReboxetineThe serum concentration of Sphingosine can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Sphingosine can be increased when it is combined with Regorafenib.Approved
ReserpineThe serum concentration of Sphingosine can be decreased when it is combined with Reserpine.Approved
RifampicinThe serum concentration of Sphingosine can be decreased when it is combined with Rifampicin.Approved
RilpivirineThe serum concentration of Sphingosine can be increased when it is combined with Rilpivirine.Approved
RitonavirThe serum concentration of Sphingosine can be decreased when it is combined with Ritonavir.Approved, Investigational
RolapitantThe serum concentration of Sphingosine can be increased when it is combined with Rolapitant.Approved
SaquinavirThe serum concentration of Sphingosine can be decreased when it is combined with Saquinavir.Approved, Investigational
ScopolamineThe serum concentration of Sphingosine can be increased when it is combined with Scopolamine.Approved
SelegilineThe serum concentration of Sphingosine can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SertralineThe serum concentration of Sphingosine can be increased when it is combined with Sertraline.Approved
SimeprevirThe serum concentration of Sphingosine can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Sphingosine can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Sphingosine can be decreased when it is combined with Sirolimus.Approved, Investigational
SorafenibThe serum concentration of Sphingosine can be increased when it is combined with Sorafenib.Approved, Investigational
SpironolactoneThe serum concentration of Sphingosine can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Sphingosine can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Sphingosine can be increased when it is combined with Staurosporine.Experimental
StreptozocinThe serum concentration of Sphingosine can be decreased when it is combined with Streptozocin.Approved
SulfinpyrazoneThe serum concentration of Sphingosine can be increased when it is combined with Sulfinpyrazone.Approved
SumatriptanThe serum concentration of Sphingosine can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Sphingosine can be increased when it is combined with Sunitinib.Approved, Investigational
TacrineThe serum concentration of Sphingosine can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Sphingosine can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Sphingosine can be decreased when it is combined with Tamoxifen.Approved
Taurocholic AcidThe serum concentration of Sphingosine can be increased when it is combined with Taurocholic Acid.Experimental
TelmisartanThe serum concentration of Sphingosine can be increased when it is combined with Telmisartan.Approved, Investigational
TemsirolimusThe serum concentration of Sphingosine can be increased when it is combined with Temsirolimus.Approved
TerazosinThe serum concentration of Sphingosine can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Sphingosine can be increased when it is combined with Terfenadine.Withdrawn
TesmilifeneThe serum concentration of Sphingosine can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Sphingosine can be increased when it is combined with Testosterone.Approved, Investigational
TicagrelorThe serum concentration of Sphingosine can be increased when it is combined with Ticagrelor.Approved
TolvaptanThe serum concentration of Sphingosine can be increased when it is combined with Tolvaptan.Approved
TrazodoneThe serum concentration of Sphingosine can be decreased when it is combined with Trazodone.Approved, Investigational
TrifluoperazineThe serum concentration of Sphingosine can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Sphingosine can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Sphingosine can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Sphingosine can be increased when it is combined with Trimipramine.Approved
TroleandomycinThe serum concentration of Sphingosine can be increased when it is combined with Troleandomycin.Approved
VenlafaxineThe serum concentration of Sphingosine can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Sphingosine can be decreased when it is combined with Verapamil.Approved
VinblastineThe serum concentration of Sphingosine can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Sphingosine can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Sphingosine can be increased when it is combined with Vinorelbine.Approved, Investigational
ZimelidineThe serum concentration of Sphingosine can be increased when it is combined with Zimelidine.Withdrawn
Food InteractionsNot Available
References
Synthesis Reference

Dennis Liotta, Alfred H. Merrill, “Method of preparing sphingosine derivatives.” U.S. Patent US5110987, issued August, 1976.

US5110987
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.995
Blood Brain Barrier+0.5839
Caco-2 permeable-0.573
P-glycoprotein substrateSubstrate0.5295
P-glycoprotein inhibitor INon-inhibitor0.9155
P-glycoprotein inhibitor IINon-inhibitor0.7564
Renal organic cation transporterNon-inhibitor0.8759
CYP450 2C9 substrateNon-substrate0.8247
CYP450 2D6 substrateNon-substrate0.706
CYP450 3A4 substrateNon-substrate0.7191
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9151
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7332
Ames testNon AMES toxic0.7957
CarcinogenicityNon-carcinogens0.7754
BiodegradationReady biodegradable0.748
Rat acute toxicity1.6142 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8822
hERG inhibition (predictor II)Non-inhibitor0.854
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point67 °CPhysProp
Predicted Properties
PropertyValueSource
Water Solubility0.0039 mg/mLALOGPS
logP5.15ALOGPS
logP4.57ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)14.12ChemAxon
pKa (Strongest Basic)9.23ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area66.48 Å2ChemAxon
Rotatable Bond Count15ChemAxon
Refractivity91.89 m3·mol-1ChemAxon
Polarizability39.36 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as sphingolipids. These are lipids containing backbone of sphingoid bases (e.g. Sphinogsine, sphinganine) usually bound to a fatty acid derivative through N-acylation.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSphingolipids
Sub ClassNot Available
Direct ParentSphingolipids
Alternative Parents
Substituents
  • Sphingoid base
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Hydrocarbon derivative
  • Primary amine
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Amine
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Lipid binding
Specific Function:
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.
Gene Name:
GLTP
Uniprot ID:
Q9NZD2
Molecular Weight:
23849.6 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Poliovirus type 1 (strain Mahoney)
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor PVR to provide virion attachment to targe...
Gene Name:
Not Available
Uniprot ID:
P03300
Molecular Weight:
246538.14 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
HRV-14
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host ICAM1 to provide virion attachment to target host cells...
Gene Name:
Not Available
Uniprot ID:
P03303
Molecular Weight:
242989.38 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
SVDV
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host CXADR to provide virion attachment to target host cells...
Gene Name:
Not Available
Uniprot ID:
P13900
Molecular Weight:
243363.48 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor to provide virion attachment to target ho...
Gene Name:
Not Available
Uniprot ID:
P03302
Molecular Weight:
246162.675 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Virus receptor activity
Specific Function:
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. Ma...
Gene Name:
PVR
Uniprot ID:
P15151
Molecular Weight:
45302.3 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Sugawara T, Kinoshita M, Ohnishi M, Tsuzuki T, Miyazawa T, Nagata J, Hirata T, Saito M: Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells. Biosci Biotechnol Biochem. 2004 Dec;68(12):2541-6. [PubMed:15618625 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23