Glypromate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Glypromate
Accession Number
DB05633
Type
Small Molecule
Groups
Investigational
Description

Neuren Pharmaceuticals was developing Glypromate (glycine-proline glutamate), a naturally occurring small-molecule neuroprotectant derived from IGF-1 which inhibits caspase III dependent apoptosis, for the potential treatment of neurodegenerative diseases by IV infusion. In December 2008, the company discontinued further development of the drug after it failed to show an observable effect.

Structure
Thumb
Synonyms
  • Gly-pro-glu
  • Glycyl-prolyl-glutamic acid
  • GPE
Categories
UNII
ZYK4RVV5LS
CAS number
32302-76-4
Weight
Average: 301.299
Monoisotopic: 301.127385344
Chemical Formula
C12H19N3O6
InChI Key
JJGBXTYGTKWGAT-YUMQZZPRSA-N
InChI
InChI=1S/C12H19N3O6/c13-6-9(16)15-5-1-2-8(15)11(19)14-7(12(20)21)3-4-10(17)18/h7-8H,1-6,13H2,(H,14,19)(H,17,18)(H,20,21)/t7-,8-/m0/s1
IUPAC Name
(2S)-2-({[(2S)-1-(2-aminoacetyl)pyrrolidin-2-yl](hydroxy)methylidene}amino)pentanedioic acid
SMILES
[H][C@@](CCC(O)=O)(N=C(O)[C@]1([H])CCCN1C(=O)CN)C(O)=O

Pharmacology

Indication

Investigated for use/treatment in neurologic disorders.

Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
2338502
ChEMBL
CHEMBL371315

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility4.11 mg/mLALOGPS
logP-3.3ALOGPS
logP-4.1ChemAxon
logS-1.9ALOGPS
pKa (Strongest Acidic)3.2ChemAxon
pKa (Strongest Basic)8.13ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area153.52 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity69.6 m3·mol-1ChemAxon
Polarizability28.93 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 18, 2007 11:26 / Updated on August 02, 2019 07:46