| 4-Methoxyamphetamine | The metabolism of 4-Methoxyamphetamine can be decreased when combined with Rolapitant. | Experimental, Illicit |
| Acebutolol | The serum concentration of Acebutolol can be increased when it is combined with Rolapitant. | Approved |
| Acetaminophen | The serum concentration of Acetaminophen can be increased when it is combined with Rolapitant. | Approved |
| Acetylcholine | The metabolism of Acetylcholine can be decreased when combined with Rolapitant. | Approved |
| Acetylsalicylic acid | The serum concentration of Acetylsalicylic acid can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Afatinib | The serum concentration of Afatinib can be increased when it is combined with Rolapitant. | Approved |
| Ajmaline | The metabolism of Ajmaline can be decreased when combined with Rolapitant. | Approved |
| Aldosterone | The serum concentration of Aldosterone can be increased when it is combined with Rolapitant. | Experimental |
| Alitretinoin | The serum concentration of Alitretinoin can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Almotriptan | The metabolism of Almotriptan can be decreased when combined with Rolapitant. | Approved, Investigational |
| Alogliptin | The metabolism of Alogliptin can be decreased when combined with Rolapitant. | Approved |
| Alprenolol | The metabolism of Alprenolol can be decreased when combined with Rolapitant. | Approved, Withdrawn |
| Alvocidib | The serum concentration of Flavopiridol can be increased when it is combined with Rolapitant. | Experimental, Investigational |
| Ambrisentan | The serum concentration of Ambrisentan can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Aminophenazone | The metabolism of Aminophenazone can be decreased when combined with Rolapitant. | Approved, Withdrawn |
| Amiodarone | The metabolism of Rolapitant can be decreased when combined with Amiodarone. | Approved, Investigational |
| Amitriptyline | The serum concentration of Amitriptyline can be increased when it is combined with Rolapitant. | Approved |
| Amoxapine | The metabolism of Amoxapine can be decreased when combined with Rolapitant. | Approved |
| Amphetamine | The metabolism of Amphetamine can be decreased when combined with Rolapitant. | Approved, Illicit |
| Amprenavir | The metabolism of Amprenavir can be decreased when combined with Rolapitant. | Approved |
| Amsacrine | The metabolism of Amsacrine can be decreased when combined with Rolapitant. | Approved |
| Antipyrine | The metabolism of Antipyrine can be decreased when combined with Rolapitant. | Approved |
| Apixaban | The serum concentration of Apixaban can be increased when it is combined with Rolapitant. | Approved |
| Aprepitant | The serum concentration of Rolapitant can be increased when it is combined with Aprepitant. | Approved, Investigational |
| Aprindine | The metabolism of Aprindine can be decreased when combined with Rolapitant. | Approved |
| Arformoterol | The metabolism of Arformoterol can be decreased when combined with Rolapitant. | Approved, Investigational |
| Aripiprazole | The serum concentration of Aripiprazole can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Arsenic trioxide | The serum concentration of Arsenic trioxide can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Artemether | The metabolism of Artemether can be decreased when combined with Rolapitant. | Approved |
| Astemizole | The metabolism of Astemizole can be decreased when combined with Rolapitant. | Approved, Withdrawn |
| Atazanavir | The metabolism of Rolapitant can be decreased when combined with Atazanavir. | Approved, Investigational |
| Atenolol | The serum concentration of Atenolol can be increased when it is combined with Rolapitant. | Approved |
| Atomoxetine | The metabolism of Rolapitant can be decreased when combined with Atomoxetine. | Approved |
| Axitinib | The serum concentration of Axitinib can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Azelastine | The metabolism of Azelastine can be decreased when combined with Rolapitant. | Approved |
| Benzatropine | The metabolism of Benzatropine can be decreased when combined with Rolapitant. | Approved |
| Benzyl alcohol | The metabolism of Benzyl alcohol can be decreased when combined with Rolapitant. | Approved |
| Bepridil | The metabolism of Bepridil can be decreased when combined with Rolapitant. | Approved, Withdrawn |
| Betamethasone | The serum concentration of Betamethasone can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Betaxolol | The metabolism of Betaxolol can be decreased when combined with Rolapitant. | Approved |
| Bexarotene | The serum concentration of Rolapitant can be decreased when it is combined with Bexarotene. | Approved, Investigational |
| Bisoprolol | The metabolism of Bisoprolol can be decreased when combined with Rolapitant. | Approved |
| Boceprevir | The metabolism of Rolapitant can be decreased when combined with Boceprevir. | Withdrawn |
| Bortezomib | The metabolism of Rolapitant can be decreased when combined with Bortezomib. | Approved, Investigational |
| Bosentan | The serum concentration of Rolapitant can be decreased when it is combined with Bosentan. | Approved, Investigational |
| Bosutinib | The serum concentration of Bosutinib can be increased when it is combined with Rolapitant. | Approved |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be increased when it is combined with Rolapitant. | Approved |
| Brexpiprazole | The serum concentration of Brexpiprazole can be increased when it is combined with Rolapitant. | Approved |
| Bromocriptine | The serum concentration of Bromocriptine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Brompheniramine | The metabolism of Brompheniramine can be decreased when combined with Rolapitant. | Approved |
| Bufuralol | The metabolism of Bufuralol can be decreased when combined with Rolapitant. | Experimental, Investigational |
| Bupivacaine | The metabolism of Bupivacaine can be decreased when combined with Rolapitant. | Approved, Investigational |
| Buprenorphine | The metabolism of Buprenorphine can be decreased when combined with Rolapitant. | Approved, Illicit, Investigational, Vet Approved |
| Bupropion | The metabolism of Bupropion can be decreased when combined with Rolapitant. | Approved |
| Buspirone | The metabolism of Buspirone can be decreased when combined with Rolapitant. | Approved, Investigational |
| Cabazitaxel | The serum concentration of Cabazitaxel can be increased when it is combined with Rolapitant. | Approved |
| Caffeine | The serum concentration of Caffeine can be increased when it is combined with Rolapitant. | Approved |
| Camptothecin | The serum concentration of Camptothecin can be increased when it is combined with Rolapitant. | Experimental |
| Canagliflozin | The serum concentration of Canagliflozin can be increased when it is combined with Rolapitant. | Approved |
| Captopril | The metabolism of Captopril can be decreased when combined with Rolapitant. | Approved |
| Carbamazepine | The serum concentration of Rolapitant can be decreased when it is combined with Carbamazepine. | Approved, Investigational |
| Carboplatin | The serum concentration of Carboplatin can be increased when it is combined with Rolapitant. | Approved |
| Carfilzomib | The serum concentration of Carfilzomib can be increased when it is combined with Rolapitant. | Approved |
| Cariprazine | The metabolism of Cariprazine can be decreased when combined with Rolapitant. | Approved |
| Carteolol | The metabolism of Carteolol can be decreased when combined with Rolapitant. | Approved |
| Carvedilol | The metabolism of Carvedilol can be decreased when combined with Rolapitant. | Approved, Investigational |
| Cephalexin | The metabolism of Cephalexin can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Ceritinib | The serum concentration of Rolapitant can be increased when it is combined with Ceritinib. | Approved |
| Cerivastatin | The serum concentration of Cerivastatin can be increased when it is combined with Rolapitant. | Withdrawn |
| Cevimeline | The metabolism of Cevimeline can be decreased when combined with Rolapitant. | Approved |
| Chlordiazepoxide | The metabolism of Chlordiazepoxide can be decreased when combined with Rolapitant. | Approved, Illicit |
| Chloroquine | The metabolism of Chloroquine can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Chlorphenamine | The metabolism of Chlorphenamine can be decreased when combined with Rolapitant. | Approved |
| Chlorpromazine | The serum concentration of Chlorpromazine can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Chlorzoxazone | The metabolism of Chlorzoxazone can be decreased when combined with Rolapitant. | Approved |
| Cholesterol | The serum concentration of Cholesterol can be increased when it is combined with Rolapitant. | Experimental |
| Cilostazol | The metabolism of Cilostazol can be decreased when combined with Rolapitant. | Approved |
| Cimetidine | The serum concentration of Cimetidine can be increased when it is combined with Rolapitant. | Approved |
| Cinnarizine | The metabolism of Cinnarizine can be decreased when combined with Rolapitant. | Approved |
| Ciprofloxacin | The serum concentration of Ciprofloxacin can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Cisplatin | The serum concentration of Cisplatin can be increased when it is combined with Rolapitant. | Approved |
| Citalopram | The serum concentration of Citalopram can be increased when it is combined with Rolapitant. | Approved |
| Cladribine | The serum concentration of Cladribine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Clarithromycin | The metabolism of Rolapitant can be decreased when combined with Clarithromycin. | Approved |
| Clemastine | The metabolism of Rolapitant can be decreased when combined with Clemastine. | Approved |
| Clevidipine | The metabolism of Clevidipine can be decreased when combined with Rolapitant. | Approved |
| Clobazam | The serum concentration of Clobazam can be increased when it is combined with Rolapitant. | Approved, Illicit |
| Clofarabine | The serum concentration of Clofarabine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Clomifene | The serum concentration of Clomifene can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Clomipramine | The metabolism of Clomipramine can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Clonidine | The serum concentration of Clonidine can be increased when it is combined with Rolapitant. | Approved |
| Clopidogrel | The serum concentration of Clopidogrel can be increased when it is combined with Rolapitant. | Approved, Nutraceutical |
| Clotrimazole | The metabolism of Rolapitant can be decreased when combined with Clotrimazole. | Approved, Vet Approved |
| Clozapine | The serum concentration of Clozapine can be increased when it is combined with Rolapitant. | Approved |
| Cobicistat | The metabolism of Rolapitant can be decreased when combined with Cobicistat. | Approved |
| Cobimetinib | The serum concentration of Cobimetinib can be increased when it is combined with Rolapitant. | Approved |
| Codeine | The therapeutic efficacy of Codeine can be decreased when used in combination with Rolapitant. | Approved, Illicit |
| Colchicine | The serum concentration of Colchicine can be increased when it is combined with Rolapitant. | Approved |
| Conivaptan | The serum concentration of Rolapitant can be increased when it is combined with Conivaptan. | Approved, Investigational |
| Conjugated estrogens | The serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Rolapitant. | Approved |
| Crizotinib | The metabolism of Rolapitant can be decreased when combined with Crizotinib. | Approved |
| Cyclobenzaprine | The metabolism of Cyclobenzaprine can be decreased when combined with Rolapitant. | Approved |
| Cyclophosphamide | The metabolism of Cyclophosphamide can be decreased when combined with Rolapitant. | Approved, Investigational |
| Cyclosporine | The metabolism of Rolapitant can be decreased when combined with Cyclosporine. | Approved, Investigational, Vet Approved |
| Dabigatran etexilate | The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Rolapitant. | Approved |
| Dabrafenib | The serum concentration of Rolapitant can be decreased when it is combined with Dabrafenib. | Approved |
| Dactinomycin | The serum concentration of Dactinomycin can be increased when it is combined with Rolapitant. | Approved |
| Dapagliflozin | The serum concentration of Dapagliflozin can be increased when it is combined with Rolapitant. | Approved |
| Darifenacin | The metabolism of Darifenacin can be decreased when combined with Rolapitant. | Approved, Investigational |
| Darunavir | The metabolism of Rolapitant can be decreased when combined with Darunavir. | Approved |
| Dasabuvir | The metabolism of Dasabuvir can be decreased when combined with Rolapitant. | Approved |
| Dasatinib | The serum concentration of Dasatinib can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Daunorubicin | The serum concentration of Daunorubicin can be increased when it is combined with Rolapitant. | Approved |
| Debrisoquin | The serum concentration of Debrisoquin can be increased when it is combined with Rolapitant. | Approved |
| Deferasirox | The serum concentration of Rolapitant can be decreased when it is combined with Deferasirox. | Approved, Investigational |
| Delavirdine | The metabolism of Rolapitant can be decreased when combined with Delavirdine. | Approved |
| Desipramine | The metabolism of Desipramine can be decreased when combined with Rolapitant. | Approved |
| Dexamethasone | The serum concentration of Rolapitant can be decreased when it is combined with Dexamethasone. | Approved, Investigational, Vet Approved |
| Dexfenfluramine | The metabolism of Dexfenfluramine can be decreased when combined with Rolapitant. | Approved, Illicit, Withdrawn |
| Dexmethylphenidate | The metabolism of Dexmethylphenidate can be decreased when combined with Rolapitant. | Approved |
| Dextroamphetamine | The metabolism of Dextroamphetamine can be decreased when combined with Rolapitant. | Approved, Illicit |
| Dextromethorphan | The metabolism of Dextromethorphan can be decreased when combined with Rolapitant. | Approved |
| Diazepam | The serum concentration of Diazepam can be increased when it is combined with Rolapitant. | Approved, Illicit, Vet Approved |
| Diethylstilbestrol | The serum concentration of Diethylstilbestrol can be increased when it is combined with Rolapitant. | Approved |
| Digitoxin | The serum concentration of Digitoxin can be increased when it is combined with Rolapitant. | Approved |
| Digoxin | The serum concentration of Digoxin can be increased when it is combined with Rolapitant. | Approved |
| Dihydrocodeine | The metabolism of Dihydrocodeine can be decreased when combined with Rolapitant. | Approved, Illicit |
| Dihydroergotamine | The metabolism of Rolapitant can be decreased when combined with Dihydroergotamine. | Approved |
| Dihydrotestosterone | The serum concentration of Dihydrotestosterone can be increased when it is combined with Rolapitant. | Illicit |
| Diltiazem | The metabolism of Rolapitant can be decreased when combined with Diltiazem. | Approved |
| Diphenhydramine | The metabolism of Diphenhydramine can be decreased when combined with Rolapitant. | Approved |
| Dipyridamole | The serum concentration of Dipyridamole can be increased when it is combined with Rolapitant. | Approved |
| Docetaxel | The serum concentration of Docetaxel can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Dolasetron | The metabolism of Dolasetron can be decreased when combined with Rolapitant. | Approved |
| Domperidone | The serum concentration of Domperidone can be increased when it is combined with Rolapitant. | Approved, Investigational, Vet Approved |
| Donepezil | The metabolism of Donepezil can be decreased when combined with Rolapitant. | Approved |
| Dopamine | The metabolism of Dopamine can be decreased when combined with Rolapitant. | Approved |
| Doxazosin | The metabolism of Doxazosin can be decreased when combined with Rolapitant. | Approved |
| Doxepin | The metabolism of Doxepin can be decreased when combined with Rolapitant. | Approved |
| Doxorubicin | The serum concentration of Doxorubicin can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Doxycycline | The metabolism of Rolapitant can be decreased when combined with Doxycycline. | Approved, Investigational, Vet Approved |
| Dronedarone | The metabolism of Rolapitant can be decreased when combined with Dronedarone. | Approved |
| Duloxetine | The metabolism of Duloxetine can be decreased when combined with Rolapitant. | Approved |
| Edoxaban | The serum concentration of Edoxaban can be increased when it is combined with Rolapitant. | Approved |
| Efavirenz | The serum concentration of Rolapitant can be decreased when it is combined with Efavirenz. | Approved, Investigational |
| Eletriptan | The serum concentration of Eletriptan can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Eliglustat | The serum concentration of Eliglustat can be increased when it is combined with Rolapitant. | Approved |
| Encainide | The metabolism of Encainide can be decreased when combined with Rolapitant. | Approved, Withdrawn |
| Enclomiphene | The metabolism of Enclomiphene can be decreased when combined with Rolapitant. | Investigational |
| Enzalutamide | The serum concentration of Rolapitant can be decreased when it is combined with Enzalutamide. | Approved |
| Epinastine | The serum concentration of Epinastine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Erlotinib | The serum concentration of Erlotinib can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Erythromycin | The metabolism of Rolapitant can be decreased when combined with Erythromycin. | Approved, Vet Approved |
| Escitalopram | The metabolism of Escitalopram can be decreased when combined with Rolapitant. | Approved, Investigational |
| Eslicarbazepine acetate | The serum concentration of Rolapitant can be decreased when it is combined with Eslicarbazepine acetate. | Approved |
| Esmirtazapine | The metabolism of Esmirtazapine can be decreased when combined with Rolapitant. | Investigational |
| Estradiol | The serum concentration of Estradiol can be increased when it is combined with Rolapitant. | Approved, Investigational, Vet Approved |
| Estriol | The serum concentration of Estriol can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Estrone | The serum concentration of Estrone can be increased when it is combined with Rolapitant. | Approved |
| Ethinyl Estradiol | The serum concentration of Ethinyl Estradiol can be increased when it is combined with Rolapitant. | Approved |
| Ethylmorphine | The metabolism of Ethylmorphine can be decreased when combined with Rolapitant. | Approved, Illicit |
| Etoposide | The serum concentration of Etoposide can be increased when it is combined with Rolapitant. | Approved |
| Etoricoxib | The metabolism of Etoricoxib can be decreased when combined with Rolapitant. | Approved, Investigational |
| Etravirine | The serum concentration of Rolapitant can be decreased when it is combined with Etravirine. | Approved |
| Everolimus | The serum concentration of Everolimus can be increased when it is combined with Rolapitant. | Approved |
| Ezetimibe | The serum concentration of Ezetimibe can be increased when it is combined with Rolapitant. | Approved |
| Fesoterodine | The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Rolapitant. | Approved |
| Fexofenadine | The serum concentration of Fexofenadine can be increased when it is combined with Rolapitant. | Approved |
| Fidaxomicin | The serum concentration of Fidaxomicin can be increased when it is combined with Rolapitant. | Approved |
| Fingolimod | The metabolism of Fingolimod can be decreased when combined with Rolapitant. | Approved, Investigational |
| Flecainide | The metabolism of Flecainide can be decreased when combined with Rolapitant. | Approved, Withdrawn |
| Fluconazole | The metabolism of Rolapitant can be decreased when combined with Fluconazole. | Approved |
| Flunarizine | The metabolism of Flunarizine can be decreased when combined with Rolapitant. | Approved |
| Fluorouracil | The serum concentration of Fluorouracil can be increased when it is combined with Rolapitant. | Approved |
| Fluoxetine | The metabolism of Fluoxetine can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Fluphenazine | The metabolism of Fluphenazine can be decreased when combined with Rolapitant. | Approved |
| Fluticasone furoate | The serum concentration of Fluticasone furoate can be increased when it is combined with Rolapitant. | Approved |
| Fluvastatin | The metabolism of Fluvastatin can be decreased when combined with Rolapitant. | Approved |
| Fluvoxamine | The metabolism of Rolapitant can be decreased when combined with Fluvoxamine. | Approved, Investigational |
| Folic Acid | The serum concentration of Folic Acid can be increased when it is combined with Rolapitant. | Approved, Nutraceutical, Vet Approved |
| Formoterol | The metabolism of Formoterol can be decreased when combined with Rolapitant. | Approved, Investigational |
| Fosamprenavir | The metabolism of Rolapitant can be decreased when combined with Fosamprenavir. | Approved |
| Fosaprepitant | The serum concentration of Rolapitant can be increased when it is combined with Fosaprepitant. | Approved |
| Fosphenytoin | The serum concentration of Rolapitant can be decreased when it is combined with Fosphenytoin. | Approved |
| Fusidic Acid | The serum concentration of Rolapitant can be increased when it is combined with Fusidic Acid. | Approved |
| Galantamine | The metabolism of Galantamine can be decreased when combined with Rolapitant. | Approved |
| Gefitinib | The serum concentration of Gefitinib can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Gemcitabine | The serum concentration of Gemcitabine can be increased when it is combined with Rolapitant. | Approved |
| Glyburide | The serum concentration of Glyburide can be increased when it is combined with Rolapitant. | Approved |
| Granisetron | The metabolism of Granisetron can be decreased when combined with Rolapitant. | Approved, Investigational |
| Grazoprevir | The serum concentration of Grazoprevir can be increased when it is combined with Rolapitant. | Approved |
| Grepafloxacin | The serum concentration of Grepafloxacin can be increased when it is combined with Rolapitant. | Withdrawn |
| Halofantrine | The metabolism of Halofantrine can be decreased when combined with Rolapitant. | Approved |
| Haloperidol | The serum concentration of Haloperidol can be increased when it is combined with Rolapitant. | Approved |
| Halothane | The metabolism of Halothane can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Hydrocodone | The metabolism of Hydrocodone can be decreased when combined with Rolapitant. | Approved, Illicit |
| Hydrocortisone | The serum concentration of Hydrocortisone can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Hydromorphone | The metabolism of Hydromorphone can be decreased when combined with Rolapitant. | Approved, Illicit |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Rolapitant. | Approved |
| Ibuprofen | The serum concentration of Ibuprofen can be increased when it is combined with Rolapitant. | Approved |
| Idarubicin | The metabolism of Idarubicin can be decreased when combined with Rolapitant. | Approved |
| Idelalisib | The serum concentration of Rolapitant can be increased when it is combined with Idelalisib. | Approved |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Rolapitant. | Approved |
| Imatinib | The serum concentration of Imatinib can be increased when it is combined with Rolapitant. | Approved |
| Imipramine | The serum concentration of Imipramine can be increased when it is combined with Rolapitant. | Approved |
| Indacaterol | The serum concentration of Indacaterol can be increased when it is combined with Rolapitant. | Approved |
| Indinavir | The metabolism of Rolapitant can be decreased when combined with Indinavir. | Approved |
| Indomethacin | The serum concentration of Indomethacin can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Ipratropium bromide | The metabolism of Ipratropium bromide can be decreased when combined with Rolapitant. | Approved |
| Irinotecan | The serum concentration of Irinotecan can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Isavuconazonium | The metabolism of Rolapitant can be decreased when combined with Isavuconazonium. | Approved, Investigational |
| Isradipine | The metabolism of Rolapitant can be decreased when combined with Isradipine. | Approved |
| Itraconazole | The metabolism of Rolapitant can be decreased when combined with Itraconazole. | Approved, Investigational |
| Ivacaftor | The serum concentration of Rolapitant can be increased when it is combined with Ivacaftor. | Approved |
| Ivermectin | The serum concentration of Ivermectin can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Ixazomib | The metabolism of Ixazomib can be decreased when combined with Rolapitant. | Approved |
| Ketazolam | The serum concentration of Ketazolam can be increased when it is combined with Rolapitant. | Approved |
| Ketoconazole | The metabolism of Rolapitant can be decreased when combined with Ketoconazole. | Approved, Investigational |
| Labetalol | The metabolism of Labetalol can be decreased when combined with Rolapitant. | Approved |
| Lamivudine | The serum concentration of Lamivudine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Lamotrigine | The serum concentration of Lamotrigine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Lansoprazole | The serum concentration of Lansoprazole can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Ledipasvir | The serum concentration of Ledipasvir can be increased when it is combined with Rolapitant. | Approved |
| Leflunomide | The serum concentration of Leflunomide can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Lenalidomide | The serum concentration of Lenalidomide can be increased when it is combined with Rolapitant. | Approved |
| Lenvatinib | The serum concentration of Lenvatinib can be increased when it is combined with Rolapitant. | Approved |
| Levetiracetam | The serum concentration of Levetiracetam can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Levodopa | The metabolism of Levodopa can be decreased when combined with Rolapitant. | Approved |
| Levofloxacin | The serum concentration of Levofloxacin can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Levomilnacipran | The serum concentration of Levomilnacipran can be increased when it is combined with Rolapitant. | Approved |
| Lidocaine | The metabolism of Lidocaine can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Linagliptin | The serum concentration of Linagliptin can be increased when it is combined with Rolapitant. | Approved |
| Lisuride | The metabolism of Lisuride can be decreased when combined with Rolapitant. | Approved |
| Lomustine | The metabolism of Lomustine can be decreased when combined with Rolapitant. | Approved |
| Loperamide | The serum concentration of Loperamide can be increased when it is combined with Rolapitant. | Approved |
| Lopinavir | The metabolism of Rolapitant can be decreased when combined with Lopinavir. | Approved |
| Loratadine | The metabolism of Loratadine can be decreased when combined with Rolapitant. | Approved |
| Lorcaserin | The metabolism of Lorcaserin can be decreased when combined with Rolapitant. | Approved |
| Losartan | The serum concentration of Losartan can be increased when it is combined with Rolapitant. | Approved |
| Lovastatin | The metabolism of Rolapitant can be decreased when combined with Lovastatin. | Approved, Investigational |
| Luliconazole | The serum concentration of Rolapitant can be increased when it is combined with Luliconazole. | Approved |
| Lumacaftor | The serum concentration of Rolapitant can be decreased when it is combined with Lumacaftor. | Approved |
| Mannitol | The serum concentration of Mannitol can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Maprotiline | The metabolism of Maprotiline can be decreased when combined with Rolapitant. | Approved |
| Mephenytoin | The metabolism of Mephenytoin can be decreased when combined with Rolapitant. | Investigational, Withdrawn |
| Mequitazine | The metabolism of Mequitazine can be decreased when combined with Rolapitant. | Approved |
| Mesoridazine | The metabolism of Mesoridazine can be decreased when combined with Rolapitant. | Approved |
| Methadone | The metabolism of Methadone can be decreased when combined with Rolapitant. | Approved |
| Methamphetamine | The metabolism of Methamphetamine can be decreased when combined with Rolapitant. | Approved, Illicit |
| Methotrexate | The serum concentration of Methotrexate can be increased when it is combined with Rolapitant. | Approved |
| Methotrimeprazine | The metabolism of Methotrimeprazine can be decreased when combined with Rolapitant. | Approved |
| Methoxyflurane | The metabolism of Methoxyflurane can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Methylphenidate | The metabolism of Methylphenidate can be decreased when combined with Rolapitant. | Approved, Investigational |
| Methylprednisolone | The serum concentration of Methylprednisolone can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Methyprylon | The metabolism of Methyprylon can be decreased when combined with Rolapitant. | Approved, Illicit, Withdrawn |
| Metoclopramide | The metabolism of Metoclopramide can be decreased when combined with Rolapitant. | Approved, Investigational |
| Metoprolol | The serum concentration of Metoprolol can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Mexiletine | The metabolism of Mexiletine can be decreased when combined with Rolapitant. | Approved |
| Mianserin | The metabolism of Mianserin can be decreased when combined with Rolapitant. | Approved |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Rolapitant. | Approved, Illicit |
| Mifepristone | The serum concentration of Rolapitant can be increased when it is combined with Mifepristone. | Approved, Investigational |
| Minaprine | The metabolism of Minaprine can be decreased when combined with Rolapitant. | Approved |
| Mirabegron | The serum concentration of Mirabegron can be increased when it is combined with Rolapitant. | Approved |
| Mirtazapine | The metabolism of Mirtazapine can be decreased when combined with Rolapitant. | Approved |
| Mitotane | The serum concentration of Rolapitant can be decreased when it is combined with Mitotane. | Approved |
| Mitoxantrone | The serum concentration of Mitoxantrone can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Moclobemide | The metabolism of Moclobemide can be decreased when combined with Rolapitant. | Approved |
| Modafinil | The serum concentration of Rolapitant can be decreased when it is combined with Modafinil. | Approved, Investigational |
| Morphine | The serum concentration of Morphine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Mycophenolate mofetil | The serum concentration of Mycophenolate mofetil can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Nadolol | The serum concentration of Nadolol can be increased when it is combined with Rolapitant. | Approved |
| Nafcillin | The serum concentration of Rolapitant can be decreased when it is combined with Nafcillin. | Approved |
| Naloxegol | The serum concentration of Naloxegol can be increased when it is combined with Rolapitant. | Approved |
| Naloxone | The serum concentration of Naloxone can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Nateglinide | The metabolism of Nateglinide can be decreased when combined with Rolapitant. | Approved, Investigational |
| Nebivolol | The serum concentration of Nebivolol can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Nefazodone | The metabolism of Rolapitant can be decreased when combined with Nefazodone. | Approved, Withdrawn |
| Nelfinavir | The metabolism of Rolapitant can be decreased when combined with Nelfinavir. | Approved |
| Netupitant | The serum concentration of Rolapitant can be increased when it is combined with Netupitant. | Approved |
| Nevirapine | The serum concentration of Rolapitant can be decreased when it is combined with Nevirapine. | Approved |
| Nicardipine | The serum concentration of Nicardipine can be increased when it is combined with Rolapitant. | Approved |
| Nicergoline | The metabolism of Nicergoline can be decreased when combined with Rolapitant. | Approved |
| Nicotine | The metabolism of Nicotine can be decreased when combined with Rolapitant. | Approved |
| Nifedipine | The serum concentration of Nifedipine can be increased when it is combined with Rolapitant. | Approved |
| Nilotinib | The serum concentration of Nilotinib can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Nintedanib | The serum concentration of Nintedanib can be increased when it is combined with Rolapitant. | Approved |
| Nitrofural | The metabolism of Nitrofural can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Nitrofurantoin | The serum concentration of Nitrofurantoin can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Nizatidine | The serum concentration of Nizatidine can be increased when it is combined with Rolapitant. | Approved |
| Nortriptyline | The metabolism of Nortriptyline can be decreased when combined with Rolapitant. | Approved |
| Olanzapine | The serum concentration of Olanzapine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Olaparib | The metabolism of Rolapitant can be decreased when combined with Olaparib. | Approved |
| Ombitasvir | The serum concentration of Ombitasvir can be increased when it is combined with Rolapitant. | Approved |
| Ondansetron | The metabolism of Ondansetron can be decreased when combined with Rolapitant. | Approved |
| Osimertinib | The serum concentration of Rolapitant can be increased when it is combined with Osimertinib. | Approved |
| Oxaliplatin | The serum concentration of Oxaliplatin can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Oxycodone | The metabolism of Oxycodone can be decreased when combined with Rolapitant. | Approved, Illicit, Investigational |
| Oxymorphone | The metabolism of Oxymorphone can be decreased when combined with Rolapitant. | Approved, Investigational, Vet Approved |
| Paclitaxel | The serum concentration of Paclitaxel can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Palbociclib | The serum concentration of Rolapitant can be increased when it is combined with Palbociclib. | Approved |
| Palonosetron | The metabolism of Palonosetron can be decreased when combined with Rolapitant. | Approved, Investigational |
| Panobinostat | The serum concentration of Panobinostat can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Paroxetine | The metabolism of Paroxetine can be decreased when combined with Rolapitant. | Approved, Investigational |
| Pazopanib | The serum concentration of Pazopanib can be increased when it is combined with Rolapitant. | Approved |
| Pentamidine | The metabolism of Pentamidine can be decreased when combined with Rolapitant. | Approved |
| Pentobarbital | The serum concentration of Rolapitant can be decreased when it is combined with Pentobarbital. | Approved, Vet Approved |
| Perhexiline | The metabolism of Perhexiline can be decreased when combined with Rolapitant. | Approved |
| Perphenazine | The metabolism of Perphenazine can be decreased when combined with Rolapitant. | Approved |
| Pethidine | The metabolism of Pethidine can be decreased when combined with Rolapitant. | Approved |
| Phenacetin | The metabolism of Phenacetin can be decreased when combined with Rolapitant. | Withdrawn |
| Phenformin | The metabolism of Phenformin can be decreased when combined with Rolapitant. | Approved, Withdrawn |
| Phenobarbital | The serum concentration of Rolapitant can be decreased when it is combined with Phenobarbital. | Approved |
| Phenytoin | The serum concentration of Rolapitant can be decreased when it is combined with Phenytoin. | Approved, Vet Approved |
| Pimozide | The serum concentration of Pimozide can be increased when it is combined with Rolapitant. | Approved |
| Pindolol | The metabolism of Pindolol can be decreased when combined with Rolapitant. | Approved |
| Piperazine | The metabolism of Piperazine can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Pipotiazine | The metabolism of Pipotiazine can be decreased when combined with Rolapitant. | Approved |
| Pitavastatin | The serum concentration of Pitavastatin can be increased when it is combined with Rolapitant. | Approved |
| Pomalidomide | The serum concentration of Pomalidomide can be increased when it is combined with Rolapitant. | Approved |
| Ponatinib | The serum concentration of Ponatinib can be increased when it is combined with Rolapitant. | Approved |
| Posaconazole | The metabolism of Rolapitant can be decreased when combined with Posaconazole. | Approved, Investigational, Vet Approved |
| Pravastatin | The serum concentration of Pravastatin can be increased when it is combined with Rolapitant. | Approved |
| Prazosin | The serum concentration of Prazosin can be increased when it is combined with Rolapitant. | Approved |
| Prednisolone | The serum concentration of Prednisolone can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Prednisone | The serum concentration of Prednisone can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Primidone | The serum concentration of Rolapitant can be decreased when it is combined with Primidone. | Approved, Vet Approved |
| Procainamide | The metabolism of Procainamide can be decreased when combined with Rolapitant. | Approved |
| Prochlorperazine | The metabolism of Prochlorperazine can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Progesterone | The serum concentration of Progesterone can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Promethazine | The metabolism of Promethazine can be decreased when combined with Rolapitant. | Approved |
| Propafenone | The serum concentration of Rolapitant can be increased when it is combined with Propafenone. | Approved |
| Propofol | The metabolism of Propofol can be decreased when combined with Rolapitant. | Approved, Investigational, Vet Approved |
| Propranolol | The serum concentration of Propranolol can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Protriptyline | The metabolism of Protriptyline can be decreased when combined with Rolapitant. | Approved |
| Prucalopride | The serum concentration of Prucalopride can be increased when it is combined with Rolapitant. | Approved |
| Pseudoephedrine | The metabolism of Pseudoephedrine can be decreased when combined with Rolapitant. | Approved |
| Quetiapine | The serum concentration of Quetiapine can be increased when it is combined with Rolapitant. | Approved |
| Quinidine | The serum concentration of Quinidine can be increased when it is combined with Rolapitant. | Approved |
| Quinine | The serum concentration of Quinine can be increased when it is combined with Rolapitant. | Approved |
| Ranitidine | The serum concentration of Ranitidine can be increased when it is combined with Rolapitant. | Approved |
| Ranolazine | The serum concentration of Ranolazine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Remoxipride | The metabolism of Remoxipride can be decreased when combined with Rolapitant. | Approved, Withdrawn |
| Reserpine | The serum concentration of Reserpine can be increased when it is combined with Rolapitant. | Approved |
| Rifabutin | The serum concentration of Rolapitant can be decreased when it is combined with Rifabutin. | Approved |
| Rifampicin | The serum concentration of Rolapitant can be decreased when it is combined with Rifampicin. | Approved |
| Rifapentine | The serum concentration of Rolapitant can be decreased when it is combined with Rifapentine. | Approved |
| Rifaximin | The serum concentration of Rifaximin can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Riluzole | The serum concentration of Riluzole can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Riociguat | The serum concentration of Riociguat can be increased when it is combined with Rolapitant. | Approved |
| Risperidone | The serum concentration of Risperidone can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Ritonavir | The metabolism of Rolapitant can be decreased when combined with Ritonavir. | Approved, Investigational |
| Rivaroxaban | The serum concentration of Rivaroxaban can be increased when it is combined with Rolapitant. | Approved |
| Romidepsin | The serum concentration of Romidepsin can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Ropivacaine | The metabolism of Ropivacaine can be decreased when combined with Rolapitant. | Approved |
| Rosuvastatin | The serum concentration of Rosuvastatin can be increased when it is combined with Rolapitant. | Approved |
| Rotigotine | The metabolism of Rotigotine can be decreased when combined with Rolapitant. | Approved |
| Salicylic acid | The serum concentration of Salicylic acid can be increased when it is combined with Rolapitant. | Approved, Vet Approved |
| Saquinavir | The metabolism of Rolapitant can be decreased when combined with Saquinavir. | Approved, Investigational |
| Selexipag | The serum concentration of Selexipag can be increased when it is combined with Rolapitant. | Approved |
| Sertindole | The metabolism of Sertindole can be decreased when combined with Rolapitant. | Approved, Withdrawn |
| Sertraline | The metabolism of Sertraline can be decreased when combined with Rolapitant. | Approved |
| Sildenafil | The metabolism of Rolapitant can be decreased when combined with Sildenafil. | Approved, Investigational |
| Silodosin | The serum concentration of Silodosin can be increased when it is combined with Rolapitant. | Approved |
| Siltuximab | The serum concentration of Rolapitant can be decreased when it is combined with Siltuximab. | Approved |
| Simeprevir | The serum concentration of Rolapitant can be increased when it is combined with Simeprevir. | Approved |
| Simvastatin | The metabolism of Simvastatin can be decreased when combined with Rolapitant. | Approved |
| Sitagliptin | The serum concentration of Sitagliptin can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Sofosbuvir | The serum concentration of Sofosbuvir can be increased when it is combined with Rolapitant. | Approved |
| Sorafenib | The serum concentration of Sorafenib can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Sparfloxacin | The serum concentration of Sparfloxacin can be increased when it is combined with Rolapitant. | Approved |
| Sparteine | The metabolism of Sparteine can be decreased when combined with Rolapitant. | Experimental |
| Sphingosine | The serum concentration of Sphingosine can be increased when it is combined with Rolapitant. | Experimental |
| St. John's Wort | The serum concentration of Rolapitant can be decreased when it is combined with St. John's Wort. | Nutraceutical |
| Stiripentol | The serum concentration of Rolapitant can be increased when it is combined with Stiripentol. | Approved |
| Sulfasalazine | The serum concentration of Sulfasalazine can be increased when it is combined with Rolapitant. | Approved |
| Sulfisoxazole | The metabolism of Rolapitant can be decreased when combined with Sulfisoxazole. | Approved, Vet Approved |
| Sumatriptan | The serum concentration of Sumatriptan can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Tamoxifen | The serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Rolapitant resulting in a loss in efficacy. | Approved |
| Tamsulosin | The metabolism of Tamsulosin can be decreased when combined with Rolapitant. | Approved, Investigational |
| Tapentadol | The metabolism of Tapentadol can be decreased when combined with Rolapitant. | Approved |
| Taurocholic Acid | The serum concentration of Taurocholic Acid can be increased when it is combined with Rolapitant. | Experimental |
| Technetium Tc-99m sestamibi | The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Rolapitant. | Approved |
| Tegaserod | The metabolism of Tegaserod can be decreased when combined with Rolapitant. | Investigational, Withdrawn |
| Telaprevir | The metabolism of Rolapitant can be decreased when combined with Telaprevir. | Withdrawn |
| Telithromycin | The metabolism of Rolapitant can be decreased when combined with Telithromycin. | Approved |
| Temsirolimus | The serum concentration of Temsirolimus can be increased when it is combined with Rolapitant. | Approved |
| Teniposide | The serum concentration of Teniposide can be increased when it is combined with Rolapitant. | Approved |
| Terfenadine | The metabolism of Terfenadine can be decreased when combined with Rolapitant. | Withdrawn |
| Teriflunomide | The serum concentration of Teriflunomide can be increased when it is combined with Rolapitant. | Approved |
| Tesmilifene | The metabolism of Tesmilifene can be decreased when combined with Rolapitant. | Investigational |
| Testosterone | The serum concentration of Testosterone can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Tetrabenazine | The metabolism of Tetrabenazine can be decreased when combined with Rolapitant. | Approved |
| Theophylline | The metabolism of Theophylline can be decreased when combined with Rolapitant. | Approved |
| Thioridazine | The serum concentration of Thioridazine can be increased when it is combined with Rolapitant. | Withdrawn |
| Ticagrelor | The serum concentration of Ticagrelor can be increased when it is combined with Rolapitant. | Approved |
| Ticlopidine | The metabolism of Rolapitant can be decreased when combined with Ticlopidine. | Approved |
| Timolol | The serum concentration of Timolol can be increased when it is combined with Rolapitant. | Approved |
| Tiotropium | The metabolism of Tiotropium can be decreased when combined with Rolapitant. | Approved |
| Tipranavir | The metabolism of Tipranavir can be decreased when combined with Rolapitant. | Approved, Investigational |
| Tocilizumab | The serum concentration of Rolapitant can be decreased when it is combined with Tocilizumab. | Approved |
| Tolterodine | The metabolism of Tolterodine can be decreased when combined with Rolapitant. | Approved, Investigational |
| Tolvaptan | The serum concentration of Tolvaptan can be increased when it is combined with Rolapitant. | Approved |
| Topotecan | The serum concentration of Topotecan can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Toremifene | The serum concentration of Toremifene can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Trabectedin | The metabolism of Trabectedin can be decreased when combined with Rolapitant. | Approved, Investigational |
| Tramadol | The therapeutic efficacy of Tramadol can be decreased when used in combination with Rolapitant. | Approved, Investigational |
| Trastuzumab emtansine | The serum concentration of Trastuzumab emtansine can be increased when it is combined with Rolapitant. | Approved |
| Trazodone | The metabolism of Trazodone can be decreased when combined with Rolapitant. | Approved, Investigational |
| Trimipramine | The metabolism of Trimipramine can be decreased when combined with Rolapitant. | Approved |
| Ulipristal | The serum concentration of Ulipristal can be increased when it is combined with Rolapitant. | Approved |
| Umeclidinium | The serum concentration of Umeclidinium can be increased when it is combined with Rolapitant. | Approved |
| Vecuronium | The serum concentration of Vecuronium can be increased when it is combined with Rolapitant. | Approved |
| Vemurafenib | The serum concentration of Vemurafenib can be increased when it is combined with Rolapitant. | Approved |
| Venetoclax | The serum concentration of Venetoclax can be increased when it is combined with Rolapitant. | Approved |
| Venlafaxine | The metabolism of Rolapitant can be decreased when combined with Venlafaxine. | Approved |
| Verapamil | The metabolism of Rolapitant can be decreased when combined with Verapamil. | Approved |
| Vilazodone | The metabolism of Vilazodone can be decreased when combined with Rolapitant. | Approved |
| Vinblastine | The serum concentration of Vinblastine can be increased when it is combined with Rolapitant. | Approved |
| Vincristine | The serum concentration of Vincristine can be increased when it is combined with Rolapitant. | Approved, Investigational |
| Vinorelbine | The metabolism of Vinorelbine can be decreased when combined with Rolapitant. | Approved, Investigational |
| Vismodegib | The serum concentration of Vismodegib can be increased when it is combined with Rolapitant. | Approved |
| Voriconazole | The metabolism of Rolapitant can be decreased when combined with Voriconazole. | Approved, Investigational |
| Vortioxetine | The metabolism of Vortioxetine can be decreased when combined with Rolapitant. | Approved |
| Yohimbine | The metabolism of Yohimbine can be decreased when combined with Rolapitant. | Approved, Vet Approved |
| Zalcitabine | The metabolism of Zalcitabine can be decreased when combined with Rolapitant. | Approved |
| Zidovudine | The serum concentration of Zidovudine can be increased when it is combined with Rolapitant. | Approved |
| Ziprasidone | The metabolism of Rolapitant can be decreased when combined with Ziprasidone. | Approved |
| Zolpidem | The metabolism of Zolpidem can be decreased when combined with Rolapitant. | Approved |
| Zuclopenthixol | The metabolism of Zuclopenthixol can be decreased when combined with Rolapitant. | Approved, Investigational |
