Hydrogen fluoride

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Hydrogen fluoride
Accession Number
DB11072
Type
Small Molecule
Groups
Approved, Investigational
Description

Hydrogen fluoride (Hydrofluoric acid) is a weak acid that is a precursor to almost all fluorine compounds, including pharmaceuticals such as Fluoxetine (Prozac). It is used as a chemical reagent in several industrial processes such as oil refinery. It is also used as etchant, cleaning agent, and a reagent to dissolve oxides and silicates.

Structure
Thumb
Synonyms
  • fluorure d'hydrogène
  • Fluorwasserstoff
  • Hydrofluoric acid
  • Hydrogen fluoride, anhydrous
  • Hydrogenfluorid
Active Moieties
NameKindUNIICASInChI Key
Fluoride ionionicQ80VPU408O16984-48-8KRHYYFGTRYWZRS-UHFFFAOYSA-M
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Henry Schein Topical Fluoride CreamCream1.23 %OralAbj Custom Packaging1997-08-192001-09-27Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Acidulated Phosphate Fluoride Oral SolutionHydrogen fluoride (.017 %) + Sodium fluoride (.65 %)SolutionDentalPdt Image Inc. Dba Pro Dentec Canada1995-12-311999-07-30Canada
All Solutions Acidulated Phosphate Fluoride FoamHydrogen fluoride (0.06 %) + Sodium fluoride (2.59 %)SolutionDentalDentsply Professional2006-04-062008-06-20Canada
Butler Protect One Minute Apf Fluoride GelHydrogen fluoride (0.17 %) + Phosphoric acid (1.31 %) + Sodium fluoride (1.23 %)GelTopicalJohn O. Butler Company2004-03-102009-07-09Canada
Henry Schein Minute Topical Fluoride GelHydrogen fluoride (0.5 %) + Phosphoric acid (1.1 %) + Sodium fluoride (1.7 %)GelDentalAbj Custom PackagingNot applicableNot applicableCanada
Henry Schein Minute Topical Foam FluorideHydrogen fluoride (0.5 %) + Sodium fluoride (1.69 %)AerosolDentalAbj Custom PackagingNot applicableNot applicableCanada
Pascal PuffHydrogen fluoride (0.75 %) + Phosphoric acid (1 %) + Sodium fluoride (1.95 %)LiquidTopicalPascal International Corporation1999-05-272000-06-13Canada
Pdf Gel 1.24%Hydrogen fluoride (3.5 mg) + Sodium fluoride (1.24 %)GelTopicalLab Bmg Inc.1980-12-311998-08-10Canada
Perfect Choice 0.717% Root and Dentin DesensHydrogen fluoride (.14 %) + Sodium fluoride (1.09 %) + Stannous fluoride (.4 %)LiquidDentalChallenge Products Inc.1996-08-282001-07-27Canada
Pro-dentx Comfort Dentin DesensitizerHydrogen fluoride (0.045 %) + Sodium fluoride (1.31 %) + Stannous fluoride (0.41 %)LiquidDental; OralPdt Image Inc. Dba Pro Dentec Canada1997-05-122007-10-23Canada
Thixotropic Acidulated Phos. Fluor. Top. GelHydrogen fluoride (0.065 %) + Sodium fluoride (2.59 %)GelDentalPdt Image Inc. Dba Pro Dentec Canada1995-12-312003-06-27Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Alpha-ProHydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g)GelDentalDental Technologies, Inc.2013-04-01Not applicableUs
Alpha-ProHydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g)GelDentalDental Technologies, Inc.2013-04-01Not applicableUs
Denti-Care Topical Fluoride Foam Bubble GumHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2011-02-09Not applicableUs
Denti-Care Topical Fluoride Foam GrapeHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2003-05-01Not applicableUs
Denti-Care Topical Fluoride Foam OrangeHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2003-05-01Not applicableUs
Denti-Care Topical Fluoride Foam RaspberryHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2011-02-09Not applicableUs
Denti-Care Topical Sodium Fluoride StrawberryHydrogen fluoride (0.010 g/1g) + Sodium fluoride (.0176 g/1g)Aerosol, foamDentalAr Medicom Inc.2003-05-01Not applicableUs
Oral-B Minute-Foam Orang-A-TangyHydrogen fluoride (2.3 mg/1g) + Sodium fluoride (10 mg/1g)AerosolDentalOral-B Laboratories2000-05-04Not applicableUs
Perfect ChoiceHydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g)GelDentalYoung Dental Manufacturing Co 1, Llc.2006-08-312020-07-31Us
Perfect ChoiceHydrogen fluoride (4.4 mg/1g) + Sodium fluoride (7.9 mg/1g)GelDentalYoung Dental Manufacturing Co 1, Llc.2006-08-312020-12-31Us
Categories
UNII
RGL5YE86CZ
CAS number
7664-39-3
Weight
Average: 20.0063
Monoisotopic: 20.006228237
Chemical Formula
FH
InChI Key
KRHYYFGTRYWZRS-UHFFFAOYSA-N
InChI
InChI=1S/FH/h1H
IUPAC Name
hydrogen fluoride
SMILES
F

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Compound
C16487
PubChem Compound
14917
PubChem Substance
347827885
ChemSpider
14214
ChEBI
29228
ChEMBL
CHEMBL1232767
Wikipedia
Hydrofluoric_acid
AHFS Codes
  • 34:00.00 — Dental Agents

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentMelanoma (Skin)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionDental
Aerosol, foamDental
CreamOral1.23 %
LiquidTopical
GelTopical
LiquidDental
DiscTopical
LiquidDental; Oral
GelDental
AerosolDental
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.15ChemAxon
pKa (Strongest Acidic)3.17ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity1.67 m3·mol-1ChemAxon
Polarizability0.79 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as halogen hydrides. These are inorganic compounds in which the heaviest atom bonded to a hydrogen atom is a halogen.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Halogen organides
Sub Class
Halogen hydrides
Direct Parent
Halogen hydrides
Alternative Parents
Inorganic hydrides
Substituents
Halogen hydride / Inorganic hydride
Molecular Framework
Not Available
External Descriptors
hydrogen halide, mononuclear parent hydride (CHEBI:29228)

Drug created on December 03, 2015 09:51 / Updated on December 10, 2018 06:10