Identification

Name
Sodium fluoride
Accession Number
DB09325
Type
Small Molecule
Groups
Approved
Description

Sodium fluoride is an inorganic chemical compound. A colorless solid, it is a source of the fluoride ion in diverse applications. Sodium fluoride is less expensive and less hygroscopic than the related salt potassium fluoride.

Structure
Thumb
Synonyms
Not Available
External IDs
NSC-77385
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DuraphatLiquid2.26 %DentalColgate Oral PharmaceuticalsNot applicableNot applicableCanada
Fluorzoin 1.23% Topical Fluoride Ion FoamAerosol1.23 %DentalAbj Custom Packaging1995-12-312000-09-28Canada
FluoticTablet, delayed release20 mgOralSanofi Aventis1995-12-312007-06-22Canada
Henry Schein 2% Neutral Topical Foam FluorideAerosol1 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Henry Schein Prophy Paste With Fluoride - Coarse GritPaste1.23 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Henry Schein Prophy Paste With Fluoride - Fine GritPaste1.23 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Henry Schein Prophy Paste With Fluoride - Medium GritPaste1.23 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Henry Schein Topical Foam FluorideAerosol1.23 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Neutra Maxx 5000Gel1.428 g/120gOralMassco Dental A Division Of Dunagin Pharmaceuticals1989-01-01Not applicableUs
Neutral RinseLiquid2 mL/100mLTopicalRoss Products2011-09-01Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
0.2% Sodium Fluoride Weekly Oral RinseSolution0.2 %DentalPdt Image Inc. Dba Pro Dentec Canada1995-12-312009-06-15Canada
1.1% Neutral Sodium Fluoride Topical GelGel1.1 %DentalPdt Image Inc. Dba Pro Dentec Canada1995-12-312009-06-15Canada
2080 K Ginger MintPaste.12 g/120gDentalAekyung Industrial Co., Ltd.2016-07-07Not applicableUs
2080 K Herbal MintPaste.12 g/120gDentalAekyung Industrial Co., Ltd.2016-07-07Not applicableUs
2080 K OriginalPaste.12 g/120gDentalAk America2017-01-02Not applicableUs
2080 K OriginalPaste.12 g/120gDentalAekyung Industrial Co., Ltd.2016-07-07Not applicableUs
ACT Anticavity Fluoride CinnamonRinse.2 mg/mLTopicalChattem, Inc.1994-04-01Not applicableUs
ACT Anticavity Fluoride Kids BubblegumRinse.2 mg/mLTopicalChattem, Inc.1993-02-01Not applicableUs
ACT Anticavity Fluoride Kids SpongebobRinse.2 mg/mLTopicalChattem, Inc.2010-02-01Not applicableUs
ACT Anticavity Fluoride MintRinse.2 mg/mLTopicalChattem, Inc.1994-04-01Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
60 Second Gel BubblegumGel, dentifrice1.69 g/100gDentalGermiphene Corporation2017-02-24Not applicableUs
60 Second Gel GrapeGel, dentifrice1.69 g/100gDentalGermiphene Corporation2017-02-24Not applicableUs
60 Second Gel MintGel, dentifrice1.69 g/100gDentalGermiphene Corporation2017-02-24Not applicableUs
60 Second Gel Orange CreamGel, dentifrice1.69 g/100gDentalGermiphene Corporation2017-02-24Not applicableUs
60 Second Gel StrawberryGel, dentifrice1.69 g/100gDentalGermiphene Corporation2017-02-24Not applicableUs
60 Second Taste BubblegumGel12.3 mg/gBuccal; Dental; TopicalPascal International Corporation1988-04-01Not applicableUs
60 Second Taste Chocolate VanillaGel27.73 mg/gBuccal; Dental; TopicalPascal International Corporation2007-01-15Not applicableUs
60 Second Taste Groovy GrapeGel27.73 mg/gBuccal; Dental; TopicalPascal International Corporation1988-04-01Not applicableUs
60 Second Taste MarshmallowGel27.73 mg/gBuccal; Dental; TopicalPascal International Corporation1988-04-01Not applicableUs
60 Second Taste MintGel27.73 mg/gBuccal; Dental; TopicalPascal International Corporation1988-04-01Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Aim Sensitive Cavity ProtectionSodium fluoride (2.4 mg/g) + Potassium nitrate (50 mg/g)Gel, dentifriceDentalChurch & Dwight Company, Inc.2015-03-25Not applicableUs
Alpha-ProSodium fluoride (7.9 mg/g) + Hydrofluoric acid (4.4 mg/g)GelDentalDental Technologies, Inc.2013-04-01Not applicableUs
Alpha-ProSodium fluoride (7.9 mg/g) + Hydrofluoric acid (4.4 mg/g)GelDentalDental Technologies, Inc.2013-04-01Not applicableUs
Aquafresh Sensitive Maximum StrengthSodium fluoride (1.5 mg/g) + Potassium nitrate (50 mg/g)PasteDentalGlaxo Smith Kline Consumer Healthcare Holdings (Us) Llc2017-02-17Not applicableUs
Aquafresh Sensitive Maximum StrengthSodium fluoride (1.5 mg/g) + Potassium nitrate (50 mg/g)PasteDentalGlaxo Smith Kline Consumer Healthcare Holdings (Us) Llc2011-03-29Not applicableUs
Arm and Hammer Orajel Sensitive Freshening with Flavor BurstSodium fluoride (1.1 mg/g) + Potassium nitrate (50 mg/g)Paste, dentifriceDentalChurch & Dwight Company, Inc.2012-01-29Not applicableUs
Atomy Propolis 200gSodium fluoride (.2 g/200g) + Sodium monofluorophosphate (.32 g/200g)Paste, dentifriceOralAtomy Co., Ltd.2015-02-01Not applicableUs
Atomy Propolis 50gSodium fluoride (.05 g/41) + Sodium monofluorophosphate (.08 g/41)Paste, dentifriceOralAtomy Co., Ltd.2015-02-01Not applicableUs
ATOMY PROPOLIS TOOTHPAS TE 200gSodium fluoride (.2 g/200g) + Sodium monofluorophosphate (.32 g/200g)Paste, dentifriceOralAtomy Co., Ltd.2016-08-01Not applicableUs
ATOMY PROPOLIS TOOTHPAS TE 50gSodium fluoride (.05 g/50g) + Sodium monofluorophosphate (.08 g/50g)Paste, dentifriceOralAtomy Co., Ltd.2016-08-01Not applicableUs
Categories
UNII
8ZYQ1474W7
CAS number
7681-49-4
Weight
Average: 41.9882
Monoisotopic: 41.98817288
Chemical Formula
FNa
InChI Key
PUZPDOWCWNUUKD-UHFFFAOYSA-M
InChI
InChI=1S/FH.Na/h1H;/q;+1/p-1
IUPAC Name
sodium fluoride
SMILES
[F-].[Na+]

Pharmacology

Indication

To prevent cavities.

Structured Indications
Pharmacodynamics

Sodium fluoride acts systemically before tooth eruption and topically afterward by increasing tooth resistance to acid dissolution, by promoting remineralization, and by inhibiting the cariogenic microbial process. Acidulation provides greater topical fluoride uptake by dental enamel than neutral solutions. When topical fluoride is applied to hypersensitive exposed dentin, the formation of insoluble materials within the dentinal tubules blocks transmission of painful stimuli.

Mechanism of action

Fluorides interfere with electron transport and calcium metabolism. Calcium is essential for maintaining cardiac membrane potentials and in regulating coagulation.

Absorption

Absorbed readily and almost completely from the GI tract. A large amount of an oral dose may be absorbed in the stomach; rate of absorption may depend on the gastric pH.

Volume of distribution

Stored in bones and developing teeth after absorption. Fluoride is distributed into sweat, tears, hair, and saliva. Fluoride crosses the placental barrier and is distributed into breast milk.

Protein binding
Not Available
Metabolism

Not metabolized.

Route of elimination

Excreted rapidly, mainly in urine. About 90% of fluoride is filtered by the glomerulus and reabsorbed by the renal tubules.

Half life

109.8 minutes

Clearance
Not Available
Toxicity

Symptom onset usually occurs within minutes of exposure, but may be delayed. Manifestations of fluoride toxicity are predominantly gastrointestinal (GI), but neurologic and cardiovascular effects also occur.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

Synthesis Reference
Not Available
General References
  1. Wikipedia [Link]
  2. Pharmacology [Link]
  3. Pubchem [Link]
  4. DRUGS.COM [Link]
External Links
KEGG Compound
C08142
PubChem Compound
5235
PubChem Substance
310265207
ChemSpider
5045
ChEBI
28741
ChEMBL
CHEMBL1528
PharmGKB
PA451388
Wikipedia
Sodium_fluoride
ATC Codes
A01AA51 — Sodium fluoride, combinationsA01AA01 — Sodium fluorideA12CD01 — Sodium fluoride
AHFS Codes
Not Available
PDB Entries
Not Available
FDA label
Not Available
MSDS
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Enrolling by InvitationTreatmentDental Decay1
0Not Yet RecruitingTreatmentDental Decay1
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I / Mycobacterium avium complex infection1
1CompletedPreventionDental Decay2
1CompletedPreventionDentin Sensitivity1
1CompletedPreventionHIV / AIDS1
1WithdrawnPreventionGingival Inflammation1
1, 2Active Not RecruitingHealth Services ResearchDental Decay1
1, 2Active Not RecruitingTreatmentHodgkins Disease (HD) / Lymphoma, Hodgkins1
1, 2CompletedTreatmentMalignant Lymphomas1
1, 2CompletedTreatmentMantle Cell Lymphoma (MCL) / Non-Hodgkin's Lymphoma (NHL)1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedSupportive CareRadiation-Induced Xerostomia1
2CompletedTreatmentDental Plaque1
2CompletedTreatmentDentin Sensitivity1
2CompletedTreatmentDentinal Hypersensitivity1
2CompletedTreatmentDentine Hypersensitivity1
2CompletedTreatmentDisseminated Sclerosis / Relapsing Remitting Multiple Sclerosis (RRMS)1
2CompletedTreatmentOral Hygiene1
2CompletedTreatmentTooth Erosion1
2RecruitingTreatmentFollicular Lymphoma (FL) / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Lymphoma, Mantle-Cell1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2Unknown StatusTreatmentLymphoma, Mantle-Cell1
3Active Not RecruitingTreatmentEarly Childhood Caries1
3CompletedTreatmentCaries1
3CompletedTreatmentCaries / Healthy Volunteers / Partial Denture Wearers1
3CompletedTreatmentDental Decay2
3CompletedTreatmentDental Plaque9
3CompletedTreatmentDentin Hypersensitivity1
3CompletedTreatmentEnamel Erosion1
3CompletedTreatmentGingival Diseases6
3CompletedTreatmentGingival Inflammation1
3CompletedTreatmentMucositis1
3CompletedTreatmentOral Bacteria1
3CompletedTreatmentPeriodontal Diseases1
3CompletedTreatmentPeriodontitis1
3CompletedTreatmentSalivary Bacteria Levels1
3RecruitingTreatmentDentine Hypersensitivity1
3RecruitingTreatmentRelapsed Follicular Lymphoma1
3Unknown StatusHealth Services ResearchDental Decay1
3Unknown StatusTreatmentPeriodontal Diseases1
4CompletedNot AvailablePeriodontal Diseases / Type 2 Diabetes Mellitus1
4CompletedPreventionDental Caries and Streptococcus Mutans Count1
4CompletedPreventionDental Decay2
4CompletedTreatmentAdherence / Cessation, Smoking / Motivation / Nicotine Dependence / Smoking1
4CompletedTreatmentDental Decay1
4CompletedTreatmentDental Plaque / Gingival Inflammation1
4RecruitingTreatmentDentin Hypersensitivity1
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4TerminatedTreatmentPregnancy / Smoking1
4Unknown StatusPreventionDental Decay1
4Unknown StatusTreatmentPostoperative paralytic ileus1
Not AvailableCompletedNot AvailableCaries1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedBasic ScienceDental Health1
Not AvailableCompletedPreventionDental Decay1
Not AvailableCompletedTreatmentAcid Wear / Dental Erosion1
Not AvailableCompletedTreatmentBreath odour1
Not AvailableCompletedTreatmentDental Decay1
Not AvailableCompletedTreatmentGingival Inflammation / Pregnancy1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentOral Hygiene2
Not AvailableNot Yet RecruitingBasic ScienceOral Salivary Streptococcus Mutans Counts1
Not AvailableNot Yet RecruitingPreventionCaries Risk Assessment / Risk Reduction1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionDental0.2 %
GelDental1.1 %
PasteDental.12 g/120g
Gel, dentifriceDental1.69 g/100g
GelBuccal; Dental; Topical12.3 mg/g
GelBuccal; Dental; Topical27.73 mg/g
GelDental12.3 mg/g
Gel, dentifriceOral5 mg/g
LiquidDental.02522 g/mL
Gel, dentifriceOral11 mg/g
RinseTopical.2 mg/mL
RinseTopical.5 mg/mL
MouthwashOral.09 mg/mL
LiquidOral0.05 %
MouthwashTopical.5 mg/mL
MouthwashOral.5 mg/mL
MouthwashTopical.2 mg/mL
RinseTopical.09 mg/mL
MouthwashTopical.09 mg/mL
Gel, dentifriceDental2.4 mg/g
LiquidOral.1 mg/mL
LiquidOral.219 mg/mL
LiquidOral219 mg/mL
Gel, dentifriceOral.187 g/85g
PasteDental2.2 mg/g
SprayOral.007 mg/35mL
MouthwashOral.0221 mL/100L
MouthwashOral999.5 mL/100L
RinseOral.02 mg/mL
RinseOral.05 mg/mL
RinseOral.05 kg/100L
RinseOral.5 mg/mL
RinseOral10.4 mg/mL
MouthwashOral.0221 kg/100L
MouthwashOral.05 kg/100L
MouthwashOral.05 mL/L
MouthwashOral1 mg/mL
RinseDental.46277 mg/mL
MouthwashOral.1 mg/mL
PasteDental1.15 mg/g
PasteDental1.4 mg/g
PasteDental1.13 mg/g
Paste, dentifriceBuccal0.22 %
Paste, dentifriceDental.221 %
PasteDental1.1 mg/g
LiquidDental.001 mg/mL
Gel; paste, dentifriceDental0.243 %
PasteDental.243 %
GelDental0.243 %
Paste, dentifriceOral
LiquidDental
Gel, dentifriceDental.25 g/100g
Paste, dentifriceDental243 mg/g
MouthwashOral.0225 g/100g
GelDental.597 g/120g
Kit
MouthwashOral2 mg/mL
Liquid; mouthwashBuccal
Paste, dentifriceDental.22 g/100g
Paste, dentifriceOral.75 g/150g
Paste, dentifriceOral5 mg/g
Paste, dentifriceOral.95 mg/g
GelDental.27 g/113.4g
GelDental.54 g/226.8g
Gel; paste, dentifriceDental0.23 %
Paste, dentifriceDental.23 %
Paste, dentifriceDental; Oral1.1 mg/g
RinseOral.05 g/100mL
PasteDental1.5 mg/g
RinseDental2.1 mg/10mL
Paste, dentifriceDental2.1 mg/g
Paste, dentifriceDental0.243 %
Paste, dentifriceDental.243 %
Paste, dentifriceDental; Oral.243 %
RinseDental.1 mg/20mL
Paste, dentifriceDental1.4 mg/g
Paste, dentifriceDental3.281 mg
MouthwashBuccal
RinseDental.1 mg/mL
Paste, dentifriceDental.32 mg/mL
Paste, dentifriceDental1.1 mg/g
Paste, dentifriceOral11 mg/g
Powder, dentifriceDental1.88 mg/g
Paste, dentifriceDental.24 mg/g
Paste, dentifriceDental243 g/g
Paste, dentifriceDental1.45 g/100mL
Paste, dentifriceDental2.43 mg/100mL
Paste, dentifriceOral243 mg/g
RinseOral.1 mg/10mL
RinseOral2.2 mg/10mL
RinseOral.0219 g/mL
Paste, dentifriceDental1.6 mg/g
Paste, dentifriceDental1.5 mg/g
Gel, dentifriceTopical2.43 mg/g
RinseDental226 ug/mL
Gel, dentifriceDental1100 ug/g
Gel, dentifriceDental5000 ug/g
PasteDental39.9 g/181.4g
PasteDental.76 g/100g
Tablet, chewableOral1.1 mg/1
Gel, dentifriceOral1.1 g/100g
GelOral1.1 g/100g
RinseOral.05 mL/100mL
Paste, dentifriceDental.1 g/100g
GelDental0.221 %
TapeDental.15 mg
Paste, dentifriceDental.09639 g/76.5g
LiquidDental0.023 %
Aerosol, foamDental.0272 g/g
GelDental.0272 g/mL
LiquidDental.02 g/mL
Aerosol, foamDental
GelDental.02 g/mL
RinseDental.02 g/mL
Gel, dentifriceDental.22 g/100mL
Gel, dentifriceDental.22 g/1000mL
Gel, dentifriceOral2.4 mg/g
MouthwashDental.02 g/100mL
LiquidTopical.05 mg/250mL
LiquidTopical.15 mg/750mL
LiquidTopical.016 mg/80mL
PasteOral2.43 mg/g
PasteDental.243 g/100g
Paste, dentifriceOral2.43 mg/g
LiquidDental2.26 %
Paste, dentifriceDental.16 g/100g
LiquidOral.021 g/mL
MouthwashOral.0221 g/100g
Aerosol, foamDental.243 mL/100mL
Paste, dentifriceDental2.43 mg/mL
LiquidDental.05 mL/100mL
Aerosol, foamDental1.732 g/100g
GelDental5 mg/mL
LiquidOral
Solution / dropsOral5.56 mg/mL
Tablet, chewableOral
SolutionOral.55 mg/.6mL
LiquidOral2.5 mg/mL
GelDental1.23 %
MouthwashOral.2 mg/mL
MouthwashOral
SolutionOral11 mg/g
Solution / dropsOral200 mg
Paste, dentifriceTopical1.1 mg/mg
Tablet, chewableOral.5 mg/1
Tablet, chewableOral1 mg/1
LiquidOral200 mg
LiquidOral.05 %
AerosolDental1.23 %
Tablet, delayed releaseOral20 mg
Solution / dropsOral2.21 mg
LiquidOral2.21 mg/.2mL
Paste, dentifriceDental.65 mg/g
PasteDental22 mg/g
Gel, dentifriceDental2.2 mg/g
Gel, dentifriceDental2 g/100g
LiquidDental; Topical1.23 %
Aerosol, foamDental; Oral; Topical2.5 g/125g
Paste, dentifriceDental.22 %
Paste, dentifriceTopical.21 g/100g
PasteTopical1.23 %
Paste, dentifriceOral.15 g/100g
Paste, dentifriceDental.243 mg/100g
PasteDental2.5 mg/g
MouthwashDental20 mg/100000mL
LiquidTopical0.5 %
AerosolDental1 %
LiquidOral.5 mg/mL
GelDental.24 %
GelDental; Oral; Topical10.241 g/490g
GelDental; Oral; Topical6.027 g/490g
Aerosol, foamDental; Oral; Topical1.5498 g/126g
GelDental; Oral; Topical4.41 g/490g
LiquidDental; Oral38 g/L
Gel, dentifriceTopical.243 mg/mg
LiquidOral1.95 mg
TabletOral1 mg
GelDental0.5 %
MouthwashOral.02 kg/100L
RinseOral.1 mg/mL
Gel, dentifriceDental1.1 mg/g
Gel, dentifriceDental2.43 mg/g
Paste, dentifriceDental0.239 g
Kit
Paste, dentifriceTopical.2592 g/108g
Aerosol, foamDental27.2 mg/g
PasteDental2.43 mg/g
MouthwashOral.221 g/mL
MouthwashDental.1 mg/mL
RinseOral.2 mg/mL
Tablet, chewableOral.25 mg/1
MouthwashDental; Oral
Paste, dentifriceDental; Oral2.2 mg/mL
Gel, dentifriceOral.1 g/100g
Paste, dentifriceDental22 g/100g
Gel, dentifriceDental.1 g/100g
Gel, dentifriceDental.15 g/100g
Paste, dentifriceDental2.4 mg/g
Paste, dentifriceDental2 g/.2g
Solution / dropsOral
PowderDental1 g/g
SolutionDental20 mg/10mL
SolutionDental2 mg/mL
MouthwashDental.2 mg/mL
GelOral1.428 g/120g
Gel, dentifriceDental1.1 g/100g
LiquidDental; Oral2 %
LiquidTopical2 mL/100mL
RinseOral20 mg/mL
PasteOral1.1 g/112g
Paste, dentifriceOral1.1 g/112g
RinseDental2 g/100g
Aerosol, foamDental1.5375 g/125g
Aerosol, foamDental27.3 mg/g
GelTopical
GelTopical2 %
TabletOral
RinseOral.0154 g/770mL
LiquidOral.06 mg/300mL
Paste, dentifriceDental.070875 g/28.35g
Gel, dentifriceDental.070875 g/28.35g
PasteDental.1 g/100g
LiquidDental.2 mg/mL
Gel, dentifriceDental6 mg/g
MouthwashOral10.41 mg/mL
MouthwashBuccal; Topical
SolutionOral12.3 mg/g
SolutionOral.5 mg/g
Paste, dentifriceDental.14 g/118g
MouthwashOral.2418 g/474mL
LiquidBuccal; Topical0.05 %
LiquidDental500 ug/mL
MouthwashDental2 mg/mL
AerosolDental10 mg/g
AerosolDental
AerosolDental9 mg/g
GelDental11 mg/g
Cream; paste, dentifriceTopical
Gel, dentifriceOral.24 g/100g
Paste, dentifriceOral.24 g/100g
MouthwashOral.15 g/100g
RinseDental
Gel, dentifriceOral.044 mL/100mL
LiquidDental; Topical
RinseOral.44 mg/mL
Paste, dentifriceDental0.22 %
Aerosol, foamDental2.5 g/125g
LiquidTopical27.2 mg/mg
GelTopical11 mg/mg
Aerosol, foamTopical.0272 mg/g
Aerosol, foamTopical20 mg/mg
GelTopical20 mg/mg
RinseTopical20 mg/mL
RinseTopical2 mg/mL
LiquidTopical20 mg/mg
RinseTopical2 mg/g
GelTopical27.2 mg/mg
GelTopical.02 mg/mL
MouthwashOral.2 %
LiquidDental.227 mg
PasteDental.24 g/100g
GelOral0.5 %
MouthwashDental1.24 %
GelDental2 %
Paste, dentifriceDental2.72 %
Paste, dentifriceDental.24 mg/100mL
SolutionDental2 %
GelBuccal; Dental; Topical9.05 mg/g
DiscTopical
DiscTopical.055 mg/1
Gel, dentifriceDental11 mg/g
RinseDental2 mg/10mL
RinseDental4.42 mg/10mL
Paste, dentifriceDental2.2 mg/g
Paste, dentifriceOral.308 g/140g
Paste, dentifriceOral.374 g/170g
Paste, dentifriceDental; Oral.4 mg/g
Paste, dentifriceDental; Oral2.4 mg/g
Paste, dentifriceDental.14 g/100g
Gel, dentifriceDental.24 g/100g
Paste, dentifriceDental6 mg/mL
Gel, dentifriceDental13.4 mg/mL
Gel, dentifriceDental13.5 mg/mL
Gel, dentifriceDental
Paste, dentifriceDental11 mg/mL
GelOral.044 mL/mL
GelOral4.3 g/g
RinseOral.9 mg/mL
LiquidBuccal0.5 %
LiquidDental; Oral0.9 %
PasteDental.23 g/100g
Gel, dentifriceDental.07 g/28.35g
PasteDental.22 g/100g
GelDental0.24 %
TapeDental0.15 mg
Paste, dentifriceOral2.4 mg/g
Paste, dentifriceOral1.5 mg/g
Gel, dentifriceDental.22 g/100g
Paste, dentifriceDental
Paste, dentifriceTopical
GelDental
PasteOral1.5 mg/g
MouthwashOral.2 mg/L
CreamDental5 mg/g
FilmDental20 mg/1
PasteDental2.4 mg/100g
LiquidDental.05 mg/100g
Paste, dentifriceDental.0024 g/g
MouthwashOral.05 mL/100mL
CreamOral.22 g/100g
SolutionOral.2 mg/mL
Solution / dropsOral.5 mg/mL
LiquidOral6.9 mg
TabletOral2.21 mg
LiquidDental.25 mg
PasteDental.198 g/90g
Gel, dentifriceDental1.5 mg/g
Paste, dentifriceDental.28 g/113g
Gel, dentifriceDental5 mg/g
Paste, dentifriceDental.33 g/133g
PasteDental1.23 %
Gel, dentifriceTopical.0002 g/251
PasteDental0.243 %
MouthwashDental.02 mg/100mL
Gel, dentifriceDental24 mg/10g
PowderDental.24 g/100g
Aerosol, foamTopical123 mg/g
AerosolDental0.9 %
SolutionOral
Paste, dentifriceDental.243 mg/g
LiquidOral.2 mg/mL
MouthwashOral.001 g/10mL
PasteOral
Gel, dentifriceDental; Oral11 mg/g
Paste, dentifriceDental2 mg/g
Paste, dentifriceDental2.43 mg/g
PasteDental
Paste, dentifriceDental.243 g/100g
PasteDental2.4 mg/g
Paste, dentifriceDental.24 g/100g
MouthwashDental
PasteTopical.26244 g/108g
Paste, dentifriceDental0.24 %
Paste, dentifriceDental.00243 g/g
LiquidBuccal; Oral0.0002 %
MouthwashOral.559 mg/mL
PasteOral2.2 mg/g
Paste, dentifriceDental.3325 g/133g
GelDental5.6 g/454g
GelDental4.086 g/454g
Aerosol, foamDental2.72 g/100g
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.77ChemAxon
pKa (Strongest Acidic)3.17ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as alkali metal fluorides. These are inorganic compounds in which the largest halogen atom is fluorine, and the heaviest metal atom is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal salts
Sub Class
Alkali metal fluorides
Direct Parent
Alkali metal fluorides
Alternative Parents
Inorganic sodium salts
Substituents
Alkali metal fluoride / Inorganic sodium salt / Inorganic salt
Molecular Framework
Not Available
External Descriptors
fluoride salt (CHEBI:28741)

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Pyridoxal phosphate binding
Specific Function
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting wi...
Gene Name
GPT
Uniprot ID
P24298
Uniprot Name
Alanine aminotransferase 1
Molecular Weight
54636.415 Da
References
  1. ejournal [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Iron ion binding
Specific Function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic su...
Gene Name
MT-CO1
Uniprot ID
P00395
Uniprot Name
Cytochrome c oxidase subunit 1
Molecular Weight
57040.91 Da
References
  1. ejournal [Link]

Drug created on November 17, 2015 11:36 / Updated on October 02, 2017 06:15