Sodium fluoride


Sodium fluoride
Accession Number
Small Molecule

Sodium fluoride is an inorganic chemical compound. A colorless solid, it is a source of the fluoride ion in diverse applications. Sodium fluoride is less expensive and less hygroscopic than the related salt potassium fluoride.

Not Available
External IDs
Active Moieties
Fluoride ionionicQ80VPU408O16984-48-8KRHYYFGTRYWZRS-UHFFFAOYSA-M
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DuraphatLiquid2.26 %DentalColgate Oral PharmaceuticalsNot applicableNot applicableCanada
Fluorzoin 1.23% Topical Fluoride Ion FoamAerosol1.23 %DentalAbj Custom Packaging1995-12-312000-09-28Canada
FluoticTablet, delayed release20 mgOralSanofi Aventis1995-12-312007-06-22Canada
Henry Schein 2% Neutral Topical Foam FluorideAerosol1 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Henry Schein Prophy Paste With Fluoride - Coarse GritPaste1.23 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Henry Schein Prophy Paste With Fluoride - Fine GritPaste1.23 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Henry Schein Prophy Paste With Fluoride - Medium GritPaste1.23 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Henry Schein Topical Foam FluorideAerosol1.23 %DentalAbj Custom PackagingNot applicableNot applicableCanada
Perfect Choice Neutral Sodium Fluoride GelGel2 %DentalBiotrol1990-12-312008-07-14Canada
Perioselect Sodium Fluoride Solution 2%Solution2 %DentalSultan Healthcare1992-12-311996-09-06Canada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
0.2% Sodium Fluoride Weekly Oral RinseSolution0.2 %DentalPdt Image Inc. Dba Pro Dentec Canada1995-12-312009-06-15Canada
1.1% Neutral Sodium Fluoride Topical GelGel1.1 %DentalPdt Image Inc. Dba Pro Dentec Canada1995-12-312009-06-15Canada
2080 K Ginger MintPaste0.12 g/120gDentalAekyung Industrial Co., Ltd.2016-07-07Not applicableUs
2080 K Herbal MintPaste0.12 g/120gDentalAekyung Industrial Co., Ltd.2016-07-07Not applicableUs
2080 K OriginalPaste0.12 g/120gDentalAk America2017-01-02Not applicableUs
2080 K OriginalPaste0.12 g/120gDentalAekyung Industrial Co., Ltd.2016-07-07Not applicableUs
60 Second Gel BubblegumGel, dentifrice1.69 g/100gDentalGermiphene Corporation2017-02-24Not applicableUs
60 Second Gel GrapeGel, dentifrice1.69 g/100gDentalGermiphene Corporation2017-02-24Not applicableUs
60 Second Gel MintGel, dentifrice1.69 g/100gDentalGermiphene Corporation2017-02-24Not applicableUs
60 Second Gel Orange CreamGel, dentifrice1.69 g/100gDentalGermiphene Corporation2017-02-24Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
4 PackSodium fluoride (2.4 mg/1g) + Sodium fluoride (2.4 mg/1g) + Potassium nitrate (50 mg/1g) + Potassium nitrate (50 mg/1g)KitTwice Smiles Llc2018-09-14Not applicableUs
4 PackSodium fluoride (2.4 mg/1g) + Sodium fluoride (2.4 mg/1g) + Potassium nitrate (50 mg/1g) + Potassium nitrate (50 mg/1g)KitTwice Smiles Llc2018-09-14Not applicableUs
Acidulated Phosphate Fluoride Oral SolutionSodium fluoride (.65 %) + Hydrogen fluoride (.017 %)SolutionDentalPdt Image Inc. Dba Pro Dentec Canada1995-12-311999-07-30Canada
Advancew White Sensitive Maximum Strength Sensitivity Relief with WhiteningSodium fluoride (2.4 mg/1g) + Potassium nitrate (50 mg/1g)Paste, dentifriceDentalChurch & Dwight Company, Inc.2001-03-012012-06-01Us
Aim Sensitive Cavity ProtectionSodium fluoride (2.4 mg/1g) + Potassium nitrate (50 mg/1g)Gel, dentifriceDentalChurch & Dwight Company, Inc.2015-03-25Not applicableUs
All Solutions Acidulated Phosphate Fluoride FoamSodium fluoride (2.59 %) + Hydrogen fluoride (0.06 %)SolutionDentalDentsply Professional2006-04-062008-06-20Canada
Aquafresh Sensitive Maximum StrengthSodium fluoride (1.5 mg/1g) + Potassium nitrate (50 mg/1g)PasteDentalGlaxo Smith Kline Consumer Heathcare Lp1990-09-302011-10-31Us
Aquafresh Sensitive Maximum StrengthSodium fluoride (1.1 mg/1g) + Potassium nitrate (50 mg/1g)PasteDentalGlaxoSmithKline Consumer Healthcare Holdings (US) LLC2017-02-17Not applicableUs
Aquafresh Sensitive Maximum StrengthSodium fluoride (1.5 mg/1g) + Potassium nitrate (50 mg/1g)PasteDentalGlaxoSmithKline Consumer Healthcare Holdings (US) LLC2011-03-292018-09-30Us
Arm and Hammer Orajel Sensitive Freshening with Flavor BurstSodium fluoride (1.1 mg/1g) + Potassium nitrate (50 mg/1g)Paste, dentifriceDentalChurch & Dwight Company, Inc.2012-01-29Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
60 Second Taste BubblegumSodium fluoride (12.3 mg/1g)GelBuccal; Dental; TopicalPascal Company, Inc.1988-04-01Not applicableUs
60 Second Taste Chocolate VanillaSodium fluoride (27.73 mg/1g)GelBuccal; Dental; TopicalPascal International Corporation2007-01-15Not applicableUs
60 Second Taste Groovy GrapeSodium fluoride (27.73 mg/1g)GelBuccal; Dental; TopicalPascal International Corporation1988-04-01Not applicableUs
60 Second Taste MarshmallowSodium fluoride (27.73 mg/1g)GelBuccal; Dental; TopicalPascal International Corporation1988-04-01Not applicableUs
60 Second Taste MintSodium fluoride (27.73 mg/1g)GelBuccal; Dental; TopicalPascal International Corporation1988-04-01Not applicableUs
60 Second Taste Orange TwistSodium fluoride (27.73 mg/1g)GelBuccal; Dental; TopicalPascal International Corporation1993-10-01Not applicableUs
60 Second Taste StrawberrySodium fluoride (27.73 mg/1g)GelBuccal; Dental; TopicalPascal International Corporation1988-04-01Not applicableUs
60-Second Fluoride Bubble GumSodium fluoride (12.3 mg/1g)GelDentalPatterson Dental1978-01-01Not applicableUs
60-Second Fluoride CherrySodium fluoride (12.3 mg/1g)GelDentalPatterson Dental1978-01-01Not applicableUs
60-Second Fluoride GrapeSodium fluoride (12.3 mg/1g)GelDentalPatterson Dental1978-01-012012-10-01Us
CAS number
Average: 41.9882
Monoisotopic: 41.98817288
Chemical Formula
InChI Key
sodium fluoride



To prevent cavities.

Associated Conditions

Sodium fluoride acts systemically before tooth eruption and topically afterward by increasing tooth resistance to acid dissolution, by promoting remineralization, and by inhibiting the cariogenic microbial process. Acidulation provides greater topical fluoride uptake by dental enamel than neutral solutions. When topical fluoride is applied to hypersensitive exposed dentin, the formation of insoluble materials within the dentinal tubules blocks transmission of painful stimuli.

Mechanism of action

Fluorides interfere with electron transport and calcium metabolism. Calcium is essential for maintaining cardiac membrane potentials and in regulating coagulation.


Absorbed readily and almost completely from the GI tract. A large amount of an oral dose may be absorbed in the stomach; rate of absorption may depend on the gastric pH.

Volume of distribution

Stored in bones and developing teeth after absorption. Fluoride is distributed into sweat, tears, hair, and saliva. Fluoride crosses the placental barrier and is distributed into breast milk.

Protein binding
Not Available

Not metabolized.

Route of elimination

Excreted rapidly, mainly in urine. About 90% of fluoride is filtered by the glomerulus and reabsorbed by the renal tubules.

Half life

109.8 minutes

Not Available

Symptom onset usually occurs within minutes of exposure, but may be delayed. Manifestations of fluoride toxicity are predominantly gastrointestinal (GI), but neurologic and cardiovascular effects also occur.

Affected organisms
Not Available
Not Available
Pharmacogenomic Effects/ADRs
Not Available


Drug Interactions
AbacavirAbacavir may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
AcarboseAcarbose may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
AcetaminophenAcetaminophen may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium fluoride.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
AclidiniumThe therapeutic efficacy of Sodium fluoride can be decreased when used in combination with Aclidinium.
AcrivastineSodium fluoride may decrease the excretion rate of Acrivastine which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
Food Interactions
Not Available


General References
  1. Wikipedia [Link]
  2. Pharmacology [Link]
  3. Pubchem [Link]
  4. DRUGS.COM [Link]
External Links
KEGG Compound
PubChem Compound
PubChem Substance
ATC Codes
A01AA51 — Sodium fluoride, combinationsA01AA01 — Sodium fluorideA12CD01 — Sodium fluoride
AHFS Codes
  • 34:00.00 — Dental Agents
  • 92:00.00 — Miscellaneous Therapeutic Agents
  • 52:28.00 — Mouthwashes and Gargles

Clinical Trials

Clinical Trials
0Enrolling by InvitationTreatmentDental Decay1
0Not Yet RecruitingTreatmentDental Decay1
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I / Mycobacterium avium complex infection1
1CompletedPreventionDental Decay2
1CompletedPreventionDentin Sensitivity1
1CompletedPreventionHuman Immunodeficiency Virus Infection(HIV)/Acquired Immunodeficiency Syndrome (AIDS)1
1WithdrawnPreventionGingival Inflammation1
1, 2Active Not RecruitingTreatmentHodgkins Disease (HD) / Lymphoma, Hodgkins1
1, 2CompletedHealth Services ResearchDental Decay1
1, 2CompletedTreatmentMalignant Lymphomas1
2Active Not RecruitingTreatmentFollicular Lymphoma (FL) / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL)1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedPreventionTooth Sensitivity1
2CompletedSupportive CareRadiation-Induced Xerostomia1
2CompletedTreatmentDental Plaque1
2CompletedTreatmentDentin Sensitivity2
2CompletedTreatmentDentinal Hypersensitivity1
2CompletedTreatmentDentine Hypersensitivity1
2CompletedTreatmentDisseminated Sclerosis / Relapsing Remitting Multiple Sclerosis (RRMS)1
2CompletedTreatmentMelanoma (Skin)1
2CompletedTreatmentOral Hygiene2
2CompletedTreatmentTooth Erosion1
2RecruitingPreventionWhite Spot Lesions1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections / Kidney Diseases1
2Unknown StatusTreatmentMantle Cell Lymphoma (MCL)1
2, 3RecruitingPreventionAntimicrobial Effect / Caries / High Caries Risk Patients / Side Effects1
3Active Not RecruitingTreatmentEarly Childhood Caries1
3CompletedTreatmentAnaesthesia therapy1
3CompletedTreatmentCaries / Healthy Volunteers / Partial Denture Wearers1
3CompletedTreatmentDental Decay2
3CompletedTreatmentDental Plaque9
3CompletedTreatmentDentin Hypersensitivity1
3CompletedTreatmentEnamel Erosion1
3CompletedTreatmentGingival Diseases6
3CompletedTreatmentGingival Inflammation1
3CompletedTreatmentOral Bacteria1
3CompletedTreatmentPeriodontal Diseases1
3CompletedTreatmentSalivary Bacteria Levels1
3RecruitingTreatmentDentine Hypersensitivity1
3RecruitingTreatmentRelapsed Follicular Lymphoma1
3Unknown StatusHealth Services ResearchDental Decay1
3Unknown StatusTreatmentPeriodontal Diseases1
3WithdrawnTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4Active Not RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4CompletedPreventionDental Caries and Streptococcus Mutans Count1
4CompletedPreventionDental Decay2
4CompletedTreatmentAdherence / Cessation, Smoking / Motivation / Nicotine Dependence / Smoking1
4CompletedTreatmentDental Decay1
4CompletedTreatmentDental Plaque / Gingival Inflammation1
4RecruitingTreatmentDentin Hypersensitivity1
4RecruitingTreatmentWhite Spot Lesion of Tooth1
4TerminatedTreatmentPregnancy / Smoking1
4Unknown StatusPreventionDental Decay1
4Unknown StatusTreatmentPostoperative paralytic ileus1
Not AvailableCompletedNot AvailableCaries1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedNot AvailablePeriodontal Diseases / Type 2 Diabetes Mellitus1
Not AvailableCompletedBasic ScienceDental Health1
Not AvailableCompletedOtherEarly Childhood Caries1
Not AvailableCompletedPreventionDental Decay1
Not AvailableCompletedTreatmentAcid Wear / Dental Erosion1
Not AvailableCompletedTreatmentBreath odour1
Not AvailableCompletedTreatmentDental Decay1
Not AvailableCompletedTreatmentGingival Inflammation / Pregnancy1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentOral Hygiene1
Not AvailableNot Yet RecruitingBasic ScienceOral Salivary Streptococcus Mutans Counts1
Not AvailableNot Yet RecruitingPreventionCaries Risk Assessment / Risk Reduction1
Not AvailableRecruitingTreatmentGum Chewing1


Not Available
Not Available
Dosage forms
SolutionDental0.2 %
GelDental1.1 %
PasteDental0.12 g/120g
Gel, dentifriceDental1.69 g/100g
GelBuccal; Dental; Topical12.3 mg/1g
GelBuccal; Dental; Topical27.73 mg/1g
GelDental12.3 mg/1g
Gel, dentifriceOral5 mg/1g
LiquidDental0.02522 g/1mL
Gel, dentifriceOral11 mg/1g
RinseTopical0.2 mg/1mL
RinseTopical0.5 mg/1mL
MouthwashOral0.09 mg/1mL
LiquidOral0.05 %
PasteTopical1.4 mg/1g
MouthwashTopical0.09 mg/1mL
MouthwashTopical0.2 mg/1mL
MouthwashTopical0.5 mg/1mL
MouthwashOral0.5 mg/1mL
RinseTopical0.09 mg/1mL
Gel, dentifriceDental2.4 mg/1g
MouthwashOral10.41 mg/1mL
LiquidOral0.1 mg/1mL
LiquidOral0.219 mg/1mL
LiquidOral219 mg/1mL
Paste, dentifriceDental0.22 g/100g
Gel, dentifriceOral0.187 g/85g
PasteDental2.2 mg/1g
PowderDental0.1 g/100g
SprayOral0.007 mg/35mL
MouthwashOral.0221 mL/100L
RinseOral0.02 mg/1mL
RinseOral0.05 mg/1mL
RinseOral0.05 kg/100L
RinseOral0.2094 mg/1mL
RinseOral0.5 mg/1mL
RinseOral10.4 mg/1mL
MouthwashOral.02 kg/100L
MouthwashOral.05 kg/100L
MouthwashOral0.05 kg/100L
MouthwashOral0.2 mg/1mL
MouthwashOral1 mg/1mL
RinseDental0.46277 mg/1mL
MouthwashOral0.1 mg/1mL
MouthwashOral10.33 mg/1mL
PasteDental1.15 mg/1g
PasteDental1.4 mg/1g
PasteDental1.13 mg/1g
Paste, dentifriceBuccal0.22 %
Paste, dentifriceDental.221 %
GelDental1.5 mg/1g
PasteDental1.1 mg/1g
PasteDental1.10 mg/1g
LiquidDental0.001 mg/1mL
Gel; paste, dentifriceDental0.243 %
PasteDental.243 %
GelDental0.243 %
Paste, dentifriceOral
Gel, dentifriceDental0.25 g/100g
Paste, dentifriceDental243 mg/1g
Gel, dentifriceDental0.1 g/100g
MouthwashOral0.0225 g/100g
Paste, dentifriceDental1.3 mg/1g
MouthwashOral0.905 mg/1mL
Liquid; mouthwashBuccal
Gel, dentifriceDental2.2 mg/1g
Paste, dentifriceOral0.75 g/150g
Paste, dentifriceOral0.950 mg/1g
GelDental0.27 g/113.4g
GelDental0.54 g/226.8g
Gel, dentifriceDental243 mg/1g
Gel; paste, dentifriceDental0.23 %
Paste, dentifriceDental.23 %
RinseOral0.05 g/100mL
PasteDental1.5 mg/1g
RinseDental2.1 mg/10mL
RinseDental0.1 mg/1mL
Paste, dentifriceDental0.243 %
Paste, dentifriceDental.243 %
Paste, dentifriceDental; Oral.243 %
Paste, dentifriceDental0.24 mg/1g
Paste, dentifriceDental1.1 mg/1g
RinseDental0.1 mg/20mL
Gel, dentifriceDental1.1 mg/1g
Paste, dentifriceDental1.4 mg/1g
Paste, dentifriceDental1 mg/1g
Paste, dentifriceDental3.281 mg
Paste, dentifriceDental
Gel, dentifriceDental
Paste, dentifriceDental0.32 mg/1mL
RinseOral0.0219 g/1mL
Paste, dentifriceOral5 mg/1g
Powder, dentifriceDental1.88 mg/1g
Kit1.5 mg/1g
Paste, dentifriceDental1.45 g/100mL
Paste, dentifriceDental2.43 mg/100mL
Paste, dentifriceOral243 mg/1g
RinseOral0.1 mg/10mL
RinseOral0.1 mg/1mL
RinseOral2.2 mg/10mL
Paste, dentifriceDental1.6 mg/1g
Gel, dentifriceTopical1.5 mg/1g
RinseDental226 ug/1mL
Gel, dentifriceDental1100 ug/1g
Gel, dentifriceDental5000 ug/1g
PasteDental39.9 g/181.4g
PasteDental0.76 g/100g
Tablet, chewableOral1.1 mg/1
Gel, dentifriceOral1.1 g/100g
GelOral1.1 g/100g
RinseOral0.05 mL/100mL
Paste, dentifriceDental0.1 g/100g
GelDental0.221 %
Kit2.43 mg/1g
MouthwashDental0.02 mg/100mL
TapeDental.15 mg
Paste, dentifriceDental0.09639 g/76.5g
LiquidDental0.023 %
LiquidDental0.02 g/1mL
Aerosol, foamDental
Aerosol, foamDental0.0272 g/1g
GelDental0.02 g/1mL
GelDental0.0272 g/1mL
GelDental0.011 g/1g
GelDental0.011 mg/1mL
RinseDental0.02 g/1mL
Paste, dentifriceDental; Oral1.1 mg/1g
Gel, dentifriceDental.22 g/100mL
Gel, dentifriceDental.22 g/1000mL
LiquidDental0.02 g/100mL
Gel, dentifriceOral0.0905 g/100g
PasteDental0.11 g/100g
Paste, dentifriceTopical0.001 g/0.7g
LiquidTopical0.05 mg/250mL
LiquidTopical0.15 mg/750mL
LiquidTopical0.016 mg/80mL
Tablet, orally disintegratingDental2 mg/1g
PasteOral2.43 mg/1g
PasteDental0.243 g/100g
PasteDental0.15 g/100g
LiquidOral0.15 g/300mL
LiquidDental2.26 %
Gel, dentifriceDental.24 g/100g
Paste, dentifriceDental0.16 g/100g
TabletOral0.55 mg/1
TabletOral1.1 mg/1
TabletOral2.2 mg/1
LiquidOral0.021 g/1mL
Aerosol, foamDental1.5 mg/1mL
Paste, dentifriceDental2.43 mg/1mL
Aerosol, foamDental1.732 g/100g
GelDental5 mg/1mL
Solution / dropsOral5.56 mg/1mL
SolutionOral0.55 mg/0.6mL
LiquidOral2.5 mg/1mL
GelDental1.23 %
SolutionOral11 mg/1g
Paste, dentifriceDental5 mg/1g
Paste, dentifriceDental0.011 g/1g
Solution / dropsOral200 mg
Paste, dentifriceTopical1.1 g/100g
Tablet, chewableOral1 mg/1
LiquidOral200 mg
LiquidOral.05 %
AerosolDental1.23 %
Tablet, delayed releaseOral20 mg
Solution / dropsOral2.21 mg
LiquidOral2.21 mg/.2mL
Paste, dentifriceDental0.65 mg/1g
PasteDental22 mg/1g
Gel, dentifriceDental2.43 mg/1g
Gel, dentifriceDental2 g/100g
LiquidDental; Topical1.23 %
GelDental0.597 g/120g
Aerosol, foamDental1.125 g/125g
Aerosol, foamDental; Oral; Topical2.5 g/125g
Paste, dentifriceDental.22 %
Paste, dentifriceTopical2.1 mg/1g
PasteTopical1.23 %
RinseDental; Topical0.5 mg/1mL
Paste, dentifriceDental; Oral2.4 mg/1g
Paste, dentifriceOral0.24 g/100g
Paste, dentifriceOral0.15 g/100g
Paste, dentifriceDental0.243 mg/100g
PasteDental2.5 mg/1g
MouthwashDental20 mg/100000mL
LiquidTopical0.5 %
Paste, dentifriceDental0.243 g/100g
Paste, dentifriceDental1.5 mg/1g
AerosolDental1 %
CreamOral1.23 %
Kit1.6 mg/1g
GelDental.24 %
GelDental; Oral; Topical10.241 g/490g
GelDental; Oral; Topical6.027 g/490g
Aerosol, foamDental; Oral; Topical1.5498 g/126g
GelDental; Oral; Topical4.41 g/490g
LiquidDental; Oral38 g/1L
Gel, dentifriceTopical0.243 mg/1mg
Gel, dentifriceTopical1.1 g/100g
Gel, dentifriceTopical1.11 g/100g
LiquidOral1.95 mg
TabletOral1 mg
GelDental0.5 %
MouthwashOral0.02 kg/100L
MouthwashOral.0221 kg/100L
RinseOral.02 mg/1mL
Paste, dentifriceDental0.239 g
Paste, dentifriceTopical0.2592 g/108g
PasteTopical0.2592 g/108g
Aerosol, foamDental12.3 mg/1g
Aerosol, foamDental27.2 mg/1g
PasteDental2.43 mg/1g
Paste, dentifriceOral2.5 mg/1g
MouthwashOral0.221 g/1mL
MouthwashDental0.1 mg/1mL
RinseOral0.2 mg/1mL
Tablet, chewableOral0.25 mg/1
Tablet, chewableOral0.5 mg/1
Tablet, chewableOral1.0 mg/1
MouthwashDental; Oral
Paste, dentifriceDental; Oral2.2 mg/1mL
Gel, dentifriceOral0.1 g/100g
Paste, dentifriceDental2.2 mg/1g
PasteDental22 g/100g
Paste, dentifriceDental22 g/100g
Gel, dentifriceDental0.10 g/100g
Gel, dentifriceDental0.15 g/100g
Paste, dentifriceDental2 g/0.2g
PasteOral2.2 mg/1g
GelDental4.086 g/454g
Tablet, chewableOral
PowderDental1 g/1g
SolutionDental20 mg/10mL
SolutionDental2 mg/1mL
MouthwashDental0.2 mg/1mL
GelOral1.428 g/120g
Gel, dentifriceDental1.1 g/100g
LiquidDental; Oral2 %
LiquidTopical2 mL/100mL
RinseOral20 mg/1mL
RinseOral9 mg/10mL
PasteOral1.1 g/112g
Paste, dentifriceOral1.1 g/112g
RinseDental2 g/100g
GelDental20 mg/1g
RinseDental20 mg/1g
GelDental25.9 mg/1g
GelTopical2 %
RinseOral0.0154 g/770mL
LiquidOral0.06 mg/300mL
Paste, dentifriceDental1.13 mg/1g
PasteDental0.1 g/100g
LiquidDental0.2 mg/1mL
Gel, dentifriceDental6 mg/1g
MouthwashBuccal; Topical
SolutionOral12.3 mg/1g
SolutionOral0.5 mg/1g
Paste, dentifriceDental.14 g/118g
MouthwashOral.2418 g/474mL
LiquidBuccal; Topical0.05 %
LiquidDental500 ug/1mL
AerosolDental10 mg/1g
AerosolDental9 mg/1g
GelDental11 mg/1g
Cream; paste, dentifriceTopical
Gel, dentifriceOral.15 g/100g
Gel, dentifriceOral0.15 g/100g
MouthwashOral0.15 g/100g
Gel, dentifriceOral.044 mL/100mL
LiquidDental; Topical
RinseOral0.199 mg/1mL
Paste, dentifriceDental0.22 %
Aerosol, foamDental2.5 g/125g
GelDental; Topical11.1 mg/1mL
GelDental; Topical27.2 mg/1mL
RinseDental; Topical27.2 mg/1mL
LiquidTopical27.2 mg/1mg
GelTopical20 mg/1g
GelDental; Topical20 mg/1mL
Aerosol, foamTopical0.0272 g/1g
GelTopical11 mg/1mg
Aerosol, foamTopical.0272 mg/1g
Aerosol, foamTopical20.0 mg/1mg
GelTopical20.0 mg/1mg
GelTopical20 mg/1mg
RinseTopical20 mg/1mL
RinseTopical2.0 mg/1mL
LiquidTopical20.0 mg/1mg
RinseTopical2.0 mg/1g
GelTopical27.2 mg/1mg
GelTopical.02 mg/1mL
Aerosol, foamDental; Topical0.0272 g/1g
Aerosol, foamDental; Topical0.02 g/1g
MouthwashOral.2 %
LiquidDental.227 mg
PasteDental0.24 g/100g
Paste, dentifriceOral0.243 g/100g
Paste, dentifriceDental2.4 mg/1g
GelOral0.5 %
MouthwashDental1.24 %
GelDental2 %
Paste, dentifriceDental2.72 %
Paste, dentifriceDental.24 mg/100mL
SolutionDental2 %
GelBuccal; Dental; Topical9.05 mg/1g
DiscTopical0.055 mg/1
RinseDental2 mg/10mL
RinseDental4.42 mg/10mL
Paste, dentifriceOral0.308 g/140g
Paste, dentifriceOral0.374 g/170g
Paste, dentifriceDental; Oral0.4 mg/1g
PasteDental14 mg/1g
PasteDental24 mg/1g
Paste, dentifriceDental0.14 g/100g
Solution / dropsOral
Gel, dentifriceDental0.24 g/100g
Gel, dentifriceDental11 mg/1g
MouthwashDental2 mg/1mL
Gel, dentifriceDental13.4 mg/1mL
Paste, dentifriceDental6 mg/1mL
Gel, dentifriceDental6.1 mg/1mL
Paste, dentifriceDental5 mg/1mL
MouthwashDental0.9 mg/1mL
GelOral0.044 mL/1mL
GelOral0.2 mg/1mL
GelOral4.3 mg/1g
GelOral4.3 g/1g
GelOral44 mg/1mL
GelOral5 mg/1g
RinseOral0.9 mg/1mL
RinseOral0.946 mL/1mL
RinseOral9 mg/1mL
LiquidBuccal0.5 %
LiquidDental; Oral0.9 %
LiquidDental; Oral
PasteDental0.23 g/100g
MouthwashOral.2 mg/1mL
LiquidOral0.02 g/100mL
Gel, dentifriceDental0.07 g/28.35g
Aerosol, foamDental1.5375 g/125g
Paste, dentifriceDental0.23 g/100g
PasteDental0.22 g/100g
GelDental0.24 %
TapeDental0.15 mg
Paste, dentifriceOral2.43 mg/1g
Paste, dentifriceOral2.4 mg/1g
Paste, dentifriceOral1.5 mg/1g
Gel, dentifriceDental0.22 g/100g
PasteOral1.5 mg/1g
MouthwashOral0.2 mg/1L
Paste, dentifriceTopical
CreamDental5 mg/1g
Paste, dentifriceOral0.0905 g/100g
FilmDental20 mg/1
PasteDental2.4 mg/100g
LiquidDental0.05 mg/100g
Paste, dentifriceDental0.00243 g/1g
Paste, dentifriceDental0.0024 g/1g
LiquidOral0.5 mg/1mL
LiquidOral0.2 mg/1mL
CreamOral0.22 g/100g
SolutionOral0.2 mg/1mL
Solution / dropsOral0.5 mg/1mL
TabletOral0.25 mg/1
TabletOral0.5 mg/1
TabletOral1.0 mg/1
LiquidOral6.9 mg
TabletOral2.21 mg
LiquidDental.25 mg
PasteDental0.198 g/90g
MouthwashDental0.02 g/100mL
Paste, dentifriceDental0.24 g/100g
Gel, dentifriceDental1.5 mg/1g
Paste, dentifriceDental0.28 g/113g
Gel, dentifriceDental5 mg/1g
Paste, dentifriceDental0.33 g/133g
PasteDental1.23 %
PasteDental0.243 %
Paste, dentifriceOral1.25 mg/1mL
Paste, dentifriceDental0.2430 g/100g
Paste, dentifriceOral0.2430 g/100g
Gel, dentifriceTopical0.0002 g/251
RinseOral0.0005 g/1g
Paste, dentifriceOral0.0024 g/1g
Gel, dentifriceDental24 mg/10g
Paste, dentifriceDental243 mg/100mL
GelDental5.6 g/454g
Gel, dentifriceDental0.00243 g/1g
PasteTopical0.06804 g/28g
PowderDental0.24 g/100g
Aerosol, foamDental27.3 mg/1g
Aerosol, foamDental0.02 g/1g
Aerosol, foamTopical123 mg/1g
AerosolDental0.9 %
Paste, dentifriceDental0.243 mg/1g
Paste, dentifriceDental.243 mg/1g
Aerosol, foamDental1.23 g/100g
MouthwashOral0.001 g/10mL
Paste, dentifriceDental2.43 mg/1g
Paste, dentifriceDental0.10 g/100g
Gel, dentifriceDental; Oral11 mg/1g
Paste, dentifriceDental2.0 mg/1g
PasteDental2.4 mg/1g
PasteTopical0.26244 g/108g
Paste, dentifriceDental0.24 %
LiquidBuccal; Oral0.0002 %
MouthwashOral0.559 mg/1mL
PasteOral0.0028 g/1g
Aerosol, foamDental2.72 g/100g
Not Available
Patent NumberPediatric ExtensionApprovedExpires (estimated)


Experimental Properties
Not Available
Predicted Properties
pKa (Strongest Acidic)3.17ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available


Mass Spec (NIST)
Not Available
Not Available


This compound belongs to the class of inorganic compounds known as alkali metal fluorides. These are inorganic compounds in which the largest halogen atom is fluorine, and the heaviest metal atom is an alkali metal.
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Alkali metal salts
Sub Class
Alkali metal fluorides
Direct Parent
Alkali metal fluorides
Alternative Parents
Inorganic sodium salts
Alkali metal fluoride / Inorganic sodium salt / Inorganic salt
Molecular Framework
Not Available
External Descriptors
fluoride salt (CHEBI:28741)


Pharmacological action
General Function
Pyridoxal phosphate binding
Specific Function
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting wi...
Gene Name
Uniprot ID
Uniprot Name
Alanine aminotransferase 1
Molecular Weight
54636.415 Da
  1. ejournal [Link]
Pharmacological action
General Function
Iron ion binding
Specific Function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic su...
Gene Name
Uniprot ID
Uniprot Name
Cytochrome c oxidase subunit 1
Molecular Weight
57040.91 Da
  1. ejournal [Link]

Drug created on November 17, 2015 11:36 / Updated on March 18, 2019 22:40