Identification Name 9-aminocamptothecin Accession Number DB12515 Type Small Molecule Groups Investigational Description
Aminocamptothecin has been used in trials studying the treatment of Lymphoma, Gastric Cancer, Ovarian Cancer, Esophageal Cancer, and Ovarian Neoplasms, among others.
Structure Synonyms External IDs NSC-603071 Product Ingredients Not Available Products Not Available International Brands Not Available Brand mixtures Not Available Categories UNII 5MB77ICE2Q CAS number 91421-43-1 Weight Average: 363.373 Monoisotopic: 363.121906039 Chemical Formula C 20H 17N 3O 4 InChI Key FUXVKZWTXQUGMW-FQEVSTJZSA-N InChI
SMILES Pharmacology Indication Not Available Structured Indications Not Available Pharmacodynamics Not Available Mechanism of action Not Available Related Articles Absorption Not Available Volume of distribution Not Available Protein binding Not Available Metabolism Not Available Route of elimination Not Available Half life Not Available Clearance Not Available Toxicity Not Available Affected organisms Not Available Pathways Not Available Pharmacogenomic Effects/ADRs Not Available Interactions Drug Interactions
Drug Interaction Drug group Acetyldigitoxin Acetyldigitoxin may decrease the cardiotoxic activities of Aminocamptothecin. Approved Bevacizumab Bevacizumab may increase the cardiotoxic activities of Aminocamptothecin. Approved, Investigational Cabazitaxel The risk or severity of adverse effects can be increased when Cabazitaxel is combined with Aminocamptothecin. Approved Cyclophosphamide Cyclophosphamide may increase the cardiotoxic activities of Aminocamptothecin. Approved, Investigational Deslanoside Deslanoside may decrease the cardiotoxic activities of Aminocamptothecin. Approved Digitoxin Digitoxin may decrease the cardiotoxic activities of Aminocamptothecin. Approved Digoxin Digoxin may decrease the cardiotoxic activities of Aminocamptothecin. Approved Docetaxel The risk or severity of adverse effects can be increased when Docetaxel is combined with Aminocamptothecin. Approved, Investigational Oleandrin Anvirzel may decrease the cardiotoxic activities of Aminocamptothecin. Experimental Ouabain Ouabain may decrease the cardiotoxic activities of Aminocamptothecin. Approved Paclitaxel The risk or severity of adverse effects can be increased when Paclitaxel is combined with Aminocamptothecin. Approved, Vet Approved Trastuzumab Trastuzumab may increase the cardiotoxic activities of Aminocamptothecin. Approved, Investigational Food Interactions Not Available References Synthesis Reference Not Available General References Not Available External Links ATC Codes Not Available AHFS Codes Not Available PDB Entries Not Available FDA label Not Available MSDS Not Available Clinical Trials Clinical Trials Properties State Not Available Experimental Properties Not Available Predicted Properties Predicted ADMET features Not Available Spectra Mass Spec (NIST) Not Available Spectra Taxonomy Description This compound belongs to the class of organic compounds known as camptothecins. These are heterocyclic compounds comprising a planar pentacyclic ring structure, that includes a pyrrolo[3,4-beta]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D) and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring). Kingdom Organic compounds Super Class Alkaloids and derivatives Class Camptothecins Sub Class Not Available Direct Parent Camptothecins Alternative Parents Aminoquinolines and derivatives / Pyranopyridines / Pyridinones / Benzenoids / Tertiary alcohols / Heteroaromatic compounds / Amino acids and derivatives / Carboxylic acid esters / Lactones / Lactams / Oxacyclic compounds / Azacyclic compounds / Monocarboxylic acids and derivatives / Carbonyl compounds / Organopnictogen compounds / Organic oxides / Primary amines / Hydrocarbon derivatives show 8 more Substituents Camptothecin / Aminoquinoline / Pyranopyridine / Quinoline / Pyridinone / Pyridine / Benzenoid / Heteroaromatic compound / Tertiary alcohol / Amino acid or derivatives / Carboxylic acid ester / Lactam / Lactone / Carboxylic acid derivative / Oxacycle / Monocarboxylic acid or derivatives / Azacycle / Organoheterocyclic compound / Organic nitrogen compound / Amine / Hydrocarbon derivative / Organic oxide / Alcohol / Carbonyl group / Organopnictogen compound / Organonitrogen compound / Organooxygen compound / Primary amine / Organic oxygen compound / Aromatic heteropolycyclic compound show 20 more Molecular Framework Aromatic heteropolycyclic compounds External Descriptors pyranoindolizinoquinoline ( CHEBI:80755 )