Echinacea

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Echinacea
Accession Number
DB14240
Type
Biotech
Groups
Approved, Experimental
Description
Not Available
Synonyms
  • Echinacea angustifolia or echinacea pallida
  • Echinacea, unspecified
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
EchinaceaCapsuleOralNutraceutical CorporationNot applicableNot applicableCanada
Echinacea - LiqLiquidOralSisu Inc.1995-12-312004-09-01Canada
Echinacea Capsules 400mgCapsuleOralMczand Herbal Inc.1995-12-311996-11-13Canada
Echinacea PlusCapsuleOralSisu Inc.1998-11-102004-09-01Canada
Echinacea Root Extract 200mg CapsulesCapsuleOralPharmetics (2011) Inc.1999-11-022009-07-30Canada
Echinacea TinctureSolution / dropsOralSt. Francis Herb Farm Inc.1989-12-311997-04-07Canada
Echinacea TinctureTinctureOralHolista Health (Canada) Inc.1997-07-142002-08-06Canada
EchinaceeCapsuleOralPns Pharma Therapy2001-09-302009-08-05Canada
EchinaceeCapsuleOralSantÉ Naturelle (Ag) LtÉe1999-03-192007-08-03Canada
EchinalifeCapsuleOralHolista Health (Canada) Inc.1996-12-312001-08-01Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Celestial Seasonings Herbal Comfort LozengesEchinacea (50 mg) + Eleuthero (25 mg)LozengeOralWarner Lambert Canada Inc.Not applicableNot applicableCanada
Herbon Sugar Free Wild CherryEchinacea (100 mg/1) + Levomenthol (2 mg/1)LozengeOralPurity Life Division of SunOpta Co.2009-09-302010-12-31Us
Herbon Wild CherryEchinacea (100 mg/1) + Levomenthol (2 mg/1)LozengeOralPurity Life Division of SunOpta2009-09-30Not applicableUs
Categories
UNII
4N9P6CC1DX
CAS number
Not Available

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be increased when combined with Echinacea.
9-aminocamptothecinThe metabolism of 9-aminocamptothecin can be increased when combined with Echinacea.
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Echinacea.
AlbendazoleThe metabolism of Albendazole can be increased when combined with Echinacea.
AlfentanilThe metabolism of Alfentanil can be increased when combined with Echinacea.
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Echinacea.
AlpelisibThe metabolism of Alpelisib can be increased when combined with Echinacea.
AlprazolamThe metabolism of Alprazolam can be increased when combined with Echinacea.
AminophyllineThe metabolism of Aminophylline can be increased when combined with Echinacea.
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Echinacea.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
Wikipedia
Echinacea
AHFS Codes
  • 92:01.00* — Herbs and Natural Products

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedPreventionAcute Rhinitis1
2WithdrawnSupportive CareMucositis / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Recurrent Verrucous Carcinoma of the Larynx / Recurrent Verrucous Carcinoma of the Oral Cavity / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage III Verrucous Carcinoma of the Larynx / Stage III Verrucous Carcinoma of the Oral Cavity / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IVA Squamous Cell Carcinoma of the Larynx / Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVA Squamous Cell Carcinoma of the Oropharynx / Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVA Verrucous Carcinoma of the Larynx / Stage IVA Verrucous Carcinoma of the Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Larynx / Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IVB Squamous Cell Carcinoma of the Oropharynx / Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IVB Verrucous Carcinoma of the Larynx / Stage IVB Verrucous Carcinoma of the Oral Cavity / Tongue Cancer1
3CompletedPreventionAcute Rhinitis / Gastroenteritis1
3CompletedTreatmentPharyngitis1
3CompletedTreatmentAcute Rhinitis1
4CompletedNot AvailableHealthy Volunteers1
4CompletedPreventionInfection NOS1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedBasic ScienceUpper Respiratory Tract Infection2
Not AvailableCompletedPreventionUpper Respiratory Tract Infection1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidOral
CapsuleOral
LozengeOral
Solution / dropsOral
TinctureOral
TabletOral
LozengeOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Classification
Not classified

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Awortwe C, Manda VK, Avonto C, Khan SI, Khan IA, Walker LA, Bouic PJ, Rosenkranz B: Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway. Xenobiotica. 2015 Mar;45(3):218-29. doi: 10.3109/00498254.2014.973930. Epub 2014 Nov 7. [PubMed:25377539]
  2. Gorski JC, Huang SM, Pinto A, Hamman MA, Hilligoss JK, Zaheer NA, Desai M, Miller M, Hall SD: The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther. 2004 Jan;75(1):89-100. doi: 10.1016/j.clpt.2003.09.013. [PubMed:14749695]

Drug created on July 05, 2018 10:04 / Updated on December 08, 2019 14:16