Respiratory Tract Infections (RTI)

Also known as: Respiratory Tract Infection / Respiratory Infections / Infections, Respiratory Tract / Respiratory Infection / Respiratory tract infections / Infections, Respiratory / Infection respiratory / Respiratory tract infection NOS / RTI / Unspecified respiratory tract infection

DrugDrug NameDrug Description
DB00415AmpicillinAmpicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
DB00567CephalexinA semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
DB01190ClindamycinClindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00618DemeclocyclineA tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. [PubChem]
DB00254DoxycyclineA synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum).
DB01017MinocyclineA tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections. [PubChem]
DB09320Procaine benzylpenicillinProcaine benzylpenicillin (INN), also known as procaine G penicillin, is an antibiotic useful for the treatment of a number of bacterial infections. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Following deep intramuscular injection, it is slowly absorbed into the circulation and hydrolysed to benzylpenicillin — thus it is used where prolonged low concentrations of benzylpenicillin are required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings. Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many infections.
DrugDrug NameTargetType
DB00415AmpicillinSerum albumincarrier
DB00415AmpicillinSolute carrier family 22 member 5transporter
DB00415AmpicillinSolute carrier family 15 member 1transporter
DB00415AmpicillinSolute carrier family 15 member 2transporter
DB00415AmpicillinPenicillin-binding protein 2atarget
DB00415AmpicillinPenicillin-binding protein 1btarget
DB00415AmpicillinPenicillin-binding protein 3target
DB00415AmpicillinPenicillin-binding protein 1Atarget
DB00415AmpicillinPenicillin-binding protein 2Btarget
DB00415AmpicillinMonocarboxylate transporter 1transporter
DB00415AmpicillinSolute carrier family 15 member 1target
DB00415AmpicillinSolute carrier family 15 member 2target
DB00415AmpicillinAngiopoietin-1 receptortarget
DB00567CephalexinSerum albumincarrier
DB00567CephalexinSolute carrier family 22 member 5transporter
DB00567CephalexinSolute carrier family 15 member 1transporter
DB00567CephalexinSolute carrier family 15 member 2transporter
DB00567CephalexinSolute carrier family 22 member 6transporter
DB00567CephalexinSolute carrier family 22 member 8transporter
DB00567CephalexinMultidrug and toxin extrusion protein 1transporter
DB00567CephalexinPenicillin-binding protein 3target
DB00567CephalexinPenicillin-binding protein 2atarget
DB00567CephalexinPenicillin-binding protein 1btarget
DB00567CephalexinPenicillin-binding protein 1Atarget
DB00567CephalexinPenicillin-binding protein 2Btarget
DB00567CephalexinCytochrome P450 3A4enzyme
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S rRNAtarget
DB00618Demeclocycline30S ribosomal protein S4target
DB00618Demeclocycline30S ribosomal protein S9target
DB00254Doxycycline30S ribosomal protein S4target
DB00254Doxycycline30S ribosomal protein S9target
DB00254Doxycycline16S rRNAtarget
DB00254DoxycyclineSolute carrier family 22 member 6transporter
DB00254DoxycyclineSolute carrier family 22 member 8transporter
DB00254DoxycyclineSolute carrier family 22 member 11transporter
DB00254DoxycyclineCytochrome P450 3A4enzyme
DB00254DoxycyclineProtein-arginine deiminase type-4target
DB00254DoxycyclineBeta-2-microglobulintarget
DB01017Minocycline30S ribosomal protein S4target
DB01017Minocycline30S ribosomal protein S9target
DB01017Minocycline16S rRNAtarget
DB01017MinocyclineInterleukin-1 betatarget
DB01017MinocyclineArachidonate 5-lipoxygenasetarget
DB01017MinocyclineMatrix metalloproteinase-9target
DB01017MinocyclineVascular endothelial growth factor Atarget
DB01017MinocyclineCaspase-1target
DB01017MinocyclineCaspase-3target
DB01017MinocyclineCytochrome ctarget
DB01017MinocyclineSolute carrier family 22 member 6transporter
DB01017MinocyclineSolute carrier family 22 member 8transporter
DB01017MinocyclineSolute carrier family 22 member 11transporter
DB01017MinocyclineSolute carrier family 22 member 7transporter
DrugDrug NamePhaseStatusCount
DB00798Gentamicin0Completed1
DB00512Vancomycin0Completed1
DB06151Acetylcysteine1Completed1
DB01060Amoxicillin1Completed1
DB00567Cephalexin1Completed3
DB00878Chlorhexidine1Completed1
DB00766Clavulanate1Completed1
DB11922Danirixin1Completed1
DB00514Dextromethorphan1Completed1
DB12134Gepotidacin1Completed4
DB00218Moxifloxacin1Completed1
DB00207Azithromycin1 / 2Terminated1
DB00362Anidulafungin2Terminated1
DB00207Azithromycin2Terminated1
DB01222Budesonide2Terminated1
DB01329Cefoperazone2Unknown Status1
DB00169Cholecalciferol2Active Not Recruiting1
DB11651Dactolisib2Active Not Recruiting1
DB00153Ergocalciferol2Completed1
DB01590Everolimus2Active Not Recruiting1
DB00983Formoterol2Terminated1
DB10791Influenza A virus A/california/7/2009 x-179a (H1N1) antigen (formaldehyde inactivated)2Active Not Recruiting1
DB00471Montelukast2Terminated1
DB00635Prednisone2Terminated1
DB09324Sulbactam2Unknown Status1
DB11094Vitamin D2Completed1
DB00878Chlorhexidine2 / 3Completed1
DB00613Amodiaquine3Completed1
DB01060Amoxicillin3Not Yet Recruiting1
DB00126Ascorbic acid3Withdrawn2
DB00207Azithromycin3Completed1
DB00207Azithromycin3Not Yet Recruiting1
DB12768BCG vaccine3Active Not Recruiting1
DB09213Dexibuprofen3Completed1
DB01050Ibuprofen3Completed1
DB00316Acetaminophen4Completed1
DB00945Acetylsalicylic acid4Completed1
DB00207Azithromycin4Completed2
DB00207Azithromycin4Terminated1
DB11897Beclomethasone dipropionate4Completed1
DB00537Ciprofloxacin4Recruiting1
DB00198Oseltamivir4Completed1
DB00319Piperacillin4Recruiting1
DB00319Piperacillin4Unknown Status1
DB09324Sulbactam4Unknown Status1
DB01606Tazobactam4Recruiting1
DB00976Telithromycin4Completed1
DB00976Telithromycin4Terminated1
DB01212CeftriaxoneNot AvailableNot Yet Recruiting1
DB01211ClarithromycinNot AvailableCompleted3
DB00760MeropenemNot AvailableNot Yet Recruiting1
DB09140OxygenNot AvailableRecruiting1
DB12343TemocillinNot AvailableNot Yet Recruiting1
DB00162Vitamin ANot AvailableCompleted1
DB01593ZincNot AvailableCompleted1