Respiratory Tract Infections (RTI)

Also known as: Respiratory tract infections NEC / Infections, Respiratory / Respiratory Infection / Respiratory Infections / Infections, Respiratory Tract / Respiratory Tract Infections / Respiratory Tract Infection / Infection respiratory / Respiratory tract infection NOS / RTI / Unspecified respiratory tract infection

DrugDrug NameDrug Description
DB00415AmpicillinAmpicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
DB00567CephalexinCephalexin is the first of the first generation cephalosporins.[A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide.[A179071] Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,Label] Cephalexin was approved by the FDA on 4 January 1971.[L6547]
DB01190ClindamycinClindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00618DemeclocyclineA tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
DB00254DoxycyclineDoxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline [FDA label]. This drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines [A174034]. Doxycycline may be used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing.
DB00199ErythromycinErythromycin is an antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the _macrolide_ group of antibiotics [FDA label]. It was originally discovered in 1952. Erythromycin is widely used for treating a variety of infections, including those caused by gram-positive bacteria, gram-negative bacteria and many other organisms [L5245], [FDA label].
DB01017MinocyclineA tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections.
DB09320Procaine benzylpenicillinProcaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It is slowly absorbed and hydrolyzed to benzylpenicillin. This drug is used where prolonged exposure to benzylpenicillin at a low concentration is required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings. Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many infections.
DrugDrug NameTargetType
DB00415AmpicillinSerum albumincarrier
DB00415AmpicillinSolute carrier family 22 member 5transporter
DB00415AmpicillinSolute carrier family 15 member 1transporter
DB00415AmpicillinSolute carrier family 15 member 2transporter
DB00415AmpicillinPenicillin-binding protein 2atarget
DB00415AmpicillinPenicillin-binding protein 1btarget
DB00415AmpicillinPenicillin-binding protein 3target
DB00415AmpicillinPenicillin-binding protein 1Atarget
DB00415AmpicillinPenicillin-binding protein 2Btarget
DB00415AmpicillinMonocarboxylate transporter 1transporter
DB00415AmpicillinSolute carrier family 15 member 1target
DB00415AmpicillinSolute carrier family 15 member 2target
DB00415AmpicillinAngiopoietin-1 receptortarget
DB00567CephalexinSerum albumincarrier
DB00567CephalexinSolute carrier family 22 member 5transporter
DB00567CephalexinSolute carrier family 15 member 1transporter
DB00567CephalexinSolute carrier family 15 member 2transporter
DB00567CephalexinSolute carrier family 22 member 6transporter
DB00567CephalexinSolute carrier family 22 member 8transporter
DB00567CephalexinMultidrug and toxin extrusion protein 1transporter
DB00567CephalexinPenicillin-binding protein 3target
DB00567CephalexinPenicillin-binding protein 2atarget
DB00567CephalexinPenicillin-binding protein 1btarget
DB00567CephalexinPenicillin-binding protein 1Atarget
DB00567CephalexinPenicillin-binding protein 2Btarget
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S rRNAtarget
DB00618Demeclocycline30S ribosomal protein S4target
DB00618Demeclocycline30S ribosomal protein S9target
DB00254Doxycycline16S rRNAtarget
DB00254DoxycyclineSolute carrier family 22 member 6transporter
DB00254DoxycyclineCytochrome P450 3A4enzyme
DB00254DoxycyclineATP-binding cassette sub-family B member 5transporter
DB00199Erythromycin23S rRNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinMultidrug resistance protein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinBacterial 50S Ribosomal Subunittarget
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB01017Minocycline30S ribosomal protein S4target
DB01017Minocycline30S ribosomal protein S9target
DB01017Minocycline16S rRNAtarget
DB01017MinocyclineInterleukin-1 betatarget
DB01017MinocyclineArachidonate 5-lipoxygenasetarget
DB01017MinocyclineMatrix metalloproteinase-9target
DB01017MinocyclineVascular endothelial growth factor Atarget
DB01017MinocyclineCaspase-1target
DB01017MinocyclineCaspase-3target
DB01017MinocyclineCytochrome ctarget
DB01017MinocyclineSolute carrier family 22 member 6transporter
DB01017MinocyclineSolute carrier family 22 member 8transporter
DB01017MinocyclineSolute carrier family 22 member 11transporter
DB01017MinocyclineSolute carrier family 22 member 7transporter
DrugDrug NamePhaseStatusCount
DB00798Gentamicin0Completed1
DB00512Vancomycin0Completed1
DB06151Acetylcysteine1Completed1
DB01060Amoxicillin1Completed1
DB00567Cephalexin1Completed3
DB00878Chlorhexidine1Completed1
DB00766Clavulanic acid1Completed1
DB11922Danirixin1Completed1
DB00514Dextromethorphan1Completed1
DB12134Gepotidacin1Completed4
DB00218Moxifloxacin1Completed1
DB00207Azithromycin1 / 2Terminated1
DB00362Anidulafungin2Terminated1
DB00207Azithromycin2Terminated1
DB01222Budesonide2Terminated1
DB01329Cefoperazone2Unknown Status1
DB00169Cholecalciferol2Active Not Recruiting1
DB11651Dactolisib2Active Not Recruiting1
DB00153Ergocalciferol2Completed1
DB01590Everolimus2Active Not Recruiting1
DB00983Formoterol2Terminated1
DB10791Influenza A virus A/california/7/2009 x-179a (H1N1) antigen (formaldehyde inactivated)2Active Not Recruiting1
DB00471Montelukast2Terminated1
DB00635Prednisone2Terminated1
DB09324Sulbactam2Unknown Status1
DB11094Vitamin D2Completed1
DB00878Chlorhexidine2 / 3Completed1
DB00613Amodiaquine3Completed1
DB01060Amoxicillin3Recruiting1
DB00126Ascorbic acid3Withdrawn2
DB00207Azithromycin3Completed1
DB00207Azithromycin3Recruiting1
DB12768BCG vaccine3Active Not Recruiting1
DB09213Dexibuprofen3Completed1
DB01050Ibuprofen3Completed1
DB00316Acetaminophen4Completed1
DB00945Acetylsalicylic acid4Completed1
DB00207Azithromycin4Completed2
DB00207Azithromycin4Terminated1
DB11897Beclomethasone dipropionate4Completed1
DB00537Ciprofloxacin4Recruiting1
DB00198Oseltamivir4Completed1
DB00319Piperacillin4Recruiting1
DB00319Piperacillin4Unknown Status1
DB09324Sulbactam4Unknown Status1
DB01606Tazobactam4Recruiting1
DB00976Telithromycin4Completed1
DB00976Telithromycin4Terminated1
DB01212CeftriaxoneNot AvailableNot Yet Recruiting1
DB01211ClarithromycinNot AvailableCompleted3
DB00760MeropenemNot AvailableNot Yet Recruiting1
DB09140OxygenNot AvailableRecruiting1
DB12343TemocillinNot AvailableNot Yet Recruiting1
DB00162Vitamin ANot AvailableCompleted1
DB01593ZincNot AvailableCompleted1