AZD-1656

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
AZD-1656
Accession Number
DB14810
Type
Small Molecule
Groups
Investigational
Description

AZD-1656 is under investigation in clinical trial NCT00747175 (A Study to Evaluate Safety, Tolerability and P-Glucose After Multiple Ascending Oral Doses of AZD1656 in Type 2 Diabetes).

Structure
Thumb
Synonyms
Not Available
External IDs
AZD1656
Categories
UNII
660M185X4D
CAS number
919783-22-5
Weight
Average: 478.509
Monoisotopic: 478.196467961
Chemical Formula
C24H26N6O5
InChI Key
FJEJHJINOKKDCW-INIZCTEOSA-N
InChI
InChI=1S/C24H26N6O5/c1-15-10-27-21(12-25-15)29-23(31)17-7-18(34-16(2)14-33-3)9-19(8-17)35-22-13-26-20(11-28-22)24(32)30-5-4-6-30/h7-13,16H,4-6,14H2,1-3H3,(H,27,29,31)/t16-/m0/s1
IUPAC Name
3-{[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy}-5-{[(2S)-1-methoxypropan-2-yl]oxy}-N-(5-methylpyrazin-2-yl)benzamide
SMILES
COC[C@H](C)OC1=CC(=CC(OC2=NC=C(N=C2)C(=O)N2CCC2)=C1)C(=O)NC1=NC=C(C)N=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
13168348
ChEMBL
CHEMBL3219124

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableGlucose Lowering1
1CompletedNot AvailableType 2 Diabetes Mellitus1
1CompletedBasic ScienceHigh Blood Sugar / Type 2 Diabetes Mellitus1
1CompletedBasic ScienceType 2 Diabetes Mellitus1
1CompletedTreatmentHealthy Volunteers2
1CompletedTreatmentType 1 Diabetes Mellitus1
1CompletedTreatmentType 2 Diabetes Mellitus13
2CompletedTreatmentType 2 Diabetes Mellitus4

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0443 mg/mLALOGPS
logP1.92ALOGPS
logP0.8ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)13.09ChemAxon
pKa (Strongest Basic)0.58ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area128.66 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity127.74 m3·mol-1ChemAxon
Polarizability50.25 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as diarylethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are aryl groups.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Ethers
Direct Parent
Diarylethers
Alternative Parents
Benzamides / Pyrazinecarboxamides / 2-heteroaryl carboxamides / Benzoyl derivatives / Phenol ethers / Phenoxy compounds / Alkyl aryl ethers / Imidolactams / Heteroaromatic compounds / Tertiary carboxylic acid amides
show 7 more
Substituents
Diaryl ether / Benzamide / Benzoic acid or derivatives / Pyrazinecarboxamide / Pyrazine carboxylic acid or derivatives / 2-heteroaryl carboxamide / Phenoxy compound / Benzoyl / Phenol ether / Alkyl aryl ether
show 18 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Drug created on May 20, 2019 08:28 / Updated on June 12, 2020 10:53

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