This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- 6-diazo-5-oxo-L-norleucine
- DrugBank Accession Number
- DB17537
- Background
6-diazo-5-oxo-L-norleucine is a broad-acting glutamine antagonist.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for 6-diazo-5-oxo-L-norleucine (DB17537)
- Weight
- Average: 171.156
Monoisotopic: 171.064391162 - Chemical Formula
- C6H9N3O3
- Synonyms
- Not Available
- External IDs
- DON
- NSC-7365
Pharmacology
- Indication
Not Available
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Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 03J0H273KZ
- CAS number
- 157-03-9
- InChI Key
- YCWQAMGASJSUIP-YFKPBYRVSA-N
- InChI
- InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
- IUPAC Name
- (2S)-2-amino-6-diazo-5-oxohexanoic acid
- SMILES
- N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 16735775
- ChEBI
- 183231
- ChEMBL
- CHEMBL97485
- ZINC
- ZINC000003953825
- Wikipedia
- 6-Diazo-5-oxo-L-norleucine
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1, 2 Recruiting Treatment Malaria, Cerebral 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 17.2 mg/mL ALOGPS logP -1.7 ALOGPS logP -4.2 Chemaxon logS -1 ALOGPS pKa (Strongest Acidic) 1.87 Chemaxon pKa (Strongest Basic) 9.36 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 97.46 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 38.4 m3·mol-1 Chemaxon Polarizability 15.81 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at February 15, 2023 17:53 / Updated at February 16, 2023 16:06