NAV

Bezuclastinib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Bezuclastinib
DrugBank Accession Number
DB18041
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 331.379
Monoisotopic: 331.143310187
Chemical Formula
C19H17N5O
Synonyms
  • 3,4-dimethyl-n-(2-phenyl-1h-pyrrolo(2,3-b)pyridin-5-yl)-1h-pyrazole-5-carboxamide
  • 3,4-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-5- carboxamide
External IDs
  • CGT9486
  • PLX-9486
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
2ROQ545LAG
CAS number
1616385-51-3
InChI Key
NVSHVYGIYPBTEZ-UHFFFAOYSA-N
InChI
InChI=1S/C19H17N5O/c1-11-12(2)23-24-17(11)19(25)21-15-8-14-9-16(22-18(14)20-10-15)13-6-4-3-5-7-13/h3-10H,1-2H3,(H,20,22)(H,21,25)(H,23,24)
IUPAC Name
4,5-dimethyl-N-{2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazole-3-carboxamide
SMILES
CC1=C(C)C(=NN1)C(=O)NC1=CN=C2NC(=CC2=C1)C1=CC=CC=C1

References

General References
Not Available
ChemSpider
115007996
BindingDB
392363
ChEMBL
CHEMBL5095229
PDBe Ligand
WEJ
PDB Entries
7khk

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentAdvanced Gastrointestinal Stromal Tumor (GIST) / Metastatic Cancer1
2Not Yet RecruitingTreatmentGastrointestinal Stromal Tumor (GIST)1
2RecruitingTreatmentAdvanced Systemic Mastocytosis (AdvSM) / Aggressive Systemic Mastocytosis / Mast Cell Leukemia (MCL) / SM With an Associated Hematologic Neoplasm (SM-AHN)1
2RecruitingTreatmentMastocytosis, Indolent / SSM / Systemic Mastocytosis / Urticaria Pigmentosa1
1, 2CompletedTreatmentGastrointestinal Stromal Tumor (GIST)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP3.28Chemaxon
pKa (Strongest Acidic)12.85Chemaxon
pKa (Strongest Basic)2.55Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area86.46 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity98.99 m3·mol-1Chemaxon
Polarizability37.36 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at September 08, 2023 18:49 / Updated at September 12, 2023 18:33