Systemic Mastocytosis

Also known as: Mastocytosis, Systemic / Malignant mastocytosis

DrugDrug NameDrug Description
DB00501CimetidineA histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. [PubChem]
DB06595MidostaurinMidostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108]. It was approved on April 28, 2017 and has shown to increase the overall survival rate in patients with AML as an adjunct therapy along with chemotherapeutic agents.
DB00338OmeprazoleA highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell.
DB00863RanitidineA non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. [PubChem]
DrugDrug NameTargetType
DB00501CimetidineHistamine H2 receptortarget
DB00501CimetidineCytochrome P450 1A2enzyme
DB00501CimetidineCytochrome P450 2D6enzyme
DB00501CimetidineCytochrome P450 2C19enzyme
DB00501CimetidineCytochrome P450 3A4enzyme
DB00501CimetidineCytochrome P450 3A5enzyme
DB00501CimetidineCytochrome P450 3A7enzyme
DB00501CimetidineMultidrug resistance protein 1transporter
DB00501CimetidineSolute carrier family 22 member 2transporter
DB00501CimetidineSolute carrier family 22 member 1transporter
DB00501CimetidineSolute carrier family 22 member 3transporter
DB00501CimetidineSolute carrier family 22 member 5transporter
DB00501CimetidineBile salt export pumptransporter
DB00501CimetidineSolute carrier family 22 member 6transporter
DB00501CimetidineSolute carrier family 22 member 8transporter
DB00501CimetidineMultidrug and toxin extrusion protein 1transporter
DB00501CimetidineSolute carrier family 22 member 4transporter
DB00501CimetidineSolute carrier family 22 member 11transporter
DB00501CimetidineSolute carrier family 22 member 7transporter
DB00501CimetidineCytochrome P450 11B1, mitochondrialenzyme
DB00501CimetidineCytochrome P450 2C8enzyme
DB00501CimetidineCytochrome P450 2C9enzyme
DB00501CimetidineCytochrome P450 2E1enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB06595MidostaurinProtein kinase C alpha typetarget
DB06595MidostaurinVascular endothelial growth factor receptor 2target
DB06595MidostaurinMast/stem cell growth factor receptor Kittarget
DB06595MidostaurinPlatelet-derived growth factor receptor alphatarget
DB06595MidostaurinPlatelet-derived growth factor receptor betatarget
DB06595MidostaurinReceptor-type tyrosine-protein kinase FLT3target
DB06595MidostaurinCytochrome p450 3A subfamilyenzyme
DB06595MidostaurinCytochrome P450 1A2enzyme
DB06595MidostaurinCytochrome P450 2B6enzyme
DB06595MidostaurinCytochrome P450 2C8enzyme
DB06595MidostaurinCytochrome P450 2C9enzyme
DB06595MidostaurinCytochrome P450 2C19enzyme
DB06595MidostaurinCytochrome P450 2D6enzyme
DB06595MidostaurinCytochrome P450 2E1enzyme
DB06595MidostaurinCytochrome P450 3A4enzyme
DB06595MidostaurinCytochrome P450 3A5enzyme
DB06595MidostaurinCytochrome P450 3A7enzyme
DB06595MidostaurinCytochrome P450 3A43enzyme
DB00338OmeprazolePotassium-transporting ATPase alpha chain 1target
DB00338OmeprazoleCytochrome P450 2C19enzyme
DB00338OmeprazoleCytochrome P450 3A4enzyme
DB00338OmeprazoleCytochrome P450 2C9enzyme
DB00338OmeprazoleCytochrome P450 1A2enzyme
DB00338OmeprazoleCanalicular multispecific organic anion transporter 2transporter
DB00338OmeprazoleMultidrug resistance protein 1transporter
DB00338OmeprazoleATP-binding cassette sub-family G member 2transporter
DB00338OmeprazoleCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00338OmeprazoleCytochrome P450 1A1enzyme
DB00338OmeprazoleCytochrome P450 1B1enzyme
DB00338OmeprazoleCytochrome P450 2C18enzyme
DB00338OmeprazoleCytochrome P450 2C8enzyme
DB00338OmeprazoleCytochrome P450 2D6enzyme
DB00338OmeprazoleAryl hydrocarbon receptortarget
DB00863RanitidineHistamine H2 receptortarget
DB00863RanitidineCytochrome P450 1A2enzyme
DB00863RanitidineCytochrome P450 2C19enzyme
DB00863RanitidineCytochrome P450 2D6enzyme
DB00863RanitidineSolute carrier family 22 member 1transporter
DB00863RanitidineMultidrug resistance protein 1transporter
DB00863RanitidineSolute carrier family 22 member 8transporter
DB00863RanitidineCytochrome P450 3A4enzyme
DB00863RanitidineCytochrome P450 3A5enzyme
DB00863RanitidineAcetylcholinesterasetarget
DB00863RanitidineCholinesterasetarget
DrugDrug NamePhaseStatusCount
DB04868Nilotinib1 / 2Completed1
DB08870Brentuximab vedotin2Recruiting1
DB01254Dasatinib2Unknown Status1
DB00004Denileukin diftitox2Completed1
DB01590Everolimus2Completed1
DB09053Ibrutinib2Terminated1
DB00619Imatinib2Completed1
DB12191Obatoclax2Terminated1
DB00242Cladribine2 / 3Recruiting1
DB00619Imatinib4Completed1