Occasional Constipation

Also known as: Constipation / Constipation, unspecified / Constipation (& symptom)

DrugDrug NameDrug Description
DB09020BisacodylBisacodyl is an organic stimulant laxative that acts directly on the colon to promote bowel movement. Bisacodyl is prescribed for constipation, neurogenic bowel dysfunction, and bowel preparation before medical examinations.
DB11089DocusateDocusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation[A32201]. Docusate acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass [L1801]. Docusate can be orally or rectally administered. Docusate is on the World Health Organization's List of Essential Medicines[L5915]. However the effectiveness of docusate in treating constipation remains unclear, as several studies report docusate to be no more effective than placebo for increasing the frequency of stool or stool softening [A32200,A32202,A176987]. Recently there has been pressure to stop prescribing docusate as it has been identified as an ineffective medicine[A176972,A176987,L5912]. Additionally, it does not appear to lessen symptoms associated with constipation such as abdominal cramps. Still docusate is available in over-the-counter products as a common laxative.
DB09462GlycerinA trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
DB00581LactuloseLactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929[A178081], investigations regarding its possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and its first clinical use for treating PSE was not until 1966.[L6202] Nevertheless, although lactulose received formal FDA approval in 1977 and has since become a readily available generic and brand-name non-prescription medication listed on the World Health Organization's List of Essential Medicines as one of the most effective and safe medicines employed in a health system[L6205], data regarding its optimal place in therapy is often ambiguous.[L6202] Especially considering the use of lactulose as a laxative is typically only considered after lifestyle and dietary modifications fail and the fact that lactulose therapy cannot be ethically withheld from patients diagnosed with PSE in a placebo study, the substance may just be one of many options available for treating constipation and its efficacy in managing PSE may never be formally confirmed or refuted via clinical investigation.[L6202]
DB01046LubiprostoneLubiprostone is a medication used in the management of idiopathic chronic constipation. A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. Activation of these channels promotes the secretion of a chloride-rich fluid that soften the stool, increase gastrointestinal motility, and induce spontaneous bowel movements (SBM).
DB09104Magnesium hydroxideMagnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used commercially as a fire retardant. It can also be used topically as a deodorant or for the relief of canker sores (aphthous ulcers).
DB00653Magnesium sulfateA small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
DB11228MethylcelluloseMethyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3, however more typical values are 1.3 2.6. Methyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. It is available under a variety of trade names as a treatment for constipation. Like cellulose, it is not digestible, not toxic, and not allergenic
DB09287Polyethylene glycolPolyethylene glycol is a polyether compound used for many purposes ranging from industrial manufacturing processes to medicine. PEG is the basis of a number of laxatives (e.g., macrogol-containing products, such as Movicol and polyethylene glycol 3350, or SoftLax, MiraLAX,ClearLAX, Osmolax or GlycoLax). Irrigation of the bowel with polyethylene glycol and electrolytes is included in bowel preparation therapy, normally indicated before a colonoscopy to ensure adequate visualization of the bowel. Therapeutic classification is as an Osmotic Laxative that works by drawing water into the lumen of the intestinal tract. Shown to decrease consistency and increase weight of stool in constipated patients at low doses.
DB00545PyridostigmineA cholinesterase inhibitor with a slightly longer duration of action than neostigmine. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants.
DB11365SennosidesSennosides (also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label][L771] and empty the large intestine before surgery. The medication is taken by mouth or via the rectum[FDA Label]. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth[FDA Label]. It is a weaker laxative than bisacodyl or castor oil[A177092]. Sennoside A, one of the sennosides present in the laxative medication, has recently proven effective in inhibiting the ribonuclease H (RNase H) activity of human immunodeficiency virus (HIV) reverse transcriptase [A19231].
DB13157Sodium lauryl sulfoacetateSodium lauryl sulfoacetate is a wetting agent and surfactant used in enema-type laxative products.
DB14503Sodium phosphate, monobasic, unspecified formNot Available
DB01638SorbitolA polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.
DrugDrug NameTargetType
DB09462GlycerinHematopoietic prostaglandin D synthasetarget
DB09462GlycerinEndoglucanase Gtarget
DB09462GlycerinGlutathione S-transferase Ptarget
DB09462GlycerinGroup IIE secretory phospholipase A2target
DB09462GlycerinInositol-3-phosphate synthase 1target
DB09462GlycerinC4-dicarboxylate transport transcriptional regulatory protein DctDtarget
DB09462GlycerinAlcohol dehydrogenase 1Btarget
DB09462GlycerinInositol 1,4,5-trisphosphate receptor type 1target
DB09462GlycerinGlycodelintarget
DB09462GlycerinAlpha-N-acetylgalactosaminidasetarget
DB09462GlycerinCytochrome c4target
DB09462GlycerinBacterioferritintarget
DB09462GlycerinTGF-beta receptor type-2target
DB09462GlycerinArgininosuccinate synthasetarget
DB09462GlycerinEnolasetarget
DB09462GlycerinADP-ribosylation factor 1target
DB09462GlycerinMultidrug resistance protein MexAtarget
DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
DB09462GlycerinHistidinol dehydrogenasetarget
DB09462GlycerinDNA mismatch repair protein MutLtarget
DB09462GlycerinGlycerol uptake facilitator proteintarget
DB09462GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
DB09462GlycerinA/G-specific adenine glycosylasetarget
DB09462GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
DB09462GlycerinCytochrome P450 2E1enzyme
DB09462GlycerinRetinal dehydrogenase 1enzyme
DB09462GlycerinPeroxisome proliferator-activated receptor deltatarget
DB00581LactuloseEvolved beta-galactosidase subunit alphatarget
DB01046LubiprostoneChloride channel protein 2target
DB01046LubiprostoneCarbonyl reductase [NADPH] 1enzyme
DB00653Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
DB00653Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00545PyridostigmineAcetylcholinesterasetarget
DB00545PyridostigmineCytochrome P450 3A4enzyme
DB00545PyridostigmineCholinesterasetarget
DB00545PyridostigmineSerum albumintarget
DB11365SennosidesReverse transcriptase/RNaseHtarget
DB11365SennosidesAquaporin-3target
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transporter 1transporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transporter 2transporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Atransporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Btransporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Ctransporter
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolMalate synthase Gtarget
DrugDrug NamePhaseStatusCount
DB08890Linaclotide1Recruiting1
DB12583Maltodextrin1Completed1
DB00218Moxifloxacin1Completed1
DB06480Prucalopride1Completed5
DB00545Pyridostigmine1 / 2Completed1
DB00346Alfuzosin2Completed1
DB06274Alvimopan2Completed1
DB06274Alvimopan2Terminated1
DB12464Bevenopran2Completed1
DB09020Bisacodyl2Completed1
DB09020Bisacodyl2Terminated1
DB11089Docusate2Terminated1
DB13112Dolcanatide2Completed1
DB12486Elobixibat2Completed1
DB00898Ethanol2Completed1
DB09462Glycerin2Completed1
DB04924Itopride2Completed1
DB00581Lactulose2Completed1
DB06800Methylnaltrexone2Completed2
DB09049Naloxegol2Recruiting1
DB01183Naloxone2Completed2
DB00497Oxycodone2Completed1
DB09287Polyethylene glycol2Completed1
DB06480Prucalopride2Completed5
DB12798Relenopride2Completed1
DB11089Docusate2 / 3Completed1
DB01046Lubiprostone2 / 3Completed1
DB09049Naloxegol2 / 3Recruiting1
DB11365Sennosides2 / 3Completed1
DB01079Tegaserod2 / 3Terminated1
DB06274Alvimopan3Completed3
DB09020Bisacodyl3Completed2
DB01151Desipramine3Completed1
DB11089Docusate3Completed1
DB09462Glycerin3Completed1
DB10538Lemon3Completed1
DB08890Linaclotide3Completed1
DB01046Lubiprostone3Completed4
DB06800Methylnaltrexone3Completed2
DB11675Mosapride3Completed1
DB09049Naloxegol3Not Yet Recruiting1
DB11158Pectin3Completed1
DB09268Picosulfuric acid3Completed1
DB09287Polyethylene glycol3Completed1
DB09287Polyethylene glycol3Not Yet Recruiting1
DB09287Polyethylene glycol3Withdrawn1
DB11077Polyethylene glycol 4003Not Yet Recruiting1
DB00761Potassium chloride3Completed1
DB06480Prucalopride3Completed8
DB11365Sennosides3Completed2
DB09512Simethicone3Completed1
DB01390Sodium bicarbonate3Completed1
DB09153Sodium chloride3Completed1
DB02772Sucrose3Completed1
DB01079Tegaserod3Completed1
DB00316Acetaminophen4Completed1
DB00316Acetaminophen4Recruiting1
DB06274Alvimopan4Recruiting1
DB00181Baclofen4Terminated1
DB09020Bisacodyl4Completed2
DB09020Bisacodyl4Recruiting1
DB00297Bupivacaine4Recruiting1
DB00482Celecoxib4Completed1
DB01234Dexamethasone4Completed1
DB11089Docusate4Completed1
DB11089Docusate4Recruiting2
DB11089Docusate4Terminated1
DB00668Epinephrine4Terminated1
DB00187Esmolol4Terminated1
DB00813Fentanyl4Recruiting1
DB00996Gabapentin4Completed1
DB00996Gabapentin4Recruiting1
DB00956Hydrocodone4Completed1
DB00956Hydrocodone4Recruiting1
DB00327Hydromorphone4Completed1
DB00327Hydromorphone4Recruiting1
DB01050Ibuprofen4Completed1
DB01221Ketamine4Recruiting1
DB00465Ketorolac4Recruiting1
DB00581Lactulose4Completed2
DB00581Lactulose4Recruiting2
DB00281Lidocaine4Recruiting1
DB00281Lidocaine4Terminated1
DB01046Lubiprostone4Completed4
DB01046Lubiprostone4Unknown Status1
DB00333Methadone4Recruiting1
DB06800Methylnaltrexone4Completed1
DB06800Methylnaltrexone4Recruiting1
DB00295Morphine4Recruiting1
DB09049Naloxegol4Recruiting1
DB09049Naloxegol4Terminated2
DB01183Naloxone4Terminated1
DB00104Octreotide4Completed1
DB00904Ondansetron4Completed1
DB01173Orphenadrine4Recruiting1
DB00497Oxycodone4Completed2
DB00497Oxycodone4Recruiting1
DB09287Polyethylene glycol4Completed6
DB09287Polyethylene glycol4Recruiting2
DB09287Polyethylene glycol4Terminated1
DB09287Polyethylene glycol4Unknown Status1
DB11077Polyethylene glycol 4004Completed1
DB11077Polyethylene glycol 4004Recruiting1
DB06480Prucalopride4Completed2
DB11365Sennosides4Recruiting2
DB11365Sennosides4Terminated1
DB01638Sorbitol4Completed1
DB01079Tegaserod4Completed1
DB00193Tramadol4Recruiting1
DB00829DiazepamNot AvailableCompleted1
DB11089DocusateNot AvailableCompleted1
DB00581LactuloseNot AvailableUnknown Status2
DB01046LubiprostoneNot AvailableCompleted3
DB01046LubiprostoneNot AvailableTerminated1
DB06800MethylnaltrexoneNot AvailableTerminated1
DB11057Mineral oilNot AvailableTerminated1
DB09287Polyethylene glycolNot AvailableCompleted1
DB09287Polyethylene glycolNot AvailableTerminated1
DB06480PrucaloprideNot AvailableCompleted1
DB06480PrucaloprideNot AvailableSuspended1
DB11365SennosidesNot AvailableCompleted2
DB01079TegaserodNot AvailableTerminated1
DB01079TegaserodNot AvailableUnknown Status1