ATP synthase subunit g, mitochondrial

Details

Name
ATP synthase subunit g, mitochondrial
Synonyms
  • ATPase subunit g
Gene Name
ATP5L
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049757|ATP synthase subunit g, mitochondrial
MAQFVRNLVEKTPALVNAAVTYSKPRLATFWYYAKVELVPPTPAEIPRAIQSLKKIVNSA
QTGSFKQLTVKEAVLNGLVATEVLMWFYVGEIIGKRGIIGYDV
Number of residues
103
Molecular Weight
11428.4
Theoretical pI
Not Available
GO Classification
Functions
hydrogen ion transmembrane transporter activity / transmembrane transporter activity
Processes
ATP biosynthetic process / ATP hydrolysis coupled cation transmembrane transport / ATP synthesis coupled proton transport / mitochondrial ATP synthesis coupled proton transport
Components
extracellular exosome / mitochondrial inner membrane / mitochondrial proton-transporting ATP synthase complex / mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) / mitochondrion
General Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Specific Function
Hydrogen ion transmembrane transporter activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion
Gene sequence
>lcl|BSEQ0049758|ATP synthase subunit g, mitochondrial (ATP5L)
ATGGCCCAATTTGTCCGTAACCTTGTGGAGAAGACCCCGGCGCTGGTGAACGCTGCTGTG
ACTTACTCGAAGCCTCGATTGGCCACATTTTGGTACTACGCCAAGGTTGAGCTGGTTCCT
CCCACCCCTGCTGAGATCCCTAGAGCTATTCAGAGCCTGAAAAAAATAGTCAATAGTGCT
CAGACTGGTAGCTTCAAACAGCTCACAGTTAAGGAAGCTGTGCTGAATGGTTTGGTGGCC
ACTGAGGTGTTGATGTGGTTTTATGTCGGAGAGATTATAGGCAAGCGGGGCATCATTGGC
TATGATGTTTGA
Chromosome Location
11
Locus
11q23.3
External Identifiers
ResourceLink
UniProtKB IDO75964
UniProtKB Entry NameATP5L_HUMAN
HGNC IDHGNC:14247
General References
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  5. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12695Phenethyl IsothiocyanateinvestigationalunknownDetails
DB11638Artenimolexperimental, investigationalunknownligandDetails